Search Results (1,916)

Purpose: This study sought to extract and characterize fucoidan from brown seaweed Padina tetrastromatica for the synthesis of fucoidan–gold nanoparticles (F-AuNPs) and to assess their physicochemical properties, as well as their antioxidant, anti-inflammatory, and anticancer activities, alongside potential molecular interactions with specific cancer-related targets. Methods: The extracted fucoidan-rich fraction was characterized for its sulfate content. Citrate-stabilized plain gold nanoparticles (plain AuNPs) were prepared and characterized as non-fucoidan nanoparticle controls. Comprehensive physicochemical characterization, including UV–Vis spectroscopy, Fourier-transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), X-ray diffraction (XRD), dynamic light scattering (DLS), zeta-potential analysis, and thermogravimetric analysis (TGA), was performed on the resultant fucoidan-functionalized AuNPs (F-AuNPs). Biological activities were assessed using different techniques: antioxidant potential (Ferric Reducing Antioxidant Power (FRAP) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) assays), anti-inflammatory effects (NO inhibition in macrophages), and anticancer efficacy against HepG2 cells (MTT and flow cytometry). Potential molecular targets relevant to these activities were further explored in silico using molecular docking against key cancer-related proteins, providing hypotheses for future experimental validation. Results: The fucoidan-rich fraction showed a sulfate content of 10.08%. Strong antioxidant activity was observed, especially in FRAP (11.20 ± 0.29 mg TE g⁻¹ DW). F-AuNPs exhibited enhanced cytotoxicity against HepG2 cells (IC₅₀ 138.1 µg mL⁻¹) compared to plain AuNPs (IC₅₀ 271.2 µg mL⁻¹) and the fucoidan-rich fraction (IC₅₀ 390.2 µg mL⁻¹), inducing G1 phase arrest. In addition, F-AuNPs reduced nitric oxide production in LPS-stimulated RAW 264.7 macrophages, reaching 21.42 ± 1.29% inhibition at 100 µg mL⁻¹. As an exploratory, hypothesis-generating step, an in silico target-prioritization screen identified HPSE and MMP-2 as the highest-scoring candidate proteins, proposed solely as targets for future experimental validation. Conclusions: F-AuNPs represent a promising multifunctional nanoplatform with antioxidant, anti-inflammatory, and antiproliferative activities. The integration of in vitro biological evaluation with in silico target prediction supports the potential biomedical relevance of F-AuNPs and generates testable hypotheses regarding their molecular targets, which require experimental validation. Full article

Heparanase 1 (HPSE1) is the only mammalian endoglycosidase that cleaves heparan sulfate (HS), a glycosaminoglycan (GAG), and is frequently upregulated in cancers, thereby promoting tumor progression. Despite extensive efforts to develop inhibitors of its HS-degrading activity, its non-enzymatic functions limit therapeutic efficacy and pose a major challenge for therapeutic development. Thus, inhibiting HPSE1 expression is critical for controlling its enzymatic and non-enzymatic functions; however, no FDA-approved inhibitors are currently available. Here, we identify auranofin (AUF), an oral gold-containing drug used to treat rheumatoid arthritis, as a potent inhibitor of HPSE1 promoter activity. High-throughput screening revealed that an atypical protein kinase C (aPKC)–NF-κB signaling axis is a key regulator of HPSE1 expression. Notably, AUF treatment reduced HPSE1 expression and significantly suppressed the invasive capacity of MDA-MB-231 cells in a Transwell migration assay. We then investigated the role of HPSE1 in the invasive activity of MDA-MB-231 cells, which produce higher levels of hyaluronan (HA) and HS than non-invasive cells. Neither HS degradation, HA supplementation in Matrigel during Transwell migration, nor HPSE1 overexpression alone was sufficient to drive invasion, suggesting that invasive capacity depends on mesenchymal features and coordinated induction of HPSE1 and GAGs rather than HS degradation. Collectively, our findings demonstrate that AUF-mediated inhibition of aPKC suppresses HPSE1 expression, thereby inhibiting both its enzymatic and non-enzymatic functions and limiting cancer progression, metastasis, and angiogenesis. These results highlight the therapeutic potential of AUF for targeting HPSE1-driven tumor progression and support its repurposing for cancer treatment. Full article

To characterize the distinct expression profiles of microRNAs (miRNAs) in serum and tissue and to delineate the heterogeneity of their regulatory mechanisms in early-stage ovarian cancer (EOC), thereby identifying candidate biomarkers for non-invasive early diagnosis. Differentially expressed miRNAs were identified by integrating publicly available datasets of EOC tissues and serum samples from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA). Core miRNAs were subsequently screened through integrated differential expression analysis, weighted gene co-expression network analysis (WGCNA), and feature importance ranking derived from optimized machine learning models. Protein–protein interaction (PPI) networks and functional enrichment analyses (GO and KEGG) were performed on predicted target genes to systematically compare the functional discrepancies between serum- and tissue-derived miRNAs. No overlapping core miRNAs were observed between the two compartments. Serum miRNAs exhibited an overall up-regulated trend, whereas tissue miRNAs were predominantly down-regulated. Although the regulatory pathways demonstrated significant heterogeneity, they ultimately converged on the cell cycle and the PI3K-Akt signaling pathway, indicating high functional homology. Furthermore, serum miRNAs are not merely passive leakage products from tissues; current evidence suggests they may be selectively packaged into exosomes to participate in tumor regulation. Despite divergent expression profiles, serum and tissue miRNAs share homologous regulatory functions in EOC. These findings suggest that serum miRNAs accurately reflect the core molecular status of tumor tissues, providing a robust molecular foundation for liquid biopsy-based early detection strategies. Full article

Heavy metal(loid) pollution in watersheds surrounding mining areas originates from multiple and complex sources, posing persistent threats to terrestrial–aquatic ecosystems and human dietary safety. This study systematically investigated the pollution characteristics, spatial distribution, ecological risks and human health hazards of seven typical heavy metal(loid)s (As, Pb, Cr, Cd, Cu, Zn, and Ni) in the integrated water–soil–vegetable continuum of a mining-affected watershed in Southwest China. Field sampling was carried out in three functional zones with different mining disturbance intensities, and inductively coupled plasma mass spectrometry (ICP-MS) was used to detect heavy metal(loid) concentrations in all samples. Multiple pollution evaluation indices and the USEPA human health risk assessment model were adopted for comprehensive quantitative analysis. The results showed that 44.0% of surface water samples exceeded national permissible limits, with high-pollution areas concentrated in intensive mining zones, presenting moderate overall aquatic heavy metal(loid) pollution. Although the average concentrations of seven heavy metal(loid)s in riparian soils complied with Chinese agricultural soil screening standards, localized significant enrichment was observed for As (1.98 times), Cd (4.62 times), Cu (1.81 times), and Zn (2.72 times) compared with regional background values, causing mild comprehensive soil pollution. Farmland soils exhibited prominent Cu and Zn accumulation, and leafy vegetables in the study area suffered severe Pb and Cd pollution, with potential dietary exposure risks. Health risk assessment indicated that children face higher non-carcinogenic and carcinogenic risks than adults via soil hand-to-mouth exposure; dietary intake of vegetables leads to moderate carcinogenic risks for children caused by As and Ni exposure. Overall, this study clarifies the migration and enrichment rules of heavy metal(loid)s in the water–soil–vegetable system of mining watersheds, confirms the prominent ecological and human health risks of Cd, As and Pb in the study area, and provides targeted basic data for regional heavy metal(loid) pollution prevention and food safety management. Full article

Identifying superior salt-tolerant germplasm and resistance genes is crucial, as wheat (Triticum aestivum L.) seedlings are highly vulnerable to salt stress. Here, using an optimized 150 mM NaCl treatment, we screened 137 Chinese wheat accessions via an organ-specific method. Phenotyping analysis revealed extensive organ-specific divergence, with 48.91% of accessions displaying inconsistent performance between shoot and root length. We then performed comparative transcriptomics on three representative phenotypes at the seedling stage: Gaoyou 2018, representing the salt dual-sensitive group; Huapei 5, representing the salt dual-tolerant group; and Jimai 60, representing the divergent group with higher tolerance in shoots rather than in roots. Analysis of overlapping differentially expressed genes (DEGs) across all three accessions revealed a basal stress response—characterized by induced osmotic defense and suppressed primary growth—exemplifying a classical growth–defense trade-off. Genotype-specific DEG profiling demonstrated that the divergent Jimai 60 maintains its shoot advantage by reinforcing physical barriers and inhibiting apoptosis. Conversely, transcriptomic profiling implies that the systemically tolerant Huapei 5 maintains coordinated shoot and root tolerance at the seedling stage by strongly activating below-ground Na⁺ homeostasis (efflux and compartmentalization) while simultaneously down-regulating non-essential immune responses to optimize defense energy reallocation. Collectively, our findings provide novel insights into the organ-differentiated salt tolerance of wheat, offering well-characterized elite germplasm and compelling genetic targets for future molecular breeding. Full article

Background: Chronic kidney disease (CKD) accelerates biological aging and amplifies the risk of adverse geriatric outcomes. Albuminuria reflects systemic endothelial dysfunction beyond renal damage, yet its specific relationship with falls, fear of falling, and frailty in predialysis CKD patients remains underexplored. Objectives: We aimed to evaluate the association between albuminuria levels (urinary albumin-to-creatinine ratio, ACR) with falls, fear of falling (Falls Efficacy Scale, FES), and frailty (FRAIL scale and Clinical Frailty Scale, CFS) in older adults with CKD. Methods: This cross-sectional study analyzed 295 patients aged ≥60 years attending nephrology and geriatrics clinics at Kayseri City Hospital, Turkey (April–June 2025). ACR was categorized per KDIGO (A1: <30, A2: 30–300, A3: ≥300 mg/g). Inflammatory indices (NLR, SII, CAR) were calculated. Hierarchical multivariable logistic regression and ROC analyses were performed. Results: Fall prevalence showed a clear dose-response across ACR categories: 31.2% (A1), 72.0% (A2), and 93.2% (A3) (p < 0.001). In the fully adjusted model, each unit increase in log-ACR was associated with a 3.84-fold increase in fall odds (OR 3.84, 95% CI 2.74–6.65). Although bivariate ACR-frailty associations were non-significant, fully adjusted models uncovered independent associations across both instruments and thresholds: FRAIL ≥ 3 (OR 1.41, 95% CI 1.05–2.03), FRAIL ≥ 2 (OR 1.49, 95% CI 1.08–2.21), CFS ≥ 5 (OR 1.87, 95% CI 1.38–2.83), and CFS ≥ 4 (OR 1.37, 95% CI 1.02–1.93). ACR showed good discriminative ability for falls (AUC 0.773, optimal cut-off 21.70 mg/g) but poor discrimination for frailty (AUC 0.50–0.54). The ACR–fall association was stronger in patients with GFR < 60 (OR 4.48) than GFR ≥ 60 (OR 2.18). Conclusions: Albuminuria is a strong, independent, and graded predictor of falls in older CKD patients, with a nearly 4-fold increase in risk per log-unit ACR increase after full adjustment. ACR measurement, already routine in CKD monitoring, could help identify older patients at increased fall risk and guide targeted geriatric assessment. However, ACR showed poor standalone discriminative ability for frailty across all definitions (AUC 0.50–0.54), establishing that it cannot serve as a frailty screening tool in isolation. Full article

Gridded precipitation datasets are increasingly used as operational tools, with growing emphasis on cloud-native processing to handle multi-decadal archives through reproducible and auditable workflows. This paper presents an end-to-end pipeline that uses Google Earth Engine for the automated extraction of ERA5-Land precipitation, enabling on-the-fly analysis and targeted spatiotemporal data retrieval. The extracted outputs are subsequently evaluated through station-based comparisons using one linear and one non-linear bias-correction technique. The workflow emphasizes scalable data access, consistent station alignment, and distribution-aware diagnostics for extremes. It is designed to support rapid national screening and to provide a transferable blueprint for hydrometeorological applications. Full article

Background and Objectives: Bladder cancer (BCa) is characterized by high rates of recurrence and progression, underscoring the need for reliable non-invasive biomarkers. Circular RNAs (circRNAs) are covalently closed non-coding RNAs generated by back-splicing and are stable in biological fluids, including urine. Increasing evidence implicates circRNAs in BCa pathogenesis. However, identification of clinically relevant circRNAs remains challenging. This study aimed to streamline circRNA selection and identification of functional urinary circRNAs for potential use as biomarkers for BCa monitoring. Methods: Using a database-screening approach, we identified circRNAs with high predicted affinity (TDMD score > 1.1) to miR-101-3p (a tumor-suppressive microRNA in BCa). In addition, candidate circRNAs were prioritized based on the following: (i) derivation from genes involved in BCa tumorigenesis; and (ii) origination from exonic or long non-coding RNA sequences. The potential contribution of Argonaute-2 (Ago2) binding sites to circRNA activity or potential usage as biomarker was also evaluated. Expression levels were assessed in urine samples and BCa cell lines, and functional relevance was examined using molecular and cellular assays. Results: circCIAO1(5) and circMALAT1 fulfilled prioritization criteria and exhibited distinct Ago2-binding site profiles. Both circRNAs were upregulated in urine from BCa patients and in aggressive BCa cell lines and showed differential expression between remission and recurrent disease. CircCIAO1(5) demonstrated higher-affinity binding to miR-101-3p, while both circRNAs interacted with miR-101-3p and Ago2. Functional assays revealed enhanced proliferation, motility, and invasion upon circRNA overexpression, consistent with miR-101-3p sequestration and reduction in depression of its target oncogene—EZH2. Conclusions: circCIAO1(5) and circMALAT1 are promising candidates as urinary biomarkers for noninvasive BCa monitoring, illustrating the value of bioinformatics-guided determination of circRNA as potential biomarkers and significance of circRNA-mediated regulatory mechanisms in BCa biology. Full article

Naturally fermented tofu whey is a nutrient-rich byproduct of tofu production that harbors diverse lactic acid bacteria (LAB) with potential probiotic properties. However, the antioxidant mechanisms of these LAB, particularly the roles of different cellular fractions and their metabolic basis, remain unclear. This study aimed to isolate LAB from naturally fermented tofu whey and evaluate their antioxidant activities across cellular fractions, combining in vitro assays, 16S rDNA-based identification, metabolomic profiling, and cellular validation to elucidate the underlying mechanisms. Six LAB strains were isolated and screened for 2,2-diphenyl-1-picrylhydrazyl and hydroxyl radical scavenging capacity and environmental stress tolerance. Among the identified isolates, Lactiplantibacillus plantarum MCS1903 exhibited the highest extracellular antioxidant activity. Non-targeted metabolomic analysis of cell-free supernatant revealed distinct metabolic profiles compared with the MRS control, with significant enrichment of antioxidant-related metabolites and pathways. In Caco-2 cells, MCS1903 supernatant (<5%, v/v) showed no significant cytotoxicity and effectively alleviated H₂O₂-induced oxidative stress by modulating the Nrf2/Keap1-HO-1 signaling pathway. These findings indicate that tofu whey is a valuable source of functional LAB, and MCS1903 represents a promising candidate for probiotic and functional food applications, supporting the valorization of tofu whey and development of natural antioxidant probiotics derived from fermented food byproducts. Full article

Background/Objectives: Antimicrobial resistance (AMR) in Staphylococcus spp. associated with poultry production is an emerging concern with implications for animal and public health. This study aimed to characterize antimicrobial susceptibility patterns and detect targeted methicillin resistance determinants in Staphylococcus isolates recovered from broiler chickens affected by bacterial chondronecrosis with osteomyelitis (BCO). Methods: A total of 200 bacterial isolates were evaluated, of which 167 were confirmed as Staphylococcus spp. Species identification was performed using presumptive phenotypic characterization followed by 16S rRNA gene sequencing. Antimicrobial susceptibility was assessed using disk diffusion, while presumptive methicillin-resistant phenotypes were evaluated using oxacillin screening and CHROMagar MRSA. Targeted molecular detection of mecA and mecC was performed by PCR. Results: The isolates demonstrated substantial species diversity, with S. aureus as the predominant species. Antimicrobial resistance was mainly observed against β-lactam antibiotics, particularly penicillin (33.5%), whereas high susceptibility was retained for non-β-lactam agents, including ciprofloxacin, tetracycline, trimethoprim–sulfamethoxazole, and azithromycin. A targeted PCR detected mecA in 7.2% of isolates, while mecC was not detected. The detection of mecA in oxacillin-susceptible isolates suggested genotype–phenotype discordance. Conclusions: BCO-associated Staphylococcus spp. from broiler chickens showed diverse species distribution, penicillin-dominant resistance, and targeted mecA detection across multiple species, supporting the use of combined phenotypic and molecular approaches for methicillin resistance surveillance. Full article

As sustainable finance continues to advance, an important question is how scientifically designed and well-targeted policies can curb corporate ESG greenwashing and improve the quality of firms’ ESG and sustainability disclosure. From the perspective of fiscal–financial policy coordination, we exploit the green loan interest subsidy policy (GLIS) as a quasi-natural experiment and develop an analytical framework around four policy components: commercial banks’ information screening, local governments’ green screening, the subsidy instrument’s leverage and certification effects, and firms’ internal green governance. Within this framework, we examine whether the GLIS can restrain corporate ESG greenwashing. Using Chinese listed firms from 2009 to 2022 as the sample and identifying the effect through a multi-period difference-in-differences (DID) model, we find that the GLIS significantly curbs corporate ESG greenwashing. In exploring the underlying channels, we find that the GLIS curbs corporate ESG greenwashing by strengthening commercial banks’ information screening, enhancing local governments’ green screening, easing firms’ external financing constraints, and reinforcing firms’ internal green governance. Further analysis indicates that the inhibitory effect of the GLIS on corporate ESG greenwashing is more pronounced among non-state-owned firms, firms in the growth stage, firms in heavily polluting industries, and firms located in regions with weaker resource endowments. In addition, the stronger a firm’s digital technology R&D capability and corporate governance capability, the greater the restraining effect of the GLIS on its ESG greenwashing. By systematically evaluating the governance effect of fiscal–financial policy coordination on corporate ESG greenwashing, our study provides useful insights for governments seeking to improve green finance policies and optimize the coordination of green policy instruments. Full article

Background: The legal dimensions of nursing practice have become increasingly complex, yet the concept of legal literacy in clinical nurses remains insufficiently defined. Existing studies use terms such as legal knowledge, legal awareness, legal cognition, and law-based practice capacity inconsistently, which hinders conceptual clarity, valid measurement, and targeted educational intervention. This study aimed to clarify the conceptual boundaries, defining attributes, antecedents, consequences, empirical referents, and operational definition of legal literacy in clinical nurses. Methods: A concept analysis was conducted using Walker and Avant’s eight-step method. A systematic literature search was performed across six databases and supplemented by searches in JSTOR and HeinOnline for non-clinical uses of the concept. The search covered database inception to December 2024. Screening and reporting followed PRISMA 2020 guidelines. Fifty-six papers were included. Data extraction and analysis were conducted using content analysis with independent dual-reviewer coding. Results: Legal literacy in clinical nurses was distinguished from four related concepts: legal knowledge, legal awareness, legal cognition, and medical ethics. Three defining attributes were identified: normative understanding, value internalization oriented toward rights and responsibilities, and law-based situational practice. Antecedents were identified at macro, meso, and micro levels, while consequences were observed for individual nurses, healthcare organizations, and patient rights. Analysis of empirical referents revealed a persistent gap between conceptualization and measurement, particularly in assessing law-based situational practice. An operational definition was developed accordingly. Conclusions: Legal literacy in clinical nurses is a multidimensional professional competency integrating legal understanding, rights- and responsibility-oriented value internalization, and the ability to translate these into lawful clinical action. The findings provide a conceptual basis for future instrument development and targeted educational and management interventions. Full article

Background: Gastrointestinal (GI) cancers, particularly colorectal, gastric, and liver cancers, account for a major global burden of incidence and mortality and remain important targets for genetic susceptibility research. Long non-coding RNAs (lncRNAs) can regulate gene expression and are increasingly studied in carcinogenesis. Numerous case–control studies have investigated associations between lncRNA polymorphisms and cancer risk, but findings are inconsistent. This study systematically evaluated the association between lncRNA single nucleotide polymorphisms (SNPs) and GI cancer susceptibility. Methods: A systematic literature search from Embase, Medline, Scopus, and Web of Science databases identified 174 potentially extractable studies. Eligible studies were case–control or cross-sectional studies published up to 8 May 2026; case reports, reviews, and meta-analyses were excluded. After screening for identical cancer type, identical SNP, and sufficient statistical data, only variants supported by at least three independent case–control studies were eligible for meta-analysis. Seven SNPs across six lncRNAs, comprising 23 studies (15,131 cases and 20,969 controls), were selected. Because of the limited number of eligible studies, subgroup analyses could not be performed consistently. Odds ratios (ORs) with 95% confidence intervals (CIs) were assessed under allelic, dominant, and recessive genetic models using fixed- or random-effects models according to heterogeneity. Results: In the primary analyses restricted to homogenous Chinese populations, H19 rs3024270 was significantly associated with hepatocellular carcinoma under allelic (OR = 1.22, 95% CI: 1.05–1.42, p = 0.01) and dominant models (OR = 1.22, 95% CI: 1.03–1.45, p = 0.02). Exploratory analyses including mixed populations identified additional associations, with the strongest observed for MEG3 rs7158663 and colorectal cancer, showing significant risk elevation under allelic (OR = 1.42, 95% CI: 1.25–1.63, p < 0.00001), dominant (OR = 1.42, 95% CI: 1.20–1.68, p < 0.0001), and recessive models (OR = 1.98, 95% CI: 1.46–2.68, p < 0.0001). PRNCR1 rs16901946 showed a significant association with gastric cancer under the dominant model (OR = 1.20, 95% CI: 1.02–1.41, p = 0.03), while GAS5 rs145204276 demonstrated a recessive-model association with gastric cancer (OR = 1.30, 95% CI: 1.16–1.46, p < 0.0001). In contrast, GAS5 rs145204276 in colorectal cancer; H19 rs2839698 and MALAT1 rs619586 in hepatocellular carcinoma yielded heterogeneous or unstable pooled estimates. Findings should be interpreted cautiously due to the limited number of studies, heterogeneity, and potential publication bias. Conclusions: Among the primary analyses, H19 rs3024270 showed the most consistent association with HCC susceptibility. Exploratory analyses identified candidate variants, including MEG3 rs7158663, PRNCR1 rs16901946, and GAS5 rs145204276. Population-specific effects and study heterogeneity remain important limitations. PROSPERO registration number for this study: CRD42023389742. Full article

Imaging of infections has the potential to improve clinical outcomes, but pathogen-specific imaging strategies are currently unavailable. Given their target specificity, antimicrobials may be useful as molecular imaging ligands to target infections. Despite substantial development efforts, no antimicrobial-based ligands are approved for clinical use. This scoping review comprehensively surveys radiolabeled antimicrobials across antibacterial, antimycobacterial, antiviral, and antifungal drug classes, examining their progression through the translational pipeline. The review utilized PubMed and Google Scholar databases (1970–2025), following PRISMA Extension for Scoping Reviews (PRISMA-ScR) guidelines. Two reviewers independently screened titles, abstracts, and full-text articles; data were extracted, and content duplicates were removed. In total, 143 preclinical and 25 clinical articles met the selection criteria. In clinical studies, most tracers showed suboptimal specificity for infections, while some proved useful for pharmacokinetic characterization. Among preclinical studies, radiolabeled plazomicin and echinocandins (caspofungin and anidulafungin) exhibited the greatest number of preferred characteristics. In conclusion, ideal antimicrobial pharmacologic properties can be counterproductive for imaging, where rapid background clearance and a high target-to-non-target ratio (T/NT) are essential. Many radioligands demonstrate good tissue penetration but suboptimal washout, limiting their diagnostic value. In vivo pharmacokinetic applications during active infections are promising, though significant challenges remain for infection imaging. Full article

Background: Modifiable lifestyle factors may contribute additively to colorectal cancer (CRC) risk in individuals who already have non-modifiable risk factors, such as prior colorectal neoplasia or significant family history of CRC. However, the impact of multicomponent lifestyle interventions (such as dietary modification, physical activity, and counselling) on behavioural modification, risk of colorectal neoplasia, and quality of life (QoL) in this population has not yet been systematically reviewed. Aims: The primary aim was behavioural change (change in body weight, diet, physical activity, sedentary lifestyle, smoking, and alcohol consumption). The secondary aim was colorectal neoplasia outcomes, including the incidence of precancerous lesions and/or cancer and CRC mortality/survival, and QoL, including specific domains. Methods: This review was conducted following the Cochrane guidelines for Systematic Reviews of Interventions. Both randomised and non-randomised studies assessing the effect of multicomponent lifestyle interventions on behavioural modification, risk of colorectal neoplasia, mortality, and quality of life in people at above-average risk of CRC were included. Medline/Ovid, Cochrane Library, Web of Science, and Scopus were searched. Screening, data extraction, and risk of bias assessment were independently performed by two reviewers using the revised Cochrane Risk of Bias (RoB) tools. Results: Of the 4174 studies screened, 10 interventional studies were eligible for inclusion, which had outcomes for behavioural change or quality of life. No interventions assessed neoplasia risk or mortality outcomes. Multicomponent lifestyle interventions mainly targeting diet and physical activity, delivered via a telephone-based or health coaching approach, showed positive effects on healthy behaviours and quality of life compared with usual care, although some studies reported inconsistent results. Conclusions: There is emerging evidence that multicomponent lifestyle interventions may offer beneficial effects on practicing healthy behaviours and improving QoL for individuals at above-average risk for CRC and undergoing colonoscopy surveillance. Full article