Search Results (54)

The subtropics are affected by severe climate change, which may induce heat stress in animals. Moreover, the region is significantly seasonal; hence, mitigating climate risks and implementing climate adaptation measures are necessary. Sustainable Development Goals 1, 2, and 13 call for no poverty, zero hunger, and climate action. These are the most severe problems affecting food security in the modern world. Food security refers to a situation in which all people have physical, social, and economic access to sufficient, proper, and healthy food that satisfies their dietary requirements. Nevertheless, the projected increase in the human population implies a greater demand for employment opportunities; hence, developing countries are building more industrial areas. The burning of fossil fuels in various industries potentiates climate change and environmental pollution. It is predicted that the ecological temperature will increase by almost 2.3–4.8 °C by 2100 due to climate change. Agriculture and animal products remain vital in Africa as drivers of the economy and transformation for sustainable livelihood and development. Sheep production has long been used as a source of income and livelihood and provides jobs for people who live in rural areas. It is also sometimes used for ritual ceremonies and to pay penalties to local authorities. Nevertheless, sheep have been identified to be sensitive to heat stress, characterized by low reproductive performance, low microbiota quantities, and poor general health. There are different strategies for mitigating heat stress; however, many smallholder farmers have limited access to education and lack the financial support required to incorporate artificial shade and plant trees for shade to limit heat stress. In this review, we aim to understand the effects of environmental heat stress on sheep production and reproductive performance. Based on this review, it can be concluded that heat stress can threaten food security if not addressed, especially for farmers who depend on sheep rearing. As a result, future studies are recommended to understand different adaptation methods that can be used to mitigate the heat stress effect on sheep productivity, reproductivity, and general health. Full article

The FAO estimates that 1660 million hectares globally are degraded due to human activities, with over 60% of this degradation affecting agricultural lands, including croplands and pastures. Given that 95% of global food production depends on land, this widespread degradation presents significant challenges to agrifood systems. This study compares patterns of human-induced land degradation in Arab countries with global and regional averages, examining drivers, impacts on agrifood systems, current yield gaps, and restoration opportunities. The results indicate that in the Arab region, two-thirds of the 70 million hectares affected by human-induced degradation—over 46 million hectares—are agricultural land, with croplands particularly impacted. However, with less than 4% of land in the Arab region designated for restoration, the region lags behind global targets. Restoring 26 million hectares of degraded cropland could reduce the yield gap by up to 50% for oil crops and help cereal, root, and tuber crops approach their potential yields. These findings underscore the pressing need for a regional initiative specifically targeting agricultural land degradation to enhance food security, reduce poverty, and support sustainable and resilient agrifood systems. Full article

Climate-induced migration has emerged as a major concern in India and Bangladesh, due to their geographical vulnerability and socioeconomic conditions. Coastal areas, such as the Sundarbans and the Ganges–Brahmaputra Delta, face relentless threats due to rising sea levels, cyclones, and floods. These factors force millions to relocate, resulting in rural–urban transitions and cross-border movements that worsen urban challenges and socioeconomic vulnerabilities. For this, a systematic literature review of the Scopus database was undertaken using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A detailed review analysis of 65 papers was carried out. The study highlighted key climatic and non-climatic drivers of migration, including natural disasters, resource depletion, poverty, and poor governance. Despite existing adaptation strategies, such as early warning systems, micro-insurance, and climate-resilient practices, gaps remain in addressing long-term resilience and legal recognition for climate migrants. The research emphasizes the need for a holistic, multi-stakeholder approach, integrating adaptive infrastructure, sustainable livelihoods, and international cooperation. Recommendations include bridging research gaps, increasing community participation, and implementing global frameworks, like the Fund for Responding to Loss and Damage. Addressing climate migration through fair, inclusive measures is essential for building resilience and ensuring long-term development in the region. Full article

Epigenetics regulates gene expression and thus cellular processes that underlie the pathogenesis of chronic lung diseases such as chronic obstructive pulmonary disease (COPD), asthma, and idiopathic pulmonary fibrosis (IPF). Environmental factors (e.g., air pollution, smoking, infections, poverty), but also conditions such as gastroesophageal reflux, induce epigenetic changes long before lung disease is diagnosed. Therefore, epigenetic signatures have the potential to serve as biomarkers that can be used to identify younger patients who are at risk for premature loss of lung function or diseases such as IPF. Epigenetic analyses also contribute to a better understanding of chronic lung disease. This can be used directly to improve therapies, as well as for the development of innovative drugs. Here, we highlight the role of epigenetics in the development and progression of chronic lung disease, with a focus on DNA methylation. Full article

Stress profoundly affects physical and mental health, particularly when experienced early in life. Early-life stress (ELS) encompasses adverse childhood experiences such as abuse, neglect, violence, or chronic poverty. These stressors can induce long-lasting changes in brain structure and function, impacting areas involved in emotion regulation, cognition, and stress response. Consequently, individuals exposed to high levels of ELS are at an increased risk for mental health disorders like depression, anxiety, and post-traumatic stress disorders, as well as physical health issues, including metabolic disorders, cardiovascular disease, and cancer. This review explores the biological and psychological consequences of early-life adversity paradigms in rodents, such as maternal separation or deprivation and limited bedding or nesting. The study of these experimental models have revealed that the organism’s response to ELS is complex, involving genetic and epigenetic mechanisms, and is associated with the dysregulation of physiological systems like the nervous, neuroendocrine, and immune systems, in a sex-dependent fashion. Understanding the impact of ELS is crucial for developing effective interventions and preventive strategies in humans exposed to stressful or traumatic experiences in childhood. Full article

Research on the Leave No One Behind principle of the Sustainable Development Goals (SDGs) within the context of the Agenda 2030 is currently prevalent; however, research on monitoring child poverty at the sub-national (local) level is still limited. This paper addresses this gap by examining indicators developed for monitoring the phenomenon at different territorial levels (global, European, and national) and assessing their territorial transposition locally, using the city of Cadiz, Spain, as a case study. Interviews with local stakeholders reveal that despite the availability and access to related indicators and data, relevant actors must enhance their efforts to utilize such indicators effectively. Based on desktop research and qualitative analysis, the paper delivers recommendations for improving local monitoring of child poverty in Europe and inducing policy changes. This knowledge can inform targeted interventions, policy formulation, and resource allocation to tackle child poverty and promote equitable and inclusive societies. Full article

An important share of the social housing stock in Flanders is outdated, resulting in a high energy demand for heating. Energetic renovation is hence urgently needed. The current economic model, however, does not stimulate this due to a split incentive. As energy prices have increased in the past few years, more tenants have suffered from energy poverty. This paper investigates three alternative economic models aiming at increasing the incentive for renovation, while financially protecting the tenants. In the first alternative model, tenants are protected by inducing a maximal cost of living based on their income. In the second alternative model, a fixed rent is applied, while the third alternative model proposes to share the cost benefits of the energetic renovation. The paper analyses the alternative models by assessing the costs and income for social housing companies and the costs for tenants for an unrenovated building, a renovation with a low investment cost and a deep energetic renovation. The results show that limiting the cost of living based on income seems most interesting as this is beneficial for the tenants and gives an incentive for the social housing companies to renovate. To reduce energy poverty, a deep renovation is necessary. Full article

Plastic production, disposal, and recycling systems represent one of the higher challenges for the planet’s health. Its direct consequence is the release of endocrine disruptors, such as bisphenol A (BPA), and its emerging substitute molecules, bisphenol F and S (BPF and BPS), into the environment. Consequently, bisphenols are usually present in human biological fluids. Since BPA, BPS, and BPF have structural analogies and similar hormonal activity, their combined study is urgently needed. The present manuscript studied the effect of the mixture of bisphenols (BP_mix) in one of the world’s largest human cohorts (NHANES cohort). Descriptive and comparative statistics, binomial and multinomial logistic regression, weighted quantile sum regression, quantile g-computation, and Bayesian kernel machine regression analysis determined a positive association between BP_mix and heart disease, including confounders age, gender, BMI, ethnicity, Poverty/Income Ratio, and serum cotinine. Endothelial dysfunction is a hallmark of cardiovascular disease; thus, the average ratio of bisphenols found in humans was used to conduct murine aortic endothelial cell studies. The first results showed that BP_mix had a higher effect on cell viability than BPA, enhancing its deleterious biological action. However, the flow cytometry, Western blot, and immunofluorescence assays demonstrated that BP_mix induces a differential effect on cell death. While BPA exposure induces necroptosis, its combination with the proportion determined in the NHANES cohort induces apoptosis. In conclusion, the evidence suggests the need to reassess research methodologies to study endocrine disruptors more realistically. Full article

Poverty increases vulnerability towards somatisation and influences the sense of mastery and well-being. The present study on adolescents living in relative poverty in a high-income group country (Israel) and a low-middle-income group country (India) explored the nature of somatisation tendency (ST) and its relationship with potency and perception of poverty (PP). Potency, a buffer against stress-induced negative health effects, was hypothesized to be negatively related to ST and mediate the link between PP and ST. Purposive sampling was used to collect questionnaire-based data from community youth (12–16 years) of two metropolitan cities—Kolkata (India, N = 200) and Tel-Aviv (Israel, N = 208). The nature of ST, PP and potency was analysed using descriptive and inferential statistics and correlation-regression statistics and mediation analysis were used to understand the relationship among them. A clinically significant level of ST was reported by both Indian and Israeli youth experiencing 5–7 somatic symptoms on average. Potency was found to be a significant predictor of ST in both countries (p < 0.05) and emerged as a significant mediator (p < 0.001) in the PP and ST relationship among Indian adolescents. The present study highlights potency as a protective buffer in economically vulnerable community adolescents and re-establishes a high prevalence of ST among them, irrespective of their country’s global economic position. Full article

The displacement and resettlement-associated poverty caused by water conservancy projects (WCP) is a worldwide issue. Re-settlers are often impoverished for extended periods due to loss, difficult re-establishment, and insufficient compensation. Addressing poverty has become a worldwide concern, and accurate measurements of poverty remain a fundamental issue. Before 2020, the Chinese government used the absolute income method to measure re-settler poverty. However, this method reflected neither the overall income gap nor potential benefits of social development and poverty alleviation policies. Therefore, we used the relative income and multidimensional methods alongside the absolute income poverty method to measure the poverty in recently resettled households. Based on survey data from over resettled 1000 households we conclude that: (1) The remaining poor measured by the absolute poverty line were mainly caused by serious diseases, disabilities and loss of labor ability, which means they have no ability to be lifted out of poverty except through the bottom line of local governments. As a result, the absolute poverty line loses its distinction to poverty. (2) Rural re-settlers were more resilient to forced majeure because land guarantees employment and food supply, allowing households to avoid secondary livelihood destruction. (3) Income derived measurement of re-settler poverty masks the benefits of poverty alleviation and other socioeconomic aid programs. A few households showed improvements in child school attendance, child mortality, nutrition, cooking fuel, asset ownership, and social insurance following resettlement. (4) To reduce the multidimensional gap, government aid programs should focus on years of schooling (including training), nutrition, household savings, and household labor force rather than simply providing monetary assistance. At the same time, we suggest that the government adopt a variety of compensation methods, such as: sharing the benefits of water conservancy projects, industrial support and improving the bottom line guarantee. Full article

This study argues that Vision 2030 and social housing should consider the elements of the sociocultural dimension of urban design (SDUD) to alleviate urban poverty-induced feelings. By examining public spaces in the context of Vision 2030 and the implementation of social housing projects, this study aims to provide a theoretical framework that may assist city policymakers in rethinking the role of public spaces in alleviating poverty-related feelings. A review of the relevant literature explores the SDUD elements and builds an index to measure poverty through bibliometric and content analysis. This index was used to analyze the gaps in Vision 2030 in South Africa, Kenya, and Egypt, which we randomly chose. It focused on SDUD elements, social housing, and public spaces. We empirically examined the role of public spaces in alleviating poverty-related feelings using the SDUD index. We applied episodic narrative and interview-based storytelling techniques to a limited group of poor residents in the Al Asmarat Housing Project in Mokattam, Cairo, Egypt. This interview discusses the role of public spaces in reducing poverty-related feelings. The results focus on exploring the four SDUD elements of poverty and examining how public spaces alleviate poverty-induced feelings. Vision 2030 revolves around SDUD elements, social housing, and public spaces. Urban design policies can alleviate poverty in development projects for the poor. Integrating urban design policies into Vision 2030 makes city dwellers in developing countries feel less inferior. Full article

Only a few studies seem to address suicidality as an effect of the COVID-19 pandemic in persons previously affected by psychiatric disorders. The relationship between fear and stress caused by the COVID-19 pandemic and the level of social support and suicidality in patients diagnosed with affective and stress-induced psychiatric disorders prior to the onset of the COVID-19 pandemic were investigated. This study was observational and involved 100 participants. The examined period was from April 2020 to April 2022. The Fear of COVID-19 Scale (FCV-19S), the Oslo Social Support Scale 3 (OSSS-3) and general psychiatric interviews were used to obtain data. A statistically significant relationship between the impact of COVID-19-related distress on the occurrence of suicidality and the year of the pandemic χ²(2, N = 100) = 8.347, p = 0.015 was observed. No statistically significant correlation was found between suicidal behavior, stress intensity, fear and the score on the social support scale (p > 0.05). Fear related to the COVID-19 pandemic can only be seen as a contributor to suicidality. Overall, social support does not always act protectively. Previously stressful experiences such as wars, poverty and natural disasters seem to play a significant role in the resilience to each new public health crisis. Full article

With the advancement of “targeted poverty alleviation”, the main problems we face at this stage are analyzing the causes of poverty and preventing poverty-stricken villages from falling back into poverty. Using the last batch of poverty-stricken villages that have been lifted out of poverty, which were announced by the Henan Provincial poverty alleviation and development office, as the research object, this research discusses the spatial distribution characteristics of 835 poverty-stricken villages in Henan Province from the perspective of the macro province by combining kernel density analysis and spatial autocorrelation analysis, analyzes their influencing factors using the least squares linear regression model, and performs a quantitative analysis of their influencing factors. The results revealed the following: (1) The spatial distribution characteristics of poverty-stricken villages in Henan Province are characterized by significant agglomeration. A banded high-density area is formed in the east of Henan Province, with a sub-density area in the west of Henan Province, and it radiates outward with the “dikaryon” as its center. (2) High-density and sub-density areas of poverty-stricken villages are mainly located in flat areas, with spatial dependence on each other. The high-high clustering areas are mainly areas dominated by agricultural economies. The low-low clustering areas mainly have limited agricultural development and rapid urban–rural integration. (3) Geographical locations and socio-economic and basic public services are the main factors affecting poverty in poverty-stricken villages. At the same time, environmental livability is an advantageous condition in areas where poverty-stricken villages are located, of which the Temperature Humidity Index factor is most closely related to the distribution density of poverty-stricken areas. The research results are intended to provide information for the policies and program intervention strategies for poverty reduction and sustainable development in poverty-stricken villages in Henan Province, and this is conducive to consolidating the results of targeted poverty alleviation and preventing a return to poverty. Full article

Global and urban-induced local warming lead to increasing heat risk in cities. The rapid increase in urban population, weak infrastructure, poverty, as well as an ageing population, make the risk more acute in developing cities. However, heat risk is not uniformly distributed and a detailed exploration of the link between urban characteristics and local variations in heat risk is needed to aid targeted mitigation. In this paper, we demonstrate a fine-grained heat risk map using existing data combined with expert opinion in a humid tropical city (Colombo, Sri Lanka) with the objective of highlighting the relative heat risk as a function of physical and socioeconomic conditions across the city. We then simulate the effects of shading and greening on the ‘high’ heat risk areas, and greening on the ‘low’ heat risk areas, to show that a combined approach will be needed to reduce risk at ‘high’ risk areas. In ‘low’ risk areas, maintaining the green cover is crucial to heat risk reduction. The paper, thus, establishes a protocol for detailed heat risk mapping with existing data and points to the differing importance of shading and greening in different parts of the city, thus, showing where, and to what extent, mitigation actions could be beneficial. Full article

Malaria remains a major world public health problem, contributing to poverty and inequality. It is urgent to find new efficacious tools with few adverse effects. Malaria has selected red blood cell (RBC) alterations linked to resistance against infection, and understanding the protective mechanisms involved may be useful for developing host-directed tools to control Plasmodium infection. Pyruvate kinase deficiency has been associated with resistance to malaria. Pyruvate kinase-deficient RBCs display an increased concentration of 2,3-diphosphoglycerate (2,3-DPG). We recently showed that 2,3-DPG impacts in vitro intraerythrocytic parasite growth, induces a shift of the metabolic profile of infected cells (iRBCs), making it closer to that of noninfected ones (niRBCs), and decreases the number of parasite progenies that invade new RBCs. As an increase of 2,3-DPG content may also have an adverse effect on RBC membrane and, consequently, on the parasite invasion, in this study, we explored modifications of the RBC morphology, biomechanical properties, and RBC membrane on Plasmodium falciparum in vitro cultures treated with 2,3-DPG, using atomic force microscopy (AFM)-based force spectroscopy and other experimental approaches. The presence of infection by P. falciparum significantly increased the rigidity of parasitized cells and influenced the morphology of RBCs, as parasitized cells showed a decrease of the area-to-volume ratio. The extracellular addition of 2,3-DPG also slightly affected the stiffness of niRBCs, making it more similar to that of infected cells. It also changed the niRBC height, making the cells appear more elongated. Moreover, 2,3-DPG treatment influenced the cell surface charge, becoming more negative in treated RBCs than in untreated ones. The results indicate that treatment with 2,3-DPG has only a mild effect on RBCs in comparison with the effect of the presence of the parasite on the host cell. 2,3-DPG is an endogenous host metabolite, which may, in the future, originate a new antimalarial tool with few adverse effects on noninfected cells. Full article