Search Results (79)

Background/Objectives: The present exploratory study evaluates the feasibility and psychological effects of a structured Qigong intervention implemented in an Italian university setting. Qigong is a traditional Chinese mind–body practice combining gentle movements, breathwork, and mindful attention, aimed at enhancing mind–body integration and interoceptive awareness. Methods: A total of 332 undergraduate students voluntarily enrolled in a 12-week Qigong program. The intervention was based on Neidan Qigong and integrated both static and dynamic exercises. Psychological functioning was assessed through several self-report measures evaluating a range of constructs, including mindfulness (FFMQ), interoceptive ability (MAIA), perceived stress (PSS), depression, anxiety, and stress (BDI; DASS-21; STAI Y), emotion regulation (DERS), alexithymia (TAS), and sleep quality (PSQI). Results: A total of 114 students completed the intervention. The protocol was well received by participants and demonstrated high feasibility in the academic context, with good attendance rates and overall engagement. Preliminary findings indicate consistent improvements across several psychological domains. Conclusions: The results suggest that Qigong may be associated with improvements in mental health and well-being in young adults and may represent a promising, low-cost intervention. The findings should be interpreted as preliminary. Further research using controlled and methodologically rigorous designs is needed to assess the stability of these effects over time, incorporate physiological measures, and clarify the specific therapeutic contribution of spontaneous movement within Qigong practice. Full article

Objectives: Psychological distress has been linked to dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis and altered cortisol secretion. Exercise is increasingly recognized as a non-pharmacologic strategy for stress regulation. This systematic review and network meta-analysis assessed the relative efficacy of different exercise modalities and the optimal dose in modulating cortisol levels in adults with psychological distress. Methods: We systematically searched five databases up to 30 June 2025 for relevant randomized controlled trials. Two reviewers independently conducted study selection, data extraction, and risk-of-bias assessments. Pairwise meta-analyses and a frequentist network meta-analysis were performed with random-effects models. Standardized mean differences (SMDs) with 95% confidence intervals (CIs) were calculated. Dose–response relationships were examined, and the certainty of evidence was evaluated using the GRADE framework. Results: Forty-four studies were included. Overall, exercise was associated with moderate cortisol reductions. Yoga demonstrated the greatest effect (SMD = −0.59; 95% CI = −0.90 to −0.28; SUCRA = 93%), followed by qigong and multicomponent exercise. High-intensity interval training tended to increase cortisol levels, although not significantly. The dose–response analysis revealed an inverted U-shaped relationship, characterized by an optimal response at approximately 530 MET-min/week, and longer intervention duration predicted greater reductions. The certainty of evidence ranged from very low to high, with yoga–control comparisons supported by the strongest evidence. Conclusions: Exercise, particularly mind–body practices such as yoga and qigong, can reduce cortisol levels in individuals with psychological distress. The dose–response relationship exhibited a non-linear pattern, with optimal efficacy observed at approximately 530 MET-min/week. Nevertheless, further high-quality trials are required to confirm the optimal modality and dose. Full article

Background: Contemplative practices encompass a variety of static and dynamic practices. These practices, by fostering insights, heightened awareness, and a deeper connection to a broader framework of meaning, may play a crucial role in significantly reducing trauma-related symptoms in both young and adult populations. Methods: The current narrative literature review used Scopus and PubMed to search for studies published between January 2018 and August 2023 that examined the effects of contemplative practices, an umbrella term that includes mindfulness-based interventions, yoga, tai chi, qigong, and meditation, on trauma recovery and PTSD symptoms among adults and youths. Results: The literature search identified 281 articles. Forty-two studies met the inclusion criteria and were critically evaluated. Among the various approaches, encompassing stand-alone contemplative practices and combined interventions, mindfulness emerged as the most employed and investigated practice for supporting trauma recovery. Contemplative practices have been shown to effectively reduce various dimensions of traumatic experience, such as reactivity, intrusion, hyperarousal, and negative cognitions and mood. Controversial results were found on avoidance symptoms and physiological parameters. Conclusions: The results give support to the idea of combining contemplative practices with trauma-focused psychotherapeutic interventions to foster a sense of safety and enhance emotional expression and awareness of feelings of fear, shame, guilt, or inferiority while improving metacognitive processes. This, in turn, supports healing the sense of self, restoring a sense of basic trust in self and others, which is often deeply affected in individuals who have experienced trauma. Full article

Background/Objectives: Since breast cancer (BC) survival rates have increased to 91% at 5 years and 80% at 15 years postdiagnosis, there is a growing awareness of the importance of addressing the long-term well-being of patients. Consequently, integrative oncology, which combines standard therapies with complementary approaches (nutrition, mind–body practices, and lifestyle modifications), has emerged as a patient-centred model aimed at improving symptom management, treatment adherence, and overall quality of life (QoL). This study aims to demonstrate how integrative therapies can benefit body composition, phase angle, and fluid and electrolyte balance through bioelectrical impedance analysis (BIA). Methods: This study considers a patient who underwent BC surgery and was enrolled in the AMICO clinic for anamnesis, as well as their oncological pathology data, assessment of QoL, and BIA. The breast surgeon specialising in integrative oncology therapies prescribed the patient curcumin and polydatin, moderate physical activity, a balanced diet, and Qigong sessions. The patient underwent monitoring through haematochemical analysis, BIA, and a QoL questionnaire, with follow-up every four months. Results: Between 4 and 12 months, fat mass (FM) and body mass index (BMI) markedly decreased, whereas fat-free mass (FFM), total body water (TBW), and skeletal muscle mass (SMM) increased progressively. Moreover, the improvements in the Na/K ratio and phase angle (PhA) suggest a shift toward better electrolyte and fluid balance and enhanced cellular integrity and membrane function. Equally outstanding were her psychological benefits in terms of mood, sleep, anxiety, and melancholy. Conclusions: Patient progress in body composition, metabolic function, pain management, and psychological status measured during the 12-month follow-up demonstrates the potential benefits of an integrative approach to supportive cancer care. Full article

Background/Objectives: Although Tai Chi has shown potential benefits for managing chronic pain, its clinical effectiveness specifically for knee pain remains inconclusive. Methods: We systematically searched ten electronic databases for randomized controlled trials (RCTs) investigating the effects of Tai Chi on knee pain. Results: This systematic review and meta-analysis included 11 RCTs involving 706 participants; among them, three studies (n = 169) were eligible for meta-analysis. A comprehensive search of ten electronic databases was conducted up to March 2025. The included RCTs were conducted in the United States (n = 5), China (n = 3), South Korea (n = 2), and Turkey (n = 1). Compared to health education, Tai Chi significantly improved knee pain, as measured using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain score (mean difference (MD) = −0.60; 95% CI: −6.52 to −3.28; p < 0.00001) and the Visual Analogue Scale (VAS) (MD = −1.44; 95% CI: −1.95 to −0.93; p < 0.00001). Tai Chi also significantly improved knee function compared to health education (WOMAC function score—MD = −13.49; 95% CI: −17.11 to −9.87; p < 0.00001). Four RCTs comparing Tai Chi with no intervention reported favorable effects on knee pain and function; however, a meta-analysis was not possible due to limited data. In contrast, two studies comparing Tai Chi with active controls, such as physical therapy and resistance training, found no significant differences in pain or functional outcomes. Two studies reported increased knee pain during initial Tai Chi sessions, but no adverse events occurred after postural corrections. Conclusions: While Tai Chi appears promising for knee pain management, further large-scale, high-quality RCTs with rigorous methodology are needed to establish definitive evidence. Full article

Noble metal nanostructures have garnered significant attention for their exceptional optical properties, particularly Localized Surface Plasmon Resonance (LSPR), which enables pronounced near-field electromagnetic enhancements. Among these, bowtie nanoantennas (BNAs) are distinguished by their intense plasmonic coupling within nanogap regions, making them highly effective for applications such as surface-enhanced Raman scattering (SERS). However, the practical utility of conventional BNAs is often hindered by small hotspot areas and significant scattering losses at their peak near-field enhancement wavelengths. To overcome these limitations, we have designed a novel notch metal-insulator-metal bowtie nanoantenna (NMIM-BNA) structure. This innovative design integrates dielectric materials with Ag-BNA nanostructures and strategically positions arrays of silver (Ag) nanorods within the central nanogap. By coupling the larger NMIM-BNA framework with these smaller Ag nanorod arrays, higher-order plasmon modes (often referred to as dark modes) are effectively excited. Consequently, the NMIM-BNA exhibits substantial electric field enhancement, particularly at the Fano dip wavelength, arising from the efficient coupling of these higher-order plasmon modes with dipole plasmon modes. Compared to conventional Ag-BNA nanoantennas, our NMIM-BNA provides a significantly larger hotspot region and an enhanced near-field amplification factor, underscoring its strong potential for advanced SERS applications. Full article

Objective: Chronic stress affects the immune system via the hypothalamic–pituitary–adrenal (HPA) axis and autonomic system. Chronic inflammation is a risk factor for cardiovascular diseases, cancer onset and progression, susceptibility to infection, and cognitive impairment. Mind–body interventions (MBIs) could affect the immune and neuroendocrine systems, and we aimed to assess the correlations among these systems through a meta-analysis. Methods: RCTs were identified by searching three databases: PubMed, Embase, and Scopus. Of the 1697 studies identified, 89 were included in this study. Risk of bias was examined using the Cochrane risk-of-bias assessment tool. Data were pooled using a random-effects model, and SMDs were calculated. I² statistics and Egger’s test were used to assess the significance of the asymmetry. Influence diagnostics were used to assess whether pooled effects were disproportionately dependent on any single study. The trim-and-fill method was applied to all identified asymmetric instances. Meta-regression was used to examine the moderating effect of MBI efficacy on biomarkers. Results: MBIs generally decreased the levels of inflammatory factors, such as the CRP, IL-6, TNF-α, IL-1, IL-8, IL-17, ESR, and cortisol, and increased IL-10, IFN-γ, IL-1ra, BDNF, and secretory IgA. In a subgroup analysis of the CNS and cancer, qigong and yoga showed increased BDNF and IL-6, respectively. Notably, IL-10 was increased in inflammatory diseases, and IFN-γ was increased in viral infections. Conclusions: This study revealed MBIs decrease inflammatory cytokine and increase anti-inflammatory, antiviral, and immune-activating factors. These results suggest the MBIs including gentle physical exercise may be beneficial for neuropsychiatric disorders or tumors. Prospero registration number: CRD42024507646. Full article

This study examines the effects of three traditional Chinese mind–body exercises—Tai Chi (TC), Baduanjin (BD), and Health Qigong Yijinjing (YJJ)—on learning abilities, executive functions, and prefrontal brain connectivity in children with learning difficulties. Seventy-two children (aged 9–11) with learning difficulties were randomly assigned to TC, BD, YJJ, or a control group (CON). Intervention groups practiced for 12 weeks (45 min, three times per week), while the control group maintained their regular physical education. Assessments included Academic Performance Ranking (APR), Pupil Rating Scale (PRS), and executive functions. Granger causality analyses were conducted on the functional near-infrared spectroscopy data to derive the effective connectivity at the brain region levels. Post-intervention, all intervention groups showed significant improvements over the control group in PRS and APR scores (p < 0.05), with the TC group achieving higher PRS scores than the BD group. The TC group also demonstrated superior improvements in executive functions, particularly in inhibition and working memory. Additionally, the TC group exhibited significantly enhanced effective connectivity from the left and right dorsolateral prefrontal cortex to Brodmann area 8, indicating improved brain communication. Traditional Chinese mind–body exercises, particularly Tai Chi, improve academic performance, executive functions, and prefrontal cortex connectivity in children with learning difficulties. Tai Chi demonstrates superior outcomes, supporting its potential as an effective intervention for cognitive and academic development. Full article

Mental disorders are highly prevalent worldwide. Unfortunately, most people with these disorders do not receive any treatment. This is due in part to a large set of barriers (e.g., no access to therapists or clinics, lack of insurance, stigma) that impede seeking and obtaining mental health services. Many lifestyle interventions that are not part of traditional mental health services have indirect effects on reducing symptoms of mental disorders. These are interventions that target a direct focus (e.g., physical health, socialization, general well-being) but also have indirect and significant impact on reducing mental disorders. This article discusses indirect interventions as an additional way of reaching people in need of help with mental health problems. Interventions such as physical activity and exercise, diet, addressing sleep problems, yoga, tai chi, qigong, and volunteering have indirect beneficial effects. This article highlights the scope of mental illness as a background, introduces indirect interventions, and details three illustrations with evidence that targeting one focus with indirect effects on improving mental disorders. The interventions point to a category of interventions are not systematically used in the care of mental health problems. Among their many advantages is the prospect of their use at the levels of individuals and populations. Indirect interventions do not replace any of the current advances in treatment but add to ways of reaching people in need. Full article

Background/objective: Althouth Qigong is commonly used to manage stress, anxiety, and depression, there have been no systematic reviews on Qigong therapy for stress management. This study aimed to analyze the clinical evidence of Qigong therapy for perceived stress. Methods: We conducted a systematic search for randomized controlled trials (RCTs) of Qigong using 11 electronic databases, namely MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Physiotherapy Evidence Database, CINAHL, and Korean Medical databases (Korea Institute of Science and Technology Information, Korean traditional knowledge portal, KoreaMed, OASIS, RISS, and the National Library of Korea). We considered RCTs in which participants with perceived stress with no restrictions on age, gender, or ethnicity. Two reviewers independently assessed risk of bias of the included RCTs using the Cochrane risk of bias tool. Nine RCTs (China: n = 5, South Korea: n = 2, United States: n = 1, Brunei Darussalam: n = 1) were included in the systematic review. Results: The quality of the included trials was generally low, as only one was rated as high quality. For the primary outcome, a meta-analysis of two RCTs showed statistically significant results on the perceived stress scale comparing the Qigong therapy group with the no-treatment group (OR −0.60; 95% CI −1.02 to −0.17; p = 0.006). The results of three other studies showed that Qigong therapy had no significant effect compared to active-control therapy on the perceived stress scale outcome (OR −2.10; 95% CI −4.68 to 0.47; p = 0.11). Regarding the secondary outcomes, including depression, anxiety scale, and quality of life, the Qigong group showed statistical improvements in most studies; however, there was no difference in the pain scale between the two groups. In two studies, no adverse events occurred, whereas in one study, six cases (24% of participants) of mild muscle soreness were reported. Conclusions: This systematic review suggests the potential of Qigong therapy for stress management; however, it is difficult to draw specific conclusions. Future studies should standardize Qigong interventions and outcomes, establish sham control groups, and include larger sample sizes in RCTs. Full article

Background/Objectives: Chronic fatigue syndrome (CFS) and post-COVID syndrome (PCS) pose a substantial socioeconomic burden. The aim of this systematic review was to assess current evidence regarding the effect of the most popular forms of movement-based mindful exercises, i.e., qigong, tai chi, and yoga, on fatigue and associated symptoms in CFS and PCS. Methods: CINAHL, Embase, PsycINFO, PubMed, Scopus, and the Cochrane Library were searched from inception to October 2023. Randomized controlled trials (RCTs) where qigong, tai chi, or yoga were compared with waitlist, no intervention, or active controls were included. Independent reviewers participated in data extraction, and evaluated risk of bias, spin of information, completeness of intervention description, and certainty of the evidence (GRADE). Meta-analyses were conducted. The primary outcome was the level of fatigue. Secondary measures were the severity of anxiety and depressive symptoms and sleep quality. Results were expressed as mean difference (MD) or standardized mean difference (SMD) with a 95% confidence interval (CI). Results: Thirteen RCTs with 661 participants were included, with most studies presenting a moderate or high risk of bias. Mindful exercises were more effective than control interventions to alleviate fatigue: SMD (95%CI) = −0.44 (−0.63 to −0.25), I² = 48%, p < 0.0001. Positive effects were also observed for secondary outcomes. The certainty of the evidence was low or very low. Conclusions: Qigong, tai chi, and yoga may be effective to reduce fatigue and improve anxiety, depression, and sleep quality in adults with CFS or PCS. However, serious methodological concerns limit the clinical applicability of these findings. Full article

Background: Despite advancements in cancer treatment, chemotherapy side effects significantly impact patients both physically and emotionally. While pharmacological treatments can mitigate these side effects, they may trigger additional side effects, exacerbating the overall discomfort experienced by patients; moreover, psychological factors influencing physical symptoms are beyond the reach of pharmacological interventions. Nonpharmacological interventions, however, offer the potential for complementary or alternative solutions. Objectives: This review aims to offer a comprehensive analysis of the literature on the effectiveness of nonpharmacological interventions in managing the physical side effects of chemotherapy. Methods: This review, based on a search of PubMed, PsycINFO, and Web of Science databases, identified 46 relevant studies. It categorizes interventions and evaluates their effectiveness in managing common chemotherapy side effects (fatigue, nausea, pain, diarrhea, and constipation). Results: Guided imagery, tailored exercises, and Qigong show promise in reducing fatigue, while interventions like yoga and cognitive-behavioral approaches address nausea and vomiting. Pain benefits result from guided imagery and educational interventions. Limited evidence exists for diarrhea and constipation interventions, necessitating further research. Conclusions: This review offers provisional conclusions, emphasizing the potential of integrating evidence-based nonpharmacological approaches alongside pharmacological interventions to enhance patient outcomes and reduce chemotherapy-induced side effects, considering factors such as accessibility, safety, customization, and adaptability in clinical settings. Full article

This study aims to assess the motivational factors influencing the participation of older adults in various exercise interventions during depressive episodes and to identify which types of exercise are most effective in alleviating depressive symptoms in this population. Therefore, randomized controlled trials (RCTs) focusing on exercise interventions and their impact on depression in older adult patients, identified by the terms “exercise” AND “depression” AND “elderly” OR “geriatric”, were selected from primary electronic databases to conduct this network meta-analysis (NMA). The primary outcome was the effect on depressive symptoms, while the secondary outcome was the comparison of dropout rates between the intervention groups and the usual care control groups, as a measure of sustained motivation and engagement. Standardized mean difference (SMD) values and the corresponding 95% confidence intervals (CIs) were computed for effect evaluation. This study protocol has been registered in IPLASY (INPLASY 202460035). The results of 31 RCTs with 3238 participants indicated that qigong (SMD −1.17, −2.28 to −0.06), Otago Exercise (SMD −1.15, −2.29 to −0.01), and yoga (SMD −0.88, −1.55 to −0.21) significantly alleviate depressive symptoms in older adults. Walking (SMD −0.82, −1.34 to −0.31) and strength training (SMD −0.67, −1.05 to −0.30) also showed significant effects. Aerobic, physical training, and tai chi had moderate effects, while multisport showed a weaker impact with no significant improvement. In summary, our research findings demonstrate that exercise can effectively alleviate depressive symptoms in older adults, with low dropout rates likely due to interconnected physiological, psychological, and social mechanisms. This is crucial for enhancing treatment strategies for older adults’ depression. Full article

Face recognition technology has been widely used with the WeChat applet on mobile devices; however, facial images are captured on mobile devices and then transmitted to a server for feature extraction and recognition in most existing systems. There are significant security risks related to personal information leakage with these transmissions. Therefore, we propose a face recognition framework for the WeChat applet in which face features are extracted in WeChat by the proposed Face Feature Extraction Model based on Attention Mechanism (FFEM-AM), and only the extracted features are transmitted to the server for recognition. In order to balance the prediction accuracy and model complexity, the structure of the proposed FFEM-AM is lightweight, and Efficient Channel Attention (ECA) was introduced to improve the prediction accuracy. The proposed FFEM-AM was evaluated using a self-built database and the WeChat applet on mobile devices. The experiments show that the prediction accuracy of the proposed FFEM-AM was 98.1%, the running time was less than 100 ms, and the memory cost was only 6.5 MB. Therefore, this demonstrates that the proposed FFEM-AM has high prediction accuracy and can also be deployed with the WeChat applet. Full article

Introduction: Electro-acupuncture, an innovative adaptation of traditional acupuncture, combines electrical stimulation with acupuncture needles to enhance therapeutic effects. While acupuncture is widely used, its biological mechanisms remain incompletely understood. Recent research has explored the neurophysiological aspects of acupuncture, particularly through functional magnetic resonance imaging (fMRI) to investigate its effects on brain activity. Methods: In this systematic review, we conducted an extensive search for randomized clinical trials examining electro-acupuncture effects measured by fMRI. We employed strict eligibility criteria, quality assessment, and data extraction. Results: Five studies met our inclusion criteria and were analyzed. The selected studies investigated electro-acupuncture in various medical conditions, including carpal tunnel syndrome, fibromyalgia, Crohn’s disease, irritable bowel syndrome, and obesity. Notably, electro-acupuncture was found to modulate brain activity and connectivity in regions associated with pain perception, emotional regulation, and cognitive processing. These findings align with the holistic approach of traditional Chinese medicine, emphasizing the interconnectedness of body and mind. Discussion: In carpal tunnel syndrome, electro-acupuncture at both local and distal sites showed neurophysiological improvements, suggesting distinct neuroplasticity mechanisms. In fibromyalgia, somatosensory electro-acupuncture correlated with reduced pain severity, enhanced brain connectivity, and increased gamma-aminobutyric acid levels. For Crohn’s disease, electro-acupuncture influenced the homeostatic afferent processing network, potentially mitigating gut inflammation. Electro-acupuncture for irritable bowel syndrome led to decreased activity in the anterior cingulate cortex, offering pain relief, while electro-acupuncture for obesity impacted brain regions associated with dietary inhibition and emotional regulation. Conclusion: This systematic review provides evidence that electro-acupuncture can positively impact a range of medical conditions, possibly by modulating brain activity and connectivity. While the quality of the reviewed studies is generally good, further research with larger sample sizes and longer-term assessments is needed to better understand the mechanisms and optimize electro-acupuncture protocols for specific health conditions. The limited number of studies in this review emphasizes the need for broader investigations in this promising field. The research protocol was registered in PROSPERO (CRD42023465866). Full article