Search Results (68)

Background/Objectives: Guillain–Barré syndrome (GBS) is a rare autoimmune peripheral neuropathy that affects both the myelin sheaths and axons of the peripheral nervous system. It is the leading cause of acute neuromuscular paralysis worldwide, with an annual incidence of less than two cases per 100,000 people. Although most patients recover, a small proportion do not regain mobility and even remain dependent on mechanical ventilation. In this study, we refer to the analysis of samples collected from GBS patients at different defined time points during hospital recovery and performed by a medical or research group. Methods: The conditions for whole blood collection, peripheral blood mononuclear cell isolation, and serum collection from GBS patients and volunteer donors are explained. Aliquots of these human samples have been used for red blood cell phenotyping, transcriptomic and proteomic analyses, and serum biochemical parameter studies. Results: The initial sporadic preservation of human samples from GBS patients and control volunteers enabled the creation of a biobank collection for current and future studies related to the diagnosis and treatment of GBS. Conclusions: In this article, we describe the laboratory procedures and the integration of a GBS biobank collection, local medical services, and academic institutions collaborating in its respective field. The report establishes the intra-disciplinary and inter-institutional network to conduct long-term longitudinal studies on GBS. Full article

Interdisciplinary teaching plays an important role in modern physics education by improving students’ understanding, problem-solving skills, and engagement through the integration of multiple disciplines. This study examines pre-service physics teachers’ perceptions of interdisciplinary teaching, focusing on their confidence in implementing interdisciplinary approaches, perceived benefits, and the challenges they expect. A Likert-scale survey was administered to 292 pre-service teachers from two universities in Kazakhstan. Findings indicate that students’ confidence in interdisciplinary teaching increases over time, while their recognition of its benefits remains consistently high across all academic years. However, barriers such as lack of training and feeling unprepared persist, even at the master’s level, indicating the need for structured interdisciplinary training. Institutional differences significantly impact students’ perceptions, with students from one university showing higher confidence levels than those from another, showing variations in curriculum and support systems. Gender differences in confidence were minimal. Additionally, perceptions of interdisciplinary teaching do not follow a linear trajectory, as students in their second and third years experienced a temporary decline in confidence before recovering in later years. Our findings indicate the need for structured interdisciplinary training in teacher education programs, institutional support to reduce disparities in confidence levels, targeted interventions during academic transitions, and ongoing professional development to address persistent barriers. Full article

The UI GreenMetric World University Ranking has become a widely adopted instrument for benchmarking institutional sustainability performance; nevertheless, empirically grounded evidence from universities in diverse regional contexts remains scarce. This study undertakes a rigorous appraisal of the extent to which Mahasarakham University (MSU) has institutionalized the United Nations Sustainable Development Goals (SDGs) within its pedagogical offerings, research portfolio, community outreach, and governance arrangements during the 2021–2024 strategic cycle. Employing a mixed-methods design and guided by the 2024 UI GreenMetric Education and Research indicators, this investigation analyzed institutional datasets pertaining to curriculum provision, ring-fenced research funding, 574 peer-reviewed sustainability publications, student-led community initiatives, and supporting governance mechanisms; the analysis was interpreted through a Plan–Do–Check–Act management lens. The number of sustainability-oriented academic programs expanded from 49 to 58. Student participation in community service activities strongly recovered following the COVID-19 pandemic, and MSU’s GreenMetric score increased from 7575 to 8475, thereby elevating the institution to the 100th position globally. These gains were facilitated by strategic SDG-aligned investment, cross-sector collaboration, and the consolidation of international partnerships anchored in Thailand’s Isaan region. The MSU case provides a transferable model for universities—particularly those operating in resource-constrained contexts—endeavoring to align institutional development with the SDGs and internationally recognized quality benchmarks. The findings substantiate the capacity of transformative education and applied research to engender enduring societal and environmental benefits. Full article

Environmental pollution has become a significant issue, and environmental protection within the realm of sports has garnered increasing attention from various sectors of the academic community. This study takes the public’s intention to purchase sports stadiums as the research object, introduces two mediating variables of green value perception and sense of accomplishment, builds a hypothetical model from the perspective of motivation protection theory, and explores the influence of perceived functional risk of green sports stadiums on consumption intention through SEM analysis based on the samples of the recovered questionnaires (N = 1073). The results are as follows: first, there is a negative influence between perceived functional risk and green sports stadium consumption intention, and the lower the perceived functional risk of green sports stadiums, the more consumers can promote their choice of green sports stadiums when they consume in stadiums; second, green value perception plays a mediating role in the relationship between perceived functional risk and green sports stadium services consumption intention; third, a sense of accomplishment plays a mediating role in the relationship between perceived functional risk and willingness to consume green sports stadium; fourth, green value perception and a sense of accomplishment play a chain mediating role between perceived functional risk and willingness to consume in the context of green sports stadiums. This study aims to contribute to the popularization and development of green sports stadiums in China and to provide green sports stadium builders and managers with more targeted and effective marketing strategies. Full article

Teachers with mental illness are vulnerable to work-related triggers that can lead to relapse, affecting their mental health and ability to recover, stay employed, and deliver quality education. This empirical study explored such triggers among public school teachers in Limpopo Province, South Africa. Using Bronfenbrenner’s Ecological Systems Theory, a qualitative phenomenological design was adopted. Semi-structured face-to-face interviews were conducted with 14 participants that were purposively selected across four hospitals. Data were audio-recorded, transcribed verbatim, and analyzed using Tesch’s eight-step open-coding method. Findings revealed being gossiped about by colleagues, excessive workload, limited leadership and parental support, classroom management challenges, high performance expectations without support, and inadequate teacher mental health policies in schools. These triggers can lead to frequent absenteeism and poor teaching outcomes. They will further increase the risk of medication resistance and long-term cognitive decline due to progressive structural brain damage as a result of multiple relapses. The study highlights the urgent need for multi-stakeholder collaboration, including clinicians, academic institutions, union representatives, and the Department of Basic Education, to co-develop effective, context-sensitive strategies to mitigate work-related triggers of mental illness relapse. These strategies are not only essential for enabling long-term workforce participation but also advancing sustainable mental health and well-being. Full article

This study simulates the spread of epidemics on university campuses using a multilayer temporal network model combined with the SEIR (Susceptible–Exposed–Infectious–Recovered) transmission model. The proposed approach explicitly captures the time-varying contact patterns across four distinct layers (Rest, Dining, Activity, and Academic) to reflect realistic student mobility driven by class schedules and spatial constraints. It evaluates the impact of various intervention measures on epidemic spreading, including subnetwork closure and zoned management. Our analysis reveals that the Academic and Activity layers emerge as high-risk transmission hubs due to their dynamic, high-density contact structures. Intervention measures exhibit layer-dependent efficacy: zoned management is highly effective in high-contact subnetworks, its impact on low-contact subnetworks remains limited. Consequently, intervention measures must be dynamically adjusted based on the characteristics of each subnetwork and the epidemic situations, with higher participation rates enhancing the effectiveness of these measures. This work advances methodological innovation in temporal network epidemiology by bridging structural dynamics with SEIR processes, offering actionable insights for campus-level pandemic preparedness. The findings underscore the necessity of layer-aware policies to optimize resource allocation in complex, time-dependent contact systems. Full article

Background: Immune checkpoint inhibitor therapy (ICI) has greatly changed cancer therapy in recent years. The main side effects are immune-related adverse events (irAEs) that can affect any organ system. With the widespread use of ICIs, even rare irAEs, like acute kidney injury due to ICI-induced nephritis (ICI-AKI), have become a more common complication. Methods: All ICI-treated patients who underwent a kidney biopsy for AKI at a single academic center between January 2020 and December 2023 were analyzed. Results: We identified twelve cases of biopsy-proven ICI-AKI. The median follow up was 11.5 months. All cases showed acute interstitial nephritis (AIN) on the biopsy. Melanoma was the most common cancer, and dual-checkpoint inhibition with Ipilimumab and Nivolumab was the most common regimen. Extrarenal irAEs were present in only 25% of cases. Two-thirds had concomitant medication with proton pump inhibitors (PPIs). Only four patients completely recovered their kidney function, and one patient remained on kidney replacement therapy. Conclusions: AIN is a common cause of AKI in ICI-treated cancer patients. Although they respond well to steroid treatment, full restitution of kidney function occurs in less than half of the subjects. As ICIs are increasingly used in cancer management, more research on the prevention and treatment of ICI-associated AKI is needed. Full article

Plastics are widely used in various industries because of their light weight, low cost, and high durability. The mass production and consumption of plastics have led to a rapid increase in plastic waste problem, necessitating the development of effective recycling technologies. The chemical recycling of plastics has emerged as a promising strategy to address these challenges, enabling the conversion of plastic waste into high-purity monomers or oils, even from contaminated or mixed plastic feedstock. This review focuses on the development of catalysts for the chemical recycling of plastics in South Korea, which has one of the highest per capita plastic consumption rates and both academic and industrial efforts in this field. We examine catalytic depolymerization processes for recovering monomers from polymers, such as polyethylene terephthalate (PET) and polycarbonate (PC), as well as catalytic pyrolysis processes for polyolefins, including polyethylene (PE), polypropylene (PP), and polystyrene (PS). By summarizing recent academic research and industrial initiatives in South Korea, this review highlights the strategic role of the country in advancing chemical recycling. Moreover, this review proposes future research directions including the development of reusable catalysts, energy-efficient recycling process, and strategies for recycling mixed or contaminated plastic waste. Full article

The COVID-19 pandemic presented an unprecedented challenge for the tourism industry, disrupting operations, reducing customer demand, and forcing businesses to adapt quickly to a new reality. This study explored the impact of COVID-19 on the tourism and hospitality industry and addresses a specific research gap: the limited application of structured theoretical frameworks—particularly the three-R stakeholder collaboration model—in examining recovery strategies. Prior studies have largely focused on individual tactics or short-term impacts, rather than a structured, stakeholder-driven, multi-phase recovery process. Employing a qualitative research design, this study used grounded theory to investigate how tourism service providers and key stakeholders navigated the challenges of the pandemic. Data were collected through semi-structured interviews with 20 participants, including tourism business owners, hotel and event managers, public sector employees, and academics. These insights offer a comprehensive, multi-perspective view of how the industry navigated the pandemic. Grounded theory was used to inductively develop a model of recovery behaviors, with data coded through open, axial, and selective stages using MAXQDA 2020 software. Findings revealed several key strategies—such as cost-cutting, digital transformation, and cultural adaptation—that enabled businesses to maintain operations during the pandemic and recover in its aftermath. Finally, refashioning business models through digital transformation, the diversification of services, and a shift to local markets helped tourism providers adapt to the changing environment and ensure long-term resilience. Full article

The ever-increasing importance of sustainable environmental remediation calls for academics’ contribution to satisfy such a need. The 3R’s criteria of recover, recycle and reuse is designed to sustain the waste stream to produce a valuable product. In this regard, the circular economy looks to deliver banana peel waste as a photocatalyst for pharmaceutical effluent oxidation, which we investigated in this study. Banana peel waste is treated thermally and chemically then augmented with magnetite nanoparticles and labeled as ACBP-Fe₃O₄. The mixture is characterized through Scanning Electron Microscopy (SEM) and the composition of the composite material is attained by energy dispersive X-ray spectroscopy (EDX), and then introduced as a Fenton catalyst. The notable oxidation of tetracycline (TC), evaluated by TC removal and chemical Oxygen Demand (COD) oxidation tenancy, is achieved. The effectiveness of the operational parameters is also assessed and the most influenced parameters are optimized through numerical optimization based on a Response Surface Methodology (RSM) tool. The effects of initial pH value, ACBP-Fe₃O₄ and H₂O₂ concentrations on the oxidation efficiency of the Tetracycline were optimized at pH 6.6 and 350 mg/L and 43 g/L for H₂O₂ and ACBP-Fe₃O₄, respectively. Thermodynamics and kinetics were also studied and the experimental and model data revealed the reaction is spontaneous and exothermic in nature and follows the first-order reaction kinetics. Also, the thermodynamic results the reaction proceeds at a low energy barrier of 34.33 kJ mol⁻¹. Such a system introduces the role of engineers and academics for a sustainable world without a waste stream. Full article

Background: Vaccines against COVID-19 target the spike protein. There is minimal information on longitudinal COVID-19 immune profiling in recovered versus naïve and vaccinated versus non-vaccinated healthcare workers (HCWs). Methods: This is a prospective longitudinal observational cohort of pediatric HCWs (pHCWs) conducted during 2020–2022 at an academic center, exploring the impact of COVID-19 vaccination on immunoglobulin G (IgG) antibody titers over time and cross-reactivity with other coronaviruses, including SARS-CoV-1, MERS-CoV, and seasonal coronaviruses (HCoV-HKU1 and HCoV-OC43). Results: A total of 642 pHCWs initially enrolled, and 337 participants had repeat IgG titers measured post-vaccine and post-booster. Most participants were female, median age range of 31–40 years. Anti-spike was higher in all vaccinated individuals versus non-vaccinated (p < 0.0001) and naïve versus infected (p < 0.0001). A single dose of vaccine was sufficient to attain maximum titers in recovered participants versus naïve who received both doses of vaccine. Anti-spike titers dropped significantly at 9 months after the primary series, whereas sustained anti-spike titers were observed at 9 months post-booster. Conclusions: All vaccinated pHCWs developed antibodies to spike. COVID-19 infection and/or vaccination yielded antibodies that cross-reacted to SARS-CoV-1, MERS-CoV, HCoV-HKU1, and HCoV-OC43. Anti-spike titers were more durable post-booster compared to the primary series. Longitudinal immune profiling of COVID-19 responses provides vital data to shape public health policies, optimize vaccine strategies, and strengthen pandemic preparedness. Full article

To fulfill the current circular economy concept, the academic and industrial communities are devoting significant efforts to plastic materials’ end-of-life. Unlike thermoplastics, which are easy to recover and re-valorize, recycling thermosets is still difficult and challenging. Conversely, because of their network structure, thermosetting polymer systems exhibit peculiar features that make these materials preferable for several applications where high mechanical properties, chemical inertness, and thermal stability, among others, are demanded. In this view, vitrimers have quite recently attracted the attention of the scientific community, as they can form dynamic covalent adaptive networks that provide the properties typical of thermosets while keeping the possibility of being processed (and, therefore, mechanically recycled) beyond a certain temperature. This review aims to provide an overview of vitrimers, elucidating their most recent advances and applications and posing some perspectives for the forthcoming years. Full article

The COVID-19 pandemic has profoundly impacted the global tourism industry, forcing tourism entrepreneurs to adapt and innovate in order to recover. This systematic review aims to identify scientific evidence on tourism entrepreneurship experiences in Latin America during the COVID-19 pandemic. Specifically, the review seeks to uncover key challenges faced by tourism entrepreneurs, the locations and types of tourism most affected, and to draw lessons from these experiences. The authors followed the PRISMA protocol, identifying 15 research studies on tourism entrepreneurship in Latin America. The review analyzed articles from seven key databases—Scopus, Web of Science, Scielo, EBSCO, Proquest, Gale Academic Onefile, and LA Referencia—focusing on studies that examined tourism entrepreneurship within the context of COVID-19. These studies employed diverse methodologies, including case studies, surveys, and data analysis. The results show tourism entrepreneurs in Latin America faced challenges like economic crises, business closures, and unemployment. They responded with biosecurity protocols, domestic tourism, and digital tools such as online platforms and QR codes. A shift toward sustainable models like ecotourism highlighted local development and conservation. The pandemic spurred innovation and resilience, with adaptability, digital transformation, and collaboration, driving recovery. Sustainable practices and authentic experiences are key to long-term success. Full article

Industry 4.0 presents an opportunity to gain a competitive advantage through productivity, flexibility, and speed. It also empowers the manufacturing sector to drive the sustainability revolution to achieve net zero carbon by reducing emissions in operations. In this paper, the aim is to demonstrate a practical implementation of a smart manufacturing application using a systematic approach based on conceptual six-gear smart factory roadmap with connectivity, integration and analytics stages to build a smart production management ecosystem using off-the-shelf technologies applied in precision manufacturing. Business benefits from the smart manufacturing application implementation are realized in terms of operational performance, economic benefits, and environmental sustainability over a period of three years (before and after smart manufacturing). The productivity improves as a result of the 47% improvement made to the machines’ utilization and the 53% reduction in the total downtime waste. Economic benefits are realized in terms of a cost saving of GBP 420 K that could cost the business and the returns of the financial investment made, which is recovered within a year. An environmental sustainability impact is realized by a reduction in the total greenhouse gas (GHG) emissions by 43%, mostly due to the reduction in the Scope 2 emissions in operations by 50%, which is significantly impacted by the reduction of energy consumption and better power consumption management. The significance of this work is the bridging of the gap between theory and practice by rapidly applying the six-gear smart factory roadmap to start, scale, and sustain the implementation of smart manufacturing applications in the manufacturing industry. This roadmap can serve as a strategic framework tool for smart manufacturing implementations. The technical architecture can serve as a guide for the practical implementation of smart manufacturing applications to reduce the complexity of development. This work also bridges the gap in academia and in industry by showcasing a real-world actual business benefits realized from smart manufacturing, as well as showcasing the practical implementations, limitations, and opportunities of smart manufacturing applications in the precision manufacturing industry, all of which reduce the internal barriers and challenges facing smart manufacturing and industry 4.0 adoption. The value realized in gaining a competitive advantage and driving environmental sustainability from smart manufacturing in this study can serve as a case study for academics and for industry business leaders, digital champions, and digital lighthouses to support value creation and to drive and accelerate smart manufacturing applications, digital transformation initiatives, and industry 4.0 adoption across the value chain. Full article

Over the past decade, there has been a growing recognition of the importance of indoor environmental quality (IEQ) in influencing occupant productivity. Researchers have studied various buildings, including offices, schools, hospitals, and residential settings, to understand the relationship between IEQ and productivity outcomes. Studies have taken a multifactorial approach, considering multiple aspects of IEQ. Evidence from the literature review suggests that the quality of the indoor environment is an essential factor that affects the productivity of building occupants, and it is one of the fundamental issues in the development of societies. This area of research requires the responsible participation of researchers at all levels, as there is significant scope to contribute to knowledge. Therefore, this study aims to conduct a bibliometric analysis of the published literature on indoor environmental quality and its impact on building occupant productivity through the scientific literature available from one of the largest and most famous academic databases, Scopus; the study was determined in 2011 to 2023. The search used differential thresholds for IEQ keywords affecting building occupant productivity. Three discrete queries were performed, resulting in approximately 3861 publications. These were filtered by reducing false positives and excluding publications irrelevant to the research topic. The final results were 72 publications. This study also used Excel and VOS viewer to analyse and create graphs and network visualisation maps to show the growth of publications and their types, active countries and institutions for recovered publications, international collaboration, author keywords, active journals, and citation analysis. This study can significantly advance our understanding of building occupant productivity and enhance quality of life and work. Evaluating the research outputs is essential for highlighting contributions to knowledge and global collaboration in this research area. The potential impact of this study is not just theoretical. It can shape the future of our built environments and the lives of those occupying them. Full article