Search Results (64)

Children’s safety, well-being and inclusion in the school environment can be severely impacted by social isolation and bullying. This study examined these threats in a sample of 14 group-classes (291 students) from four different primary education schools. A total of 44 special educational needs (SEN) students and 44 students without SEN were selected. The social network structure of each group-class was analysed, as well as the number of friendship ties, the degree of emotional well-being and social participation (both inside and outside of the school), and the possible cases of bullying. The results show a significantly greater rate of social rejection, emotional distress and risk of exclusion in SEN students with respect to their peers, as well as a considerably higher perception of bullying (38.6% vs. 4.8%). The SEN students who reported bullying were mostly schooled in social networks with a more segregated and fragmented structure. Moreover, the mean value obtained in these groups was lower for all the analysed indicators, although the differences were not statistically significant. These data support the idea that the social capital of the group class could influence the prevention of violence and bullying towards SEN students. However, further studies with larger samples are needed to confirm this. Lastly, strategies to promote the social inclusion of SEN students in primary education schools are discussed. Full article

Dementia-related stigma significantly influences help-seeking and affects the quality of care and support received by people with the condition. This review examines the impact of stigma on help-seeking among people with dementia and identifies key factors influencing this relationship. A systematic search across Web of Science, CINAHL, PsycINFO, PubMed, and Scopus identified seventeen qualitative studies that met the inclusion criteria. These criteria encompassed studies focusing on individuals aged 60 and older addressing public- or self-stigma and exploring help-seeking behaviors and related influencing factors. A thematic synthesis was employed to analyze the findings. The following five major themes emerged: reluctance to disclose the condition, internalization or rejection of stigmatizing beliefs, influence of family and community, attitudes of healthcare professionals, and lack of awareness in the broader society. Factors such as psychological decline, loss of autonomy, limited service access, peer support, and need for policy-level intervention were identified as central in shaping stigma. Findings related to the factors that influence this relationship indicate that stigma delays diagnosis and treatment, restricting access to adequate care. Both individual (e.g., autonomy, psychological well-being) and contextual (e.g., social networks, public policies) factors are crucial in moderating this dynamic. Targeted interventions addressing these dimensions are urgently needed to reduce stigma and facilitate timely help-seeking in dementia. Full article

Background: Stigma is a pervasive, though understudied, psychosocial factor affecting people with multiple sclerosis. This review synthesizes the literature on the impact of perceived, enacted, and internalized stigma on psychological health and illness identity in PwMS. Methods: A comprehensive narrative review approach was adopted, integrating findings from peer-reviewed quantitative and qualitative studies. Databases including PubMed, PsycINFO, and Scopus were searched using combinations of terms such as “multiple sclerosis”, “stigma”, “internalized stigma”, “mental health”, and “illness identity”. Studies were included if they reported on stigma-related outcomes in PwMS, discussed psychological or identity variables, or examined interventions aimed at reducing stigma or enhancing adaptive identity. The analysis focused on thematic synthesis, identifying recurrent findings, mediating mechanisms, and clinical implications. Results: Stigma in MS is consistently linked to higher depression, anxiety, and lower quality of life. Internalized stigma disrupts illness identity, often fostering engulfment and rejection of the self. Psychological mediators—such as cognitive fusion, diminished self-compassion, and weakened sense of coherence—amplify these outcomes. Particularly vulnerable are individuals with progressive disease, severe disability, minority status, or limited social support. A recursive loop emerges: stigma triggers psychological distress, which increases stigma awareness and social withdrawal. In addition to traditional psychological interventions, several emerging approaches have shown promise in reducing internalized stigma and fostering adaptive identity integration. Conclusions: Stigma is a central factor in emotional suffering and identity fragmentation in PwMS. Integrative, narrative-informed, and culturally sensitive interventions are essential to reduce stigma and foster resilience. Future research should prioritize longitudinal, mixed-method approaches to develop effective, scalable solutions. Full article

Fuchs endothelial corneal dystrophy (FECD) is the most common corneal endothelial dystrophy. It is characterized by the progressive loss of corneal endothelial cells (CECs), guttae formation on the Descemet membrane, and corneal edema, leading to visual impairment. Corneal transplantation remains the standard treatment, but it has limitations such as donor shortages, infection risk, and graft rejection. Rho-kinase (ROCK) inhibitors have emerged as a promising pharmacological alternative. These agents promote CEC proliferation, migration, and adhesion while inhibiting apoptosis and enhancing corneal endothelial wound healing. Several studies have demonstrated the efficacy of ROCK inhibitors in improving corneal clarity and endothelial function, particularly when used as an adjunct to Descemet Stripping Only (DSO) surgery. Additionally, they show potential in preventing corneal edema in FECD patients undergoing cataract surgery. The methodology involved a literature search through the PubMed and Medline databases using relevant keywords. Only peer-reviewed articles in English were included, with additional references from selected articles reviewed to ensure comprehensive coverage. ROCK inhibitors offer a novel pharmacological approach to managing FECD. They have shown potential in promoting endothelial cell regeneration and improving corneal functIion. Despite promising results, further research is required to determine ROCK inhibitors’ long-term safety, optimal dosing, and efficacy in surgical and non-surgical FECD patients. Their potential to delay or prevent corneal transplantation represents a significant advancement in FECD management. Full article

Internet addiction has been associated with decreased prosocial behavior in adolescents, and minority studies have investigated the underlying mechanisms involved. This study aimed to examine the mediating effects of self-control and the moderating effects of peer rejection. A longitudinal study with two waves (6 months apart) was used to measure internet addiction (T1), peer rejection (T1), self-control (T1/T2), and prosocial behavior (T1/T2) among 1048 secondary school students (M_age = 14.80 years old, SD = 1.61) in a southern Chinese metropolitan area. A longitudinal path analysis model was applied to analyze the data and derive insights about the relationships between these variables. The findings indicated that T1 internet addiction negatively influenced later prosocial behavior through reduced self-control, particularly among adolescents with lower levels of peer rejection. These findings clarify how internet addiction impairs prosocial development, and we propose a framework for intervention: mitigating peer rejection and harnessing self-control as a mediator to counteract the adverse effects of internet addiction. Full article

Background/Objectives: Although child-to-parent violence (CPV), peer violence (PV), and dating violence (DV) share risk factors and tend to co-occur, little is known about the common and differential mechanisms involved in the development of these types of youth violence. This study aims to (1) analyze the relationship between youth violence (CPV, PV, and DV) and perceived parental warmth and moral disengagement mechanisms and (2) explore the mediating role of moral disengagement mechanisms in the relationship between the lack of perceived parental warmth and youth violence. Methods: A cross-sectional population-based survey study was conducted. The sample consisted of 2124 Spanish adolescents (57.9% girls) aged between 13 and 17 years from educational centers. Results: The lack of perceived parental warmth (parental criticism-rejection in particular) is a common risk factor for all three types of violence and, more relevantly, is related to youth violence through moral disengagement mechanisms, highlighting a differential contribution of these mechanisms according to the type of violence. In particular, advantageous comparison and attribution of blame are specific mediators of CPV, and moral justification and distortion of consequences are specific to PV, whereas euphemistic language seems to be a common mediator of PV and DV. Conclusions: This study suggests that adolescents who perceive a lack of parental warmth are more likely to develop different dysfunctional cognitive mechanisms, which in turn are related to different types of youth violence. It would be important to promote warm parenting practices and address the cognitive mechanisms underlying youth violence. Full article

Background/Objectives: Human pancreatic islet transplantation shows promise for long-term glycemic control in diabetes patients. A shortage of healthy donors and the need for continuous immunosuppressive therapy complicates this. Enhancing our understanding of the immune tolerance mechanisms related to graft rejection is crucial to generate safer transplantation strategies. This review will examine advancements in immune protection strategies for stem cell-derived islet therapy and discuss key clinical trials involving stem cell-derived β-cells and their protective strategies against the host immune system. Methods: A comprehensive literature search was performed on peer-reviewed publications on Google Scholar, Pubmed, and Scopus up to September 2024 to extract relevant studies on the various strategies of immune evasion of stem cell-derived β-cells in humans. The literature search was extended to assimilate all relevant clinical studies wherein stem cell-derived β-cells are transplanted to treat diabetes. Results: Our analysis highlighted the importance of human pluripotent stem cells (hPSCs) as a potentially unlimited source of insulin-producing β-cells. These cells can be transplanted as an effective source of insulin in diabetes patients if they can be protected against the host immune system. Various strategies of immune protection, such as encapsulation and genetic manipulation, are currently being studied and clinically tested. Conclusions: Investigating immune tolerance in hPSC-derived islets may help achieve a cure for diabetes without relying on exogenous insulin. Although reports of clinical trials show promise in reducing insulin dependency in patients, their safety and efficacy needs to be further studied to promote their use as a long-term solution to cure diabetes. Full article

Background/Objectives: Children showing emotional–behavioral problems experience lower psychosocial well–being concurrently and in later stages. Developmental research suggests that emotion regulation abilities and the quality of peer relationships play a central role in predicting several behavioral and emotional difficulties. The present study investigates the way emotion regulation skills and peer acceptance and rejection contribute to behavior problems in a sample of Italian schoolers, also verifying the role of gender. Methods: The participants were 220 children (97 boys) aged between 7 and 9 years attending four primary schools in northern Italy. The level of social acceptance and rejection of each child was measured using the sociometric technique of Peer Nomination. In addition, the Emotion Regulation Checklist filled in by the teachers, and the Child Behavior Checklist, completed by the parents, were used to assess children’s emotion regulation abilities and the presence of behavior difficulties, respectively. Results: The main results confirm that behavioral problems are both negatively associated with emotional regulation skills and positively with the social rejection level. However, the impact of peer rejection on the manifestation of problem behavior is fully mediated by children’s ability to regulate their emotions. Interestingly, this pattern of interrelationships only applies to male participants. Conclusions: The study helps to clarify the mechanism through which the degree of peer rejection influences emotional–behavioral difficulties and emphasizes the importance of considering gender-specific processes within interpersonal risk models of problem behavior. Full article

Background/Objectives: Fibromyalgia syndrome (FMS) is a chronic, debilitating condition characterized by widespread pain, fatigue, and psychological distress. There is a lack of qualitative studies on the unique experiences of patients with FMS in Arab countries, particularly through social media. Despite the availability of diagnostic criteria, diagnosing and managing patients remains challenging. This study aimed to describe the experiences of patients with FMS in Arab countries, their understanding of the illness, and perceptions of treatment. Methods: A qualitative study was conducted using a content analysis of patients’ narratives published in a supportive group, describing their experiences with fibromyalgia. The dataset included 2305 quotes from 192 main posts and 2113 comments collected between 2019 and 2024. Results: The analysis of the posts and associated comments revealed six main themes: patients’ experiences with the syndrome, symptoms, searching for a doctor, pharmacological management, self-management, and the impact of fibromyalgia and peer support. Most posts and comments focused on patients’ experiences with self-management approaches and coping strategies, highlighting significant noncompliance with therapeutic modalities. Factors influencing patients’ experiences and decisions included their relationship with physicians, medication side effects, personal fears, and physical and mental health. Conclusions: Patients with FMS in Arab countries face similar challenges to those in other regions, including physical, psychological, social, and economic impacts. Many patients reject conventional therapeutic management strategies and adopt coping mechanisms to mitigate adverse effects and healthcare costs. The findings suggest that the physician–patient relationship, as well as the physician’s knowledge and attitude toward fibromyalgia syndrome, are the cornerstones of gaining patients’ trust. Full article

Research expands the boundaries of a subject, economy, and civilization. Peer review is at the heart of research and is understandably an expensive process. This work, with human-in-the-loop, aims to support the research community in multiple ways. It predicts quality, and acceptance, and recommends reviewers. It helps the authors and editors to evaluate research work using machine learning models developed based on a dataset comprising 18,000+ research papers, some of which are from highly acclaimed, top conferences in Artificial Intelligence such as NeurIPS and ICLR, their reviews, aspect scores, and accept/reject decisions. Using machine learning algorithms such as Support Vector Machines, Deep Learning Recurrent Neural Network architectures such as LSTM, a wide variety of pre-trained word vectors using Word2Vec, GloVe, FastText, transformer architecture-based BERT, DistilBERT, Google’s Large Language Model (LLM), PaLM 2, and TF-IDF vectorizer, a comprehensive system is built. For the system to be readily usable and to facilitate future enhancements, a frontend, a Flask server in the cloud, and a NOSQL database at the backend are implemented, making it a complete system. The work is novel in using a unique blend of tools and techniques to address most aspects of building a system to support the peer review process. The experiments result in a 86% test accuracy on acceptance prediction using DistilBERT. Results from other models are comparable, with PaLM-based LLM embeddings achieving 84% accuracy. Full article

Background/Objectives: Empathy for pain enhances our ability to perceive pain and recognize potential dangers. Empathic bias occurs when members of the in-group evoke more intense empathic responses compared to out-group members. In the process of interacting with peers, children develop peer status and spontaneously form peer groups. The present study examined how peer status affects pain empathy in mid-childhood individuals. Methods: A behavior and an event-related potential (ERP) study were conducted. Participants were exposed to pictures of different peers in painful or non-painful situations and completed the pain and unpleasantness rating tasks. Four types of peers were included: popular, rejected, neglected and unfamiliar peers. Results: The behavioral results suggested that the influence of peer status on cognitive empathy is more salient, and the empathic response to unfamiliar peers is higher than neglecting and rejecting peers. The ERP results indicated that larger P3 and LPP amplitude were observed in the painful stimulus condition than in the non-painful stimulus condition. The findings also showed that the popular peers elicited larger LPP amplitude than other peers. The LPP response to unfamiliar peers was larger than to neglected peers. Conclusions: All these results demonstrated that mid-childhood individuals showed empathic bias to in-group members, but it was influenced by peer status in the cognitive processes of pain empathy. Full article

Type 1 diabetes mellitus is an autoimmune condition characterized by the destruction of pancreatic β-cells, necessitating insulin therapy to prevent life-threatening complications such as diabetic ketoacidosis. Despite advancements in glucose monitoring and pharmacological treatments, managing this disease remains challenging, often leading to long-term complications and psychological burdens, including diabetes distress. Advanced treatment options, such as whole-pancreas transplantation and islet transplantation, aim to restore insulin production and improve glucose control in selected patients with diabetes. The risk of transplant rejection necessitates immunosuppressive therapy, which increases susceptibility to infections and other adverse effects. Additionally, surgical complications, including infection and bleeding, are significant concerns, particularly for whole-pancreas transplantation. Recently, stem cell-derived therapies for type 1 diabetes have emerged as a promising alternative, offering potential solutions to overcome the limitations of formerly established transplantation methods. The purpose of this scoping review was to: (1) summarize the current evidence on achieved insulin independence following various transplantation methods of insulin-producing cells in patients with type 1 diabetes; (2) compare insulin independence rates among whole-pancreas transplantation, islet cell transplantation, and stem cell transplantation; and (3) identify limitations, challenges and potential future directions associated with these techniques. We systematically searched three databases (PubMed, Scopus, and Web of Science) from inception to November 2024, focusing on English-language, peer-reviewed clinical studies. The search terms used were ‘transplantation’ AND ‘type 1 diabetes’ AND ‘insulin independence’. Studies were included if they reported on achieved insulin independence, involved more than 10 patients with type 1 diabetes, and had a mean follow-up period of at least one year. Reviewers screened citations and extracted data on transplant type, study population size, follow-up duration, and insulin independence rates. We identified 1380 papers, and after removing duplicates, 705 papers remained for title and abstract screening. A total of 139 English-language papers were retrieved for full-text review, of which 48 studies were included in this review. The findings of this scoping review indicate a growing body of literature on transplantation therapy for type 1 diabetes. However, significant limitations and challenges, like insufficient rates of achieved insulin independence, risks related to immunosuppression, malignant diseases, and ethical issues remain with each of the established techniques, highlighting the need for innovative approaches such as stem cell-derived islet transplantation to promote β-cell regeneration and protection. Full article

Objectives: to examine the nature and context of discriminatory experiences among adolescents in Spain. Methods: A mixed study of discourse content analysis in 1000 randomly selected Spanish adolescents aged 12 to 16 years stratified by age, gender and territorial distribution. Data were analyzed to identify perpetrators, actions, and locations of discrimination. Results: Overall, 66% of adolescents reported witnessing or experiencing discrimination, primarily manifested through teasing, insults, and harassment. Peers were identified as the main perpetrators (73.9%), with schools being the primary context (69.4%) where discrimination occurs. Discrimination often lacked clear reasons (27.78%), but ethnicity (23.83%) and physical appearance (22.51%) were the most common factors, followed by gender (5.99%) or academic/ability issues (5.99%) or having an illness or developmental disorder (5.41%). Conclusions: Discrimination among adolescents is frequent, with racism and rejection of minority groups as the main causes. The findings underscore the need for interventions to address discriminatory behaviors in schools and broader society, with implications for adolescent well-being and mental health. Full article

Background: Research has consistently shown increased drug use among lesbian, gay, bisexual, transgender, intersex, queer/questioning, and asexual (LGBTQIA+) individuals. This is particularly the case among LGBTQIA+ adolescents. Substance use within this vulnerable community can propagate mental health issues, leading to psychiatric disorders, self-harm, and even suicide. Therefore, the objective of this scoping review was to evaluate the determinants of drug use among LGBTQIA+ adolescents. Methods: A comprehensive search of mainly primary research was conducted, using several databases. Peer-reviewed articles published between 2018 and 2023 were included. The scoping review was conducted using the framework outlined by Joanna Briggs Institute (JBI) and reported using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses—Extension for Scoping Reviews (PRISMA-ScR) statement. Results: A total of 29 articles (including 400,194 participants) were included in the analysis. The articles reported that the main determinants of drug use among LGBTQIA+ adolescents include homelessness, peer–peer interactions, mental health, and protective factors. The articles reported that mental health issues, which were mainly triggered by rejection, were the main determinants of drug use among LGBTQIA+ adolescents. Conclusions: Findings from this scoping review provide relatively reliable evidence that homelessness, mental health, peer–peer interactions, and protective factors are the main determinants of illicit drug use among LGBTQ+ adolescents. Rigorous studies including large sample sizes and systematic reviews are needed to further confirm these findings and assist in developing interventions to combat the unusually high level of drug use among this group. Full article

The existing literature on sexual consent is extensive, but a new social approach to this topic is emerging, necessitating further research. This article addresses a gap in understanding how men’s interactions with other men, who are not their sexual partners, both before and during sexual encounters, influence their approach to consent beyond sexual cues. The study involved sixteen interviews and two focus groups with men aged 18–25. Conducted within the framework of the Consent project (PID2019-110466RB-100), this research aims to analyze how communicative acts, beyond verbal exchanges, shape relationships where either consent or coercion prevails. The findings reveal that when men engage in coercive interactions with non-sexual male peers, these interactions can encourage the violation of consent in their sexual relationships. Conversely, some men reject this coercive behavior, take a stand, and support others in avoiding situations that compromise consent. These results underscore the importance of addressing norms of masculinity and male interactions to ensure that all individuals can autonomously make decisions about their sexual lives. Full article