Search Results (105)

The use of opioids for cancer-related pain is essential but poses significant challenges due to the risk of misuse and the development of opioid use disorder (OUD). This review takes a multidisciplinary perspective based on the current scientific literature to analyze the pharmacological mechanisms, classification, and therapeutic roles of opioids in oncology. Key risk factors for opioid misuse—including psychiatric comorbidities, prior substance use, and insufficient clinical monitoring—are discussed in conjunction with validated tools for pain assessment and international guidelines. The review emphasizes the importance of integrating toxicological, pharmacological, physiological, and public health perspectives to promote rational opioid use. Pharmacogenetic variability is explored as a determinant of treatment response and addiction risk, underscoring the value of personalized medicine. Evidence-based strategies such as early screening, psychosocial interventions, and the use of buprenorphine-naloxone are presented as effective measures for managing OUD in cancer patients. Ultimately, this work advocates for safe, patient-centered opioid prescribing practices that ensure effective pain relief without compromising safety or quality of life. Full article

To analyze the hydrodynamic performance of the Voith–Schneider Propeller (VSP) under high eccentricity (e = 0.9), open-water performance numerical calculations were conducted for the VSP at different eccentricities. The results were compared with experimental data, revealing significant discrepancies at high eccentricity. Analysis identified that during the experiment, the VSP blades did not strictly move according to the prescribed “normal intersection principle” when passing near the eccentric point, which was the primary cause of the errors between the calculation and experiment. Further research demonstrated that when the blades pass near the eccentric point, both the individual blade and the overall propeller exhibit strong unsteady pulsation phenomena. The characteristics of these unsteady forces become more pronounced with increasing eccentricity. For the VSP under high eccentricity (e = 0.9), different Blade Steering Curves near the eccentric point were designed using a parametric method. The hydrodynamic performance of the VSP under these different curves was compared. The study demonstrates that rationally optimizing the motion of blades is a key approach to improving their hydrodynamic performance. At J = 2.4, the adoption of Opt-5 enables a 4.67% increase in thrust, a 25.19% reduction in thrust pulsation, a 12.74% reduction in torque, an 81.94% reduction in torque pulsation, and a 19.95% improvement in efficiency for the VSP. Full article

Background: The misuse of antibiotics in dental practice significantly contributes to the escalation of antimicrobial resistance. This study aimed to assess the knowledge and attitudes of final-year dental students regarding perioperative antibiotic prophylaxis in oral surgery and to identify potential curricular improvements based on the findings. Methods: A questionnaire was administered to 117 final-year students at Gazi University Faculty of Dentistry in December 2024. The survey presented clinical scenarios related to common oral surgical procedures, evaluating participants’ antibiotic prescribing behaviors. Statistical analyses were performed using descriptive statistics and a One-Sample Chi-Square Test. Results: Students demonstrated a general tendency toward rational antibiotic use in routine clinical scenarios, with statistically significant response patterns favoring the avoidance of unnecessary prescriptions (p < 0.05). However, in complex or borderline cases such as impacted third molar extraction and dental implant placement, response variability was observed. Post hoc analyses revealed no statistically significant differences between closely distributed options, indicating inconsistencies in decision-making in more challenging scenarios. Conclusions: While final-year dental students exhibited a satisfactory level of knowledge regarding appropriate antibiotic use in standard surgical procedures, the variability observed in complex cases underscores the necessity for enhanced educational interventions. Incorporating updated, evidence-based antimicrobial stewardship principles and promoting clinical decision-making through case-based learning are essential to prepare future dental practitioners for responsible antibiotic prescribing, contributing to global efforts to mitigate antimicrobial resistance. Full article

Background: Antimicrobial resistance (AMR) is a public health concern worldwide, particularly in low-to-middle-income countries with few antimicrobial stewardship programs and few laboratories equipped for diagnosis. Methods: As point-prevalence surveys (PPSs) are a well-known tool for assessing antimicrobial use, we adjusted standardized Global-PPS for use in two hospitals in Benin and included an analysis based on the 2021 WHO AWaRe classification. Results: Of the 450 patients enrolled, 148 received antimicrobials (AMs) (overall prevalence 32.9%), most of them orally (54.2%). Both hospitals had a high rate of Access and Watch antibiotics use, and both prescribed mainly metronidazole. In four prescriptions, hospital A used a non-recommended association of antibiotics, such as ceftriaxone + sulbactam and ofloxacin + ornidazole. While hospital A prescribed predominantly amoxicillin + clavulanic acid (19/92; 21%) and ceftriaxone (14/92; 15%), hospital B prescribed ampicillin (24/120; 20%) and cefuroxime (14/120; n = 12%). In hospital B, surgical antimicrobial prophylaxis (SAP) was suboptimal. While there were no single-dose prophylaxis prescriptions, all one-day prophylaxis (SP2) involved ampicillin for cesarean sections. In patients in intensive care units, prolonged prophylaxis (>1 day, SP3) accounted for all postoperative prescriptions. Conclusions: These findings highlight the critical need for implementing antimicrobial stewardship programs, expanding diagnostic laboratory capacity to minimize empirical prescribing, and strengthening medical student training to ensure quality and rational antibiotic use, thereby addressing the growing challenge of resistance in resource-limited settings. Full article

This paper investigates the event-triggered dissipative fuzzy tracking control problem of nonlinear networked systems with dynamic quantization and stochastic deception attacks, where the Takagi–Sugeno (T-S) fuzzy system theory is utilized to represent the studied nonlinear networked systems. The event-triggered scheme and the dynamic quantization scheme with general online adjustment rule are employed to significantly decrease the data transmission amount and achieve the rational use of the limited communication and computation resources. A stochastic variable satisfying the Bernoulli random binary distribution is utilized to model the phenomenon of the stochastic deception attacks. The main purpose of this paper is to develop a secure event-triggered quantized tracking control scheme. This scheme guarantees the stochastic stability and prescribed dissipative tracking performance of the closed-loop system under stochastic deception attacks. Moreover, the design conditions for the desired static output feedback tracking controller are formulated in the form of linear matrix inequalities based on the matrix inequality decoupling strategy. Finally, two examples are exploited to illustrate the effectiveness of the developed tracking control scheme. Full article

The present review discusses the solution of the Heun, confluent, biconfluent, double confluent, and triconfluent equations in terms of polynomial expansions, and applies the results to generate exactly solvable Schrödinger potentials. Although there are more general approaches to solve these differential equations in terms of the expansions of certain special functions, the importance of polynomial solutions is unquestionable, as most of the known potentials are solvable in terms of the hypergeometric and confluent hypergeometric functions; i.e., Natanzon-class potentials possess bound-state solutions in terms of classical orthogonal polynomials, to which the (confluent) hypergeometric functions can be reduced. Since some of the Heun-type equations contain the hypergeometric and/or confluent hypergeometric differential equations as special limits, the potentials generated from them may also contain Natanzon-class potentials as special cases. A power series expansion is assumed around one of the singular points of each differential equation, and recurrence relations are obtained for the expansion coefficients. With the exception of the triconfluent Heun equations, these are three-term recurrence relations, the termination of which is achieved by prescribing certain conditions. In the case of the biconfluent and double confluent Heun equations, the expansion coefficients can be obtained in the standard way, i.e., after finding the roots of an (N + 1)th-order polynomial in one of the parameters, which, in turn, follows from requiring the vanishing of an (N + 1) × (N + 1) determinant. However, in the case of the Heun and confluent Heun equations, the recurrence relation can be solved directly, and the solutions are obtained in terms of rationally extended X₁-type Jacobi and Laguerre polynomials, respectively. Examples for solvable potentials are presented for the Heun, confluent, biconfluent, and double confluent Heun equations, and alternative methods for obtaining the same potentials are also discussed. These are the schemes based on the rational extension of Bochner-type differential equations (for the Heun and confluent Heun equation) and solutions based on quasi-exact solvability (QES) and on continued fractions (for the biconfluent and double confluent equation). Possible further lines of investigations are also outlined concerning physical problems that require the solution of second-order differential equations, i.e., the Schrödinger equation with position-dependent mass and relativistic wave equations. Full article

Background/Objectives: Improper use of systemic antibiotics remains a significant concern in hospital settings, contributing to increased antimicrobial resistance and suboptimal clinical outcomes. The COVID-19 pandemic exacerbated this issue. This study aimed to evaluate long-term trends in antibiotic utilization in low-resource settings at a tertiary care teaching hospital, focusing specifically on the changes before, during, and after the COVID-19 pandemic. Methods: This retrospective observational study analyzed antibiotic utilization data from the University Clinical Centre of the Republic of Srpska over ten years (2015–2024). Antibiotic consumption was expressed in defined daily doses (DDD) per 100 bed-days, and compared across three periods: pre-COVID-19 (2015–2019), COVID-19 (2020–2022), and post-COVID-19 (2023–2024). Additionally, antibiotic use was categorized according to the WHO AWaRe classification. Results: Antibiotic utilization peaked during the COVID-19 period, with the highest rate observed in 2021 (91.5 DDD/100 bed-days), despite a decrease in hospital admissions. The most frequently used antibiotics were cephalosporins, penicillins, and metronidazole. A significant increase in the use of azithromycin, meropenem, piperacillin/tazobactam, vancomycin, and colistin was noted during the COVID-19 and post-COVID-19 periods (p < 0.05), along with a notable decline in penicillin use. Watch and Reserve antibiotic use rose significantly (p < 0.05), while Access group use fell from 67% to 49.2%. Conclusions: These findings underscore the lasting impact of the COVID-19 pandemic on antibiotic prescribing patterns and emphasize the urgent need for strengthened antimicrobial stewardship efforts to ensure rational antibiotic use and combat antimicrobial resistance. Full article

Background: Antimicrobial resistance is a growing global health threat, with antibiotic misuse in pediatric populations being a significant contributing factor. In Romania, antibiotic consumption and resistance rates are among the highest in Europe. Objective: To assess Romanian parents’ knowledge, attitudes, and practices regarding antibiotic use in children, and to identify key misconceptions and behavioral risks contributing to inappropriate antibiotic use. Methods: A cross-sectional survey was conducted among 400 parents of hospitalized children in a pediatric department in Romania. Participants completed a 15 item structured questionnaire. Data were analyzed using descriptive statistics, chi-square tests, and binary logistic regression to examine associations and control for potential confounding effects between education level, residential environment, and parental misconceptions regarding antibiotic use. Results: Among the 400 surveyed caregivers, 86% (n = 344) held at least one misconception regarding antibiotic use. Additionally, 42.5% (n = 170) of participants reported that they had never heard of the concept of antibiotic resistance. Misconceptions were significantly more prevalent among individuals with lower levels of education and those residing in rural areas (p < 0.001). While 89.8% (n = 359) stated that they had never administered antibiotics to their children without a physician’s recommendation, a separate subset of 28% (n = 112) acknowledged that they had asked a doctor to prescribe antibiotics for their child. Moreover, 23.3% (n = 93) reported seeking a second medical opinion when antibiotics were not initially prescribed. Conclusions: Despite high adherence to medical advice, widespread misconceptions persist. These findings highlight the need for targeted, population-specific educational interventions to promote rational antibiotic use and address AMR in high-burden settings like Romania. Full article

Performance-based seismic design (PBD) has emerged as a key approach for rationalizing prescriptive code provisions and improving the explicit assessment of structural performance. In Chile, where reinforced concrete shear wall buildings are the predominant structural typology, evaluating their seismic response beyond traditional linear methodologies is crucial. This study assesses the seismic performance of a representative Chilean shear wall residential building using the ACHISINA manual’s performance-based seismic design framework. A nonlinear static (pushover) analysis is performed to verify compliance with prescribed design criteria, incorporating capacity design principles and a moment envelope approach to prevent premature yielding in upper stories. The results confirm that the building meets the performance objectives for both Immediate Occupancy and Additional Deformation Capacity limit states. The application of capacity design effectively controls shear demand, preventing brittle failure, while the flexural design ensures the formation of the yielding mechanism (plastic hinge) at the intended critical section. Additionally, the study highlights the limitations of pushover analysis in capturing higher-mode effects and recommends complementary nonlinear time-history analysis (NLTHA) for a more comprehensive assessment. The computed response reduction factors exceed those used in the prescriptive design, suggesting a conservatively safe approach in current Chilean practice. This research reinforces the need to integrate performance-based methodologies into Chilean seismic design regulations, particularly for shear wall structures. It provides valuable insights into the advantages and limitations of current design practices and proposes improvements for future applications. Full article

Background: The discovery of antibiotics revolutionized healthcare by significantly reducing morbidity and mortality. However, excessive and inappropriate use has led to a global surge in antimicrobial resistance, particularly in low- and middle-income countries. This study aimed to evaluate antibiotic use patterns among inpatients at Jimma Medical Center (JMC) in Southwest Ethiopia. Methods: A longitudinal observational study was conducted in February and March 2019 at JMC, focusing on patients admitted for over 24 h who received antibiotics. Data on patient demographics, clinical indications, and antibiotics prescribed were systematically collected. Antibiotic consumption rates were measured as days of therapy (DOTs) per 100 patient-days, and utilization was classified according to the World Health Organization (WHO) AWaRe (Access, Watch, and Reserve) framework. Results: A total of 384 inpatients were included, with a male predominance (53.9%) and a median age of 24 years (IQR: 5–37). In total, 634 antibiotic regimens were prescribed. According to the WHO AWaRe classification, 48.3% (306/634) were “Access” and 51.7% (328/634) were “Watch” antibiotics. Patients were treated with antibiotics for a median duration of 4 days (IQR: 2–7), leading to a total of 2880 days of antibiotic therapy. Ceftriaxone was the most commonly prescribed antibiotic, with a usage rate of 44.65 DOTs per 100 patient-days. Substantial variability was observed in empirical antibiotic regimens among treating physicians and across wards. Culture and antibiotic susceptibility testing (AST) were performed for only 4.2% of patients, and none of the treatments were modified based on susceptibility data. Conclusions: The study highlights critical issues in antibiotic prescribing at JMC, including over-reliance on “Watch” antibiotics, predominantly ceftriaxone, limited use of AST results, and deviations from standard treatment guidelines. Addressing these challenges requires implementing antimicrobial stewardship programs, developing evidence-based local treatment guidelines, and strengthening and encouraging the use of microbiology services to improve rational antibiotic use. Full article

Background: The evaluation of internationally comparable indicators of medicine use is important to devise strategies to promote the rational use of medicines (RUM). Methods: A cross-sectional study was conducted in a tertiary care hospital from January to June 2024. Prescriptions were collected from the outpatient pharmacy using systematic random sampling and analyzed for WHO/INRUD core prescribing indicators, index of rational drug prescribing (IRDP) and completeness (general, treatment and prescribers’ details). Results: Out of 844 prescriptions collected, 607 were analyzed. A total of 1837 drugs were prescribed, with a mean (SD) of 3.03 (1.51) drugs per prescription; 1378 (75%) drugs were prescribed as generic names; 125 prescriptions (20.59%) had an antibiotic prescribed; and injectables were given in 7 (1.15%) prescriptions. Of the total 1837 drugs, 1018 (55.4%) were mentioned in the National List of Essential Medicines (NLEM) 2022, while 934 (50.8%) were included in the Haryana state essential medicines list (2013–2014). The IRDP was calculated as 3.86. The mean (SD) completeness score of the prescriptions was 10.33 (0.8) (range 5 to 11). Conclusions: There was a high incidence of polypharmacy, brand name and non-essential drug prescribing, while antibiotic and injection use were in accordance with WHO standards. Full article

Background/Objectives: Acute upper respiratory tract infections (URIs) are defined as inflammatory diseases of the nose, sinuses, pharynx, larynx, or trachea. They are common in children. The prescription of antibiotics for the treatment of URIs became a relevant theme in the scientific literature in recent decades. One of the most important ways to deal with increasing antimicrobial resistance is rational antibiotic therapy. This study aimed to evaluate the tendencies of antibiotic prescribing practices for Lithuanian children with URIs from 2018 to 2022. We describe how many children with URIs were prescribed antibiotics, which antibiotics were used, and whether prescribing practices meet national guidelines. Methods: Secondary data, which were used in this observational study, were collected from the Lithuanian Compulsory Health Insurance Fund (CHIF) electronic records. The study population consisted of children aged between 0 and 18 years who visited their primary care doctors (pediatricians or family doctors) between January 2018 and December 2022 and were prescribed antibiotics for the treatment of URIs. Results: Between 2018 and 2022, there were 445,328 visits reported when antibiotics, which belong to the J01 group according to the Anatomical Therapeutic Chemical Classification (ATC), were prescribed to children aged 0–18. In more than half of the visits (51.70%), children aged 0–5 were consulted. Penicillins were mostly prescribed for the treatment of acute nasopharyngitis. Macrolides were mostly used to treat acute laryngitis and tracheitis. Of all penicillin-class antibiotics, the most popular choice was amoxycillin. The primary choice of cephalosporin was cefadroxil, and the primary choice of macrolide was clarithromycin. Conclusions: During the period of 2018–2022, the number of prescriptions for antibiotics for URTIs decreased, but prescriptions for penicillin-class antibiotics increased in a relative manner. The most common diagnoses during these visits were acute tonsillitis and acute pharyngitis, and most antibiotic prescriptions were for children in the 0–5 age group. If Lithuania’s National Recommendations on the Rational Use of Antibiotics were implemented during the analyzed period, the prescribing tendencies would not meet them. Full article

Introduction: Antimicrobial stewardship (AMS) can improve the rational use of antibiotics in hospitals. This study assessed the impact of a multifaceted AMS intervention on antibiotic use and prescribing patterns at three tertiary hospitals in Zambia. Methods: Point Prevalence Surveys (PPS) were conducted in three tertiary hospitals in August 2022 and in October 2023. It was part of a 3-year AMS demonstration project that aimed to optimize the use of antibiotics in treating urinary tract infections (UTIs) and bloodstream infections (BSIs) in various health sector settings in Zambia. Up to 170 medical records in 2022 and 265 in 2023 were included in the assessment. Results: Overall, the prevalence of antibiotic use in this PPS was 75%. Eighty-one percent (81%) and 71% of patients assessed were on at least one antibiotic in 2022 and 2023, respectively, indicating a decrease of 10%. Similarly, prescribing ceftriaxone, the most prescribed antibiotic, declined from an average of 48% in 2022 to 38% in 2023. Adherence to Standard Treatment Guidelines (STGs) slightly increased from 42% in 2022 to 45% in 2023. Additionally, antibiotic prescribing was reduced from 1.38 to 1.21. Conclusions: Antimicrobial stewardship had an early positive impact on antibiotic use and adherence to Standard Treatment Guidelines. Full article

Background: It is well established by research that large-scale and indiscriminate prescribing, dispensing, and use of antimicrobials drive antimicrobial resistance (AMR) endangering the health and well-being of people, animals, and the environment. In the context of low- and middle-income countries (LMICs), the prescribing of antimicrobials is often not based on biomedical rationality but involves alternative logic driven by social, cultural, and institutional factors. This paper seeks to develop a “biosocial” perspective, reflecting a unified perspective that treats the biomedical and social conditions as two sides of the same coin. Methods: This analysis is based on an empirical investigation of prescription slips that patients carry to buy drugs from the pharmacy following an outpatient department encounter with the clinician. Data collection involves mixed methods, including the quantitative analysis of the antimicrobials prescribed and a qualitative analysis of the underlying reasons for these prescriptions, as described by doctors, pharmacists, and patients. Data analysis involved triangulating quantitative and qualitative data, to develop a “biosocial” perspective, which can provide implications for the development of antimicrobial stewardship policies, particularly relevant for health institutions in low- and middle-income countries. Results: Our analysis of 1175 prescription slips showed that 98% contained antimicrobials, with 74% being broad-spectrum antimicrobials. Only 9% of cases were advised antimicrobial sensitivity testing (AST) before initiating treatment. Qualitative findings indicated that patients had poor awareness of antimicrobials and pharmacists played a crucial role in counseling. Conclusions: This study highlights that antimicrobial prescriptions in public health settings are influenced by both biomedical and social factors, supporting a biosocial perspective. Although AMS interventions are predominantly biomedical, adhering to clinical standards and best practices, this study underscores the necessity of integrating a biosocial viewpoint by incorporating the experiences of pharmacists and patient groups. Strengthening diagnostic support, patient education, and interprofessional collaboration could improve rational antimicrobial uses in low-resource settings. Full article

In machine learning, the processing of datasets is an unavoidable topic. One important approach to solving this problem is to design some corresponding algorithms so that they can eventually converge to the optimal solution of the optimization problem. Most existing acceleration algorithms exhibit asymptotic convergence. In order to ensure that the optimization problem converges to the optimal solution within the prescribed time, a novel prescribed-time convergence acceleration algorithm with time rescaling is presented in this paper. Two prescribed-time acceleration algorithms are constructed by introducing time rescaling, and the acceleration algorithms are used to solve unconstrained optimization problems and optimization problems containing equation constraints. Some important theorems are given, and the convergence of the acceleration algorithms is proven using the Lyapunov function method. Finally, we provide numerical simulations to verify the effectiveness and rationality of our theoretical results. Full article