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20 pages, 3182 KB  
Article
Application of Machine Learning Algorithms in Estimating Live Weight of Yucatecan Criollo Pigs Through Biometric Measurements
by Angel C. Sierra-Vasquez, Cem Tırınk, Jesus A. Mezo-Solis, Hasan Önder, Naomi Cih-Angulo, Uğur Şen, Julio C. Rodriguez-Perez, Jorge C. Bojorquez-Cat, Kadyrbai Chekirov, İsa Coşkun and Alfonso Juventino Chay-Canul
Animals 2026, 16(8), 1134; https://doi.org/10.3390/ani16081134 - 8 Apr 2026
Abstract
This study compares the performance of XGBoost and LightGBM models for predicting live weights of Yucatecan Criollo pigs from biometric measurements and examines the structural and algorithmic differences that affect model fit. Detailed analysis of the models’ hyperparameter optimization and variable importance revealed [...] Read more.
This study compares the performance of XGBoost and LightGBM models for predicting live weights of Yucatecan Criollo pigs from biometric measurements and examines the structural and algorithmic differences that affect model fit. Detailed analysis of the models’ hyperparameter optimization and variable importance revealed how each model approaches the data and prioritizes features. This study was conducted on 182 Yucatecan Criollo pigs (134 females and 48 males). When model performances were evaluated, the XGBoost model showed superior prediction performance with acceptable accuracy and lower error rates in the test dataset, with R2 = 0.905, RMSE = 5.704, and MAE = 3.636. In contrast, the LightGBM model produced acceptable results under certain hyperparameter combinations with R2 = 0.824, RMSE = 7.772, and MAE = 5.505. While the robust performance of both models requires strategic decisions in model selection and optimization, it is recommended to consider the dataset’s nature in feature selection and hyperparameter settings. This study provides important insights for simplifying the model and improving its efficiency in machine learning applications, and serves as a reference for more effective model use. Full article
(This article belongs to the Section Animal Physiology)
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17 pages, 726 KB  
Review
Menopausal Hormone Therapy in Clinically Vulnerable Women: A Narrative Review of Guidelines and Real-World Evidence
by Vesselina Yanachkova, Hristina Lebanova and Svetoslav Stoev
Medicina 2026, 62(4), 712; https://doi.org/10.3390/medicina62040712 (registering DOI) - 8 Apr 2026
Abstract
Background and Objectives: Menopausal hormone therapy (MHT) is the most efficacious treatment for vasomotor symptoms and genitourinary conditions associated with menopause. Modern menopause care increasingly encompasses women with multimorbidity, renal or hepatic impairment, previous malignancies or thromboembolic disorders, advanced age, and polypharmacy—groups frequently [...] Read more.
Background and Objectives: Menopausal hormone therapy (MHT) is the most efficacious treatment for vasomotor symptoms and genitourinary conditions associated with menopause. Modern menopause care increasingly encompasses women with multimorbidity, renal or hepatic impairment, previous malignancies or thromboembolic disorders, advanced age, and polypharmacy—groups frequently underrepresented in randomized clinical trials. This evidence gap prompts significant inquiries about the relevance of trial-based recommendations to actual clinical practice. Materials and Methods: This narrative review offers a concentrated assessment of prominent worldwide clinical guidelines regarding menopausal hormone therapy through thematic synthesis. We examined position statements from the North American Menopause Society (NAMS), the European Menopause and Andropause Society (EMAS), NICE clinical guidelines, the ACOG Practice Bulletin on menopausal symptom management, the Endocrine Society clinical practice guideline, and pertinent UK guidance from RCOG, BMS, and BGCS. Data from systematic reviews, meta-analyses, and extensive observational studies were analyzed to contextualize guideline recommendations for populations often underrepresented in clinical trials, including women aged ≥65 years and individuals with multimorbidity or polypharmacy. Results: Only the NICE and EMAS recommendations expressly acknowledge clinical vulnerability or complexity (multimorbidity, frailty, and cancer survivorship) as foundational principles. NAMS and ACOG delineate risk categories but fail to offer a cohesive taxonomy of vulnerability. Polypharmacy and drug–drug interactions are inconsistently addressed across guidelines, and there is a deficiency of standardized prescribing algorithms. While routine safety monitoring is universally advocated, the intervals for follow-up and methods for risk categorization differ. Observational evidence consistently indicates route-dependent variations in cardiovascular and thromboembolic risk, with transdermal estrogen linked to a more advantageous safety profile in higher-risk individuals. Conclusions: Present menopausal therapy guidelines are methodologically sound; however, they insufficiently address the complexities of multimorbidity, polypharmacy, and organ dysfunction. A systematic conceptual framework that incorporates areas of clinical vulnerability may facilitate personalized benefit–risk evaluation in practical applications. Future guideline revisions should enhance clarity by incorporating polypharmacy concerns, monitoring strategies, and systematic risk stratification methods for clinically complicated patients. Full article
(This article belongs to the Section Endocrinology)
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22 pages, 2332 KB  
Article
A Multi-Model Machine Learning Framework for Predicting and Ranking High-Risk Urban Intersections in Riyadh
by Saleh Altwaijri, Saleh Alotaibi, Faisal Alosaimi, Adel Almutairi and Abdulaziz Alauany
Sustainability 2026, 18(8), 3651; https://doi.org/10.3390/su18083651 - 8 Apr 2026
Abstract
Road traffic accidents at intersections pose a persistent challenge in Riyadh, Saudi Arabia, contributing significantly to public health burdens and economic losses. Traditional statistical approaches often fail to capture the complex, non-linear interactions among geometric design, traffic parameters, and accident severity. This study [...] Read more.
Road traffic accidents at intersections pose a persistent challenge in Riyadh, Saudi Arabia, contributing significantly to public health burdens and economic losses. Traditional statistical approaches often fail to capture the complex, non-linear interactions among geometric design, traffic parameters, and accident severity. This study develops a multi-methodological machine learning framework to predict intersection accident severity using the Equivalent Property Damage Only (EPDO) metric. Historical data (2017–2023) from Riyadh Municipality for 150 high-risk intersections were analyzed, incorporating predictors such as service road distance (SRD), U-turn distance (UTD), median width (MW), peak hour volume (PHV), heavy vehicle percentage (HV%), and injury/frequency counts. Six algorithms, i.e., Decision Tree, Random Forest, Gradient Boosting, Support Vector Machine, Linear Regression, and Artificial Neural Network, were compared using a 70/30 train–test split and k-fold cross-validation in this study. The Gradient Boosting model achieved superior performance (R2 = 0.89 with MSE = 63.43 and RMSE = 7.96) and was selected for final deployment. SHAP feature importance analysis revealed minor injuries (MIs), serious injuries (SRIs), and fatalities (FAs) as the most important dominant predictors, with geometric factors (UTD, MW) and traffic composition (HV%) providing actionable infrastructure insights. The model ranked intersections and identified the “Jeddah Road with Taif Road” (predicted EPDO = 137.22) as the highest-risk location. Evidence-based recommendations include enforcing the minimum 300 m U-turn buffers with staggering service road exits ≥150 m and restricting heavy vehicles during peak hours. The scalable framework developed in this study supports the data-driven prioritization of safety interventions and aligns with sustainable urban mobility goals and offers transferability to other metropolitan contexts worldwide. Full article
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32 pages, 823 KB  
Article
A Hybrid Temporal Recommender System Based on Sliding-Window Weighted Popularity and Elite Evolutionary Discrete Particle Swarm Optimization
by Shanxian Lin, Yuichi Nagata and Haichuan Yang
Electronics 2026, 15(8), 1544; https://doi.org/10.3390/electronics15081544 - 8 Apr 2026
Abstract
This paper proposes a hybrid non-personalized temporal recommendation framework integrating Sliding-Window Weighted Popularity (SWWP) with Elite Evolutionary Discrete Particle Swarm Optimization (EEDPSO) to address the challenges of extreme data sparsity and temporal dynamics in global popularity-based recommendation. We first formally prove the NP [...] Read more.
This paper proposes a hybrid non-personalized temporal recommendation framework integrating Sliding-Window Weighted Popularity (SWWP) with Elite Evolutionary Discrete Particle Swarm Optimization (EEDPSO) to address the challenges of extreme data sparsity and temporal dynamics in global popularity-based recommendation. We first formally prove the NP hardness of the temporal-constrained recommendation problem, justifying the adoption of a metaheuristic approach. The proposed SWWP model employs a dual-scale sliding-window mechanism to balance short-term trend adaptation with long-term periodicity capture. A novel deep integration mechanism couples SWWP with EEDPSO through a “purchase heat” indicator, which guides temporal-aware particle initialization, position updates, and fitness evaluation. Extensive experiments on the Amazon Reviews dataset with extreme sparsity (density < 0.0005%) demonstrate that SWWP achieves an NDCG@20 of 0.245, outperforming nine temporal baselines by at least 13%. Furthermore, under a unified fitness function incorporating temporal prediction accuracy, the SWWP-EEDPSO framework achieves 5.95% higher fitness compared to vanilla EEDPSO, while significantly outperforming Differential Evolution and Genetic Algorithms. The temporally informed search strategy enables SWWP-EEDPSO to discover recommendations that better align with future user behavior, while maintaining sub-millisecond online query latency (0.52 ms) through offline precomputation and caching, demonstrating practical feasibility for deployment scenarios where periodic offline updates are acceptable. Full article
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28 pages, 1936 KB  
Article
Multi-Objective Optimization of Façade and Roof Opening Configurations for Sustainable Industrial Heritage Retrofit: Enhancing Daylight Availability, Non-Visual Potential, and Energy Performance
by Jian Ma, Zhenxiang Cao, Jie Jian, Kunming Li and Jinyue Wu
Sustainability 2026, 18(7), 3644; https://doi.org/10.3390/su18073644 - 7 Apr 2026
Abstract
During the adaptive reuse of industrial heritage buildings, existing opening systems and envelope performance often pose major constraints. These restrictions make it difficult for the building to meet the requirements of the updated indoor environment, resulting in insufficient daylight and increased energy consumption. [...] Read more.
During the adaptive reuse of industrial heritage buildings, existing opening systems and envelope performance often pose major constraints. These restrictions make it difficult for the building to meet the requirements of the updated indoor environment, resulting in insufficient daylight and increased energy consumption. Therefore, optimizing lighting and energy performance has become the primary goal of the retrofit design. However, with limited interventions, the retrofit of heritage buildings to achieve significant overall performance improvement is still a challenge. From a sustainability perspective, improving daylight utilization and reducing energy demand are essential strategies for achieving low-carbon and resource-efficient building retrofit. This study proposes a grid-based parametric multi-objective optimization approach to optimize the window openings of the building envelope. The approach defines the position, size and material properties of the roof and facade openings as design variables. Implemented via the Honeybee and Octopus platforms, it integrates a genetic algorithm with EnergyPlus and Radiance simulations to co-optimize daylight performance, circadian frequency, and energy use intensity. Taking a single-story typical industrial heritage building in China’s cold climate zone as a case study, it is shown that coordinated multi-objective constraints significantly improve the overall performance across various evaluation metrics. The optimization results also provide interpretable window configuration strategies and recommended parameter ranges, which fully consider the climate adaptability of the surrounding environment. These findings offer useful guidance for sustainable retrofit design decision-making in similar single-story industrial heritage buildings. Full article
(This article belongs to the Section Green Building)
21 pages, 1551 KB  
Article
A Hybrid Model for Deliverability Prediction in Fractured Tight Sandstone Energy Storage Reservoirs
by Dengfeng Ren, Ju Liu, Chengwen Wang, Xin Qiao, Junyan Liu and Fen Peng
Energies 2026, 19(7), 1800; https://doi.org/10.3390/en19071800 - 7 Apr 2026
Abstract
Fractured tight sandstone reservoirs are promising targets for underground energy storage, but their heterogeneous nature and often-incomplete historical test data pose significant challenges for accurate deliverability prediction and reservoir evaluation. To address this, a novel hybrid methodology is proposed. For wells with complete [...] Read more.
Fractured tight sandstone reservoirs are promising targets for underground energy storage, but their heterogeneous nature and often-incomplete historical test data pose significant challenges for accurate deliverability prediction and reservoir evaluation. To address this, a novel hybrid methodology is proposed. For wells with complete historical data, deliverability is calculated using a binomial inflow performance relationship (IPR) model. For wells with incomplete data, a weighted fusion model integrating a Random Forest algorithm and least squares regression is developed to predict natural blowout capacity, a key proxy for energy storage injectivity/productivity. The fusion model achieved superior performance with a mean absolute error (MAE) of 7.19 × 104 m3/day and a Mean Relative Error (MRE) of 8.5%, outperforming standalone methods. Based on the predicted deliverability, reservoirs in the Bozi–North block (Kuche Depression, Tarim Basin) were classified into three potential grades (I, II, III). The study provides a data-adaptive framework for deliverability prediction and offers tailored reformation process recommendations (e.g., sand fracturing for Grade I reservoirs), thereby providing a more reliable and practical decision support tool for the efficient development of tight sandstone energy storage reservoirs. Full article
(This article belongs to the Topic Advanced Technology for Oil and Nature Gas Exploration)
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30 pages, 2962 KB  
Article
Optimized Decision Model for Soil-Moisture Control Lower Limits and Evapotranspiration-Based Irrigation Replenishment Ratios Based on AquaCrop-OSPy, PyFAO56, and NSGA-II and Its Application
by Xu Liu, Zhaolong Liu, Wenhui Tang, Zhichao An, Jun Liang, Yanling Chen, Yuxin Miao, Hainie Zha and Krzysztof Kusnierek
Agriculture 2026, 16(7), 806; https://doi.org/10.3390/agriculture16070806 - 4 Apr 2026
Viewed by 132
Abstract
As water resources are becoming increasingly scarce in the North China Plain, irrigation strategies that simultaneously improve grain yield and reduce irrigation water input are needed for winter wheat (Triticum aestivum L.) production. Current irrigation decision rules are based either on fixed [...] Read more.
As water resources are becoming increasingly scarce in the North China Plain, irrigation strategies that simultaneously improve grain yield and reduce irrigation water input are needed for winter wheat (Triticum aestivum L.) production. Current irrigation decision rules are based either on fixed soil moisture thresholds or on evapotranspiration (ET)-based ratios applied uniformly across the growing season, limiting their flexibility for growth stage-specific irrigation management. In this study, a multi-objective simulation optimization framework was developed to jointly optimize soil moisture lower control limits (irrigation trigger thresholds) and evapotranspiration-based irrigation replenishment ratios across key winter wheat growth stages. The framework integrated the AquaCrop-OSPy crop model with the PyFAO56 soil moisture balance, irrigation scheduling model and the NSGA-II evolutionary optimization algorithm. A field experiment was conducted during the 2024–2025 growing season in Laoling City, Shandong Province, China, employing a four-dense–one-sparse strip cropping pattern with two irrigation treatments: T1 (subsurface sprinkler irrigation) and T2 (shallow subsurface drip irrigation). The AquaCrop-OSPy model was calibrated and validated using measured canopy cover, aboveground biomass, grain yield, and soil moisture content in the 0–60 cm soil layer. Simulated canopy cover and grain yield showed good agreement with observations, with the coefficient of determination (R2) ranging from 0.87 to 0.94. For grain yield, the normalized root mean square error (NRMSE) ranged from 2.24% to 3.75%, and the root mean square error (RMSE) ranged from 0.29 to 0.54 t·ha−1. For aboveground biomass, R2 was 0.99, while RMSE ranged from 1.02 to 1.11 t·ha−1, and NRMSE ranged from 14.25% to 15.49%. The PyFAO56 irrigation strategy model simulated average root-zone soil-moisture dynamics with satisfactory accuracy, with an R2 of 0.86 and an RMSE of 5%. Multi-objective optimization (maximizing yield while minimizing irrigation volume) generated 23 Pareto-optimal irrigation strategies, with irrigation volumes ranging from 51 to 128 mm, corresponding yields ranging from 9.8 to 10.8 t·ha−1, and irrigation water use efficiency (IWUE) ranging from 0.08 to 0.19 t·ha−1·mm−1. Correlation analysis within the Pareto set indicated that soil-moisture control lower limits during the regreening–jointing stage and higher soil-moisture control lower limits during the flowering–maturity stage were key controlling factors for achieving high yields and irrigation water use efficiency. The Entropy-Weighted Ranked Minimum Distance method identified an optimal irrigation scheme involving two irrigations (one at the end of the jointing stage and another at the beginning of the grain filling stage) involving an irrigation depth of 75 mm, achieving a simulated yield of 10.4 t·ha−1 and an IWUE of 0.16 t·ha−1·mm−1. The proposed AquaCrop-PyFAO56-NSGA-II framework provides a flexible, process-based workflow for jointly optimizing irrigation control thresholds and evapotranspiration-based irrigation replenishment ratios across different winter wheat growth stages. Under the monitored conditions of the 2024–2025 wet season, the framework identified a two-irrigation strategy that balanced grain yield and irrigation input. This study should, therefore, be regarded as a proof-of-concept evaluation conducted in a well-instrumented single-site field setting rather than as a universally transferable recommendation. Because model calibration, within-season validation, and optimization were all based on one wet growing season at one site, the derived stage-specific thresholds, Pareto front, and S5 recommendation are most applicable to hydro-climatic conditions similar to the study year and should be further tested across contrasting year-types and locations before broader extrapolation. Full article
(This article belongs to the Topic Water Management in the Age of Climate Change)
28 pages, 2284 KB  
Article
Optimization of Multi-Cycle Distribution of Emergency Perishable Materials Based on a Two-Stage Algorithm Under Demand Fuzzy
by Yang Xu, Xiaodong Li, Kin-Keung Lai and Hao Ji
Appl. Sci. 2026, 16(7), 3519; https://doi.org/10.3390/app16073519 - 3 Apr 2026
Viewed by 92
Abstract
Post-disaster emergency perishable material distribution is an essential part of emergency relief, which is of great significance to reducing disaster losses and casualties and improving rescue efficiency. However, in actual rescue, the demand information of disaster sites is often complex to determine, and [...] Read more.
Post-disaster emergency perishable material distribution is an essential part of emergency relief, which is of great significance to reducing disaster losses and casualties and improving rescue efficiency. However, in actual rescue, the demand information of disaster sites is often complex to determine, and the demand for emergency perishable materials needs to be clarified. Therefore, the single-cycle distribution makes it difficult to meet the demand for emergency perishable materials at disaster sites. To effectively improve the efficiency of emergency relief, this paper constructs a distribution optimization model with a multi-cycle vehicle path and the dual objectives of minimizing the distribution delay penalty and corruption cost and minimizing the unsatisfied demand. Initially, the fuzzy demand is addressed through the application of triangular fuzzy numbers and the most probable value weighting method. Following this, a two-stage optimization algorithm is devised by integrating the K-means++ algorithm with an enhanced Differential Evolutionary Whale Optimization Algorithm (DE-WOA). This algorithm operates by first clustering the affected points and subsequently solving the multi-objective model, thereby providing a robust methodology and strategic recommendations for the distribution of perishable materials across diverse scenarios. Our study reveals that the multi-objective model developed in this paper exhibits remarkable operability and practicality in the distribution of post-disaster emergency perishable materials, as evidenced by the verification via numerical examples. Through a comparison with the single-stage whale optimization algorithm, it is evident that the enhanced two-stage differential evolutionary whale optimization algorithm not only demonstrates a substantially faster convergence rate and a superior solution quality but also proves to be more suitably adapted to the proposed model. Significantly, the overall optimization performance has been augmented by 33%, thereby providing further substantiation of the efficacy of the designed improved algorithm. Full article
(This article belongs to the Special Issue Fuzzy Control Systems and Decision-Making)
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23 pages, 1369 KB  
Article
Evidence-Driven Simulated Data in Reinforcement Learning Training for Personalized mHealth Interventions
by Juan Carlos Caro, Giorgio Galgano, Melissa Muñoz, Jorge Díaz Ramírez and Jorge Maluenda
Appl. Sci. 2026, 16(7), 3463; https://doi.org/10.3390/app16073463 - 2 Apr 2026
Viewed by 278
Abstract
Physical inactivity is a major preventable cause of non-communicable disease and premature mortality. Mobile health interventions can promote physical activity, but their effectiveness depends on the ability to adapt to user’s context and motivation. Reinforcement learning (RL), particularly contextual bandits (CBs), offers a [...] Read more.
Physical inactivity is a major preventable cause of non-communicable disease and premature mortality. Mobile health interventions can promote physical activity, but their effectiveness depends on the ability to adapt to user’s context and motivation. Reinforcement learning (RL), particularly contextual bandits (CBs), offers a promising framework for such adaptive personalization. However, in practice, RL-based models face the cold start problem (CSP), due to the lack of initial training data. This study examines whether theory-driven simulated data can mitigate the CSP in training RL systems for personalized physical activity recommendations. A scoping review of 18 empirical studies on the Integrated Behavioral Change Model (IBC) provided population parameters for key constructs, used to simulate 2000 virtual users via multivariate modeling and structural equation calibration. A CB algorithm with an ε-greedy policy was trained with this dataset and compared with data from real world pilot using the Apptivate mHealth web-app (n = 588). Results showed close alignment between simulated and real behaviors. Our findings demonstrate that behaviorally informed synthetic data can effectively be used to train RL algorithms, offering an interpretable, sustainable, scalable, and privacy-safe solution to the CSP in personalized digital health interventions. Full article
(This article belongs to the Special Issue Health Informatics: Human Health and Health Care Services)
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28 pages, 3558 KB  
Systematic Review
AI-Based Academic Advising Across the Student Lifecycle: A Systematic Literature Review
by Ilyas Alloug, Mohamed Daoudi and Ilham Oumaira
Information 2026, 17(4), 335; https://doi.org/10.3390/info17040335 - 1 Apr 2026
Viewed by 277
Abstract
Academic advising is fundamental to student success, yet the rapid integration of Artificial Intelligence (AI) and Machine Learning (ML) is fundamentally transforming the delivery of academic support. While predictive models and Recommendation Systems (RS) are becoming more accessible, the existing literature remains fragmented [...] Read more.
Academic advising is fundamental to student success, yet the rapid integration of Artificial Intelligence (AI) and Machine Learning (ML) is fundamentally transforming the delivery of academic support. While predictive models and Recommendation Systems (RS) are becoming more accessible, the existing literature remains fragmented across diverse technical architectures and institutional objectives, preventing a clear understanding of the field’s evolution. In view of this, we present a Systematic Literature Review (SLR) of AI-driven academic advising, adhering to the PRISMA 2020 framework. We analyzed 27 peer-reviewed studies published between 2018 and 2025 to synthesize methodological trends and functional applications. Our findings reveal that while most systems prioritize pathway recommendations via classical ML or hybrid architectures, Early-Warning Systems (EWS) remain anchored in predictive classification. Furthermore, a nascent shift toward Generative AI (GenAI) indicates a move toward more interactive advising, though transparency and evaluation standards remain inconsistent. This review identifies a critical tension between algorithmic performance and institutional interpretability. We conclude by proposing a research agenda that emphasizes the need for cross-context validation and the development of socio-technical frameworks that integrate AI into existing higher education management structures. Full article
(This article belongs to the Topic Explainable AI in Education)
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21 pages, 1631 KB  
Review
Renal Denervation for Uncontrolled Hypertension: A Measurement-First, Program-Based Approach
by Lukasz Szarpak, Burak Katipoglu, Milosz J. Jaguszewski, Andrea Baier, Jacek Kubica, Maciej Maslyk, Michal Pruc, Karol Momot, Basar Cander and Queran Lin
J. Clin. Med. 2026, 15(7), 2648; https://doi.org/10.3390/jcm15072648 - 31 Mar 2026
Viewed by 327
Abstract
Background/Objectives: Renal denervation (RDN) has re-emerged as an adjunctive treatment option for patients with uncontrolled or resistant hypertension, with contemporary sham-controlled trials showing a modest but reproducible reduction in out-of-office blood pressure. However, in routine practice, apparent treatment resistance often reflects pseudoresistance [...] Read more.
Background/Objectives: Renal denervation (RDN) has re-emerged as an adjunctive treatment option for patients with uncontrolled or resistant hypertension, with contemporary sham-controlled trials showing a modest but reproducible reduction in out-of-office blood pressure. However, in routine practice, apparent treatment resistance often reflects pseudoresistance caused by the white-coat effect, poor measurement quality, therapeutic inertia, or nonadherence. This review aimed to summarize the contemporary evidence on renal denervation in uncontrolled or resistant hypertension and to propose a pragmatic, measurement-first framework for patient selection, integration into routine care, and a structured post-procedural response assessment. Methods: This article is a narrative, implementation-focused review. A structured search of PubMed, Embase, Cochrane CENTRAL, and Web of Science was performed from database inception through January 2026. We prioritized the randomized sham-controlled RDN trials, major meta-analyses, guidelines, consensus documents, and studies addressing ABPM, HBPM, medication adherence, and telemonitoring. Results: The contemporary sham-controlled trials support RDN as an adjunctive option with a modest blood pressure-lowering effect, which is best assessed by out-of-office measurements. The placebo-adjusted reductions in ambulatory systolic blood pressure were generally in the 4–6 mmHg range. Appropriate use requires the confirmation of sustained uncontrolled hypertension, the exclusion of pseudoresistance, the optimization of treatment, and an adherence assessment. We identified three phenotypes most likely to benefit and proposed a three-axis framework for a response assessment at 3 and 6 months. Conclusions: RDN should be viewed not as a substitute for antihypertensive therapy but as a program-based adjunct for carefully selected patients. The measurement-first care pathway presented here should be interpreted as a pragmatic clinical model intended to operationalize the available trial and guideline evidence in routine care, rather than as a prospectively validated algorithm or formal consensus recommendation. Full article
(This article belongs to the Special Issue Hypertension: Clinical Treatment and Management)
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54 pages, 2144 KB  
Systematic Review
Demystifying Artificial Intelligence: A Systematic Review of Explainable Artificial Intelligence in Medical Imaging
by Muhammad Fayaz, Kim Hagsong, Sufyan Danish, L. Minh Dang, Abolghasem Sadeghi-Niaraki and Hyeonjoon Moon
Sensors 2026, 26(7), 2131; https://doi.org/10.3390/s26072131 - 30 Mar 2026
Viewed by 335
Abstract
This comprehensive literature review explores the latest advancements in explainable artificial intelligence (XAI) techniques within the field of medical imaging (MI). Over the past decade, machine learning (ML) and deep learning (DL) technologies have made significant strides in healthcare, enabling advancements in tasks [...] Read more.
This comprehensive literature review explores the latest advancements in explainable artificial intelligence (XAI) techniques within the field of medical imaging (MI). Over the past decade, machine learning (ML) and deep learning (DL) technologies have made significant strides in healthcare, enabling advancements in tasks such as disease diagnosis, medical image segmentation, and the detection of various medical conditions. However, despite these successes, the widespread adoption of AI-driven tools in clinical practice remains slow, primarily due to the “black-box” nature of many AI models. These models make decisions without transparent reasoning, which poses significant barriers in critical medical and legal environments, where accountability and trust are paramount. This review investigates various XAI methods, focusing on both intrinsic and post-hoc techniques, to evaluate their potential in addressing these challenges. The paper examines how XAI can enhance the transparency of healthcare algorithms, thereby fostering greater trust and confidence among clinicians, patients, and regulators. Key challenges faced by XAI in healthcare, such as limited interpretability, computational complexity, and the absence of standardized evaluation frameworks, are discussed in detail. Furthermore, this work highlights existing gaps in the literature, including the lack of detailed comparative analyses of specific XAI techniques, especially in terms of their mathematical foundations and applicability across diverse medical imaging contexts. In response to these gaps, the paper introduces a new set of standardized evaluation metrics aimed at assessing XAI performance across various medical imaging tasks, such as image segmentation, classification, and diagnosis. The review proposes actionable recommendations for enhancing the effectiveness of XAI in healthcare, with a focus on real-world clinical applications. Unlike previous studies that focus on broader overviews or limited subsets of methods, this work provides a comprehensive comparative analysis of over 18 XAI techniques, emphasizing their strengths, weaknesses, and practical implications. By offering a detailed understanding of how XAI methods can be integrated into clinical workflows, this paper aims to bridge the gap between cutting-edge AI technologies and their practical use in medical settings. Ultimately, the insights provided are valuable for researchers, clinicians, and industry professionals, encouraging the adoption and standardization of XAI practices in clinical environments, thus ensuring the successful integration of transparent, interpretable, and reliable AI systems into healthcare. Full article
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17 pages, 5699 KB  
Article
Data-Driven Material Selection for Flexible Wearable Sensors Under Environmental Coupling Conditions
by Yanping Lu, Myun Kim and Hanwen Zhang
Sensors 2026, 26(7), 2122; https://doi.org/10.3390/s26072122 - 29 Mar 2026
Viewed by 443
Abstract
Flexible wearable electronics have shown strong potential for medical and health monitoring; however, conventional materials often fail to simultaneously satisfy the requirements of signal stability, wear comfort, and environmental adaptability under dynamic use conditions. To address this issue, this study proposes a data-driven [...] Read more.
Flexible wearable electronics have shown strong potential for medical and health monitoring; however, conventional materials often fail to simultaneously satisfy the requirements of signal stability, wear comfort, and environmental adaptability under dynamic use conditions. To address this issue, this study proposes a data-driven material selection framework for flexible wearable sensors based on the extreme gradient boosting (XGBoost) algorithm. The model integrates user perception, material physical parameters, and environmental coupling performance indicators to enable intelligent material matching and recommendation. Experimental results show that the proposed model achieves a recommendation accuracy of 94.5%, outperforming conventional comparison methods. Among the candidate materials, silver nanowires (AgNWs) exhibit superior overall performance, including a higher signal-to-noise ratio, lower skin-contact impedance, and stronger sweat resistance. In physiological monitoring experiments, the maximum deviation of the sensor response was below 3% under both static and motion conditions. In environmental coupling tests, the recommended material improved the system signal-to-noise ratio by 68% and reduced 24-h sensitivity decay by 75%. These results indicate that the proposed XGBoost-based framework can effectively support material selection for flexible wearable sensors and improve signal reliability and environmental adaptability in complex application scenarios. Full article
(This article belongs to the Special Issue Wearable Devices for Physical Activity and Healthcare Monitoring)
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24 pages, 972 KB  
Article
Emotional Embodiment in the Digital Age: The Digitization of Emotions
by Vincenzo Auriemma
Behav. Sci. 2026, 16(4), 487; https://doi.org/10.3390/bs16040487 - 25 Mar 2026
Viewed by 314
Abstract
The objective of this paper is to propose a sociological and interdisciplinary framework for analyzing the digitization of emotions in adolescence. This contribution aims to promote theoretical reflection and inform educational and political interventions in the digital age, framing adolescents’ digital experiences as [...] Read more.
The objective of this paper is to propose a sociological and interdisciplinary framework for analyzing the digitization of emotions in adolescence. This contribution aims to promote theoretical reflection and inform educational and political interventions in the digital age, framing adolescents’ digital experiences as emotionally embodied and socially integrated processes. These aspects are of paramount importance due to the rapid proliferation of digital technologies and artificial intelligence, which have precipitated a profound transformation in the emotional, relational, and educational experiences of adolescents. The role of digital and AI-based environments in mediating communication is expanding beyond the scope of simple facilitation. These environments are increasingly implicated in the production, modulation, and regulation of emotions, thereby influencing developmental trajectories and identity formation processes. This phenomenon is theorized as a socio-technical process, wherein emotions are embodied, narrated, and governed within digital environments. The article introduces the concept of digital emotional embodiment, drawing on the sociology of emotions, theories of embodiment, and critical perspectives on artificial intelligence. Specifically, the concept refers to the manner in which adolescents experience and express emotions through avatars, images, emojis, algorithmic feedback, and AI-mediated interactions. Therefore, it is imperative to underscore the evolution of empathy, which is progressively configured as a virtualized and datafied process, diverging from the tradition established by Hume and characterized by sympathy. In contemporary processes, shaped by the logic of platforms, recommendation systems, and emotionally reactive technologies, conventional emotional concepts have undergone deconstruction, and digital constructs are undergoing a gradual restructuring. In this context, AI systems do not merely reflect adolescents’ emotions but rather actively contribute to the construction of emotional narratives, influencing emotional regulation, social connection, and future orientation. Digital environments have been shown to encourage emotional expressiveness, experimentation, and inclusivity. Conversely, they have the capacity to encourage emotional standardization, dependency, and forms of affective vulnerability, particularly during a sensitive developmental stage such as adolescence. Full article
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Article
Forecasting a Hailstorm in Western China Plateau by Assimilating XPAR Radar Network Data with WRF-FDDA-HLHN
by Jingyuan Peng, Bosen Jiang, Qiuji Ding, Lei Cao, Zhigang Chu, Yueqin Shi and Yubao Liu
Remote Sens. 2026, 18(7), 968; https://doi.org/10.3390/rs18070968 - 24 Mar 2026
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Abstract
Hailstorms frequently develop in Yun-Gui Plateau, Western China, which bring about significant economic damage. Due to the high terrain, these storms are typically shallow, rapidly evolving, and challenging to forecast. An X-band phased-array radar (XPAR) network is set up at Weining in Yun-Gui [...] Read more.
Hailstorms frequently develop in Yun-Gui Plateau, Western China, which bring about significant economic damage. Due to the high terrain, these storms are typically shallow, rapidly evolving, and challenging to forecast. An X-band phased-array radar (XPAR) network is set up at Weining in Yun-Gui Plateau to study these storms. To explore these XPAR data for numerical prediction of hailstorms in this region, we implement the Weather Research and Forecast (WRF) model and Hydrometeor and Latent Heat Nudging (HLHN) method to assimilate the data and conduct prediction experiments. The XPAR data was evaluated along with the operational Severe Weather Automatic Nowcast (SWAN) system radar mosaic data. Furthermore, a humidity adjustment scheme is used to overcome inconsistency of the humidity field and related prediction errors. The model results show that in comparison to the SWAN data, assimilating XPAR data in 1-min intervals significantly reduces the model error, and improves the representation of rapid hail cloud evolution. Additionally, adjusting the model humidity based on vertically integrated liquid (VIL) derived from the radar data can effectively correct model analyses of humidity and temperatures, suppressing spurious convection, thus improving the hailstorm forecast. Overall, we recommend joint assimilation of the high spatiotemporal resolution XPAR data along with SWAN radar data with the improved WRF-HLHN for hailstorm prediction over the study region, and the algorithm can be promptly adapted to forecasting hailstorms in other regions. Full article
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