Search Results (4,295)

In this work, a comprehensive analysis of the relationship between photoluminescent, thermo-oxidative, and photocatalytic (upon simulated sunlight exposure) properties of ZnO powders is performed. The correlation between the X-ray diffraction and microscopic data is studied. ZnO powders of various sizes and morphologies were used: pseudo-spherical nanoparticles (30–50 nm), submicron faceted crystallites (100–500 nm), and plate- and rod-like microstructures (up to 20 μm). The mean specific surface area values were 32 m²/g, 3.8 m²/g, and 2.6 m²/g for pseudo-spherical nanoparticles, submicron faceted crystallites, and plate- and rod-like microstructures, respectively. According to the XRD data, microstresses and carbon-based impurities were present in ZnO nanoparticles, which is characteristic of nanomaterials synthesized at low temperatures. According to the photoluminescence spectroscopy data, the emission in ZnO was reduced due to high defectiveness, and characteristic emission bands indicated the presence of organic impurities. Upon long signal registration times, an intensive luminescence band with an effective maximum at 579 nm occurred, which indicated the presence of long-term components exhibiting decay times τ ~300 μs. According to the XRD data, the crystal structure parameters of ZnO submicro- and microparticles were close, with no impurities present. In their photoluminescence spectra, pronounced UV and defect-related bands were present with intensity ratios of 11.6 and 6.88, respectively. The decrease in the UV and defect-related luminescence band intensity ratios indicates deviation from the stoichiometry toward an increased Zn over oxygen content. At long signal registration times, in submicron ZnO particles, a luminescence band with maxima at 425 and 490 nm is present, which decays rapidly. An emission band in the 530 nm region is also present, which decays for ≤80 μs, and a weak long-wavelength emission decaying for ~100 μs. At long delay and strobe times (up to milliseconds), only an emission in the 460 nm region is observed, which we connect to the triplet–singlet transition of a defect center (F*, F⁺*). At lower intensities, an emission connected to the surface contamination by organic impurities is observed. In photoluminescence spectra of ZnO microparticles, no long-wavelength emission components are observed. However, upon immersing into methylene blue solution, a modification of the surface and UV region of the spectra is observed with signs of charge carrier recombination rate acceleration. It is shown that the catalytic action of ZnO powders in polyethylene thermo-oxidation processes is determined by a combination of factors. In addition to dispersity and concentration, which are the key parameters, the morphology of ZnO particles, the presence of impurities, the surface state, and the distribution of active sites have a significant influence on catalysis. It has been experimentally demonstrated that these secondary factors can markedly affect the rate of radical formation in polyethylene films and alter their resistance to oxidation. ZnO nanoparticles exhibited low catalytic activity in both photocatalysis (rate constant 0.146 min⁻¹) and thermocatalysis due to the high defect density of the crystallites and the presence of carbon-containing impurities. Submicron ZnO particles, owing to a high carrier generation rate and suppressed recombination (via trapping), demonstrated the highest photoactivity (rate constant 0.729 min⁻¹). Submicron ZnO particles exhibit a catalytic effect on the thermo-oxidation of polyethylene (PE films); however, at concentrations above 8 wt.% a transition to an inhibiting effect is observed. ZnO microparticles catalyzed the oxidation of PE films over a broader concentration range (1–12 wt.%), with oxidation inhibition observed only at 18 wt.%. At the same time, they demonstrated moderate photocatalytic activity (rate constant 0.256 min⁻¹). These characteristics of the samples correlate with data obtained by microscopy, photoluminescence spectroscopy, and X-ray diffraction analysis. Full article

Cataracts are the leading cause of reversible blindness worldwide; this condition results from the aggregation of lens proteins. Currently, surgery remains the only treatment; however, there is growing interest in non-surgical approaches, including the use of bioactive compounds incorporated into nanostructured systems designed to enhance solubility, enable controlled release, and improve bioavailability and bioactivity. Among the bioactive compounds investigated, curcumin has attracted considerable attention due to its antioxidant and anti-inflammatory properties, positioning it as a potential anticataractogenic agent. In the present study, curcumin-loaded nanoemulsion was developed via ultrasonication and characterized by average particle size, D90 percentile, ζ potential, and rheological behavior. In addition, its anti-cataract efficacy was evaluated both using an in vivo model in rats and an ex vivo model employing human cataract samples. The resulting curcumin-loaded nanoemulsion exhibited an average particle size of 152 ± 19.79 nm with a monomodal distribution, along with good physical stability over time. The nanoemulsion exhibited apparent viscosity between 30 and 25 mPa·s, at shear rate values (100 to 0 s⁻¹), indicating slight shear-thinning behavior. Regarding the effect on cataracts, in the in vivo model, cataract reversal was observed. Furthermore, ex vivo isothermal titration calorimetry (ITC) analyses indicated exothermic heat exchange between the curcumin nanoemulsions and cataract fragments, consistent with binding interactions occurring within lens components, likely involving crystallin proteins. These findings provide biophysical and in vivo evidence that intravitreally administered curcumin-loaded nanoemulsions not only prevent but actively reverse lens opacity, positioning them as a promising non-surgical therapeutic approach for cataract treatment. Full article

Deep eutectic systems (DESs) have evolved from sustainable solvent alternatives to promising bioactive platforms with reported antimicrobial, anti-inflammatory, regenerative, cryoprotective, and cytoprotective properties. However, despite the growing number of biological studies, the mechanistic basis of these effects remains poorly understood because biological activity is still interpreted predominantly from the chemical identity of the hydrogen-bond donor and acceptor, rather than from the supramolecular organization of the eutectic system itself. This review is intended to provide anyone interested in the biomedical and pharmaceutical applications of DESs with a conceptual framework for understanding how supramolecular organization may influence the biological performance of DES-based systems, without requiring extensive expertise in physical chemistry. It critically analyzes the current evidence linking DES structure with biological function. The literature reveals that many reported biological responses cannot be fully explained by the properties of the individual constituents alone, supporting the existence of emergent physicochemical behavior associated with eutectic formation. Current evidence further demonstrates that DESs are dynamic supramolecular systems characterized by hydrogen-bond networks, nanoscale heterogeneity, hydration-dependent structural rearrangement, and persistent local organization under biologically relevant conditions. These structural features generate localized physicochemical microenvironments capable of modulating membrane organization, protein hydration, osmotic balance, and biomolecular interactions, providing a plausible mechanistic basis for the diverse biological effects reported to date. Our analysis also highlights a fundamental disconnect between the extensive physicochemical characterization of DESs and the predominantly composition-based interpretation of their biological activity. While conventional Quantitative Structure–Activity Relationship (QSAR) approaches rely on molecular descriptors of individual components, they fail to capture the higher levels of organization that characterize these dynamic multicomponent systems. Based on concepts established in supramolecular chemistry, self-assembled biomaterials, colloidal science, and soft matter, we propose a Hierarchical Structure–Activity Relationship (H-SAR) framework in which biological activity emerges from successive levels of organization extending from molecular composition and hydrogen-bond networks to nanostructural organization, hydration-dependent restructuring, localized physicochemical microenvironments, and biological interfaces. This framework provides a mechanistic basis for interpreting DES bioactivity and could offer a conceptual roadmap for the rational design, predictive modeling, and biomedical translation of next-generation bioactive deep eutectic systems. Full article

Oleanolic acid is a naturally occurring pentacyclic triterpenoid with broad preclinical promise in inflammation, oxidative stress, liver injury, metabolic disorders, cancer-related models, skin disease, and wound repair. Its further development, however, is constrained by poor aqueous solubility, low and variable bioavailability, limited barrier transport, crystallinity, and strong dependence of biological response on the formulation used. These properties make oleanolic acid a useful example of a hydrophobic natural compound whose pharmacological performance is inseparable from delivery design. This review examines polymeric nanocarriers and polymer-assisted delivery platforms developed for oleanolic acid delivery. Polymeric nanocarriers discussed in the review include biodegradable PLA/PLGA nanoparticles, PEGylated polymeric nanoparticles, polymeric micelles, nanogels, hyaluronic-acid-based nanoprodrugs, and selected polymer-assisted hybrid nanostructures. Hydrogels, polymeric fiber membranes, local depots, and microneedle systems are included as route-enabling delivery platforms when the polymeric matrix directly contributes to OA incorporation, carrier stabilization, local retention, barrier bypass, or release control. Non-polymeric delivery systems are discussed only as comparators or when their performance depends on integration with a polymeric component. Rather than treating these carriers only as solubility enhancers, the review evaluates how polymer composition, carrier architecture, drug physical state, release behavior, and route of administration affect oleanolic acid exposure. Particular attention is given to controlled release, local retention, disease-oriented delivery, and critical quality attributes such as particle size, loading, encapsulation efficiency, solid-state form, stability, residual solvent, sterility, and batch-to-batch reproducibility. Representative quantitative data on carrier size, drug loading, encapsulation efficiency, release, stability, tissue exposure, and biological outcomes are compared to illustrate both formulation-specific performance and the substantial methodological heterogeneity of the available studies. The available evidence indicates that increased apparent solubility, increased biological exposure, and improved therapeutic response should be treated as related but distinct outcomes. The most realistic near-term opportunities may lie in local and tissue-targeted applications, including inflammatory skin disease, wound healing, dermal delivery, and osteoarthritis, where sustained target-site exposure may be more relevant than systemic bioavailability. Future progress will depend on demonstrating that each formulation provides reproducible, safe, and route-appropriate OA exposure, together with a measurable advantage over simpler delivery approaches. Full article

The hydrogen temperature-programmed reduction (H₂-TPR) method was used to analyze the sensing properties of nanostructured indium oxide for hydrogen detection. Commercial and mechanically activated In₂O₃ samples were selected for investigation. Mechanical activation leads to the generation of surface defects and an increase in specific surface area, which enhances sensitivity to H₂ and lowers the sensor operating temperature. An approach is proposed that allows a qualitative and quantitative relationship to be established between the H₂-TPR profiles of the oxides and the sensor response. This relationship is based on a model of electron transfer across a potential barrier at grain boundaries, formed with the participation of adsorbed oxygen. The temperature dependence of the sensor response is found to be determined by the concentration of negatively charged oxygen on the surface of the nanoparticles, which, in turn, depends on temperature. Using the sensor sensitive layer based on indium oxide as an example, a correlation is established between the parameters of the TPR profiles and the sensor response. Full article

In this study, zinc-doped magnesium ferrite (Zn_x-Mg_1−xFe₂O₄) nanoparticles were synthesized using a facile combustion method and investigated for their electrochemical sensing and photocatalytic applications. The structural, morphological, and optical properties of the synthesized nanoparticles were characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM), Energy-dispersive X-ray spectroscopy (EDAX), Fourier-transform infrared spectroscopy (FTIR), Energy band gap (Eg) and UV-Vis spectroscopy. The synthesized Zn–MgFe₂O₄ nanoparticles exhibited crystallite sizes ranging from 18.7 to 27.9 nm with an optical band gap of 1.86–1.89 eV. The catalyst achieved degradation efficiencies of 78% for Eriochrome Black T and 85% for Methyl Orange within 120 min, while the electrochemical sensor exhibited excellent linearity toward HgCl₂ detection (R² = 0.99664), demonstrating the multifunctional capability of the synthesized nanostructure. The synergistic effects of Zn doping contributed to enhanced electrical conductivity, catalytic activity, and structural stability. The novelty of this work lies in the development of combustion-synthesized Zn–MgFe₂O₄ nanoparticles as a multifunctional material capable of simultaneously achieving efficient photocatalytic degradation of organic dyes and sensitive electrochemical detection of mercury chloride using a simple and scalable synthesis route. These findings demonstrate that Zn–MgFe₂O₄ nanoparticles hold significant potential for integrated environmental remediation and electrochemical sensing applications. Full article

Nanostructured copper oxide (CuO) holds significant promise for optoelectronic, photocatalytic, and biomedical applications, yet its performance is critically dictated by its morphology, crystallite size, and surface chemistry. In this work, pure monoclinic CuO nanoparticles were successfully synthesized via a facile, kinetically controlled aqueous co-precipitation route using three distinct precursor salts: copper acetate (CO-Ac), copper sulfate (CO-S), and copper chloride (CO-Cl). To achieve precise architectural control, the synthesis was conducted near the thermodynamic solubility limit of the precursors combined with an abrupt NaOH injection, effectively decoupling the nucleation stage from crystal growth. Rietveld refinement of X-ray diffraction (XRD) data confirmed the structural integrity of the monoclinic lattice across all samples, χ² = 1.04 − 2.02, crystallinity 53–55%, while demonstrating that the precursor anion strongly governs the volume-averaged crystallite size, which expanded from 16 nm (CO-Ac) to 30 nm (CO-S) and 52 nm (CO-Cl). Morphological analyses revealed that acetate acts as a non-specific capping ligand, promoting isotropic, quasi-spherical nanoparticles that aggregate into high-surface-area (69.04 m²/g) “bead-chain” assemblies. Conversely, sulfate and chloride ions act as shape-directing agents via facet-selective adsorption on nucleation seeds, yielding two-dimensional plates and anisotropic acicular/needle-like architectures, respectively. X-ray photoelectron spectroscopy (XPS) and modified Auger parameter (α ~1851 eV) analyses confirmed the absolute dominance of Cu²⁺ states, with a minor fraction (~2.5 mol %) of lower-coordinated surface edge states. XPS further unveiled that the strongly alkaline environment (pH ~14) drives precursor-dependent surface chemistry: CO-Ac nanoparticles retain a clean, hydroxylated layer with minor acetate residues, whereas CO-S and CO-Cl samples develop a passive copper hydroxycarbonate (Cu₂(OH)₂CO₃) surface barrier that blocks active sites and reduces porosity. Optical properties analyzed via UV-vis diffuse reflectance revealed a pronounced, size-dependent blueshift relative to bulk CuO, with fundamental indirectly allowed bandgaps of 2.6 eV, 2.36 eV and 1.93 eV for CO-Ac, CO-S and CO-Cl samples, while the direct bandgaps shifted from 3.0 eV, 3.2 eV, and 3.57 eV for the mentioned samples. This behavior is attributed to quantum confinement governed by fine individual nanocrystals. These findings establish that precursor engineering offers a robust pathway to tailor the morphological, optical, and interfacial properties of CuO nanostructures for targeted functional devices. Full article

LaFeO₃ nanoperovskites were synthesized through a sugarcane-molasses-assisted combustion route using mechanically stirred (MLP) and ultrasonic-assisted (ULP) activation strategies to investigate the influence of synthesis conditions on structural and interfacial electrochemical properties. X-ray diffraction and Rietveld refinement confirmed the formation of orthorhombic LaFeO₃, while ultrasonic-assisted synthesis promoted improved phase homogeneity and reduced crystallite size compared with mechanically stirred combustion. Transmission electron microscopy revealed lower agglomeration and improved particle dispersion for ULP materials, whereas thermal and vibrational analyses confirmed the formation of thermally stable LaFeO₃ nanoperovskites containing residual biomass-derived species associated with the combustion process. Electrochemical characterization at screen-printed carbon electrodes demonstrated that ultrasonically synthesized LaFeO₃ significantly enhanced interfacial charge-transfer behavior, yielding lower charge-transfer resistance (435 Ω), increased electroactive surface area (0.149 cm²), and improved heterogeneous electron-transfer kinetics relative to MLP and bare electrodes. The LaFeO₃-modified interfaces additionally exhibited distinct electrochemical oxidation behavior toward 2-aminothiazole (2AT) and 2-aminooxazole (2AO) under acidic conditions. Scan-rate analyses revealed predominantly diffusion-controlled irreversible oxidation processes, while pH-dependent studies indicated proton-coupled electron-transfer behavior during electrooxidation. The combined structural and electrochemical results establish clear process–structure–property relationships linking ultrasonic-assisted green synthesis, nanostructural organization, and interfacial electrochemical performance in LaFeO₃ nanoperovskites. Full article

Nanocomposite rare-earth permanent magnets composed of exchange-coupled hard magnetic nanoparticles offer a promising route toward high-performance, rare-earth-efficient magnet technologies. In this work, we investigate the structural self-organization and magnetic hysteresis behavior of 40 nm Sm₂Co₁₇/Nd₂Fe₁₄B hybrid nanoparticles using a combined molecular dynamics (MD) and micromagnetic simulation framework. First, MD simulations are employed to study the Brownian motion and field-induced assembly of the hybrid nanoparticles at two particle concentrations (1 and 5 mg/cm³). In the absence of an external magnetic field, the nanoparticles display dispersed configurations governed by thermal fluctuations and interparticle interactions. Upon application of a high magnetic field (500 mT), the particles align into linear chain-like assemblies, with a more pronounced and rapid aggregation at higher concentration. Subsequently, micromagnetic calculations performed using the OOMMF are used to determine the magnetization reversal behavior of the assemblies. Quasi-static hysteresis loops at low field (40 mT) and room temperature reveal enhanced coercivity and remanence for field-aligned chain structures compared to randomly oriented particle ensembles. Additionally, increasing particle concentration amplifies the field-induced collective response due to stronger dipolar coupling. The combined MD–micromagnetic approach provides insight into structure–property relationships in magnetic nanocomposite systems and highlights the critical role of particle arrangement and concentration in determining magnet performance. These results contribute to the design principles for advanced nanostructured permanent magnets with tunable magnetic anisotropy and energy density. Full article

Semiconductor-based photocatalytic water splitting is a promising pathway for sustainable hydrogen production; however, the reported performance depends not only on the intrinsic properties of the photocatalyst but also on reactor configuration and operating conditions. This systematic technical review examines the interplay between nanostructured semiconductor photocatalysts and the principal engineering variables governing photocatalytic hydrogen evolution. Particular attention is given to particle size, morphology, surface area, defect density, heterojunction design, cocatalyst incorporation, aggregation, and catalyst immobilization, as well as their interaction with reactor geometry, optical path length, photon distribution, catalyst loading, working volume, pH, sacrificial agents, mixing, thermal control, gas purging, and product quantification. The reviewed evidence indicates that these material and reactor parameters jointly determine light absorption, charge-carrier separation and transfer, suspension turbidity, mass transport, catalyst recovery, stability, and the measured hydrogen evolution rate. Batch slurry reactors remain the most widely used laboratory configuration, whereas annular, flat-panel, microreactor, fixed-bed, continuous-flow, and photofluidized systems offer specific advantages for photon utilization, catalyst reuse, product removal, and scale-up. The review also emphasizes the need to distinguish overall water splitting from sacrificial-agent-assisted hydrogen evolution. Standardized reporting of photocatalyst properties, irradiance, spectral distribution, illuminated area, reactor dimensions, reaction atmosphere, and gas-analysis procedures is essential to improve reproducibility and enable reliable comparisons among nanostructured photocatalytic systems. Full article

Molten carbonate salt nanofluids have emerged as a promising approach to improve the power generation efficiency of next-generation concentrated solar power (CSP) systems due to their enhanced thermophysical properties at high temperatures. However, corrosion upon salt nanofluids remains a key challenge for the use of cost-effective steels as construction materials in CSP applications. In this work, the corrosion behavior of AISI 301LN stainless steel exposed to molten carbonate salt nanofluids containing 1.0 wt.% SiO₂ nanoparticles with <20 nm and <50 nm has been studied. Corrosion tests were conducted in a static Li₂CO₃-Na₂CO₃-K₂CO₃ molten salt mixture at 600 °C for 1000 h. The oxide scales formed after exposure to the three nanofluids and the base salt were compared. The results revealed that the corrosion rate of AISI 301LN steel on molten salt was reduced by the addition of SiO₂ nanoparticles. The incorporation of SiO₂ nanoparticles into the oxide scale leads to the formation of dense reticulated nanostructures composed of Si-containing oxides, respectively. This increases the hardness of the oxide scale and enhances its protective performance in molten salt, particularly when using SiO₂ nanoparticles with the smallest size (<20 nm). Full article

Despite the fact that oxygen plasma treatments are widely used to modify the surface properties of polytetrafluoroethylene (PTFE), the long-term stability of these surface modifications has not been fully investigated. Specifically, the roles of morphological restructuring and chemical modifications at the surface remain to be understood. In this work, we treat commercial PTFE samples using O₂ plasmas at different discharge pressures to investigate their surface modifications and subsequent ageing at atmospheric pressure. We provide direct evidence that ageing behavior is governed by nanoscale and microscale restructuring of the plasma-modified interface, revealing a novel link between morphology dynamics and wettability properties. To capture this surface evolution, the modified interface was characterized using water contact angle (WCA) measurements, scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) spectroscopy, and mass spectrometry (MS). Initial plasma treatment enhances PTFE hydrophobicity, shifting the WCA from ${\theta }_c\simeq 105°$ to a highly hydrophobic state of ${\theta }_c\simeq 135°$. By monitoring the samples in contact with air over a 67-day period a gradual transition toward hydrophilicity was revealed, with WCAs stabilizing at ${\theta }_c\simeq 70°$ after approximately 20 days. SEM observations identified time-dependent morphological degradation of plasma-induced nanostructures, while qualitative and quantitative FTIR analysis—utilizing the Specified Area Under Band (SAUB) method—confirmed corresponding shifts in carbonyl and hydrocarbon indices. These results demonstrate that ageing kinetics are a direct function of plasma pressure. The transition is further supported by a phenomenological fractal model, which confirms a morphological shift from an initial fractal surface ($d_s\simeq 2.25$) toward a standard flat geometry ($d_s=2$). Furthermore, calculations indicate a sign reversal in solid-gas interface tension parameters, reflecting the changed chemical nature of the surface. We conclude that the loss of hydrophobicity is driven by a synergistic interplay between morphological relaxation and chemical restructuring. Full article

Antimicrobial resistance is a critical global challenge that necessitates the development of durable, material-based strategies to limit pathogen survival and transmission. Conventional cleaning and disinfection methods only provide transient protection due to rapid surface re-contamination. This study investigates the fabrication of polyethylene terephthalate (PET) surfaces designed for antibacterial applications via femtosecond laser-induced micro- and nanostructuring. Surface texturing was performed using a Ti:sapphire femtosecond laser (wavelength λ = 800 nm, pulse duration τ = 70 fs) at peak laser fluences (F) of 2.04 J/cm² and 4.08 J/cm², generating hierarchical surface textures with controlled morphology, spacing, and geometry through ultrafast, non-contact laser processing while preserving the bulk properties of PET. The resulting patterns, including parallel and intersecting microchannels decorated with laser-induced nanostructures, enabled tunable surface roughness and wettability, with water contact angles ranging from 33.21° to 118.2°. Comprehensive surface characterization, including morphological, topographical, and wettability analyses, was performed to establish structure–property relationships associated with previously reported antibacterial surface design principles. However, direct antibacterial performance was not evaluated in the present study and will be the subject of future investigations. In addition, the durability of the laser-structured PET was evaluated under simulated real-life conditions, including thermal cycling, ultraviolet exposure, abrasion, chemical resistance, and dust contamination. The structured surfaces demonstrated high structural and functional stability following environmental testing. The results indicate that the laser-induced surface modifications remain stable under conditions representative of prolonged practical use, supporting their potential long-term applicability for antibacterial and self-cleaning PET surfaces. Full article

Natural, synthetic, and modified zeolites are widely recognized as versatile materials for environmental remediation due to their high capacity for cation-exchange, adjustable pore structure, and strong chemical stability. These properties enable their effective application in removing diverse contaminants, including heavy metals, ammonium ions, dyes, and various organic pollutants, making them highly relevant in water, wastewater, and soil treatment systems. However, although research in this field has expanded considerably, the overall global development patterns and knowledge structure of zeolite-related studies have not been thoroughly quantified. This study conducts a bibliometric assessment of global research on zeolite applications in water, wastewater, and soil remediation covering the period from 2010 to 2024, using a dataset of 203 peer-reviewed Scopus-indexed publications. The analysis was carried out using VOSviewer to examine publication trends, leading authors, productive countries and institutions, as well as thematic clusters and emerging research directions. The findings indicate a consistent increase in scientific output over the study period, with China, India, Malaysia, and the United States emerging as the most influential contributors in terms of both publication volume and citation impact. Key journals publishing in this area include the Journal of Hazardous Materials, Chemosphere, and Science of the Total Environment. Keyword co-occurrence mapping reveals dominant research themes such as adsorption processes, ion exchange mechanisms, heavy metal remediation, nanostructured materials, and advanced oxidation technologies, highlighting a clear shift toward integrated and hybrid remediation approaches. Overall, the results emphasize the growing significance of modified and composite zeolite materials in enhancing pollutant removal efficiency and supporting sustainable environmental management. This bibliometric evaluation provides a structured overview of the research landscape and offers insights into future directions for zeolite-based remediation technologies. Full article

Background: Colorectal cancer (CRC) is a major clinical challenge due to high metastasis and therapy resistance. Photodynamic therapy (PDT) offers precise tumor ablation but lacks sustained anti-metastatic activity. Peptidic urokinase-type plasminogen activator (uPA) inhibitors suppress metastasis but suffer from short half-life and poor tumor retention. This study aimed to develop a dual-functional self-assembled nanoplatform integrating PDT and selective uPA inhibition for synergistic CRC treatment. Methods: We designed and synthesized a conjugate by linking pyropheophorbide-a (PPA) with uPA-targeted cyclic peptide IG2, which self-assembled into nanoparticles (PINPs). Physicochemical properties, reactive oxygen species (ROS) generation, and uPA inhibitory activity were characterized. In vitro studies included cellular uptake, cytotoxicity, and invasion assays. In vivo therapeutic efficacy was evaluated in subcutaneous CT26 tumor models and lung metastasis models, with biosafety assessed by body weight monitoring. Results: PINPs exhibited uniform spherical nanostructure, prolonged blood circulation, and enhanced tumor accumulation via the enhanced permeability and retention (EPR) effect. Under 680 nm irradiation, PINPs generated robust ROS and induced tumor cell apoptosis. PINPs potently inhibited uPA activity and suppressed tumor cell invasion. In vivo, PINPs plus PDT achieved significant tumor growth inhibition (73.6%) and strong anti-metastatic efficacy (60.7%), superior to free IG2. No obvious systemic toxicity was observed. Conclusions: The dual-functional PINPs achieve short-term acute tumor ablation via PDT and sustained anti-metastatic potential via uPA inhibition within the tested observation windows, with favorable biosafety. This carrier-free self-assembly strategy provides proof-of-concept validation and a generalizable design paradigm for developing synergistic anti-metastatic nanotherapeutics against metastatic CRC. Full article