Search Results (2,569)

With the rapid growth of urban motorization, personalized travel modes, including taxis and private cars, have expanded considerably. However, conventional public transportation systems, constrained by fixed routes and limited service flexibility, often struggle to satisfy residents’ increasingly diversified and high-quality commuting needs. To address this issue, this study proposes an integrated planning framework for customized bus services using taxi trajectory data. First, passenger origin–destination (OD) information is extracted by detecting changes in the taxi passenger-status field. The extracted OD records are then used to identify potential commuting demand by jointly considering peak-hour travel characteristics and regional OD stability. Second, the identified potential commuting demand is used to generate candidate boarding and alighting stops through an improved DBSCAN-based clustering method, namely IDK-SG. For route planning among the candidate stops, a bi-objective optimization model is developed to simultaneously account for passenger travel-time costs and bus operating costs, and the model is solved using a genetic algorithm. Finally, timetable optimization is formulated as a Markov decision process and solved using a Deep Q-Network (DQN) algorithm. Case studies using taxi GPS trajectory data from Chongqing demonstrate that the proposed framework can effectively identify stable commuting demand, optimize stop layouts and route schemes, and improve vehicle occupancy and service quality. These findings provide practical decision-making support for the operation and dynamic scheduling of customized bus services in urban peak-hour commuting corridors. Full article

Background/Objectives: Small-scale workplaces often have limited access to occupational health services, despite potential exposure to hazardous solvents. Biological monitoring can provide worker-level evidence of internal exposure when routine environmental monitoring is limited. This study evaluated urinary biomarkers of benzene and toluene exposure among workers in small-scale printing workplaces in South Korea and examined whether self-reported chemical handling corresponded with biomarker patterns. Methods: In this cross-sectional field biomonitoring study, 21 workers from eight printing companies provided end-of-shift urine samples. Creatinine-adjusted urinary concentrations of trans,trans-muconic acid (t,t-MA), S-phenylmercapturic acid (SPMA), phenol, and o-cresol were analyzed and compared with applicable biological reference values. Associations between reported chemical handling and elevated biomarker levels were estimated using Firth’s penalized logistic regression, and correlations among log-transformed biomarkers were explored. Results: Nine workers (42.9%) had urinary o-cresol concentrations at or above the American Conference of Governmental Industrial Hygienists (ACGIH) biological exposure index of 300 μg/g creatinine. Workers reporting benzol handling, a local term for petroleum-based cleaning products, had higher odds of elevated SPMA, although the estimate was imprecise and hypothesis-generating (age-adjusted OR 6.04, 95% CI 0.75–104.90, p = 0.093). The correlation between SPMA and t,t-MA was stronger among workers reporting benzol handling (r = 0.94) than among those reporting toluene handling (r = −0.01). Conclusions: These exploratory findings indicate that toluene-related internal exposure is a relevant occupational health concern in small-scale printing workplaces, while reported benzol handling may indicate possible low-level benzene-related exposure. Urinary biomonitoring may support exposure surveillance and preventive occupational healthcare in small enterprises when interpreted alongside workplace observations, product information, ventilation, protective equipment use, and worker education. Full article

Background/Objectives: Work-related musculoskeletal disorders (WMSDs) and occupational stress substantially affect workforce health and productivity. This systematic review aimed to synthesize evidence regarding the effectiveness of the Pilates method as a biopsychosocial intervention for employees, examining its impact on physical, psychological, and occupational outcomes. Methods: A systematic search was conducted across major electronic databases and search engines (PubMed, Scopus, Web of Science, PEDro, and Google Scholar) following PRISMA 2020 guidelines. The review protocol was prospectively registered in PROSPERO (CRD420261390771). Eligible studies included randomized controlled trials, quasi-experimental, and observational designs involving employees participating in Pilates programs. Outcomes were categorized into three domains: physical health, mental well-being, and occupational performance. Results: Twenty-three studies (n = 1179 participants) met the inclusion criteria. The evidence indicates that Pilates may reduce pain intensity and disability in workers with chronic low back or neck pain, with moderate certainty based on randomized controlled trials. Improvements in psychological outcomes, including anxiety and job-related stress, were also reported, although the certainty of evidence was lower. Occupational benefits included enhanced job satisfaction and, in limited cases, favorable cost-utility findings. Conclusions: Pilates appears to be a feasible multidimensional intervention for workplace health, with potential benefits across physical and psychosocial domains. Further high-quality trials are needed to clarify long-term effects, economic impact, and optimal implementation strategies within occupational settings. Full article

Background/Objectives: Patient- and family-initiated abuse of nurses is widely recognized as workplace violence, but it also raises a distinct professional-regulatory question: when may a nurse end or restrict an established therapeutic relationship without creating an allegation of abandonment or discriminatory denial of care? This perspective focuses on Alberta and examines whether the province’s nursing regulator provides a comprehensive, nurse-specific, all-registrant standard comparable in clarity to Alberta’s physician standard. The concern is not the absence of every form of protection but the absence of a clearly defined regulatory pathway for all Alberta RNs and NPs. Methods: Publicly available legal, occupational health and safety, regulatory, legal-risk and scholarly materials were purposively selected where they addressed relationship termination, discontinuing or declining care, workplace violence, immediate safety risk, abandonment, documentation, continuity of care or patient safeguards. Results: The College of Physicians and Surgeons of Alberta standard provides a clearly defined regulatory pathway, including immediate discharge where a patient poses a safety risk, is abusive or fails to respect professional boundaries. Alberta nursing materials contain important elements but do not yet constitute a dedicated Alberta RN/NP standard applicable across office-based, community, virtual, home care and independent nursing practice. Interprovincial nursing standards demonstrate feasibility, operational detail, emerging professional consensus and potential templates for policy transfer; however, they do not bind the CRNA or create an Alberta regulatory benchmark for complaint review. Conclusions: Alberta should adopt a nurse-specific standard for ending or restricting abusive patient- and family-initiated relationships. Such a standard should include ordinary and urgent safety pathways, prohibited grounds, documentation requirements, continuity safeguards, employer integration and practical templates. Nurse protection and patient protection are mutually reinforcing regulatory objectives. Full article

The discharge of metal-containing effluents into aquatic systems remains a major environmental concern because metal ions can persist in water bodies and accumulate in biological systems, potentially affecting ecosystem and human health. Among these contaminants, Cr(III) is frequently encountered in waste streams generated by industrial activities, making its removal an important objective in water quality management. This study investigated the adsorption behavior of Cr(III) using lignocellulosic biosorbents obtained from tamarind shell (Tamarindus indica) after water, H₂O₂, and HCl pretreatments, with particular emphasis on equilibrium behavior, thermodynamic characteristics, and pretreatment-induced physicochemical modifications. Batch adsorption experiments were conducted to evaluate equilibrium behavior. The highest adsorption capacity (41.6 mg g⁻¹) was obtained with the water-treated biosorbent at 60 °C. The equilibrium data were best represented by the Sips model, suggesting that Cr(III) adsorption occurred on surfaces containing adsorption sites with different energetic characteristics. Thermodynamic analysis revealed that the adsorption process was spontaneous, while the enthalpy changes indicated predominantly endothermic behavior for the pretreated biosorbents. ATR-FTIR, SEM, EDS, and XRD analyses were performed to characterize the biosorbents before and after adsorption. The characterization results indicated that oxygen-containing functional groups, particularly hydroxyl and carbonyl functionalities, were associated with the adsorption process. SEM images showed morphological changes associated with pore occupation, while EDS confirmed chromium adsorption and suggested possible ion-exchange mechanisms. XRD patterns indicated a mainly amorphous structure. The results demonstrated that pretreatment-induced modifications strongly influenced the adsorption performance of tamarind shell. Water pretreatment produced the most favorable adsorption behavior, yielding the highest adsorption capacity among the evaluated biosorbents. The combined interpretation of equilibrium, thermodynamic, and characterization results revealed a close relationship between surface properties and Cr(III) uptake. Full article

Zinc processing generates large volumes of tailings enriched with potentially toxic elements such as zinc, lead, arsenic, and antimony, creating environmental challenges. Conventional disposal in tailings dams is associated with land occupation, contamination risks, and geotechnical concerns, reinforcing the need for more sustainable management strategies. This study presents a bibliometric and semi-systematic review of alkali-activated binders for the stabilization and solidification of zinc mine tailings, based on nine studies published between 2019 and 2026. The results indicate that this is a recent and expanding research field, with a marked concentration of studies in China. Current research mainly focuses on the links between microstructure, heavy metal immobilization, and mechanical performance. Alkali-activated systems, commonly based on blast furnace slag, fly ash, and coal gangue, can produce dense matrices with compressive strengths of up to 100.77 MPa and high immobilization efficiency. Their performance is largely governed by the type of reaction products formed, particularly calcium silicate hydrate, calcium aluminosilicate hydrate, and sodium aluminosilicate hydrate gels, which control microstructural development and stabilization mechanisms such as encapsulation, structural incorporation, and secondary phase formation. Overall, the reviewed studies suggest that alkali-activated binders have potential as alternative binders to Portland cement for the management and valorization of zinc mine tailings. Full article

Building energy consumption accounts for 30% of global energy use, making building management pivotal to achieving global sustainability. Occupants have profound impacts on the building environment. Incorporating occupant-related factors into the environmental control process is essential for optimizing the efficiency of building management systems (BMSs), which thus gives rise to the concept of occupant-centric control (OCC). Conventional methods rely on simplified models and fixed schedules that fail to satisfy environmental control and occupant requirements, while constructing credible models places strict requirements on the dataset. In this paper, we propose a Model-Aware Predictive Control (MAPC) framework that can construct credible models with limited data and provide room-level control strategies to optimize the trade-off between occupant comfort and energy consumption. The technological innovations of this research are twofold. On the one hand, we design a model construction and fine-tuning method that combines data-driven subspace projection approach with physical priors that can construct credible thermal dynamic models with limited data. On the other hand, to balance the potential conflicts between enhancing occupant comfort and saving energy, we present a hierarchical decision-making mechanism that enables adaptive multi-objective room-level control considering dynamic occupant comfort requirements and energy usage. The experimental results obtained on an EnergyPlus-based simulation dataset and a publicly available dataset demonstrate that MAPC can provide room-level control strategies based on dynamic occupant requirements and user preferences and achieve superior trade-offs between occupant comfort and energy consumption. The ablation experiments also demonstrated the superiority of MAPC in constructing reliable models on limited datasets. MAPC provides pivotal support for the advancement of the intelligent buildings and sustainable indoor environment. Full article

Areas where mining activities overlap with agricultural production may promote the mobilization of potentially toxic elements (PTEs) into soils and water resources, thereby creating exposure pathways for populations living or working in these environments. This study analyzes the concentration of PTEs in agricultural soils and irrigation water from Santa Rosa, southern Ecuador, and assesses the associated health risks for exposed agricultural workers. For this purpose, 35 soil samples were collected from farms and 12 water samples from the irrigation canal during the dry season of 2025. The concentration of PTEs in soil and water was determined using X-ray fluorescence (XRF) and inductively coupled plasma mass spectrometry (ICP-MS), respectively. The PTE concentration in both matrices was compared with the maximum permissible limits (MPL) established by Ecuadorian regulations. Non-carcinogenic hazard indices ($\mathrm{H}\mathrm{I}$) and carcinogenic risk ($\mathrm{T}\mathrm{C}\mathrm{R}$) were estimated following the U.S. EPA methodology. In soil, As and Cr were the PTEs of greatest concern, exceeding the MPL in 93% of the samples and by up to 4.4 and 2.4 times, respectively, while in water, all PTEs were below the MPL. Non-carcinogenic risk was below the recommended limit for soil and water ($\mathrm{H}{\mathrm{I}}_{\mathrm{s}\mathrm{o}\mathrm{i}\mathrm{l}}$ = 3.00 × 10⁻² and $\mathrm{H}{\mathrm{I}}_{\mathrm{w}\mathrm{a}\mathrm{t}\mathrm{e}\mathrm{r}}$ = 2.00 × 10⁻³), with As as the dominant contributor. Cancer risk was tolerable in soil ($\mathrm{T}\mathrm{C}{\mathrm{R}}_{\mathrm{s}\mathrm{o}\mathrm{i}\mathrm{l}}$ = 4.34 × 10⁻⁵), while in water it remained at a low level ($\mathrm{T}\mathrm{C}{\mathrm{R}}_{\mathrm{w}\mathrm{a}\mathrm{t}\mathrm{e}\mathrm{r}}$ = 1.65 × 10⁻⁶). These findings identify As and Cr as priority contaminants and support targeted monitoring and source-control measures in mining-influenced agricultural areas. Overall, by integrating agricultural soil and irrigation water quality with an occupational health risk assessment in Santa Rosa, this study contributes evidence to support future research in mining–agriculture coexistence areas. Full article

Background: Meralgia paresthetica (MP) of the lateral femoral cutaneous is a rare, nerve-entrapment condition, often related to an inflammatory and fibrotic pathological component. Although most cases resolve with conservative management, refractory presentations may require interventional or surgical treatment. Platelet-rich plasma (PRP) has demonstrated emerging potential in peripheral neuropathies through anti-inflammatory, neurotrophic, and antifibrotic mechanisms. Case Presentation: We report the case of a 64-year-old professional scuba diving instructor with occupational MP related to repetitive compression from a tight lead weight belt. Symptoms persisted for six months despite conservative therapies. Clinical examination supported lateral femoral cutaneous nerve (LFCN) entrapment. The patient underwent three serial perineural PRP injections prepared from autologous blood and administered along the inguinal course of the nerve. Progressive symptom reduction was observed after each session, reaching approximately 90% improvement at two months. At six months, the patient was pain-free and had returned to full professional activity without limitations. Discussion: Occupational microcompression may induce intraneural edema, ischemia, and perineural fibrosis, creating a biological substrate amenable to regenerative intervention. PRP delivers concentrated growth factors capable of promoting axonal regeneration, angiogenesis, and modulation of the neuroinflammatory microenvironment. Preclinical and clinical evidence in other compressive neuropathies supports this translational rationale. Conclusions: Perineural PRP infiltration may represent a safe and promising regenerative strategy for refractory occupational MP. Controlled clinical studies are needed to define optimal protocols, patient selection criteria, and long-term efficacy in peripheral compressive neuropathies. Full article

Background/Objectives: The G protein-coupled estrogen receptor (GPER) is known to interact with cellular stress responses and DNA damage pathways. Therefore, exposure to ionizing radiation may modulate the biological consequences of single-nucleotide polymorphisms in the GPR30 gene. This study aims to evaluate the association between GPER polymorphisms and radiation sensitivity. Methods: The study included 50 healthcare workers exposed to ionizing radiation and 36 healthy individuals with no known occupational exposure to radiation. Genomic DNA was isolated and PCR products were purified using GeneAll kits. Genomic regions encompassing three GPER single-nucleotide polymorphisms (rs3808350, rs3808351, and rs11544331) were amplified by polymerase chain reaction (PCR), followed by DNA sequencing analysis using the BigDye Cycle Sequencing Kit. In addition, an in silico functional and clinical annotation of rs11544331 was performed using Ensembl VEP, SIFT, PolyPhen-2, AlphaMissense, CADD, UniProt, and ClinVar. Results: Genotypic, dominant, and allelic analyses revealed no significant association between radiation exposure and the rs3808350 or rs3808351 polymorphisms. In contrast, a statistically significant association was observed for rs11544331. The frequency of individuals carrying the CT and TT genotypes (CT + TT) was significantly higher in the ionizing radiation-exposed group compared with the control group (OR = 2.981; 95% CI: 1.106–7.904; p = 0.0241). In allelic analysis, the T allele was more prevalent in the exposed group and was significantly associated with radiation exposure (OR = 2.959; 95% CI: 1.282–6.606; p = 0.0110). In silico analysis confirmed that rs11544331 corresponds to the p.Pro16Leu substitution in GPER1; however, SIFT, PolyPhen-2, AlphaMissense, CADD, and ClinVar consistently indicated a tolerated, benign, likely benign, or low-deleteriousness profile. Conclusions: GPER-mediated stress responses and genetic polymorphisms may play a potential role in determining genetic susceptibility following exposure to ionizing radiation. Full article

Artisanal and small-scale gold mining (ASGM) generates complex metal mixtures, yet their biological effects remain poorly characterized in high-altitude populations, where occupational exposure occurs against a hypoxic environmental background. This study evaluated 49 occupationally exposed gold miners from the Vetas–California mining district, near the Santurbán páramo in Colombia, and 25 non-exposed individuals from a comparable high-altitude area. Hair concentrations of essential and toxic elements were quantified by ICP-MS, and serum catalase (CAT), superoxide dismutase (SOD), reduced glutathione (GSH), oxidized glutathione (GSSG), and the GSH/GSSG ratio were assessed. Miners showed a distinct multielement profile, with a higher toxic-metal burden and a dominant mixture mainly characterized by Fe, Mn, As, Pb, Cd, and Hg. CAT and SOD activities did not differ markedly between groups, although SOD activity decreased along the main exposure gradient among exposed workers. In contrast, glutathione-related biomarkers showed a more consistent exposure-related pattern, with higher GSSG and a lower GSH/GSSG ratio, suggesting a shift toward a more oxidized glutathione redox status. Together with positive within-group associations between selected elements and the GSH/GSSG ratio, these results are consistent with a mixture-associated perturbation of glutathione redox homeostasis, with heterogeneous adaptive responses. Overall, this study supports the use of integrated biomonitoring strategies and highlights glutathione-related markers as potential indicators of early redox perturbation in high-altitude mining populations. Full article

Integrating neural and muscular signals into wearable robotics enables adaptive assistance during real-world tasks. This study proposes a multimodal neural interface for passive exoskeletons that combines electroencephalography (EEG) and electromyography (EMG) signals to classify motor gestures and estimate real-time cognitive and muscular effort, supported by finite-element-based biomechanical modeling. The system was implemented on the Ottobock Shoulder X passive exoskeleton© and validated using synchronous EEG–EMG acquisition via the LiveAmp platform©, a commercially available platform that was not developed specifically for this study. A hybrid CNN–LSTM architecture with deep fusion was employed to enhance robustness and responsiveness under realistic operating conditions. This study proposes a multimodal neural interface for the software-level adaptive assistance of passive upper-limb exoskeletons. While the physical device maintains a static mechanical profile, the proposed digital framework achieves adaptation by interpreting the user’s physiological and motor states. Ten healthy participants performed three functional tasks (screwing, moving the box, and lifting the box) under five assistive conditions. Finite element modeling (FEM) was used to characterize the torque–angle relationship of the passive exoskeleton and to support the interpretation of experimentally observed assistive torque profiles. The FEM model, used as an offline biomechanical analysis tool to aid in the interpretation of experimental results, has not been integrated into the real-time control loop. Results showed an average classification accuracy of 90%, an F1-score of 0.85, and inference latency below 180 ms, confirming real-time applicability. Cognitive indices such as the Cognitive Load Index (CLI) and Frontal Asymmetry Index (FAI) enabled adaptive modulation of assistance strategies without requiring active actuation, thereby preserving the device’s intrinsic passive nature. Comparative torque analysis highlighted the ergonomic benefits of passive systems in mid-range postures, while Finite Element Method (FEM) supported analysis clarified their limitations under highly dynamic loads compared to active solutions. These findings advance multimodal brain–machine interfaces for wearable robotics by integrating physiological sensing, deep learning, and biomechanical modeling, offering a safe, energy-efficient, and adaptive approach with potential rehabilitation, occupational ergonomics, and human–robot applications. Full article

Ubiquitin-specific protease 22 (USP22) regulates epigenetic gene expression by deubiquitinating histone H2B (H2Bub1) and upregulating oncogenic proteins and pathways, while antagonizing p53-mediated tumor suppression. USP22 is frequently overexpressed in cancers and associated with therapy resistance and poor prognosis yet remains largely untargeted pharmacologically. Here, using a fluorescence-based USP22 deubiquitinase assay to screen the LOPAC^®1280 library, we identified β-Lapachone, a natural ortho-naphthoquinone with strong anticancer activities, as a potent USP22 inhibitor. β-Lapachone potently inhibited USP22 enzymatic activity, with a half-maximal inhibitory concentration (IC₅₀) of ~0.75 μM, and molecular docking revealed its occupation of the catalytic pocket adjacent to the USP22 active-site triad, supporting a potential binding mode. Functionally, β-Lapachone suppressed proliferation and induced apoptosis in A549 and H1299 RAS-mutant lung adenocarcinoma (LUAD) cells, while USP22 knockout conferred marked resistance, indicating partial USP22 dependence. In patient-derived LUAD models, β-Lapachone inhibited sphere formation and reduced CD133⁺ cancer stem cell populations. Notably, it synergized with cisplatin to enhance DNA damage and apoptosis. In vivo, β-Lapachone significantly suppressed tumor growth in a syngeneic KRAS-mutant/p53-Null mouse lung cancer model and further potentiated cisplatin-induced antitumor effects. Collectively, these findings identify β-Lapachone as a potent inhibitor of USP22 and validate USP22 inhibition as a key mechanism underlying its anticancer activity in LUAD cells, both in vitro and in vivo. Full article

Mosquito control personnel work within health departments, public works, private companies, and other agencies. These essential outdoor workers have highly specialized training and are faced with a variety of potential health and safety hazards (e.g., arthropod bites and stings, exposure to insecticides and other chemicals, working with heavy equipment, noise, heat, solar ultraviolet radiation, slips, trips, and/or falls). Mosquito control personnel undergo employer-provided and other types of training on a variety of topics from regulatory updates to new surveillance and control techniques that are required for safety purposes and to maintain their applicator license. Here, an exploratory baseline survey was conducted among members of the North Carolina Mosquito and Vector Control Association (NCMVCA) and the Virginia Mosquito Control Association (VMCA). There was a 28% response rate so results should be interpreted with caution in this pilot study. Most respondents reported utilizing ultra-low volume insecticide application equipment for controlling adult mosquitoes. Backpack sprayers were utilized by less than half of respondents. Those who reported using respirators showed higher concern about insecticide-related health effects than those who did not use respirators. Outdoor workers encounter various potential hazards and utilize several forms of personal protective equipment to reduce risks. This baseline work can be considered a starting point for implementing and strengthening occupational safety and health awareness and preventive measures for mosquito control workers. Knowledge of health and safety hazards can reduce workplace risk. Full article

Objective: This retrospective cross-sectional study aimed to characterize HIV-1 genotypes, assess drug resistance, and analyze molecular transmission networks in Zhongwei City to inform prevention strategies. Methods: Plasma samples were collected from antiretroviral therapy (ART)-treated patients (2007–2024) with viral load ≥ 200 copies/mL. HIV-1 pol was amplified by nested PCR; successful sequences were genotyped by maximum likelihood (ML) (IQ-TREE, TVM+F+I+G4, 1000 bootstrap). Drug resistance (DR) was interpreted using Stanford HIV Drug Resistance Database (HIVDB) v9.0; detected mutations represent acquired drug resistance (ADR). Pairwise genetic distances (GD) (TN93 model) were calculated; transmission networks were constructed in Cytoscape 3.10.3. Results: 75 sequences were obtained. Males (84.00%), and heterosexual transmission (64.00%) predominated. CRF07_BC (46.67%) and CRF01_AE (38.67%) were the major subtypes; the overall ADR rate was 40.00%, mainly NNRTIs-associated (30.67% of all participants, including 16.00% single-class NNRTIs and 14.67% dual-class NRTIs-NNRTIs). Network inclusion rate was 40.00% of the 75 sequences; CRF07_BC showed higher betweenness centrality (p = 0.028), while CRF01_AE and CRF85_BC showed higher closeness centrality (p < 0.001). Occupation significantly affected network enrollment (p ≤ 0.05). Conclusion: HIV-1 subtypes are diverse with high ADR. CRF07_BC may act as a transmission bridge, whereas CRF01_AE and CRF85_BC exhibit faster potential spread. Baseline DR testing and network-guided interventions are recommended. Full article