Search Results (1,214)

Quantitative gait analysis is essential for understanding motor function and guiding clinical decisions. While marker-based motion capture (MoCap) systems are accurate, they are costly and require specialized facilities. OpenCap, a markerless alternative, offers a more accessible approach; however, its reliability across different walking speeds remains uncertain. This study assessed the agreement between OpenCap and MoCap in measuring spatiotemporal parameters, joint kinematics, and center of mass (CoM) displacement during level walking at three speeds: slow, self-selected, and fast. Fifteen healthy adults performed multiple trials simultaneously, recorded by both systems. Agreement was analyzed using intraclass correlation coefficients (ICC), minimal detectable change (MDC), Bland–Altman analyses, root mean square error (RMSE), Statistical Parametric Mapping (SPM), and repeated-measures ANOVA. Results indicated excellent agreement for spatiotemporal variables (ICC ≥ 0.95) and high consistency for joint waveforms (RMSE < 2°) and CoM displacement (RMSE < 6 mm) across all speeds. However, the joint range of motion (ROM) showed lower reliability, especially at the hip and ankle, at higher speeds. ANOVA revealed no significant System × Speed interactions for most variables, though a significant effect of speed was noted, with OpenCap underestimating walking speed more at fast speeds. Overall, OpenCap is a valuable tool for gait assessment, very accurate for spatiotemporal data and CoM displacement. Still, caution should be taken when interpreting joint kinematics and speed at different walking speeds. Full article

This study quantifies the influence of soil–structure interaction (SSI) on key parameters of performance-based seismic design (PBSD) for steel moment-resisting frames. Specifically, PBSD is extended as a methodology in which explicit structural performance levels, such as immediate occupancy, damage limitation, life safety, and collapse prevention, serve as the basis for sizing and detailing structural members under specified seismic hazard levels, instead of traditional force-based design. The PBSD framework is further developed to incorporate SSI by adopting a beam on a nonlinear Winkler foundation model. This model captures the nonlinear soil response and its interaction with the structure, enabling a more realistic design framework within a performance-based context. To evaluate and quantify the influence of SSI in the PBSD method, an extensive parametric study is performed using 100 far-field ground motions, categorized into four groups (25 records each) corresponding to EC8 soil types A, B, C, and D. Nonlinear time history analyses reveal consistent trends across the examined frames. When SSI is neglected, the fundamental natural period (T) is systematically underestimated by approximately up to 3.5% on EC8 soil type C and up to 15% on soil type D. As a result, the base shear and the mean values of maximum interstorey drift ratios (IDRs) are overestimated compared to cases accounting for soil flexibility, with the largest drift discrepancies observed in frames with eight or more storeys on soil D. The analyses further reveal that softer soils (e.g., Soil D) lead to significantly higher q values, particularly for moderate-to-long period structures, whereas stiffer soils (e.g., Soil B) cause only minor deviations, remaining close to fixed-base values. A complementary machine learning module, trained on the same dataset, is employed to predict base shear, maximum IDR, and the behavior factor q. It successfully reproduces the deterministic SSI trends, achieving coefficients of determination (R²) ranging from 0.986 to 0.992 for maximum IDR, 0.947 to 0.948 for base shear, and 0.944 to 0.952 for q. Feature importance analysis highlights beam and column ductility, soil class, and performance level as the most influential predictors of structural response. Full article

Ship-to-ship impacts can lead to serious outcomes such as environmental contamination, cargo and economic losses, and risks to crew safety. The steady growth of maritime traffic has amplified the likelihood of such incidents, emphasizing the necessity of more reliable mitigation technologies. Conventional protective systems are often inadequate for present-day demands, underscoring the need for improved energy-absorbing solutions. In this study, a double-chamber airbag is developed to strengthen the lateral crash resistance of vessels, particularly under deliberate collision conditions. The model is analyzed using finite element simulations, which are further verified through experimental comparison to ensure computational accuracy. The proposed configuration is benchmarked against a single-chamber airbag, and the findings reveal its superior capability in attenuating impact forces. Parametric analyses under varying velocities and impact angles confirm that the new design offers stable crashworthiness and effectively redistributes collision energy. At low speeds, it reduces local deformation, while under high-energy or oblique impacts, it cushions the structure and prevents severe hull damage. The observed trends demonstrate the potential of the double-chamber concept for future ship protection applications in complex operational environments. Full article

Mental health challenges in academic settings are increasingly recognised, yet research on staff wellbeing remains limited, particularly within African universities. This study provides the first institution-wide assessment of psychological distress and burnout among academic staff at a South African university. A cross-sectional survey using validated tools, the 28-item General Health Questionnaire (GHQ-28 ) and the Oldenburg Burnout Inventory (OLBI) was administered to 157 academic employees, and data were analysed using descriptive statistics, non-parametric tests, and ordinal regression. The median age of participants was 42 years (Interquartile range [IQR] = 34–50; SD = 11.4), and the majority of participants were female (n = 110, 70%). The sample included staff across academic ranks, with lecturers being the most common (n = 64, 41%). Results showed that nearly half of participants (49%) exhibited severe psychological distress, and over a quarter (27%) reported high levels of burnout. Female staff reported significantly higher distress and burnout scores compared to their male counterparts. Less than a third (28%) of participants reported feeling safe to disclose mental health concerns, while over half expressed dissatisfaction with institutional support. Participants indicated strong support for both individual-level services, such as confidential counselling and workshops, and systemic changes, including flexible work arrangements and leadership-driven mental health initiatives. Findings highlight the need for integrated, participatory mental health strategies that are culturally and contextually tailored. These results offer timely evidence to inform the development of institutional strategies, policies, and practices to promote mental health among academic staff. Full article

Background: Sepsis with Urinary Tract Infection (UTI) is a serious condition with high morbidity and mortality, increasingly complicated by multidrug-resistant (MDR) infections. Prompt diagnosis and appropriate treatment are key to improving outcomes and limiting antimicrobial resistance. The URO-RESIST study aimed to assess the relationship between clinical features, inflammatory biomarkers (C-reactive protein and procalcitonin, CRP and PCT, respectively), microbiological profiles, and outcomes in patients with sepsis with UTI. A secondary aim was to compare microbiological patterns between institutionalized patients and those living at home without known MDR risk factors. Methods: A retrospective cohort study was conducted on 231 patients with sepsis with UTI. admitted to the Infectious Diseases Unit of Chieti Hospital, Italy, between 2014 and 2024 (excluding 2020–2021). Data on clinical, laboratory, and microbiological variables were collected. MDR organisms were defined per European Centre for Disease Prevention and Control (ECDC) criteria. Analyses included non-parametric tests and logistic regression. Results: MDR pathogens were identified in over 40% of cases. Patients from long-term care facilities had higher CRP levels and a higher prevalence of MDR infections. Carbapenems were frequently used, though empirical treatment was sometimes inappropriate. PCT did not differ significantly between MDR and non-MDR groups and had limited prognostic value. CRP and MDR presence were both associated with worse outcomes and longer hospital stays. Functional dependence and dementia were strongly linked to MDR infections. Age correlated with comorbidities but was not an independent predictor of outcome. Conclusions: MDR infections worsen the course of sepsis with UTI. CRP may outperform PCT in assessing severity, especially in institutionalized patients. Functional and cognitive impairments increase vulnerability to MDR pathogens. These findings support the need for rapid diagnostics, targeted antibiotic use, and personalized care strategies. Full article

Emerging virtual reality (VR) technologies provide objective and immersive methods for assessing cognitive–motor function, particularly in elite sport. This study evaluated the reliability and validity of VR-based cognitive–motor assessments in a large sample of elite male athletes (n = 829). Ten cognitive–motor tests, delivered via Oculus Quest 2 headsets, were used, covering four domains: Balance and Gait (BG), Decision-Making (DM), Manual Dexterity (MD), and Memory (ME). A Confirmatory Factor Analysis (CFA) was conducted to establish a four-factor model and generate data-driven weights for domain-specific composite scores. The results demonstrated that the composite scores for BG, MD, ME, and a Global Cognitive–Motor (CM) score were all normally distributed. However, the DM score significantly deviated from normality, exhibiting a pronounced ceiling effect. Test–retest reliability was high across all cognitive–motor domains. In summary, VR assessments offer ecologically valid and precise measurements of cognitive–motor abilities by capitalising on high-fidelity motion tracking and standardised test delivery. In particular, the Global CM Score offers a robust metric for parametric analyses. While future work should address the DM ceiling effect and validate these tools in diverse populations, this approach holds significant potential for enhancing the precision and sensitivity of psychological and clinical assessment. Full article

Tailings dams are unique structures due to the materials they store and the methods applied in their construction, often resulting in complex three-dimensional (3D) problems. Most current slope-stability analyses neglect the 3D effects without significant consequences. However, certain conditions, such as the valley shape, the spatial variability of the tailings’ resistance, and the presence of internal dikes, may render the 2D simplification inadequate. For translational slides, the sliding-mass width-to-height ratio (W/H) is a reliable estimator of the 3D effects. However, it is unclear whether this geometric ratio is the most suitable for rotational slides, where the width of the sliding mass varies along its height. This paper presents a parametric study of the 3D effects of the dam’s height (H_M) and the valley shape, namely the abutments’ slope angle with the horizontal (β) and the thalweg width (L_M), on the overall stability of a tailings dam raised by the upstream method, by means of 2D and 3D Limit Equilibrium (LE) analyses. The study evaluates the dam stability using a straightforward and practical methodology, specifically the FS_3D to FS_2D ratio (R_3D/2D), to compare the results of the 3D and 2D analyses, adapting current state-of-the-art techniques originally for translational slides, focused on pre-defined, closed-form slip-surface geometry, to rotational ones where the main focus is the geometry of the whole structure as a physical constraint for the sliding mass. The results show that the model average width-to-height ratio (W_M,avr/H_M), developed in this study, may be a better estimator of the 3D effects for rotational slides than the W/H ratio. Full article

To improve the energy efficiency and indoor environmental quality of rural dwellings in China’s cold regions, this study selected a typical rural dwelling in Linyi, Shandong Province, as a case study. Integrating field measurements with parametric simulations, the Orthogonal Experimental Design method was employed to systematically evaluate the impacts of 12 envelope design parameters on building energy demand (ED_tot, ED_H, ED_C), thermal comfort (PNT_ave), daylight performance (UDI_ave), and economic outcomes (retrofit cost and return on investment, ROI). Three sets of orthogonal experiments with varying value ranges (Case 1–3) were conducted. The results revealed that U-Window and SHGC are the most critical factors influencing energy demand and thermal comfort, while light transmittance (Trans) exerts the greatest influence on daylighting. The economic analysis demonstrated that window material is the primary determinant of retrofit costs, whereas building depth and the south window-to-wall ratio (WWR-South) significantly affect ROI. Additional range and variance analyses quantified the significance of each parameter and revealed nonlinear influence patterns. This research provides data support and decision-making references for the energy-efficient retrofit and multi-objective optimization of rural dwellings in cold regions, offering strong practical implications. Full article

The European mink Mustela lutreola is one of the most threatened carnivores in Europe, having suffered dramatic range contractions and severe population fragmentation. Accurate knowledge of its genetic diversity is crucial for conservation planning, yet earlier studies based on partial mitochondrial markers offered limited resolution and often underestimated haplotype richness. In this study, complete mitochondrial genomes from four extant populations (Russia, n = 11; Romania, n = 16; Germany, n = 24; France–Spain, n = 15) were analysed using a suite of non-parametric and asymptotic estimators (Fisher’s α, ACE, Jackknife1, Bootstrap, Chao1-based iNEXT) together with negative binomial modelling. A total of 41 haplotypes were detected, but extrapolated estimates indicated substantially higher richness, particularly in populations dominated by singletons. Rarefaction and extrapolation analyses revealed that sample sizes of 70–130 individuals per population are needed to approach complete haplotype detection. The France–Spain and Romania populations harboured the highest predicted richness, whereas Germany and Russia, both represented by ex situ stocks, showed lower diversity. These results refine earlier assumptions of extreme homogeneity in the Western population and demonstrate that significant mitochondrial variation persists at the continental scale. The study provides quantitative benchmarks for sampling design and genetic management, supporting preservation of evolutionary potential in this critically endangered species. Full article

Background: Surgical procedures and alterations of the gastrointestinal (GI) tract increase the risk of small intestinal bacterial overgrowth (SIBO), which is associated with GI symptoms and complications that compromise postoperative recovery. However, the prevalence and clinical impact of SIBO after various upper GI surgical procedures remain poorly understood. Objective: This study aimed to evaluate the prevalence of SIBO after different types of upper GI surgery and to investigate the associated clinical factors. Methods: We conducted an observational study involving 157 patients with a history of upper GI surgery: Roux-en-Y gastric bypass (RYGB), laparoscopic single-anastomosis gastric bypass (OAGB), subtotal (STG) or total gastrectomy (TG), subtotal (SP)or total pancreatectomy (TP), cephalic duodenopancreatectomy (WR), and small bowel resection for Crohn’s disease. A glucose–hydrogen breath test was performed, and demographic, clinical, and treatment-related data were collected. Statistical analyses included t-tests, non-parametric tests, ANOVA, and correlation analyses using R software. Results: At a median follow-up of 25.7 ± 18.1 months, 31% (48/157) of patients tested positive for SIBO. The highest prevalence was observed after RYGB and OAGB (43%), followed by TG (30%), STG (29%), TP/WR (28%), and Crohn’s disease bowel resection (19%). No cases of SIBO were observed after SP. SIBO positivity was significantly associated with bloating and flatulence (p = 0.002), lactose intolerance (p = 0.047), systemic sclerosis (p = 0.042), T2D (p = 0.002), and exposure to adjuvant chemotherapy (p = 0.001) and radiotherapy (p = 0.027). In addition, the risk of SIBO increased proportionally with the duration of GI resection or exclusion (p = 0.013). Conclusions: In our study, the prevalence of SIBO after upper GI surgery was 31%, with the highest incidence (43%) observed in metabolic surgery patients. Importantly, adjuvant radio/chemotherapy was associated with an increased risk of SIBO, and extensive small bowel resection or exclusion was strongly associated with an increased risk of SIBO. Furthermore, the limitations of current diagnostic methods, which lack sufficient sensitivity and specificity, highlight the importance of early screening and standardization of diagnostic techniques to improve patient management and outcomes. Full article

Microgrids with high renewable energy penetration face critical challenges in frequency stability due to reduced system inertia and the presence of parameter uncertainties. This study introduces a novel adaptive virtual inertia control strategy utilizing a combination of the Walrus Optimization Algorithm (WaOA), a recent metaheuristic optimization technique, and Proportional–Integral–Derivative (PID) controllers (WaOA-PID) to improve frequency regulation in islanded microgrids under diverse operating conditions. The proposed method is evaluated across three scenarios: medium inertia, low inertia, and parametric uncertainty. Comparative analyses with conventional, IMC-tuned PID and H∞ Vector Internal Controllers (VIC) reveal that the WaOA-PID controller achieves the lowest overshoot, undershoot, and rate of change of frequency (RoCoF), while maintaining acceptable settling times in all cases. At an estimated load deviation of 0.18, the demand is varied from 200 MW to 250 MW to evaluate the system’s performance. The proposed technique yields an Integral Time Absolute Error (ITAE) of 0.000576, with PID gains of Ki = 0.9994, Kd = 0.185, and Kp = 0.774. Compared to traditional methods, the proposed controller demonstrates high reliability and efficiency in maintaining load frequency control and enhancing power system management, validating its suitability for real-time renewable energy-integrated microgrid applications. Full article

This study investigates the determinants of Romanian workers’ migration intentions towards Italy, integrating economic, social, and psychological perspectives. Based on a sample of 358 respondents, four hypotheses were tested concerning perceived living standards, working conditions, quality of public services, and anticipated integration difficulties. Data were analysed using descriptive statistics, Spearman’s rho correlation, Mann–Whitney U, Chi-square, ANOVA, and ordinal logistic regression. The results confirm that higher perceived living standards and better working conditions in Italy significantly increase the likelihood of expressing migration intentions, while favourable evaluations of healthcare and education act as additional pull factors. Conversely, anticipated integration difficulties, particularly language barriers and cultural adaptation, reduce migration intentions, indicating that socio-psychological obstacles can counterbalance economic incentives. By combining non-parametric and multivariate analyses, the study demonstrates that migration is a multidimensional process shaped not only by structural opportunities but also by behavioural and psychological appraisals. These findings are consistent with recent research on European labour mobility and contribute to the literature by highlighting the role of subjective perceptions in shaping migration decisions. Implications for policy include the need to address both economic disparities and integration barriers to support more balanced mobility within the European space. Full article

Settlement-relevant load combinations play a critical role in the serviceability design of buildings, particularly for structures on soils with time-dependent deformation behavior. While permanent loads must be fully considered, the contribution of variable actions depends on their duration relative to soil response. This study investigates suitable settlement-relevant load combinations and their influence on the restrained load redistribution within buildings, based on parametric finite element analyses of wall-type and frame-type structures on sand, silt, and clay using PLAXIS 3D (Version 2024.3). Results show that structural stiffness significantly affects force redistribution due to settlements: stiffer structures exhibit greater redistribution, while soft soils generate higher absolute restraining forces but are less sensitive to load combinations. Based on these findings, the reduced characteristic load combination (including α_n) is recommended for coarse-grained, drained soils, as it balances safety and realistic deformation. For fine-grained, low-permeability soils, the quasi-permanent combination should be applied to capture long-term consolidation effects. Short-term load variations after consolidation have negligible impact and should be addressed through safety factors rather than separate settlement analyses. These recommendations provide a clear and practical framework for selecting settlement-relevant load combinations, enhancing reliability and efficiency in structural design. Full article

This study investigates the bidirectional bending performance of double- and triple-spliced steel-ribbed composite slabs for substation applications. Full-scale experiments and numerical parametric analyses were conducted to evaluate ultimate load, ductility, stiffness, failure modes, and load-transfer mechanisms. Results indicate that double-spliced slabs exhibit better performance than triple-spliced slabs, showing a 24.5% higher ultimate load and 65.3% greater ductility, with well-developed orthogonal cracks and yielding of both longitudinal prestressing steel and transverse reinforcement. Triple-spliced slabs display partial bidirectional behavior due to reduced transverse integrity, with stresses in edge slabs concentrated at the corners. Compared with monolithic slabs, spliced slabs show nearly identical stiffness at cracking onset but progressively reduced stiffness, load capacity, and ductility in the mid-to-late loading stages. Joint-crossing reinforcement is critical for transverse load transfer, and increasing its diameter is more effective than increasing its strength in preventing premature joint-controlled failure. These findings provide significant theoretical guidance and technical support for the prefabricated construction of high-voltage substation floor systems. Full article

Background: Multiple System Atrophy (MSA) is a rapidly progressing neurodegenerative movement disorder characterized by autonomic failure, parkinsonism, and cerebellar ataxia. While its non-motor symptoms are well-documented, personality features in MSA remain underexplored. This study characterizes the personality traits of non-demented patients with MSA and explores their association with clinical variables. Methods: Twenty-six patients with MSA were assessed using the Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF). Dementia was excluded by Montreal Cognitive Assessment. Descriptive statistics and non-parametric analyses were conducted to examine clinical, demographic, and MMPI-2-RF variables. Results: Patients commonly showed elevated scores in somatic domains: Somatic Complaints (39%), Malaise (58%), and Neurological Complaints (85%), as well as in internalizing emotional traits: Low Positive Emotions (39%), Introversion (46%), Suicidal Ideation (46%), and Hopelessness (54%). Externalizing behavioral traits were absent, with only 4–8% of patients showing elevations in aggression or behavioral dysfunction. Strong correlations were found between somatic and emotional traits (r = 0.656, p < 0.001), and between Neurological Complaints and disease duration (r = 0.662, p < 0.001). Conclusions: This exploratory study reveals a distinct personality pattern in MSA, characterized by marked suicidal ideation, emotional vulnerability with internalizing coping, and absence of externalizing behaviors. These features highlight the need for suicide risk screening, interventions to alleviate psychological suffering, and tailored multidisciplinary care. Larger, longitudinal studies are warranted to confirm these preliminary results and clarify whether these traits reflect premorbid personality, early disease manifestations, or secondary responses, as well as their prognostic and clinical relevance. Full article