Search Results (45,064)

Background: Migraine in older adults represents an increasingly relevant yet underrecognized clinical challenge in aging societies, where multimorbidity, frailty, and polypharmacy complicate both diagnosis and management. Although traditionally considered a disorder of younger individuals, migraine frequently persists or presents after the age of 60 with atypical features, contributing to diagnostic uncertainty. Methods: This narrative review, conducted in accordance with the SANRA principles, aims to provide a comprehensive overview of the epidemiology, clinical presentation, pathophysiology, and management of migraine in older adults, with particular emphasis on age-related complexities, therapeutic challenges, and unmet clinical needs. Results: Migraine in this population often presents with atypical or misleading features, such as aura without headache, vestibular symptoms, or overlap with cerebrovascular conditions, leading to delayed or incorrect diagnoses. The burden of disease is substantial, affecting physical function, mobility, cognition, emotional well-being, and social participation, and is further amplified by comorbid conditions including cardiovascular and metabolic disorders, mood disturbances, and chronic pain syndromes. Aging-related neurobiological changes, such as impaired pain modulation, endothelial dysfunction, and neuroinflammation, may influence disease expression and treatment response. Therapeutic management is challenged by contraindications, increased susceptibility to adverse drug effects, and the complexity of polypharmacy, highlighting the importance of individualized and non-pharmacological approaches. Conclusions: Migraine in older adults is a significant but often overlooked contributor to disability and reduced quality of life. Improved recognition of its unique clinical features and age-specific vulnerabilities is essential to optimize patient-centered care. Future research should prioritize the inclusion of older populations and the development of tailored, safe, and effective management strategies. Full article

Traditional malware classification approaches primarily address fixed sets of well-studied malware types and therefore struggle to accommodate the continual emergence of novel or previously unseen malware strains. While visualization-based strategies have shown promise in few-shot malware classification, existing methods often produce representations with limited semantic richness. In parallel, few-shot learning models frequently converge with suboptimal solutions, limiting their ability to generalize effectively to new classes. To address these challenges, we propose MetaWave, a unified framework that jointly optimizes both data representation and model learning for few-shot malware classification. Rather than treating feature representation and learning strategy as largely independent stages, MetaWave is formulated as an explicit representation–adaptation integration framework that combines multi-view malware encoding with meta-learning-based optimization. At the data level, we propose a Wavelet Transform-based Malware Representation method that leverages multi-scale frequency analysis and complementary views to generate semantically enriched representations. At the model level, we adopt Model-Agnostic Meta-Learning (MAML) to optimize model initialization for rapid adaptation to unseen tasks under limited data conditions. Extensive experiments are conducted on two benchmark datasets, EMBER and Malicia, under a 5-way 5-shot protocol with disjoint class splits to ensure evaluation on previously unseen malware families. The proposed framework achieves superior performance, reaching 97.8% accuracy on EMBER and 96.2% on Malicia, consistently outperforming state-of-the-art methods. These results indicate that jointly enhancing representation quality and model adaptability can improve classification accuracy and unseen-family performance under the evaluated 5-way 5-shot protocol. Overall, MetaWave provides an effective framework for few-shot malware classification and offers a promising basis for detecting emerging malware under limited-data conditions, while robustness to adversarial perturbation, obfuscation, and polymorphism remains to be validated through dedicated future evaluation. Full article

Patients with heavily calcified coronary arteries represent a challenge in percutaneous coronary intervention (PCI), as severe calcification impairs device delivery and limits optimal stent expansion, leading to higher risks of stent thrombosis, restenosis, and adverse clinical outcomes. Approximately 20% of patients undergoing PCI exhibit severe coronary calcification, which independently predicts incomplete revascularization, increased mortality, and higher rates of major adverse cardiovascular events over mid-term follow-up. Recent advances have focused on improving the assessment and management of calcified lesions. Intracoronary imaging modalities, including intravascular ultrasound and optical coherence tomography, allow precise detection and characterization of calcium burden, overcoming the limitations of angiography. These tools play a pivotal role in guiding procedural strategy, enabling tailored selection of calcium-modifying techniques based on lesion morphology, and optimizing stent deployment. Technological innovations have significantly expanded therapeutic options. While non-compliant balloon angioplasty alone is often insufficient, adjunctive devices such as cutting and scoring balloons improve plaque modification in focal disease. Atherectomy techniques, including rotational and orbital systems, are effective for more complex lesions but require technical expertise and carry procedural risks. Intravascular lithotripsy has emerged as a promising, less aggressive modality capable of fracturing deep calcium, while excimer laser atherectomy offers an alternative for resistant lesions. Despite these advances, current evidence supporting calcium-modifying strategies is largely based on procedural outcomes rather than definitive improvements in long-term clinical endpoints. Meta-analyses and randomized trials have not demonstrated clear superiority of any single technique, and most studies remain underpowered. Intriguingly, recent data suggest that outcomes in treated calcified lesions may approximate those of non-calcified disease, raising the hypothesis that these technologies could mitigate the adverse impact of calcification. However, this remains unproven, highlighting the urgent need for adequately powered randomized trials to determine their true clinical benefit. Full article

Addressing the lack of high-fidelity test cycles for fuel cell light-duty trucks, this paper proposes an automated driving cycle construction method that integrates unsupervised clustering and reinforcement learning. Firstly, based on large-sample real-world driving data, four libraries of typical driving pattern segments are extracted through dimensionality reduction via Principal Component Analysis (PCA) and K-means clustering. Subsequently, the cycle construction process is formulated as a sequential decision-making problem, and a framework based on the Proximal Policy Optimization (PPO) algorithm, incorporating an action masking mechanism, is designed. This framework innovatively injects macro-level time budget allocation as a hard constraint into the agent’s policy space via action masking, while utilizing micro-level Markov transition probabilities as a soft guide. This dual approach drives the agent to learn an optimal segment concatenation strategy, thereby simultaneously ensuring both the macro-level statistical representativeness and the micro-level driving logic coherence of the synthesized cycle. Validation results demonstrate that the cycle constructed by the proposed method achieves an average relative error of only 7.53% in key characteristic parameters, and its joint speed-acceleration distribution exhibits a similarity as high as 0.9886 with the original data, significantly outperforming traditional methods such as the clustering method, the Markov chain method, and standard driving cycles. This study provides an effective tool for generating high-fidelity driving cycles and testing energy management strategies for fuel cell commercial vehicles. Full article

To improve vehicle user service quality and address data privacy and security issues in intelligent transportation vehicle networking systems, a three-tier communication architecture with cloud-edge-end collaboration was designed in this paper. A Bayesian decision criterion was utilized to divide user data segments into fine-grained slices based on their privacy levels, and differential privacy techniques were applied to protect the offloaded data. To achieve multi-objective optimization between user service quality and data privacy and security, the problem was formulated as a constrained Markov decision process. A communication model, a caching model, a latency model, an energy consumption model, and a data-fragment privacy protection model were designed. Additionally, a deep reinforcement learning algorithm based on the actor–critic approach was proposed for the collaborative and centralized training of multiple intelligent agents (CTMA-AC), enabling multi-objective optimization decision-making for the protection of offloaded private user data. Simulation experiments demonstrate that the proposed multi-agent collaborative privacy data offloading protection strategy can effectively safeguard private user data while ensuring high service quality. Full article

With the rapid development of complex engineering systems, many real-world optimization problems are characterized by high dimensionality, strong nonlinearity, and variable coupling. To address these challenges, this paper proposes a Public Management–Augmented Multi-Strategy Adaptive Enterprise Development Optimization algorithm (PMAED), which integrates adaptive differential evolution, an eigen-based rotated search strategy, and a hierarchical performance governance mechanism to enhance convergence efficiency and robustness. Experimental results on the CEC2020 and CEC2022 benchmark suites demonstrate that PMAED achieves superior performance across different problem types and dimensionalities. In the Friedman ranking test, PMAED consistently obtains the best average rank (1.90 and 1.60 on CEC2020; 2.00 and 1.92 on CEC2022 for 10D and 20D, respectively), outperforming all compared algorithms. The Wilcoxon rank-sum test further confirms that PMAED achieves statistically significant improvements on the majority of benchmark functions. In high-dimensional scenarios, PMAED shows remarkable optimization accuracy, for example, achieving a mean fitness value of 1.15 × 10³ on the 20-dimensional CEC2020 F1 function, significantly outperforming classical methods. In addition, PMAED is applied to a three-dimensional UAV path planning problem. The results show that the proposed method achieves the lowest average path cost (277.62) and the smallest standard deviation among all algorithms, indicating superior stability and reliability. The planned paths are smoother, safer, and more efficient compared to those generated by other methods. Overall, the proposed PMAED provides a robust and efficient solution for complex continuous optimization problems and demonstrates strong potential for real-world engineering applications. Full article

The increasing penetration of photovoltaic (PV) systems in distribution networks has introduced new challenges in voltage regulation and energy loss mitigation, particularly under time-varying loading conditions. This paper presents a constrained multi-objective mathematical optimization framework for the optimal allocation and sizing of PV-STATCOM devices in radial distribution systems. The problem is formulated as a nonlinear optimization model that minimizes the daily energy losses over a 24 h operating horizon while satisfying network operational constraints, inverter capacity limits, and renewable penetration restrictions. To efficiently solve the resulting non-convex optimization problem, a metaheuristic algorithm based on the weighted mean of vectors (WMV) is employed. The WMV method integrates wavelet-based weighting mechanisms, mean-driven update rules, vector combination strategies, and a local refinement operator to balance global exploration and local exploitation within the feasible search domain. Constraint violations are handled through a penalty-based mathematical transformation of the objective function. The proposed framework is validated on the IEEE 33-bus and IEEE 69-bus distribution systems under realistic daily load variations. The numerical results demonstrate significant reductions in daily energy losses compared to differential evolution, particle swarm optimization, artificial rabbits optimization, and golden search optimization algorithms. Furthermore, convergence analysis confirms the robustness and computational efficiency of the WMV approach in solving large-scale constrained power system optimization problems. Full article

To address the vulnerability of renewable-dominated power grids to cascading failures under extreme conditions and the limitations of existing methods in jointly handling vulnerability identification, energy storage allocation, and online control, this paper proposes an energy-storage-assisted coordinated defense strategy. First, a source-load uncertainty model is constructed and seven typical extreme operating scenarios are identified. Second, a cascading-failure evolution model that accounts for thermal accumulation is established to identify critical vulnerable branches. Third, for areas prone to local disconnection and weak terminal voltages, a coordinated ESS allocation model is developed by jointly considering active power, energy capacity, and reactive power support to determine candidate deployment locations and capacities. Finally, a graph neural network (GNN) is used to extract time-varying topological and electrical-state features, and proximal policy optimization (PPO) is employed to generate coordinated control commands for multiple ESSs, thereby linking overload suppression with voltage support. The results for the modified IEEE 39-bus system show that the proposed method identifies high-risk branches more accurately and forms an integrated defense chain covering identification, allocation, and control. The method reduces thermal stress in critical sections during the early stage of a fault, mitigates load shedding, and enhances system survivability. Full article

Image communication represents a fundamental domain of human experience that intersects cognitive neuroscience, educational psychology, and visual communication theory. The increasing digitalization of contemporary society has amplified the importance of visual literacy, defined as the ability to interpret, use, and create visual media. While neuroscientific research highlights the brain’s proficiency in processing visual information, significant gaps remain in understanding the underlying psychological mechanisms and their practical applications in educational contexts. This study proposes a multidisciplinary research design to systematically analyze these psychological dimensions. The research will integrate cognitive, perceptual, and pedagogical perspectives to understand how visual representations influence learning. The methodological design includes a multi-method approach combining experimental analysis, ethnographic observation, and psychometric evaluation on a stratified sample of 240 participants (aged 16–25) divided into three groups: high school students (n = 80), university students (n = 80), and young professionals (n = 80). The proposed methodology will utilize eye-tracking to analyze visual perception patterns, integrated with semantic differential methods to evaluate cognitive and affective associations with visual imagery. The expected results should clarify how the effectiveness of image communication depends on the coherence between technical and semantic aspects of visual imagery. The research aims to contribute to the theoretical framework of educational neuroscience, offering empirical evidence for optimizing teaching strategies based on multimodal visual communication. Full article

In insurance portfolios, classifying customers without a prior history at a given company is particularly challenging due to the absence of historical behavior, extreme class imbalance, heavy-tailed loss distributions, and strict operational constraints. Traditional machine learning approaches, including the baseline methodology proposed in previous studies, typically optimize global predictive accuracy and therefore fail to capture business-critical outcomes, especially the identification of high-risk clients. This study extends the existing approach by evaluating two complementary business-aware classification strategies: (i) a balanced bagging ensemble specifically designed to handle class imbalance and maximize expected profit under explicit customer-omission constraints, and (ii) a lightweight Transformer-based architecture capable of learning richer feature representations. Both approaches incorporate the asymmetric financial cost structure of insurance and operate under operational selection limits. The empirical analysis is conducted on a proprietary large-scale auto insurance dataset comprising 51,618 customers and is complemented by validation on nine synthetic datasets to assess robustness. Model performance is evaluated using statistical tests (ANOVA, Friedman, and pair-wise comparisons) together with business-oriented metrics. The results show that both proposed approaches consistently outperform the baseline methodology (p < 0.001) in terms of profit, with the ensemble offering a better balance of performance and efficiency, while the Transformer shows stronger robustness and generalization under data perturbations. The balanced ensemble provides the most favourable trade-off between predictive performance, robustness, interpretability, and computational efficiency, making it suitable for deployment in regulated insurance environments, while the Transformer achieves competitive results and exhibits stronger generalization under data perturbations. The proposed approach aligns machine learning with actuarial portfolio optimization by explicitly integrating profit-driven objectives and operational constraints, offering two practical and scalable solutions for risk-based decision-making in real-world insurance settings. Full article

Trajectory planning in dynamic multi-vehicle interaction environments faces three critical challenges, including the difficulty of quantifying spatial risk distributions, the complexity of characterizing behavioral uncertainty arising from the multimodal maneuvers of surrounding vehicles, and the challenge of simultaneously optimizing multiple competing objectives such as safety, efficiency, comfort, and energy consumption. To address these challenges, this paper proposes an Improved Driving Risk Field-based Multi-objective Trajectory Optimization (IDRF-MTO) method. First, a joint spatiotemporal social attention mechanism achieves unified modeling of spatial interactions, temporal dependencies, and spatiotemporal coupling, combined with a lateral–longitudinal intent strategy for multimodal trajectory prediction. Second, an improved dynamic risk field model is constructed comprising three components: a vehicle risk field that incorporates spatial orientation and motion direction factors for anisotropic risk representation, along with a collision tendency factor that converts objective risk into effective risk; a predicted trajectory risk field that achieves anticipatory quantification of future risk from surrounding vehicles through confidence-weighted fusion; and a driving environment risk field that encapsulates road geometry, static obstacles, and environmental conditions. Finally, a multi-objective cost function embedding risk field gradients is formulated, and multi-objective coordinated optimization is realized through a three-dimensional spatiotemporal situation graph with adaptive safety sampling. Simulation results demonstrate that the proposed method enhances safety while simultaneously improving comfort and efficiency and reducing energy consumption, exhibiting excellent planning performance in complex dynamic environments. Full article

Whether and how digital financial inclusion (DFI) is associated with ecological efficiency (EE) is a critical issue for the sustainable development of the Yangtze River Economic Belt (YREB). Based on panel data from 2011 to 2023, this study measures EE using the PCA-Super SBM model, and employs panel fixed-effects models and mediation models to systematically examine the association, mechanisms, and regional patterns of DFI with EE in the YREB. The findings are as follows: (1) DFI and EE exhibit notable spatiotemporal co-evolution characteristics, with the DFI index increasing nearly 14-fold and the EE level rising by approximately 21.5% over the study period. (2) DFI shows a statistically significant positive association with EE improvement; this finding remains robust after various robustness checks. (3) The association between DFI and EE is partially mediated through four pathways: capital allocation optimization, green technological innovation, industrial structure upgrading, and environmental regulation strengthening, among which green technological innovation is the most prominent mediating pathway. (4) Numerically, the association strength varies across functional zones, being higher in the ecological barrier zone (EBZ) and the coordinated development zone (CDZ) than in the high-quality development zone (HQDZ); however, differences in coefficients across zones are not statistically significant and should be interpreted cautiously. Based on these findings, this study proposes policy recommendations including establishing a DFI-EE linkage platform, implementing differentiated functional-zone strategies, and strengthening cross-basin collaborative governance, thereby providing a reference for the green transformation of the YREB. Full article

In response to the reduced system inertia and increased frequency security risks in high-renewable power systems, as well as the limitations of single energy storage technologies, a coordinated optimal scheduling method for electrochemical energy storage (EES) and compressed air energy storage (CAES) considering the minimum inertia requirement (MIR) is proposed. The method constructs a coordination framework, leveraging the fast response of EES and the sustained support and equivalent inertia contribution of CAES. An MIR evaluation model considering RoCoF and frequency nadir constraints is established, and the inertia deficit is converted into fast reserve demand, forming an inertia–reserve coupling mechanism. To address nonlinear frequency constraints, an adaptive piecewise linearization method is adopted to transform the model into a mixed-integer linear programming problem. Case studies show that, compared with the benchmark hybrid energy storage scheduling strategy without inertia–reserve coordination, the proposed method reduces thermal generation cost by 4.5% and renewable curtailment by 74.8%. Moreover, the proposed APWL method improves computational efficiency by 47% compared with the conventional PWL method. Full article

Synthetic Aperture Radar (SAR) imagery is inherently degraded by multiplicative speckle noise, rendering traditional superpixel methods—which rely on hard assignment and uniform initialization—suboptimal for boundary preservation. This study proposes a complexity-aware superpixel generation framework featuring differentiable soft-assignment optimization. The approach employs an F-LGRP (Fusion of Local Gradient Pattern Representation) feature descriptor that fuses regional gradient statistics via Gaussian filtering to suppress speckle, coupled with a complexity-driven recursive quadtree initialization strategy yielding non-uniform seed density. A U-Net architecture predicts soft pixel–superpixel association maps within a 9-neighborhood constraint, supervised by a multi-objective loss integrating edge information reconstruction and boundary feature reconstruction. Comprehensive evaluations on simulated and real SAR images (WHU-OPT-SAR and Munich) demonstrate that the proposed method achieves state-of-the-art performance across Boundary Recall, Undersegmentation Error, Compactness, and Achievable Segmentation Accuracy compared to SLIC, SNIC, Mean-Shift, PILS, and SSN. Validation on downstream segmentation tasks further confirms superior accuracy and computational efficiency, establishing the framework as an effective solution for end-to-end SAR image analysis. Full article

With advancements in Earth observation capabilities, the demand for large-scale mapping using remote sensing images has increased significantly. However, selecting an optimal image set for the area of interest (AOI) from a large collection of remote sensing images remains challenging. On the one hand, it is crucial to select images with minimal redundancy and low cloud cover to enhance production efficiency and the effective coverage of mapping products. On the other hand, adjacent selected images should transition naturally so that the resulting mapping products appear visually cohesive. Unfortunately, most existing remote sensing image selection algorithms focus only on the former, with little attention to visual consistency. Meanwhile, images from the same swath inherently offer advantages in both redundancy reduction and visual consistency. However, a larger coverage area also carries the potential for greater variation in cloud cover, and cloud distribution within a swath can be highly complex. Managing the relationships among swaths, images, and cloud cover is also challenging. To address these issues, this paper proposes a novel image selection model, SwathSel. Candidate images are grouped through a composite grouping strategy based on swaths, cloud cover, and topological connectivity, thereby expanding the fundamental unit for image selection from individual scenes to connected image subsets. A dynamic adjustment mechanism is introduced to enhance grouping flexibility. Additionally, local and global swath consistency constraints are designed to strengthen visual consistency among images, and a subset evaluation module is used to comprehensively assess swath consistency, coverage, cloud cover, and metadata information. Through a greedy strategy combined with a rapid refinement technique, the final selected image set is obtained. Experiments were conducted on four datasets, and four quantitative metrics were designed to evaluate the visual consistency of the results. Compared with baseline models, SwathSel achieves lower redundancy and cloud cover while delivering superior visual consistency. Full article