Search Results (17,400)

The registration system reform (RSR) represents a landmark innovation in China’s IPO system, aiming to promote a more transparent, competitive, and sustainable market. Exploiting the staggered implementation of RSR as a quasi-natural experiment, we employ a difference-in-differences (DID) model using a sample of Chinese A-share IPO firms from 2016 to 2022 to investigate its impact on corporate sustainability, as proxied by environmental, social, and governance (ESG) performance. Our findings indicate that RSR significantly enhances corporate ESG performance, especially the governance (G) performance. Mechanism analysis suggests that market competition, investor rationality, and sponsor reputation are potential channels through which the reform facilitates corporate sustainability. Furthermore, the above relationship is more pronounced in regions with a higher degree of marketization, among non-state-owned enterprises, and those with weaker profitability. Moreover, the reform not only exhibits long-term effects but also demonstrates positive spillover effects on peer firms originally listed under the approval-based system. Overall, our study extends the understanding of how capital market institutional reforms promote corporate sustainability in the era of the digital economy and provides valuable insights for regulators to standardize and enhance RSR, thereby establishing a resilient and sustainable financial ecosystem. Full article

Cannabidiol (CBD), a non-psychoactive phytocannabinoid derived from Cannabis sativa L., has emerged as a promising multifunctional agent in dermatology and cosmetic science. The review provides an updated synthesis of CBD’s topical therapeutic potential, challenges, and evolving regulatory frameworks. CBD exhibits diverse biological effects, including anti-inflammatory, antioxidant, antibacterial, analgesic, lipostatic, antiproliferative, moisturising, and anti-ageing properties through interactions with the skin’s endocannabinoid system (ECS), modulating CB1, CB2, TRPV channels, and PPARs. Preclinical and clinical evidence support its efficacy in managing acne, psoriasis (including scalp psoriasis), atopic and seborrheic dermatitis, and allergic contact dermatitis. CBD also relieves pruritus through neuroimmune modulation and promotes wound healing in conditions such as pyoderma gangrenosum and epidermolysis bullosa. In hair disorders such as androgenetic alopecia, it aids follicular regeneration. CBD shows promise in managing skin cancers (melanoma, squamous cell carcinoma, Kaposi sarcoma) and pigmentation disorders such as melasma and vitiligo. It enhances skin rejuvenation by reducing oxidative stress and boosting collagen and hydration. However, there are challenges regarding CBD’s physicochemical stability, skin penetration, and regulatory standardisation. As consumer demand for natural, multifunctional skincare grows, further research is essential to validate its long-term safety, efficacy, and optimal formulation strategies. Full article

Natural resource assets inherently integrate tripartite synthesis of legal, economic, and ecological attributes. They serve dual critical functions as foundational elements supporting the evolution of new-quality productive forces and pivotal mechanisms safeguarding ecosystemic integrity. It has become a global consensus and direction of action to advance comprehensive supervision of natural resource assets and practice the concept of “Community of Life for Human and Nature”. Under the background of the super-ministry system restructuring in China, comprehensive supervision of natural resource assets remains challenged by system fragmentation in supervision objectives and multifaceted interest conflicts among stakeholders. In light of this, this research focuses on the theoretical justification and system optimization of the comprehensive supervision of natural resource assets in China. Using comparative analysis and normative analysis methods, we validate the system’s function on the comprehensive supervision of natural resource assets, summarize foreign experiences, and ultimately aim to explore the optimization pathway of the legal system for the comprehensive supervision of natural resource assets. The results show the following: (1) The choice of the legal system for the comprehensive supervision of natural resource assets emerges as the functional product aligning societal objectives, the rational paradigm for achieving efficient resource allocation, and the adaptive response to the external effects of common property. (2) The system supply of comprehensive supervision of natural resource assets in foreign countries is characterized by normative convergence in conceptual elements and typological categorization in objectives and objects. Therefore, this research recommends that, in order to optimize the system of the comprehensive supervision of natural resource assets in China, (1) in terms of protection of source, natural resource assets should be categorized, with operational natural resource assets focusing on management and public welfare natural resource assets focusing on conservation. (2) In terms of valuation, the economic valuation of natural resource assets should be integrated with ecosystem service assessments to enhance fair market equity. (3) In terms of method, the big data center should be established to enable the synergistic integration of technological innovation and system reforms. (4) In terms of subject, requiring the participation of various government departments, non-governmental organizations, the general public, and other parties could realize the connection of different legal bases for the comprehensive supervision of natural resource assets and the balance of multiple rights and interests, which should help to achieve balanced resource efficiency and biodiversity conservation and safeguard national ecological security. Full article

Carbon dioxide is naturally present in the Earth’s atmosphere and plays a role in regulating and balancing the planet’s temperature. However, due to various human activities, the amount of carbon dioxide is increasing beyond safe limits, disrupting the Earth’s natural temperature regulation system. Today, CO₂ is the most prevalent greenhouse gas; as its concentration rises, significant climate change occurs. Therefore, there is a need to utilize anthropogenically released carbon dioxide in valuable fuels, such as formic acid (HCOOH). Single-atom catalysts are widely used, where a single metal atom is anchored on a surface to catalyze chemical reactions. In this study, we investigated the potential of Cu@Phosphorene as a single-atom catalyst (SAC) for CO₂ reduction using quantum chemical calculations. All computations for Cu@Phosphorene were performed using density functional theory (DFT). Mechanistic studies were conducted for both bimolecular and termolecular pathways. The bimolecular mechanism involves one CO₂ and one H₂ molecule adsorbing on the surface, while the termolecular mechanism involves two CO₂ molecules adsorbing first, followed by H₂. Results indicate that the termolecular mechanism is preferred for formic acid formation due to its lower activation energy. Further analysis included charge transfer assessment via NBO, and interactions between the substrate, phosphorene, and the Cu atom were confirmed using quantum theory of atoms in molecules (QTAIM) and non-covalent interactions (NCI) analysis. Ab initio molecular dynamics (AIMD) calculations examined the temperature stability of the catalytic complex. Overall, Cu@Phosphorene appears to be an effective catalyst for converting CO₂ to formic acid and remains stable at higher temperatures, supporting efforts to mitigate climate change. Full article

Organic agriculture is a production system based on environmentally friendly practices that promote the conservation of natural resources, biodiversity, and the production of high-quality food. Its tenets are linked to the concept of sustainable development, which integrates environmental, social, and economic goals. In the face of global competition and changes in food systems, studying their competitiveness of organic agriculture is essential. It is key to assessing its potential for long-term development and competition with conventional agriculture. The purpose of this study is to identify and assess the spatial differentiation in the competitiveness of organic agriculture in EU countries. This study assessed the level of input and output competitiveness of organic agriculture in selected EU countries using the author’s synthetic taxonomic indicators consisting of several sub-variables. The competitiveness of organic farming in twenty-three countries (Cyprus, Latvia, Portugal, and Finland were not included due to a lack of statistical data) was analysed using one of the linear ordering methods, i.e., a non-pattern method with a system of fixed weights. The research has shown significant spatial differentiation in both the input competitiveness and the outcome competitiveness of organic agriculture in EU countries. In 2023, Estonia had the highest level of input competitiveness, followed by Austria, the Czech Republic, and Sweden. In 2023, Estonia had the highest synthetic indicator of outcome competitiveness, followed by the Netherlands and Denmark. In addition, an assessment was made of changes in EU organic agriculture in 2014–2023 by analysing the direction and dynamics of changes in selected measures of the development potential of organic agriculture in all member states (27 countries). This sector is characterised by high growth dynamics, including both the area under cultivation and the number of producers and processors of organic food. This study identified several important measures to support the development of organic farming (especially in countries where this type of activity is relatively less competitive) through targeted support mechanisms, such as policy and regulatory measures, financing, agricultural training and advisory services, scientific research, encouraging cooperation, and stimulating demand for organic products. Full article

Crop leaves naturally exhibit a curved morphology and primarily display bending deformation and vibrational responses under wind load. The curved surface structure of leaves plays a critical role in the deposition and retention of pesticide droplets. In this study, wind tunnel experiments combined with high-speed photography and digital image analysis were conducted to systematically investigate the curvature and flexibility distributions of three typical crop leaves: walnut, peach, and pepper, across a range of wind speeds. The results indicate that with increasing wind speed, all three types of leaves gradually transition from smooth, uniform bending to a multi-peak pattern of pronounced local curvature, with increasingly prominent nonlinear deformation characteristics. Moreover, once the wind speed exceeds the critical threshold of 6 m/s, the primary deformation region generally shifts from the leaf base to the tip. For example, the maximum curvature of walnut leaves increased from 0.018 mm⁻¹ to 0.047 mm⁻¹, and that of pepper leaves from 0.031 mm⁻¹ to 0.101 mm⁻¹, both more than double their original values. In addition, all three types of leaves demonstrated a distinct structural gradient characterized by strong basal rigidity and high apical flexibility. The tip flexibility values exceeded 1.5 × 10⁻⁵, 4 × 10⁻⁴, and 5.6 × 10⁻⁴ mm⁻²·mN⁻¹ for walnut, peach, and pepper leaves, respectively. These findings elucidate the mechanical response mechanisms of non-uniform flexible crop leaves under wind-induced bending and provide a theoretical basis and data support for the optimization of air-assisted spraying parameters. Full article

This paper investigates the global dynamics of timelike geodesics of a spherically symmetric black hole under Lorentz-violating effects governed by parameters $\lambda$ (scaling exponent) and ${\rm Y}$ (Lorentz violation strength). By employing dynamical system techniques, including Poincaré compactification and blow-up methods, we systematically explore finite and infinite equilibrium states of the system derived from a black hole solution with power-law corrections to the Schwarzschild metric. For varying $\lambda$ (ranging from −2 to 2) and fixed ${\rm Y}$ values, we classify the nature of equilibrium states (saddle, center, and node) and analyze their stability. Key findings reveal that the number of equilibrium states increases as $\lambda$ decreases: two states for $\lambda =2$, three for $\lambda =1$, four for $\lambda =2/3$, and additional configurations for $\lambda =-2$. The phase plane diagrams and global dynamics demonstrate distinct topological structures, including attractors at infinity and multi-horizon black hole solutions. Furthermore, degenerate equilibrium states at infinity are resolved through directional blow-ups, elucidating their non-hyperbolic behavior. This study highlights the critical role of Lorentz-violating parameters in shaping the stability and long-term evolution of timelike geodesics, offering new insights into modified black hole physics and spacetime dynamics. Full article

Cissampelos pareira is a medicinal plant with the potential effect of treating diabetes, commonly used by the Dai people in southern Yunnan Province. However, the wild resources of C. pareira are currently scarce. Endophytic fungi are a natural component of medicinal plants, while also serving as important repositories for discovering active natural products. In this study, we focused on 2-year-old C. pareira plants cultivated in potted and non-potted conditions. The community structure of endophytic fungi in the roots, stems, leaves, and flowers of two cultivation methods of C. pareira was investigated by using high-throughput sequencing (HTS) and traditional culture methods. Through HTS, we discover that the richness and diversity of endophytic fungi in C. pareira are associated with its growth environment and plant tissues. The endophytic fungi richness of C. pareira showed significant differences between the two habitats. And significant differences existed in the diversity of root endophytic fungi of C. pareira compared to those in the stems, leaves, and flowers. Additionally, the richness of endophytic fungi in the stems showed significant differences from that in the roots, leaves, and flowers. The results obtained using traditional culture methods revealed 69 endophytic fungi strains, classified into 2 phylum, 4 classes, 11 orders, 23 families, and 69 genera. The fermentation products of the obtained strains were evaluated for in vitro α-glucosidase inhibitory activity, and the results demonstrated that 11 endophytic fungi strains exhibited an inhibition rate exceeding 80%. The above-mentioned study can provide a theoretical basis for a comprehensive understanding of the community composition and diversity of endophytic fungi in C. pareira. Full article

Eczema is the most common skin disease among Hong Kong’s adults and children, affecting an estimated 30% of the total population. Western and Chinese medicinal ointments are the usual treatment for eczema. Conventional Western medicinal ointments are topical corticosteroids and non-steroidal agents. Eczema skin products include “Aveeno Parabens Lotion”, “Cerave Moisturizing Cream”, and “Cetaphil Lotion”. However, these are not a long-term solution for managing significant erythema. Chinese medicinal ointments are based on adjusting the formula, including the ingredients and amount, to address an individual’s skin condition and other factors that may be worsening symptoms. This approach aims to regulate the immune system and make it less reactive to environmental and food allergies. This approach is mainly for local topical use. The ingredients of eczema skin products should include Coptis chinensis Franch, Phellodendron chinense Schneid, Angelica sinensis (Oliv.) Diels, Rehmannia glutinosa Libosch, Curcuma longa L., and sesame oil. Chinese medicinal ointments are natural ingredients, personalized formulas, and concerned with holistic healing, while Western medicinal ointments provide fast-acting relief, targeted action, and a standardized dosage. Methods: Nine electronic databases, such as WanFang Data, PubMed, Science Direct, Scopus, Web of Science, Springer Link, SciFinder, and the China National Knowledge Infrastructure (CNKI), were searched mainly within the past twenty years and without any language restrictions. The inclusion criteria were the keywords “Western medicine and ointment”, “Chinese medicine and ointment”, and “Western and Chinese medicines and ointment”. Differences in effectiveness between Western and Chinese ointments were evaluated to determine if they had functions against eczema. This review included an analysis and summary of all relevant papers. Results: Western medicinal ointments are topical corticosteroids, and they exert their pharmacological activities via many mechanisms, including anti-inflammatory, immunosuppressive, antiproliferative, and vasoconstrictive effects on eczema. Similarly, Chinese medicinal ointments have the same pharmacological functions, but they may focus on the immune system for the treatment of inflammatory and skin conditions, including erythema, edema, dryness, desquamation, and callus exfoliation. Conclusion: Based on the clinical research, the effectiveness rate of integrated Chinese and Western medicines was 88%, which was greater than the 70% rate for using Western medicine alone to treat eczema. Western and Chinese medicinal ointments have different active ingredients with advantages and disadvantages for eczema or when acting as skin care products. The most important thing is knowing “How” to use Western and Chinese medicinal ointments properly, especially for some formulations of Chinese ointments. It may be beneficial to consider the pharmacokinetic studies of herbal ingredients, which offer personalized formulas tailored to individual body constitutions and conditions, as well as to emphasize holistic healing, addressing both symptoms and underlying imbalances in the body. Much more work needs to be carried out, such as safety assessments of these ointments for use as skin care products for eczema. Full article

This research examines the impact of the project ‘Development of Science Experiential Education Programs and Science Experiential Centres’, implemented by the Mobilis Science Center in Győr between 2017 and 2021. The professional and societal relevance of the program and research lies in the growing importance of STEM disciplines and careers worldwide in recent decades, ensuring a long-term supply of skilled workers. A vital tool for this is the development of curricula that meet the needs of the 21st century, as well as the innovation of teaching methods in science subjects. The research involves a review of the literature on experiential science teaching and subject attitudes, the role of science centers, and relevant project documents. The present research, involving 592 students, focused on attitudes toward technology and science, openness to STEM careers, and the experiences and memories of participants in the student lab theme days. The results of the statistical data analyses confirm the effectiveness of the experiential education methods used in the theme day sessions, as the students’ openness to STEM careers is higher for those who participated in the sessions compared to the non-participants. There are significant differences in the attitudes of girls and boys participating in the program toward science subjects. The results suggest that the success in stimulating interest in science was mainly due to the experiential nature of the sessions. Moreover, the research found that the project led to the strengthening of the participants’ personal and social skills. This study is the first to look at the impact of the project. The results shed light on how teaching STEM subjects using experiential pedagogical methods can contribute to the long-term effectiveness of Széchenyi István University’s enrollment efforts and lead to the economic success of companies in a region facing a significant labor shortage in STEM careers. Full article

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia, with current therapies offering only limited symptomatic relief and lacking disease-modifying efficacy. Addressing this critical therapeutic gap, natural multi-target compounds like mulberroside A (MsA)—a bioactive glycoside from Morus alba L.—present promising alternatives. This study investigated MsA’s neuroprotective potential using scopolamine-induced AD-like mice and N2a/APP695swe cells. In vivo, MsA significantly ameliorated cognitive deficits and neuronal loss, concurrently enhancing cholinergic neurotransmission through increased acetylcholine levels and inhibited acetylcholinesterase (AChE)/butyrylcholinesterase (BChE) activities. MsA also upregulated neurotrophic factors (BDNF, CREB) in critical brain regions. In vitro, MsA restored cholinergic function, mitigated oxidative stress, and crucially reduced amyloid-β (Aβ) production by dual regulation of APP processing: promoting the non-amyloidogenic pathway via ADAM10 upregulation and inhibiting the amyloidogenic pathway via suppression of BACE1 and γ-secretase components. Mechanistically, these multi-target benefits were mediated by MsA’s activation of the PI3K/AKT pathway, which triggered downstream inhibitory phosphorylation of GSK3β—directly reduced tau hyperphosphorylation—and activation of CREB/BDNF signaling. Collectively, our findings demonstrate that MsA confers comprehensive neuroprotection against AD pathology by simultaneously targeting cholinergic dysfunction, oxidative stress, Aβ accumulation, tau phosphorylation, and impaired neurotrophic signaling, highlighting its strong therapeutic candidacy. Full article

Background/Objectives: Lysozyme-based amyloid aggregates offer a promising platform for RNA delivery due to their stability, cationic nature, biocompatibility, and ability to form well-defined structures. In this study, we evaluated their potential as drug carriers, focusing on the delivery of polyinosinic–polycytidylic acid (Poly(I:C)), an immunostimulatory synthetic RNA. To validate RNA delivery capability and rule out the possibility that observed effects arose from the lysozyme–Poly(I:C) complex itself, small interfering RNA (siRNA) was also used to verify that the successful delivery of intact and functional RNA was the cause of the observed effects. Methods: The aggregates were characterized by particle size, zeta potential, morphology, and RNA encapsulation efficiency. Results: In vitro studies using RAW 264.7 macrophage-like cells demonstrated that Poly(I:C)-loaded aggregates improved RNA uptake and triggered significant immune activation without inducing toxicity. To further confirm the potential of lysozyme amyloids in RNA delivery, GFP siRNA-loaded aggregates were evaluated in A549-GFP cells. A notable decrease in GFP expression, confirmed through confocal microscopy and flow cytometry, confirmed successful intracellular delivery. Conclusions: These results highlight the potential of lysozyme amyloids as non-viral vectors for RNA delivery, with promising applications in immunotherapy. Full article

Mid–long-term streamflow prediction (MLSP) plays a critical role in water resource planning amid growing hydroclimatic and anthropogenic uncertainties. Although AI-based models have demonstrated strong performance in MLSP, their capacity to quantify predictive uncertainty remains limited. To address this challenge, a DeepAR-based probabilistic modeling framework is developed, enabling direct estimation of streamflow distribution parameters and flexible selection of output distributions. The framework is applied to two case studies with distinct hydrological characteristics, where combinations of recurrent model structures (GRU and LSTM) and output distributions (Normal, Student’s t, and Gamma) are systematically evaluated. The results indicate that the choice of output distribution is the most critical factor for predictive performance. The Gamma distribution consistently outperformed those using Normal and Student’s t distributions, due to its ability to better capture the skewed, non-negative nature of streamflow data. Notably, the magnitude of performance gain from using the Gamma distribution is itself region-dependent, proving more significant in the basin with higher streamflow skewness. For instance, in the more skewed Upper Wudongde Reservoir area, the model using LSTM structure and Gamma distribution reduces RMSE by over 27% compared to its Normal-distribution counterpart (from 1407.77 m³/s to 1016.54 m³/s). Furthermore, the Gamma-based models yield superior probabilistic forecasts, achieving not only lower CRPS values but also a more effective balance between high reliability (PICP) and forecast sharpness (MPIW). In contrast, the relative performance between GRU and LSTM architectures was found to be less significant and inconsistent across the different basins. These findings highlight that the DeepAR-based framework delivers consistent enhancement in forecasting accuracy by prioritizing the selection of a physically plausible output distribution, thereby providing stronger and more reliable support for practical applications. Full article

Non-urbanized areas (NUAs), including residual urban green areas, urban parks, agricultural, natural and semi-natural areas, are a fundamental part of the green infrastructure. They are essential in sustaining life and future development, providing a series of ecosystem services (ESs) vital to human society. However, the rapid expansion of urban areas has led to a significant reduction in green spaces. Land-take, reducing available land resources, impacts ecosystem functionality, making it crucial to preserve high-quality territories and the relative ESs provided. In this context, the aim of this study was to evaluate the reduction in ESs due to the land-take having occurred in the last 20 years in the Province of Monza–Brianza, the Italian province with the highest land-take. To achieve this goal, authors used the official data of land use/cover of the Lombardy Region, with three time thresholds (T0: 1999–2003, T1: 2012–2013, T2: 2021) and applied a methodology for ESs assessment originally developed for the municipal level, adapting it to the provincial scale. The study analyzes trends in land-take and land-use changes and assesses how these changes have led to variations in ES provision. The approach involves calculating multiple indices reflecting different ESs provided by NUAs: provisioning ESs coming from agriculture, regulating ESs provided by natural resources, cultural ESs provided by landscape. Findings reveal that urban expansion has decreased provisioning ESs coming from agriculture, while ESs provided by landscape and natural resources have remained stable or improved, respectively. The natural quality index has improved due to conservation policies, despite the high land-take recorded. Anyway, although regional policies have mitigated some negative effects, the overall reduction in green spaces remains a critical issue. Full article

The rubber industry is facing increasing pressure to adopt sustainable practices due to environmental concerns associated with the use of non-renewable resources and the growing accumulation of waste tyres and agricultural byproducts. This study explores the potential of partially replacing conventional carbon black (CB) with sustainable alternatives derived from agricultural waste (wine by-products) and pyrolysed waste tyres in natural rubber/styrene-butadiene rubber (NR/SBR) composites for tyre applications. A series of NR/SBR composites were formulated with varying ratios of CB to agricultural waste and pyrolysed tyre waste, while maintaining consistent levels of other additives. The resulting composites were then subjected to a comprehensive suite of analyses, including scanning electron microscopy (SEM), Brunauer–Emmett–Teller (BET) surface area measurements, Fourier transform infrared spectroscopy (FTIR), bound rubber content determination, Payne effect analysis, thermogravimetric analysis (TGA), dynamic mechanical thermal analysis (DMTA), and mechanical property testing. Furthermore, a Life Cycle Assessment (LCA) and Life Cycle Costing (LCC) analysis were conducted to evaluate the environmental and economic viability of the proposed CB replacements. The results reveal that the incorporation of agricultural waste and pyrolysed tyre waste can significantly impact the curing behaviour, mechanical properties, and thermal stability of rubber composites. Importantly, some of the formulations demonstrate comparable tensile strength, elongation at break, and hardness compared to traditional CB-filled composites. The LCA and LCC analyses further highlight the potential for substantial reductions in greenhouse gas emissions, fossil resource depletion, and overall production costs, thereby supporting the transition toward more sustainable tyre manufacturing practices. Full article