Search Results (1,382)

Understanding particle transport in rough-walled fractures is essential for predicting flow behavior, clogging, and permeability evolution in natural and engineered subsurface systems. This study develops a fully coupled CFD–DEM framework to investigate how self-affine fractal roughness, represented by the Joint Roughness Coefficient (JRC), governs fluid–particle interactions across multiple scales. Nine fracture geometries with controlled roughness were generated using a fractal-based surface model, enabling systematic isolation of roughness effects. The results show that increasing JRC introduces a hierarchy of geometric perturbations that reorganize the flow field, amplify shear and velocity-gradient fluctuations, and enhance particle–wall interactions. Particle migration exhibits a nonlinear response to roughness due to the competing influences of disturbance amplification and the formation of preferential high-velocity pathways. Furthermore, roughness-controlled scaling relations are identified for mean particle velocity, residence time, and energy dissipation, revealing JRC as a fundamental parameter linking geometric complexity to transport efficiency. Based on these findings, a unified mechanistic framework is established that conceptualizes fractal roughness as a multiscale geometric forcing mechanism governing hydrodynamic heterogeneity, particle dynamics, and dissipative processes. This framework provides new physical insight into transport behavior in rough fractures and offers a scientific basis for improved prediction of clogging, proppant placement, and transmissivity evolution in subsurface engineering applications. Full article

Background: The role of cognitive load theory (CLT) in understanding effective pedagogy has received increased attention in the fields of education and psychology in recent years. A considerable amount of literature has been published on the CLT construct as foundational guidance for instructional design by focusing on managing cognitive load in working memory to enhance learning outcomes. However, recent neuroscientific findings and practical critiques suggest that CLT’s emphasis on content-focused instruction and cognitive efficiency may overlook the complexity of human learning. Methods: This conceptual paper synthesises evidence from cognitive science, developmental psychology, neuroscience, health sciences and educational research to examine the scope conditions and limitations of CLT when applied as a general framework for K–12 learning. One of the major theoretical issues identified is the lack of consideration for the broad set of interpersonal and self-management skills, creating potential limitations for real-world educational contexts, where social-emotional and self-regulatory abilities are as crucial as cognitive competencies. Results: As a result of the critique, this paper introduces the Neurodevelopmental Informed Holistic Learning and Development Framework as a neuroscience-informed construct that integrates cognitive, emotional, and interpersonal dimensions essential for effective learning. Conclusions: In recognising the limitations of CLT, the paper offers practitioners contemporary, neurodevelopmentally informed insights that extend beyond cognitive efficiency alone and better reflect the multidimensional nature of real-world learning. Full article

The article presents a comprehensive comparative performance evaluation and validation of composite adsorbents based on the Se-derivative of 4-amino-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide for U (VI) recovery from complex multicomponent aqueous media. Our results indicate the composite materials to be comparable to, and in some cases to surpass, existing adsorbents in recovery efficiency. Under static sorption conditions for trace U (VI) from real multicomponent solutions (tap, river, and sea water), the sorption efficiency reached 80–98%, while the distribution coefficients ranged from 10⁴ to 10⁶ cm³ g⁻¹. The sorption-selectivity properties of the materials were evaluated in the presence of competing ions (EDTA and oxalate ions), which possess a high chelating capacity and a strong tendency to form complexes with uranium. The dependence of sorption efficiency on the concentration of these ions and the solution pH was investigated. The possibility of reusing the materials over multiple sorption-desorption cycles was assessed. An optimal regenerating eluent agent was identified (NaHCO₃/NH₄NO₃), providing a desorption efficiency of >95% without degrading the material’s sorption properties over repeated cycles. Using a combination of physicochemical methods, including sorption techniques, the mechanism of uranium sorption and its dependence on the material structure were determined. The efficiency of uranium recovery from multicomponent natural waters was also investigated under dynamic conditions over repeated sorption-desorption cycles. The results demonstrate through comparative analysis that the developed composites exhibit a high sorption capacity and possess a high practical potential for the concentration and recovery of uranium from high-salinity solutions with complex composition. Full article

In this study, magnesium-modified clinoptilolite (MZ) was successfully synthesized via precipitation and calcination to efficiently remove Pb(II) from aqueous solutions. The material was systematically characterized using BET, XRD, SEM-EDX, FT-IR, and XPS. Adsorption kinetics followed a pseudo-second-order model (R² = 0.9956), with MZ removing over 70% of Pb(II) within the first 3 h. Isotherm data were best described by the Langmuir model (R² = 0.9686), confirming monolayer chemical adsorption, with a maximum adsorption capacity (qₘ) of 1656 mg/g. Notably, MZ maintained high adsorption capacity across a pH range of 3.0~5.5, and its performance was largely unaffected by the presence of high concentrations of competing ions (0.1~1.0 M NaNO₃). Mechanistic analysis revealed that the loaded MgO facilitates the chemical conversion of Pb(II) to hydroxycarbonate (Pb₃(CO₃)₂(OH)₂) via surface complexation, which constitutes the primary removal mechanism. These findings demonstrate that magnesium modification can transform natural zeolites into high-capacity, stable adsorbents, offering promising potential for the treatment of Pb(II)-contaminated water. Full article

Regulatory T cells (Tregs), particularly their phenotypically distinct subpopulations, are critical for the establishment of maternal immune tolerance during embryo implantation. Despite advances in assisted reproductive technologies, implantation failure remains a frequent and often unexplained clinical challenge. Variations in Treg frequency and phenotype have been proposed to influence implantation success, particularly under differing hormonal conditions. This study aimed to investigate peripheral blood Treg levels and their subpopulations on the day of blastocyst transfer in both stimulated in vitro fertilization (IVF/ICSI) cycles involving controlled ovarian hyperstimulation (COH) and true natural cycles with frozen embryo transfer (FET), and to examine their associations with systemic hormone levels and anti-Müllerian hormone (AMH). A prospective observational study was conducted including women undergoing IVF/ICSI with fresh embryo transfer (ET) and women undergoing natural cycle FET. Peripheral blood samples were collected on the day of ET and analyzed using 13-colour flow cytometry, enabling detailed subdivision of Tregs into multiple subpopulations based on the expression of differentiation and chemokine markers, including CXCR5. In addition, because common $\gamma$-chain cytokines may influence pregnancy success by modulating the balance between suppressive Treg and non-Treg subsets, intracellular STAT5 signaling was assessed using phospho-specific flow cytometry. Serum estradiol, progesterone, FSH, LH, and AMH levels were measured in parallel. Significant differences were observed in Treg subpopulation distributions between women who conceived and those who did not. Higher frequencies of naïve CXCR5⁻ Tregs were associated with clinical pregnancy, independent of age, and correlated with serum progesterone levels. Moreover, both naïve Treg frequency and enhanced IL-7-dependent STAT5 signaling in naïve Tregs from women undergoing COH were associated with AMH levels, suggesting a link between ovarian reserve and Treg homeostasis mediated by signal transducer and activator of transcription 5 (STAT5) signaling. In conclusion, Treg subpopulations, particularly CXCR5⁻ naïve Tregs, appear to play a central role in implantation success following ET. Their distribution differs between stimulated and natural cycles and is influenced by systemic progesterone levels and STAT5 signaling. These findings suggest that peripheral Treg profiling may represent a potential biomarker of implantation competence and could inform personalized approaches in assisted reproduction. Full article

Placed in the broader discourse on Intercultural Citizenship Education (ICitE) this study explores the anticipated impact of bilingual education (BE) on intercultural competence (IC) and global civic orientations associated with intercultural citizenship (ICit) among students in their final year of secondary school (4th-year ESO) in Spain, focusing on differences in perceptions between bilingual and non-bilingual participants. A quantitative methodology was employed, utilising a closed-ended validated questionnaire administered to 2187 students from bilingual and non-bilingual settings across the whole country. The results reveal that bilingual students perceive BE as beneficial for their IC, whereas their monolingual counterparts assign less such utility to BE. We conclude that even though intercultural education is not explicitly taught in the curriculum, it is implicit in bilingual education programmes due to the positioning of the additional language as a medium and lived daily practice with tangible outcomes rather than an academic requirement. We also discovered that within the bilingual students’ group there are lower expectations regarding BE’s impact on the anticipated development of their global civic identity compared to intercultural awareness. The findings indicate that BE offers a context naturally conducive to IC development and has potential for fostering ICit which appears to be untapped. This study has implications for the discussion on the role of BE in education for the 21st century and urges stakeholders to address BE affordances for nurturing ICit by adding the critical citizenship component to it as proposed in the Intercultural Citizenship Education framework. Full article

Serious games are increasingly recognized as powerful pedagogical tools, often offering engaging, interactive, and practical learning experiences. This paper presents the design, implementation, and evaluation of a 3D virtual serious game specifically tailored for cybersecurity governance and policy education. In particular, the nature of the game is an escape room, drawing on military training principles: players must solve a problem to escape one room before advancing to the next. Set within a virtual company environment, the game features three interactive zones that guide students through analyzing cyber risks, aligning security frameworks, and drafting appropriate policies. This structure cultivates critical thinking and decision-making skills and strengthens practical cybersecurity competencies. The primary contribution lies in the integration of game-based learning and 3D virtual technology to create robust, hands-on educational materials. The design incorporates structural features that create barriers to generative AI delegation to address challenges related to generative AI misuse, ensuring that the activities cannot be easily replicated and thereby supporting academic integrity. A post-activity perception survey (n = 20) suggests that students found this approach both engaging and effective, with participants self-reporting enhanced understanding and enthusiasm toward cybersecurity governance and policy concepts. These findings highlight the potential of gamified environments to bridge theory and practice in cybersecurity education, equipping learners with industry-relevant skills while fostering deeper engagement and active learning. Full article

This study investigates flooding and erosion impacts and human responses in Aoraki Mount Cook and Westland Tai Poutini national parks in Aotearoa New Zealand. These fast-eroding landscapes provide important test cases and insights for considering the public access dimensions of climate change. Our objectives were to explore and characterise the often-overlooked role of public access as a ubiquitous concern for protected areas and other area-based conservation approaches that facilitate connections between people and nature alongside their protective functions. We employed a mixed-methods approach including volunteered geographic information (VGI) from a park user survey (n = 273) and detailed case studies of change on two iconic mountaineering routes based on geospatial analyses of digital elevation models spanning 1986–2022. VGI data identified 36 adversely affected locations while 21% of respondents also identified beneficial aspects of recent landscape changes. Geophysical changes could be perceived differently by different stakeholders, illustrating the potential for competing demands on management responses. Impacts of rainfall-triggered erosion events were explored in case studies of damaged access infrastructure (e.g., roads, tracks, bridges). Adaptive responses resulted from formal or informal (park user-led) actions including re-routing, rebuilding, or abandonment of pre-existing infrastructure. Three widely transferable dimensions of public access management are identified: providing access that supports the core functions of protected areas; evaluating the impacts of both physical changes and human responses to them; and managing tensions between stakeholder preferences. Improved attention to the role of access is essential for effective climate change adaptation in parks and reserves. Full article

The natural gas sector, as a pivotal transition fuel, is fundamentally constrained by the “Energy Trilemma”—the intertwined and often competing goals of energy security, affordability, and sustainability. Current research predominantly focuses on the demand side, leaving a significant gap in understanding the synergistic dynamics within production regions, which are critical to resolving this trilemma at its source. To address this gap, this study constructs a “Safety–Economy–Green” (S-E-G) evaluation framework aligned with the trilemma’s dimensions. Utilizing panel data (2011–2021) from four major Chinese natural gas production regions (Sichuan, Chongqing, Shaanxi, and Shanxi). By integrating the Entropy Weight Method, a Coupling Coordination Model, and Kernel Density Estimation, it delineates the system’s synergistic dynamics from both temporal and regional perspectives. The key findings are as follows: (1) Significant disparities and polarization are observed in the S and G dimensions, while the E dimension shows a narrowing gap, with its peak height increasing by 177.8% and bandwidth shrinking by 64.2%. G has emerged as a constraint on overall system coupling coordination. The persistently high coupling degree—rising from 0.87 in 2011 to 0.97 in 2021 while consistently exceeding the coordination degree, which increased from 0.45 to 0.62—underscores the continued need for improvement in synergistic development. (2) The coupling coordination degree of the S-E-G system underwent a three-stage evolution: rapid improvement (2011–2013, from 0.36 to 0.58 at 7.3% annually), fluctuating adjustment (2014–2017, between 0.58 and 0.66), and finally high-level stability (2018–2021, stabilizing at 0.76–0.80). (3) Obvious regional differentiation exists: Sichuan achieved a moderate level of 0.76 by 2021, Shaanxi maintained primary coupling coordination (0.6–0.7), while Chongqing and Shanxi remained marginal, fluctuating between 0.4 and 0.6. Enhancing subsystem coordination and implementing differentiated pathways are therefore essential for these regions’ sustainable development. The study suggests promoting the sustainable development of natural gas production regions by enhancing subsystem coordination and exploring differentiated pathways, thereby providing practical guidance for the energy transition of resource-based regions. Full article

This paper introduces flourishing circularity as a transformative approach to resource assessment that transcends both traditional Resource-Based View (RBV) theory and conventional circular economy concepts. We demonstrate RBV’s fundamental limitations in addressing the polycrisis of breached planetary boundaries and social inequities. Similarly, while the circular economy focuses on resource reuse and recycling, it often merely delays environmental degradation rather than reversing it. Flourishing circularity addresses these shortcomings by reconceptualizing natural and social capital not as externalities but as foundational sources of all value creation. We develop a comprehensive framework for assessing resources within an open systems perspective, where competitive advantage increasingly derives from a firm’s ability to regenerate the systems upon which all business depends. The paper introduces novel assessment tools that capture the dynamic interplay between organizational activities and coevolving social and ecological systems. We outline the core competencies required for flourishing circularity: regenerative approaches to social and natural capital, and systems thinking with cross-boundary collaboration capabilities. These competencies translate into competitive advantage as stakeholders increasingly favor organizations that enhance system health. The framework provides practical guidance for transforming resource assessment from extraction to regeneration, enabling business models that create value through system enhancement rather than depletion. Full article

The cut-off low that struck Valencia (Spain) on 29 October 2024, causing 229 deaths, underscored the pressing need to promote awareness and strengthen education on natural hazards, particularly among school-aged students. In this scenario, revising the school curriculum becomes essential to ensure that future generations are prepared to confront the challenges posed by climate change. This study examines how knowledge related to natural hazards is incorporated into the official curricula of Secondary (ages 12 to 16) and Baccalaureate education (ages 16 to 19), based on the Royal Decrees enacted since 2022. The study aims to determine which contents are included, the Specific Competencies addressed, and the pedagogical approaches employed (descriptive, preventive, or critical), while also evaluating the coherence of these elements across subjects and educational levels. Findings reveal a scarce and often fragmented presence of such contents, with a predominance of descriptive approaches and limited emphasis on prevention or critical reflection. The study concludes that risk education should be transversal, contextually grounded, and transformative. Current curricular gaps and that current gaps and overlaps represent an opportunity to reinforce territorial literacy and enhance students’ resilience. Full article

Arthropod-borne orthoflaviviruses, including dengue, Zika, Japanese encephalitis, yellow fever and West Nile viruses, pose a significant global public health threat, causing hundreds of millions of infections annually with severe clinical symptoms. However, the lack of effective vaccines and antiviral drugs, coupled with the biosafety risks associated with handling live highly pathogenic strains, hinders progress in antiviral research. Pseudovirus technology, which uses single-round infectious viral particles lacking replication competence, has thus gained prominence as a safe and versatile tool for antiviral research. This review systematically summarizes the construction, optimization, and applications of orthoflavivirus pseudoviruses in antiviral research. The primary construction strategies of orthoflavivirus pseudoviruses rely on multi-plasmid co-transfection of viral replicons and structural protein expression vectors, leveraging the host cell secretory pathway to mimic natural viral assembly and maturation. The core applications of pseudovirus technology are highlighted, including high-throughput screening and detection of neutralizing antibodies, identification of antiviral drugs targeting viral entry or replication, and evaluation of vaccine immunogenicity. Despite these strengths, the approach still faces limitations, such as incomplete simulation of native viral structures and batch-to-batch titer variability, which may affect the physiological relevance of findings. In summary, orthoflavivirus pseudovirus technology has become an essential platform in both basic virology research and translational medicine, providing critical insights and tools in the ongoing fight against arthropod-borne orthoflaviviruses diseases. Full article

This study examines how green finance influences high-quality economic development, with a particular focus on its spatial spillover mechanisms. Specifically, we investigate the competing roles of technology spillover and the pollution haven effect. Using provincial panel data from China (2010–2021) and applying a Spatial Durbin Model (SDM), we deconstruct the total effect of green finance into three distinct components: the local technological progress effect, the positive technology spillover effect, and the negative pollution haven effect. While acknowledging limitations related to the macro-level data granularity and the indirect nature of the mechanism tests, our analysis yields three main findings. First, green finance development shows significant regional disparities. It has progressed most rapidly in the eastern region, remained relatively stable in the central region, and declined in the western region. Second, green finance exerts a strong positive direct effect on local high-quality economic development. This promoting effect becomes even stronger in more developed regions. Third, green finance generates significant negative spatial spillovers on neighboring regions. These are primarily driven by the pollution haven effect, which involves the cross-regional relocation of polluting industries. However, local technological progress partially mitigates these adverse externalities. Overall, our findings reveal the dual nature of the spatial externalities associated with green finance. They also highlight the urgency of coordinated regional environmental governance to prevent “green leakage” and to promote balanced, high-quality economic development. Full article

A condition-based maintenance modeling approach is proposed for a multi-state system under competing failures and imperfect repairs. The system experiences three states (normal, defective and failed) over its lifecycle. Two competing failure processes, i.e., natural degradation and external shocks, cause these state changes. If the system becomes defective, an imperfect repair is adopted to restore it to a normal state. Imperfect repairs addressing defects are mathematically characterized. Based on this, two system renewal scenarios and their occurrence probabilities are simulated and derived. The cost of downtime caused by hidden failures is then deduced. A maintenance model of the expected cost rate is constructed, and the optimal inspection period that minimizes the expected cost rate is determined. Finally, a numerical example verifies the correctness and effectiveness of the maintenance model. Full article

For decades, cervical insufficiency (CI) has been framed predominantly as a mechanical failure of the cervix resulting in painless mid-trimester dilatation. This disease-centered paradigm, reinforced by clinical teaching and administrative coding, does not fully capture the dynamic and biologically integrated nature of cervical remodeling. Accumulating evidence suggests that cervical change is governed by coordinated mechanical, inflammatory, and immunologic interactions rather than by a purely anatomic defect. To outline a process-oriented conceptual framework that situates CI within the broader preterm-birth continuum, this perspective aims to integrate biomechanical, inflammatory, and immunologic dimensions of cervical remodeling and to emphasize that infection- and inflammation-related changes represent dynamic, potentially modifiable elements that may inform more individualized, biology-guided clinical decision-making. This Perspective traces the evolution from a traditional “disease entity” interpretation of CI toward a more integrated view of cervical remodeling as a dynamic, biology-responsive process. Emerging data suggest that when intra-amniotic infection or inflammation is appropriately managed, cervical competence may be partially restored, and mechanical support can be applied more safely in selected patients. Clinical observations indicate that infection-controlled cerclage is associated with meaningful prolongation of gestation. Earlier reports describing double-level mechanical reinforcement techniques conceptually align with contemporary interpretations of infection-controlled emergent cerclage by linking surgical timing with the underlying biology of cervical change. Rather than proposing a prescriptive management pathway, this framework highlights how mechanical, inflammatory, and immunologic factors may interact across heterogeneous CI etiologies and how individualized intervention may be guided by biologic context. Understanding CI as a dynamic rather than a fixed condition provides a framework that integrates its mechanical, inflammatory, and immunologic dimensions within the preterm birth continuum. Such a perspective encourages individualized, biology-informed interpretation of cervical change and supports more context-specific use of established interventions such as cerclage. By emphasizing developmental processes rather than a static defect, this approach seeks to bridge classical clinical practice with contemporary insights into cervical remodeling. Full article