Search Results (8,446)

In patients undergoing endotracheal intubation and mechanical ventilation, damage to the endotracheal tube or inflation line is a potential risk with life-threatening consequences. Although various devices and bite blocks have been developed to secure the endotracheal tube and prevent its dislodgement or damage, they are not suitable for children or newborns. We describe a 1-year-and-2-month-old girl who required long-term endotracheal intubation and mechanical ventilation. The eruption of the lower deciduous incisors caused damage to the inflation line. A mouthguard was not appropriate because her teeth had erupted only slightly, and the retention was insufficient. After collaborating with a dental technician to fabricate a protective device, we were able to provide the optimal treatment while minimizing invasiveness to the patient. It is necessary to collaborate with other professionals as a team to select the optimal medical care tailored to each patient. Full article

Gastrointestinal (GI) parasitic infections are still a major concern for cattle health and productivity in tropical and subtropical regions. However, epidemiological data on GI parasitism in cattle from western Thailand remain limited, particularly in border areas with frequent animal movement. This study focuses on establishing the prevalence of gastrointestinal parasitic infections and identifies its related risk factors among the cattle in Kanchanaburi province, western Thailand. Cross-sectional study was performed from December 2022 to January 2023 involving 153 cattle from the following three study populations: local cattle from Thong Pha Phum district, Sangkhlaburi district, and cross-border cattle imported from Myanmar. Fecal samples were examined using both simple flotation and formalin-ethyl acetate sedimentation techniques, and data on animal and management factors were collected through questionnaire surveys. Overall, 35.9% (55/153) of the cattle had at least one GI parasite species positive. Six parasite taxa were identified, with Strongyle-type nematodes being the most frequently detected (26.1%), followed by other helminth parasites. The prevalence of infection and parasite diversity increased progressively in cattle populations located closer to the Thai–Myanmar border, suggesting that this region may represent a potential hotspot for GI parasite transmission. From a One Health perspective, these findings highlight the potential for some helminths to circulate across animal, human, and environmental interfaces. The presence of 1.3% for both Capillaria spp., Trichuris spp. and 0.7% of Fasciola spp. suggests possible zoonotic transmission pathways, particularly via the fecal-oral route. Although 93.5% of cattle had reportedly received anthelmintic treatment, no apparent protective effect was observed. These findings highlight that the Thai–Myanmar border acts as a hotspot for parasite transmission and the need for improved parasite control strategies in this region, alongside integrated One Health surveillance linking animal, human, and environmental health in this cross-border region. Full article

Background and Objectives: Individuals with heroin-related opioid use disorder are at high risk of poor oral health and impaired oral health-related quality of life (OHRQoL). However, data on the determinants of OHRQoL in this population remain limited. This study aimed to assess oral health status and OHRQoL and to identify key predictors of OHRQoL among hospitalized patients with heroin-related opioid use disorder. Materials and Methods: A cross-sectional study was conducted among 97 hospitalized patients with heroin-related opioid use disorder. Data were collected through structured interviews and clinical oral examinations, including the Decayed, Missing, and Filled Teeth (DMFT) index and the Simplified Oral Hygiene Index (OHI-S). OHRQoL was assessed using the Oral Health Impact Profile-14 (OHIP-14). Spearman correlation and multiple linear regression analyses were performed to examine associations and identify predictors of OHRQoL. Results: Participants had poor oral health, with high DMFT (19.1 ± 6.1) and OHI-S (2.0 ± 1.2) scores. OHRQoL was markedly impaired, with a mean OHIP-14 score of 29.6 ± 7.0, particularly in the psychological and social domains. OHIP-14 scores were strongly correlated with DMFT (r = 0.754, p < 0.001) and OHI-S (r = 0.552, p < 0.001). Longer duration of heroin use was associated with higher DMFT scores, poorer oral hygiene, and greater OHRQoL impairment. Multiple linear regression analysis identified unstable housing/homelessness (β = 0.166, p = 0.012), DMFT (β = 0.624, p < 0.001), and OHI-S (β = 0.272, p = 0.007) as significant predictors of poorer OHRQoL. Conclusions: Individuals with heroin-related opioid use disorder experienced substantial oral health burden and impaired OHRQoL, strongly associated with caries experience, poor oral hygiene, and housing instability. These findings highlight the need to integrate prevention-oriented dental care into addiction treatment services and to address the broader social determinants of oral health. Full article

Background and Objectives: Periodontal health represents a condition characterized by homeostasis between the teeth and the surrounding supporting tissues and implies the absence of inflammation, confirmed by the lack of bleeding, epithelial attachment loss, mobility, or periodontal pocket formation. Fixed prosthetic restorations may compromise periodontal health already during the fabrication phase, given that decisions made during their planning and placement affect long-term clinical outcomes. The aim of this manuscript was to provide insight into the interaction between periodontal tissues and fixed prosthetic restorations. Materials and Methods: A narrative literature review was conducted using a structured search of the PubMed/MEDLINE, Scopus, and Google Scholar databases to identify studies addressing periodontal health in relation to fixed dental prostheses. The impacts of tooth preparation, gingival retraction methods, supracrestal tissue attachment, periodontal phenotype, crown emergence profile, and marginal fit of various biomaterials were analyzed. Results: According to the literature data, subgingival margin placement and violation of the supracrestal tissue attachment (biological width) induce chronic inflammation, loss of epithelial attachment, and alveolar bone resorption. Gingival retraction agents, used in chemomechanical retraction procedures, particularly ferric sulfate-based agents, may lead to a transient but significant spike in inflammatory markers and dysbiosis of the subgingival microbiome. Contemporary approaches, such as the biologically oriented preparation technique and the use of CAD/CAM (Computer-Aided Design and Computer-Aided Manufacturing) technology, may improve the precision of marginal fit. Zirconia restorations exhibit significantly better biocompatibility and reduced microbial adhesion compared to metal–ceramic restorations. Conclusions: Biological response of the periodontium to fixed prosthetic restorations depends on the complex interaction between the material, position of the marginal line, and oral hygiene control. Regardless of the material used or the fabrication technique employed, adequate plaque control and regular maintenance remain key factors in preserving periodontal health. Full article

Capsaicin is a bioactive substance with diverse health-promoting properties, but its intense pungency and irritant side effects limit oral application. This study developed a Pueraria lobata particle-based Pickering emulsion (PE) as an oral delivery platform for capsaicin. Modified Pueraria lobata particles (MP-ps) were prepared using a microwave-assisted enzymolysis technique (15% hydration, 252 J/g microwave energy and 8 h pullulanase hydrolysis). MP-ps exhibited surface cracks and pores, altered starch crystallinity, and enhanced water-holding capacity and swelling power. Compared with original Pueraria lobata particles, MP-ps avoided the burst release of puerarin in the upper gastrointestinal tract, dropping from approximately 54% to 20%. An optimized capsaicin-loading PE with excellent physical stability was obtained from 4% MP-ps and a 9:1 (v/v) water-to-corn oil ratio, exhibiting complete core–shell architecture and oil-phase sequestration of capsaicin in TEM images. Gastrointestinal transit analysis in male KM mice indicated that MP-p-based PE reduced the exposure of the encapsulated lipophilic substance in the stomach and small intestine and promoted its accumulation in the colon. Irritation assays in male KM mice and Sprague-Dawley rats further demonstrated that this effective encapsulation alleviated the gastrointestinal irritation of capsaicin and improved its palatability. This study provided a food-derived material and an easy-to-build PE platform for oral lipophilic/irritant substance delivery, with potential for future health-regulating applications. Full article

Dental caries is one of the most prevalent chronic diseases affecting older adults and remains an important, underrecognized contributor to pain, impaired nutrition, systemic illness, and reduced quality of life. Older adults access medical care more often than dental care, positioning non-dental clinicians to identify risk, initiate prevention, and facilitate timely referral. A narrative review of English-language literature was conducted using PubMed and Google Scholar. Search terms included “dental caries,” “root caries,” and “older adults.” Sources included original studies, clinical guidelines, consensus statements, and high-quality reviews, with an emphasis on relevance to older adults and applicability to non-dental clinicians. Dental caries in older adults commonly presents as root and recurrent decay and isstrongly associated with xerostomia, polypharmacy, chronic disease, functional impairment, cognitive decline, and limited access to dental care. The literature supports fluoride-based prevention, management of salivary dysfunction, dietary counseling, minimally invasive therapies such as silver diamine fluoride, and interprofessional care models. Non-dental providers play a critical role in screening, risk assessment, preventive counseling, symptom triage, and referral. Integrating oral health into routine medical care is an essential and achievable strategy to reduce morbidity and improve health outcomes in older adults. Full article

There are several regions characterized by exceptional longevity and lifestyle that promote health and well-being. Loma Linda, California, in the United States, provides a unique context to examine how lifestyle behaviors relate to oral health-related quality of life (OHRQoL). This cross-sectional study surveyed adults residing in Loma Linda (N = 321) to evaluate associations among physical activity, lifestyle adherence, and OHRQoL. Physical activity was assessed using the Godin Leisure-Time Exercise Questionnaire, lifestyle adherence using a composite lifestyle score, and OHRQoL using the Oral Health Impact Profile-14 (OHIP-14). Higher physical activity and greater lifestyle adherence were associated with lower OHIP-14 scores in bivariate analyses (ρ = −0.237, p < 0.001; ρ = −0.15, p < 0.01, respectively), indicating better perceived OHRQoL. OHIP-14 scores differed across physical activity categories (Kruskal–Wallis H = 6.99, p = 0.030), with the lowest scores observed among active participants. These associations were attenuated after adjustment for demographic factors and lifestyle adherence and were not statistically significant in multivariable models (p > 0.05). These findings suggest that OHRQoL reflects the combined influence of interconnected lifestyle behaviors rather than a single factor, supporting a holistic approach to promoting oral and systemic health. Full article

Background/Objectives: Access to dental care is a multilevel challenge shaped by healthcare systems, individual characteristics, and broader social determinants. This study aimed to identify parent-reported barriers to dental care among a sample of children in Saudi Arabia using Levesque’s Conceptual Framework for Access to Healthcare. Methods: A cross-sectional survey was conducted between March and April 2023 among parents of children aged 1–18 years. The 44-item survey assessed sociodemographic, oral health, and dental care utilization, organized using Levesque’s access dimensions. Difficulty accessing needed dental care within the past 12 months served as the main outcome. The chi-square test was used to examine bivariate associations between potential barriers and difficulty accessing needed dental care. Multivariable logistic regression was used to identify factors independently associated with difficulty accessing needed dental care after adjustment for the other variables. Results: This study included 351 parents. The mean age of children was 10.7 ± 4.7 years, and 45.9% were male. One-third of parents reported difficulty accessing needed dental care for their children. The adjusted regression model identified fair/poor oral health (aOR = 13.39, 95% CI: 6.19–28.97), general health condition (aOR = 2.31, 95% CI: 1.11–4.82), and the absence of a nearby dental clinic (aOR = 2.08, 95% CI: 1.11–3.90) as factors independently associated with difficulty accessing dental care. Conclusions: Applying Levesque’s framework highlighted the multidimensional nature of barriers to accessing dental care for the study population. These findings provide preliminary evidence on parent-reported access barriers and may inform larger, representative studies and future policies to improve equitable pediatric oral healthcare in alignment with Saudi Vision 2030. Full article

Background: Human papillomavirus (HPV) has traditionally been considered a sexually transmitted infection, yet accumulating evidence demonstrates that HPV can be acquired through multiple non-sexual routes. Understanding these alternative transmission pathways is critical for interpreting HPV detection in non-sexually active populations and for refining public health strategies. Methods: This review synthesizes current evidence on non-sexual HPV transmission routes, including vertical (transplacental, intrapartum), perinatal oropharyngeal colonization, fomite contamination, breast milk transmission, and horizontal non-sexual contact. We examine HPV prevalence data from female virgins, neonates, infants, and children, and evaluate metagenomic evidence positioning HPV as a component of the human virome across multiple body sites. Results: Published studies report that vertical transmission occurs in approximately 18.2% of HPV-positive mothers, with neonatal HPV positivity of 3.4% at birth and 100% genotype concordance in transmission pairs. Transplacental transmission has been documented in 10.2% of concordant mother–placenta–newborn triads. Reviewed studies report oropharyngeal colonization at birth reaching 58.2% following vaginal delivery, with 94.3% of colonized neonates clearing infection by 24 months. HPV DNA has been detected on fomites and medical devices, in breast milk (8.6–15%), and across body sites in healthy adults (skin 61.3%, vagina 41.5%, oral cavity 30%, gut 17.3%). Metagenomic studies identify HPV DNA in 68.9% of healthy individuals, with 109 distinct types detected. Female virgins show HPV prevalence ranging from 0–51.1% across studies. Conclusions: The reviewed evidence suggests that HPV exhibits characteristics of a ubiquitous virome component with multiple non-sexual acquisition routes. These findings have important implications for vaccination strategies, screening interpretation, infection control in healthcare settings, and counseling of pediatric cases and non-sexually active individuals. Full article

On behalf of the Canadian Association of Psychosocial Oncology, we are pleased to present the abstracts from the 2026 Annual Conference, titled “A New Horizon: Expanding the Access and Impact of Psychosocial Oncology”. The 41st Annual CAPO Conference was held in St. John’s, Newfoundland from 8 June 2026 to 9 June 2026. As we stand at a new horizon in psychosocial oncology, we recognize the unprecedented opportunities to expand both the access to and the impact of comprehensive cancer care. This conference will explore innovative strategies for breaking down traditional barriers that have historically limited access to psychosocial support, including geographic isolation, resource constraints, cultural disparities, and systemic inequities in healthcare delivery. This expansion of reach and influence represents not merely growth in service numbers, but a fundamental transformation in how we conceptualize, design, and implement patient-centered psychosocial care across diverse communities and care settings. We will explore scalable solutions that amplify impact while maintaining the deeply personal, human-centered approach that defines excellence in psychosocial oncology. From telehealth innovations and peer support networks to community-based interventions and integrated care models, this conference will showcase evidence-based strategies that expand our collective ability to support individuals and families navigating the cancer journey, wherever they may be. This conference brought together key stakeholders including multidisciplinary professionals from nursing, psychology, psychiatry, social work, spiritual care, nutrition, medicine, rehabilitation medicine, occupational health and radiation therapy for both adult and pediatric populations. Participants included clinicians, researchers, educators in cancer care, community-based organizations and patient representatives. Patients, caregivers and family members presented abstracts that speak to their role in managing cancer experiences and care. Over one-hundred and fifty (150) abstracts were submitted for presentation as symposia, 20 min oral presentations, 10 min oral presentations, 90 min workshops and poster presentations. We congratulate all the presenters on their research work and contributions. Full article

Background: Oral diseases remain a major public health challenge globally and in Hungary, where untreated caries, periodontal disease, and edentulism are highly prevalent. Diet is a key modifiable determinant of oral health, yet the cumulative impact of multiple unfavorable nutritional behaviors on self-perceived oral health has not been assessed at the national level in Hungary, nor have population-attributable fraction (PAF) estimates been reported. Methods: This cross-sectional study analyzed data from 5146 adults in the 2019 Hungarian European Health Interview Survey. A six-component nutritional-risk score was constructed from self-reported dietary behaviors (fruit intake, vegetable intake, sugary soft drink consumption, sweets consumption, processed meat consumption, and water intake). Survey-weighted logistic regression estimated associations between nutritional-risk categories and poor self-perceived oral health, adjusting for sociodemographic, lifestyle, and health-related covariates. Counterfactual PAFs with 95% Monte Carlo uncertainty intervals (1000 bootstrap replications) were estimated for three nutritional-risk scenarios. Results: The weighted prevalence of poor self-perceived oral health was 19.2%. Compared with participants with 0–1 unfavorable nutritional factors, those with 3 factors (OR = 1.37; 95% CI: 1.09–1.73) and 4–6 factors (OR = 1.46; 95% CI: 1.15–1.85) had significantly higher odds of poor oral health. Low water intake was independently associated with poor oral health (OR = 1.38; 95% CI: 1.16–1.64). The main counterfactual PAF analysis estimated that 16.1% (Monte Carlo 95% UI: 5.93–26.48%) of poor oral health burden was attributable to unfavorable nutritional profiles. High nutritional risk was also associated with active caries, gum bleeding, and tooth loss. Conclusions: Cumulative nutritional risk is independently associated with poor self-perceived oral health in Hungarian adults. Integrating dietary improvements into oral health prevention strategies may substantially reduce the population-level burden of oral disease. Full article

Type 2 diabetes mellitus represents an important worldwide health problem. Annona muricata L. (AM) is used for diabetes management. Additional research is required to elucidate its hypoglycemic mechanism; we evaluate its effect on serum leptin, glucagon, insulin, neuropeptide Y concentrations and protein levels of glucagon and insulin in diabetic model. Diabetes was induced in male Wistar rats using a high-fat diet (HFD) combined with 35 mg/kg streptozotocin (STZ). The animals were randomly assigned to four groups (n = 5): Ctrl (healthy animal), HFD (untreated HFD), AM (50 mg/kg of AM) and HFD Met (300 mg/kg of metformin). Treatments were administered orally for four weeks. Serum levels of leptin, glucagon, NPY, insulin, lipid renal and hepatic profiles were quantified before and after treatment. Pancreatic insulin and glucagon content were assessed by immunohistochemistry. Two-way ANOVA with repeated measures (intragroup) and ANOVA (intergroup) were used. The HFD AM group showed lower serum glucose (41.2%), total cholesterol (38.8%), triglycerides (69.6%) and NPY (73.4%) levels than pretreatment values (p < 0.05). Increased serum leptin concentration (53.7%), pancreatic insulin (42.0%), and glucagon (48.0%) protein levels (p < 0.05) were observed. Our study provides additional insights into the hypoglycemic effects of AM and supports its potential use as a complementary treatment for diabetes. Full article

Background: Individuals with sensory impairments often encounter barriers to oral health information, preventive care, and dental services. Despite a growing body of research, oral health among individuals with hearing and visual impairments has not been comprehensively evaluated across the full spectrum of oral health outcomes. This systematic review aimed to evaluate oral health outcomes and dental treatment needs in individuals with hearing and visual impairments. Methods: A literature search was performed in Ovid MEDLINE, Ovid Embase, and Web of Science from database inception to 8 January 2026, in collaboration with a medical information specialist, and in accordance with the PRISMA 2020 guidelines. Observational studies reporting oral hygiene, periodontal status, dental caries, dental needs, and other relevant oral health outcomes in individuals with hearing and visual impairments were included. Given the substantial clinical and methodological heterogeneity across the included studies, findings were synthesized using a narrative approach. Results: A total of 5650 records were identified, of which 84 studies were included. Oral health problems were frequently reported among individuals with sensory impairments. Dental caries was the most common finding. Poor oral hygiene, gingival inflammation, periodontal problems, and unmet treatment needs were also often described. Additional findings included traumatic dental injuries, malocclusion, salivary and microbiological alterations, functional oral limitations, and reduced oral health-related quality of life. Conclusions: Individuals with sensory impairments are likely to experience poorer oral health and considerable unmet dental needs. These findings highlight the need for improved preventive strategies, effective communication approaches, and more inclusive dental care. Full article

Acute kidney injury (AKI) is a major global health challenge associated with substantial morbidity, mortality, and progression to chronic kidney disease. Increasing evidence indicates that oxidative stress, mitochondrial dysfunction, inflammatory signaling, regulated cell death, and maladaptive tissue repair play central roles in AKI pathogenesis, yet effective disease-modifying pharmacological therapies remain unavailable. This narrative review critically evaluated current evidence regarding the pharmacological characteristics, molecular mechanisms, and translational potential of alpha-mangostin (AM), the principal prenylated xanthone isolated from the pericarp of Garcinia mangostana L., through a comprehensive synthesis of experimental and mechanistic studies. Available preclinical evidence consistently demonstrates that AM improves renal function and attenuates histopathological injury, particularly in cisplatin-induced nephrotoxicity and glycerol-induced rhabdomyolysis models. These renoprotective effects are primarily associated with suppression of oxidative stress, activation of the Nrf2/HO-1 antioxidant pathway, inhibition of NF-κB-mediated inflammatory signaling, preservation of mitochondrial function, and attenuation of apoptosis. Several emerging pathways may also contribute to AM-mediated renoprotective effects; however, current evidence remains indirect, and their roles require validation in kidney-specific models. Clinical translation remains limited by poor oral bioavailability, insufficient pharmacokinetic data, lack of standardized formulations, and the absence of human clinical trials. Overall, current evidence suggests that AM has preliminary renoprotective potential in experimental AKI models. However, the limited number of available studies, predominance of cisplatin-induced nephrotoxicity models, insufficient pharmacokinetic and safety data, and absence of human clinical studies preclude conclusions regarding its clinical efficacy or translational readiness. Further validation in diverse and clinically relevant AKI models is required before clinical investigation can be considered. Full article

Lycium barbarum polysaccharides are major bioactive constituents of Lycium barbarum fruit and are widely recognized for antioxidant, immunomodulatory, and intestinal protective activities. Selenium nanoparticles are considered a safer selenium formulation than conventional inorganic selenium because they generally provide improved bioavailability and reduced toxicity. In this study, Lycium barbarum polysaccharide-stabilized selenium nanoparticles were prepared under mild conditions, characterized, and evaluated for antibacterial, antibiofilm, and antidiarrhoeal activities. The optimized nanoparticles exhibited a hydrodynamic diameter of 304.4 ± 32.9 nm, a polydispersity index of 0.369 ± 0.05, and a zeta potential of −20.8 ± 1.5 mV, indicating good colloidal stability. Scanning electron microscopy, Fourier transform infrared spectroscopy, and X-ray photoelectron spectroscopy supported the structural assignment of spherical elemental selenium particles with a polysaccharide-rich surface layer. In vitro assays showed concentration-dependent inhibition of Escherichia coli, with minimum inhibitory and minimum bactericidal concentrations of 100 and 200 μg Se/mL, respectively. Biofilm formation was also markedly reduced, and scanning electron microscopy demonstrated severe bacterial surface damage after treatment. In a KM mouse model of Escherichia coli-induced diarrhea, oral administration of the nanoparticles significantly lowered diarrhea scores, improved body weight recovery, and alleviated intestinal mucosal injury compared with untreated infected mice. Major organs showed no obvious histopathological abnormalities under the experimental conditions. Overall, these findings identify Lycium barbarum polysaccharide-stabilized selenium nanoparticles as a promising selenium-based nanomaterial for controlling bacterial diarrhea and protecting intestinal health. These results provide a practical foundation for future mechanistic, pharmacokinetic, microbiological, and translational studies aimed at broader intestinal applications. Full article