Background/Objectives: To review the dimensions of the round window region (round window niche, bony structures surrounding the niche, and the membrane itself). Methods: Medline, EMBASE, Cochrane Library, and Google Scholar databases were searched by...
Surgery for cochlear implant is a traumatic procedure, with inflammatory responses leading to immediate and delayed intracochlear changes, resulting in newly formed fibrous and bony tissue. This newly formed tissue is thought to affect speech percept...
Sonoporation using microbubble-assisted ultrasound increases the permeability of a biological barrier to therapeutic molecules. Application of this method to the round window membrane could improve the delivery of therapeutics to the inner ear. The a...
The sound stimulus received by the pinna is transmitted to the oval window of the inner ear via the outer ear and middle ear. Assuming that the perilymph in the scala vestibuli and scala tympani is compressible, we report that the sound wave generate...
Background and Objectives: We aimed to identify prognostic computed tomography (CT) findings in retrofenestral otosclerosis, with particular attention paid to the role of otosclerotic lesion area in predicting post-stapedotomy outcome. Materials and...
Round window (RW) stimulation is a new application of middle ear implants for treating hearing loss, especially for those with middle ear disease. However, most reports on it are based on the use of the floating mass transducer (FMT), which was not o...
Introduction: The round window membrane (RWM) acts as a pressure-relieving membrane for incompressible cochlear fluid. The reinforcement of the RWM has been used as a surgical intervention for the treatment of superior semicircular canal dehiscence a...
In the clinical setting, the pathophysiology of sensorineural hearing loss is poorly defined and there are currently no diagnostic tests available to differentiate between subtypes. This often leaves patients with generalized treatment options such a...
Modern therapy of inner ear disorders is increasingly shifting to local drug delivery using a growing number of pharmaceuticals. Access to the inner ear is usually made via the round window membrane (RWM), located in the bony round window niche (RWN)...
Hearing loss and balance disorders are highly common disorders, and the development of effective oto-therapeutics remains an area of intense research. Drug development and screening in the hearing research field heavily rely on the use of preclinical...
This report describes the design of a new piezoelectric transducer for round window (RW)-driven middle ear implants. The transducer consists of a piezoelectric element, gold-coated copper bellows, silicone elastomer (polydimethylsiloxane, PDMS), meta...
It is estimated that hearing loss currently affects more than 1.5 billion people, or approximately 20% of the global population; however, presently, there are no Food and Drug Administration-approved therapeutics or prophylactics for this condition....
The aim of this study was to develop and validate a semi-automated segmentation approach that identifies the round window niche (RWN) and round window membrane (RWM) for use in the development of patient individualized round window niche implants (RN...
Background: Preserving residual hearing after cochlear implant (CI) surgery remains a crucial challenge. The application of dexamethasone (DEX) has been proven to positively affect residual hearing. To deliver DEX in a localized and controlled way, a...
Delivery of substances into the inner ear via local routes is increasingly being used in clinical treatment. Studies have focused on methods to increase permeability through the round window membrane (RWM) and enhance drug diffusion into the inner ea...
Electrical stimulation with cochlear implants is able to significantly suppress the tinnitus sensations in 25–72% of implanted patients. Up to this point, no clear predictors for the effectiveness of tinnitus suppression with cochlear implants have b...
This study investigates the dynamic properties of the human middle ear and the energy transfer phenomena between the stapes footplate (SF) and the round window membrane (RWM) under sound stimulation. A series of laboratory tests were conducted, and a...
A novel approach for the long-term medical treatment of the inner ear is the diffusion of drugs through the round window membrane from a patient-individualized, drug-eluting implant, which is inserted in the middle ear. In this study, drug-loaded (10...
Background: Since the discovery of the perilymphatic fistula (PLF), the diagnosis and treatment remain controversial. If successfully recognized, the PLF is surgically repairable with an obliteration of the fistula site. Successful treatment has a ma...
Objectives: Precision medicine for inner ear disorders has seen significant advances in recent years. However, unreliable access to the inner ear has impeded diagnostics and therapeutic delivery. The purpose of this review is to describe the developm...
Processing of land surface temperature from long time series of AVHRR (Advanced Very High Resolution Radiometer) requires stable algorithms, which are well characterized in terms of accuracy, precision and sensitivity. This assessment presents a comp...
The round-arch solar greenhouse (RASG) is widely used in the alpine and high latitude areas of China for its excellent performance. Common high temperature and high humidity environments have adverse effects on plants. It is extremely important to ex...
The design and implementation of a novel piezoelectric-based actuator for an implantable middle-ear hearing aid is described in this paper. The proposed actuator has excellent low-frequency output characteristics, and can generate high output in a sp...
To overcome the inherent deficiencies of hearing aids, implantable middle ear hearing devices (IMEHDs) have emerged as a new treatment for hearing loss. However, clinical results show that the IMEHD performance varies with its transducer’s stim...
To alleviate the lower performance of Transmission Control Protocol (TCP) congestion control over complex network, especially the high latency and packet loss scenario, Google proposed the Bottleneck Bandwidth and Round-trip propagation time (BBR) co...
Introduction: Based on clinical practice guidelines, the application of corticosteroids as a first-line therapy is common. Although sudden sensorineural hearing loss (SSHL) etiology is primarily idiopathic, hearing loss can result from a perilymphati...
Background/Objectives: Adolescence is a sensitive developmental window shaped by both vulnerabilities and adaptive potential. From an evolutionary standpoint, mental health difficulties in this period may represent functional responses to environment...
This research investigates building energy consumption in the Fujian region of China, characterized by warm winters and hot summers. The study focuses on window configurations and their impact on heat exchange and solar gain management. Initially exa...
Improving the energy performance of buildings in the context of external climatic conditions and the requirements of indoor environments is a hot topic in the construction industry. It primarily concerns reducing the energy used for heating and cooli...
Model simulations for bioenergy harvest planning need to utilize equipment-capacity relationships for equipment operating under the high-yield conditions typical of a biomass crop. These performance assumptions have a direct bearing on the estimates...
This study systematically investigates the effects of manufacturing errors on the drag reduction performance of micro-grooves fabricated using roll-to-roll hot embossing technology. Numerical simulations were conducted to analyze the drag reduction c...
In general, uncertainties should preferably be determined following the principles laid down in ISO/IEC Guide 98-3, the Guide to the expression of uncertainty in measurement (GUM:1995). According to current knowledge, it seems impossible to formulate...
We developed a set of assessment tools for health professionals to evaluate the physical functions, mental functions, and social abilities of people with stroke (PWS) from 6 months to 3 years after stroke onset, to design a tailored “Rehabilita...
L-proline is directly loaded on the multi-wall carbon nanotubes (MWCNTs) with exceptionally high loading content of 67 wt.%. The obtained L-proline/MWCNTs catalyst is on par with the catalytic activity of free L-proline, even after 7 rounds of recycl...
Drone localization is essential for various purposes such as navigation, autonomous flight, and object tracking. However, this task is challenging when satellite signals are unavailable. This paper addresses database-free vision-only localization of...
This research work presents the use of the Quality by Design (QbD) concept for optimization of the spherical agglomeration crystallization method in the case of the active agent, ambroxol hydrochloride (AMB HCl). AMB HCl spherical crystals were formu...
There are many factors influencing the energy consumption of buildings in complex working conditions. In order to study the factors influencing the energy consumption of residential buildings with nearly zero energy in cold and arid regions of northw...
5 March 2023
Since the beginning of March 2022, a new round of COVID-19 outbreaks in Shanghai has led to a sharp increase in the number of infected people. It is important to identify possible pollutant transmission routes and predict potential infection risks fo...
The purpose of this study is to enhance the performance of Multistream Fast Transmission Control Protocol (TCP) keeping in view the recent web-based applications that are being deployed on long-range, high-speed, and high-bandwidth networks. To achie...
Background: Middle ear active implants, such as the Vibrant Soundbridge (VSB), offer an alternative to reconstructive surgery and other implantable hearing aid systems for patients with conductive, mixed, or sensorineural hearing loss. The primary ob...
Currently, the most widely used protocol for the transportation layer of computer networks for reliable transportation is the Transmission Control Protocol (TCP). However, TCP has some problems such as high handshake delay, head-of-line (HOL) blockin...
This paper examines reliable and energy-efficient transmission in low earth orbit (LEO) satellite communication systems. In particular, we analyze the link transmission characteristics of the LEO satellite to the ground user and model the channel as...
Hypoxic–Ischemic Encephalopathy (HIE) occurs in patients who experience a decreased flow of blood and oxygen to the brain, with the optimal window for effective treatment being within the first six hours of life. This puts a significant demand...
Along with the rapid urbanization and economic growth of China over the past decades, the thermal comfort needs of the people in this region have risen dramatically, and at the same time, promoting building energy efficiency is cited as part of the m...
Chemical labyrinthectomy using gentamicin is a popular method for treating intractable vertigo attacks in Meniere’s disease. However, the risk of hearing loss remains a major concern for clinicians. We investigated the effect of simultaneous de...
This article presents a trajectory design problem concerning the exploration of potentially hazardous near-Earth asteroids (PHAs) with reusable probes from cislunar space. A total of 20 probes, making round trips departing from and returning to a ser...
For smooth integration with middleboxes on the Internet, TCP (Transmission Control Protocol) is favorably considered as a transport-layer protocol for IoT (Internet of Things) networks. In constrained networks, TCP tends to perform well with a small...
This study examines how the combined design of the window-to-wall ratio (WWR) and glazing type affects thermal comfort and energy use in Qingdao, China, which has a temperate monsoon climate. A prototypical four-story office was modeled using TRNSYS...
Introduction: During cochlear implantation, electrode insertion can cause cochlear damage, inflammation, and apoptosis, which can affect the residual hearing. Nanoparticles are increasingly studied as a way to increase the availability of inner ear p...
In-process measurement of machining precision is of great importance to advanced manufacturing, which is an essential technology to realize compensation machining. In terms of cost-effectiveness and repeatability of computer vision, it has become a t...
of 3