Search Results (8)

Sin Nombre virus (SNV) is the main causative agent of hantavirus cardiopulmonary syndrome (HCPS) in North America. SNV is transmitted via environmental biological aerosols (bioaerosols) produced by infected deer mice (Peromyscus maniculatus). It is similar to other viruses that have environmental transmission routes rather than a person-to-person transmission route, such as avian influenza (e.g., H5N1) and Lassa fever. Despite the lack of person-to-person transmission, these viruses cause a significant public health and economic burden. However, due to the lack of targeted pharmaceutical preventatives and therapeutics, the recommended approach to prevent SNV infections is to avoid locations that have a combination of low foot traffic, receive minimal natural sunlight, and where P. maniculatus may be found nesting. Consequently, gaining insight into the SNV bioaerosol decay profile is fundamental to the prevention of SNV infections. The Biological Aerosol Reaction Chamber (Bio-ARC) is a flow-through system designed to rapidly expose bioaerosols to environmental conditions (ozone, simulated solar radiation (SSR), humidity, and other gas phase species at stable temperatures) and determine the sensitivity of those particles to simulated ambient conditions. Using this system, we examined the bioaerosol stability of SNV. The virus was found to be susceptible to both simulated solar radiation and ozone under the tested conditions. Comparisons of decay between the virus aerosolized in residual media and in a mouse bedding matrix showed similar results. This study indicates that SNV aerosol particles are susceptible to inactivation by solar radiation and ozone, both of which could be implemented as effective control measures to prevent disease in locations where SNV is endemic. Full article

Xizang boasts a vast and geographically complex landscape with an average elevation surpassing 4000 m. Understanding the spatiotemporal distribution of surface solar radiation is indispensable for simulating surface processes, studying climate change, and designing photovoltaic power generation and solar heating systems. A multi-dimensional, long-term, spatial, and temporal investigation of solar radiation in Xizang was conducted using three unique datasets, including the difference in surface solar radiation (SSR) between high-resolution satellite and ground station data, the annual and monthly distribution of SSR, and the interannual–monthly–daily variation and the coefficient of hourly variability. Combined with high-resolution elevation data, a strong linear correlation was shown between the radiation and the elevation below 4000 m. Furthermore, analysis reveals greater differences in data between east and west compared to the center, as well as between summer and winter seasons. SSR levels vary in steps, reaching the highest from Ngari to Shigatse and the lowest in a U-shaped area formed by southeastern Shannan and southern Nyingchi. In June, high monthly SSR coverage was the highest of the year. Since 1960, the annual mean SSR has generally exhibited a declining trend, displaying distinctive trends across various seasons and datasets. Owing to intricate meteorological factors, some regions exhibited double peaks in monthly SSR. Finally, we have introduced a solar resource assessment standard, along with a multidimensional evaluation of the resources, and categorized all townships. We offer a thorough analysis of Xizang’s solar radiation to provide a comprehensive understanding, which will help to prioritize recommendations for PV construction in Xizang. Full article

Solar radiation is the main risk factor for cSCC development, yet it is unclear whether the progression of cSCC is promoted by solar radiation in the same way as initial tumorigenesis. Additionally, the role of miRNAs, which exert crucial functions in various tumors, needs to be further elucidated in the context of cSCC progression and connection to solar radiation. Thus, we chronically irradiated five cSCC cell lines (Met-1, Met-4, SCC-12, SCC-13, SCL-II) with a custom-built irradiation device mimicking the solar spectrum (UVB, UVA, visible light (VIS), and near-infrared (IRA)). Subsequently, miRNA expression of 51 cancer-associated miRNAs was scrutinized using a flow cytometric multiplex quantification assay (FirePlex^®, Abcam). In total, nine miRNAs were differentially expressed in cell-type-specific as well as universal manners. miR-205-5p was the only miRNA downregulated after SSR-irradiation in agreement with previously gathered data in tissue samples. However, inhibition of miR-205-5p with an antagomir did not affect cell cycle, cell growth, apoptosis, or migration in vitro despite transient upregulation of oncogenic target genes after miR-205-5p knockdown. These results render miR-205-5p an unlikely intracellular effector in cSCC progression. Thus, effects on intercellular communication in cSCC or the simultaneous examination of complementary miRNA sets should be investigated. Full article

Solar radiation can cause damage to the skin, leading to various adverse effects such as sunburn, reactive oxygen species production, inflammation, DNA damage, and photoaging. To study the potential of photoprotective agents, full-thickness skin models are increasingly being used as in vitro tools. One promising approach to photoprotection involves targeting the redox-sensitive transcription factor Nrf2, which is responsible for regulating various cellular defense mechanisms, including the antioxidant response, inflammatory signaling, and DNA repair. Obacunone, a natural triterpenoid, has been identified as a potent Nrf2 agonist. The present study aims to evaluate the relevance of full-thickness (FT) skin models in photoprotection studies and to explore the potential photoprotective effects of obacunone on those models and in human keratinocytes. Phenion^® full-thickness skin models and keratinocytes were incubated with increasing concentrations of obacunone and irradiated with solar-simulated radiation (SSR). Various photodamage markers were evaluated, including histological integrity, oxidative stress, apoptosis, inflammation, photoaging-related dermal markers, and photocarcinogenesis markers. Increasing doses of SSR were found to modulate various biomarkers related to sun damage in the FT skin models. However, obacunone attenuated cytotoxicity, inflammation, oxidative stress, sunburn reaction, photoaging, and photocarcinogenesis in both keratinocytes and full thickness skin models exposed to SSR. These results suggest that obacunone may have potential as a photoprotective agent for preventing the harmful effects of solar radiation on the skin. Full article

In this work, the effect that two basic air quality indexes, aerosols and tropospheric NO₂, exert on surface solar radiation (SSR) is studied, along with the effect of liquid and ice clouds over 16 locations in Greece, in the heart of the Eastern Mediterranean. State-of-the-art satellite-based observations and climatological data for the 15-year period 2005–2019, and a radiative transfer system based on a modified version of the Santa Barbara DISORT Atmospheric Radiative Transfer (SBDART) model are used. Our SSR simulations are in good agreement with ground observations and two satellite products. It is shown that liquid clouds dominate, with an annual radiative effect (RE) of −36 W/m², with ice clouds (−19 W/m²) and aerosols (−13 W/m²) following. The radiative effect of tropospheric NO₂ is smaller by two orders of magnitude (−0.074 W/m²). Under clear skies, RE_aer is about 3–4 times larger than for liquid and ice cloud-covered skies, while RE_NO2 doubles. The radiative effect of all the parameters exhibits a distinct seasonal cycle. An increase in SSR is observed for the period 2005–2019 (positive trends ranging from 0.01 to 0.52 W/m²/year), which is mostly related to a decrease in the aerosol optical depth and the liquid cloud fraction. Full article

The annual mean surface solar radiation (SSR) trends under all-sky, clear-sky, all-sky-no-aerosol, and clear-sky-no-aerosol conditions as well as their possible causes are analyzed during 2005–2018 across China based on different satellite-retrieved datasets to determine the major drivers of the trends. The results confirm clouds and aerosols as the major contributors to such all-sky SSR trends over China but play differing roles over sub-regions. Aerosol variations during this period result in a widespread brightening, while cloud effects show opposite trends from south to north. Moreover, aerosols contribute more to the increasing all-sky SSR trends over northern China, while clouds dominate the SSR decline over southern China. A radiative transfer model is used to explore the relative contributions of cloud cover from different cloud types to the all-types-of-cloud-cover-induced (ACC-induced) SSR trends during this period in four typical sub-regions over China. The simulations point out that the decreases in low-cloud-cover (LCC) over the North China Plain are the largest positive contributor of all cloud types to the marked annual and seasonal ACC-induced SSR increases, and the positive contributions from both high-cloud-cover (HCC) and LCC declines in summer and winter greatly contribute to the ACC-induced SSR increases over East China. The contributions from medium-low-cloud-cover (mid-LCC) and LCC variations dominate the ACC-caused SSR trends over southwestern and South China all year round, except for the larger HCC contribution in summer. Full article

Nowadays, the industry is quite commonly using nanoparticles of titanium dioxide (nTiO₂) especially in sunscreens, due to its higher reflective index in comparison to micron size TiO₂. Its high demand causes its widespread environmental occurrence, thus damaging the environment. The aquatic ecosystems are the most vulnerable to contamination by nTiO₂. Like other engineered nanoparticles, nTiO₂ has demonstrated generation of reactive oxygen species (ROS) and reactive halogen species (RHS) in the aquatic environment under UV radiation. This study investigated the toxicity of nTiO₂ towards two aquatic indicator organisms, one from freshwater (Daphnia magna) and the other from seawater (Artemia sp.), under simulated solar radiation (SSR). Daphnia magna and Artemia sp. were co-exposed in 16 h SSR and 8 h darkness cycles to different concentrations of nTiO₂. The estimated EC50 at 48 h for D. magna was 3.16 mg nTiO₂/L, whereas for A. sp. no toxic effects were observed. When we exposed these two organisms simultaneously to 48 h of prolonged SSR using higher nTiO₂ concentrations, EC50 values of 7.60 mg/L and 5.59 mg/L nTiO₂ for D. magna and A. sp., respectively, were obtained. A complementary bioassay was carried out with A. sp., by exposing this organism to a mixture of nTiO₂ and organic UV filters (benzophenone 3 (oxybenzone, BP3), octocrylene (OC), and ethyl 4-aminobenzoate (EtPABA)), and then exposed to SSR. The results suggested that nTiO₂ could potentially have negative impacts on these organisms, also this work outlines the different characteristics and interactions that may contribute to the mechanisms of environmental (in salted and freshwater) phototoxicity of nTiO₂ and UV radiation, besides their interaction with organic compounds. Full article

The distribution and trend of clear-sky surface solar radiation (SSR) and the quantitative effects of aerosol and water vapor are investigated in northern China during 2001–2015 using radiation simulations and satellite observations. Clear-sky SSR in northern China is high in summer and low in winter, which is dominated by astronomical factors and strongly modulated by the seasonal variations of radiative effects of aerosol (ARE) and water vapor (WVRE). The larger variation of WVRE than ARE indicates that water vapor plays a more important role in moderating the seasonal variation of clear-sky SSR. Clear-sky SSR shows an overall decreasing trend of –0.12 W/m² per year, with decrease more strongly than –0.60 W/m² per year in west-central Shandong and increase (about 0.40 W/m²) in south-central Inner Mongolia. The consistency of spatial distribution and high correlation between clear-sky SSR and ARE trend indicate that the clear-sky SSR trend is mainly determined by aerosol variation. Dust mass concentration decreases about 16% in south-central Inner Mongolia from 2001 to 2015, resulting in the increase in clear-sky SSR. In contrast, sulfate aerosol increases about 92% in west-central Shandong, leading to the decreasing trend of clear-sky SSR. Full article