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37 pages, 1416 KB  
Systematic Review
A Systematic Review of Soil Properties to Support Mycotoxin Model Development with In-Field Soil Sensing
by Eleonora Granata, Marco Camardo Leggieri, Daniele Trinchero and Paola Battilani
Sensors 2026, 26(13), 4044; https://doi.org/10.3390/s26134044 (registering DOI) - 25 Jun 2026
Abstract
Recently, mycotoxin prediction has mainly relied on meteorological data and crop physiology. The contribution of soil characteristics as additional environmental variables remains largely unexplored. A systematic literature search was carried out to analyze the latest research (from 2020 to 2025) on the relationship [...] Read more.
Recently, mycotoxin prediction has mainly relied on meteorological data and crop physiology. The contribution of soil characteristics as additional environmental variables remains largely unexplored. A systematic literature search was carried out to analyze the latest research (from 2020 to 2025) on the relationship between soil properties (temperature, water content, pH, and electrical conductivity), fungal communities (particularly Aspergillus and Fusarium), and different crops (mainly peanut, wheat, and maize). Measurement methodologies were analyzed, with a focus on the use of in-field soil sensors in correlation studies and predictive models. Disease incidence and mycotoxin occurrence were related to stressful soil conditions, such as different pH levels, wetness or drought, and temperatures above 25 °C. Other external variables (crop and field management) must also be considered. Laboratory equipment was primarily used in correlation studies, with limited in-field sensor implementation. Although recent predictive models included soil properties as effective inputs, they mostly relied on satellite data. However, real-time conditions and fluctuations, which can be captured by in-field soil sensors, are essential for training new functional models. To monitor soil properties, IoT technologies must be considered, but their implementation is still not sufficient to collect widespread data. Therefore, groundwork is needed to fill this gap with high-quality soil data for future in-field experimentation. Full article
(This article belongs to the Section Smart Agriculture)
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16 pages, 917 KB  
Review
Ethical, Legal, and Social Implications of Newborn Screening in Africa: A Scoping Review
by Victory Oghenetega Samuel, Abdullahi Adeyinka Adejare and Ushotanefe Useh
Int. J. Neonatal Screen. 2026, 12(3), 46; https://doi.org/10.3390/ijns12030046 (registering DOI) - 25 Jun 2026
Abstract
Newborn screening initiatives have the potential to mitigate childhood morbidity in Africa, but they also have special ethical, legal, and social implications (ELSI) that are influenced by issues with the health system, cultural diversity, and limited resources. This scoping review explores the ELSI [...] Read more.
Newborn screening initiatives have the potential to mitigate childhood morbidity in Africa, but they also have special ethical, legal, and social implications (ELSI) that are influenced by issues with the health system, cultural diversity, and limited resources. This scoping review explores the ELSI of newborn screening across Africa to identify key challenges, gaps, and future research needs. A systematic search identified 27 peer-reviewed studies published between 2008 and 2025, covering 12 African countries. Data were extracted on study characteristics, disease types, and ELSI dimensions from African Journals Online (AJOL), Scopus, PubMed, Web of Science, and BMJ Journals. Thematic analysis mapped recurring ethical, legal, and social concerns. Most studies examined ethical and social dimensions, while legal frameworks were rarely addressed. South Africa, Tanzania, and Ghana contributed the largest number of publications. Sickle cell disease (52%) and hearing screening (30%) were the dominant foci. Common ethical issues included informed consent, privacy, and justice; legal gaps centered on the absence of data protection and frameworks; and social concerns involved stigma, awareness, and cultural perceptions of hereditary disease. Ethical and social issues dominate NBS discourse in Africa, whereas legal oversight remains limited. To guarantee fair, reliable, and long-lasting newborn screening programs, national policy guidelines, community involvement, and context-specific ethical frameworks must be strengthened. Full article
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17 pages, 8630 KB  
Article
Combined Application of Ultra-High-Pressure Homogenization and Non-Saccharomyces Yeasts to Reduce Sulfites and Improve Wine Quality
by Maria Soler, Carmen Gonzalez, Antonio Morata and Iris Loira
Foods 2026, 15(13), 2271; https://doi.org/10.3390/foods15132271 (registering DOI) - 25 Jun 2026
Abstract
In recent years, the wine industry has searched for alternatives to reduce the use of sulfites, with ultra-high-pressure homogenization (UHPH) emerging as a promising technology. The objective of this study was to evaluate the combined effect of UHPH and non-Saccharomyces yeasts ( [...] Read more.
In recent years, the wine industry has searched for alternatives to reduce the use of sulfites, with ultra-high-pressure homogenization (UHPH) emerging as a promising technology. The objective of this study was to evaluate the combined effect of UHPH and non-Saccharomyces yeasts (Lachancea thermotolerans and Metschnikowia pulcherrima) on wine quality. To this end, fermentations were carried out using control Verdejo must, must treated with UHPH, and must treated with 50 mg/L SO2, using pure cultures and co-inoculations. Enological parameters, volatile compounds, colour, redox potential, and sensory profile were analyzed. The results showed that the co-inoculation of L. thermotolerans and M. pulcherrima reduced the final ethanol content by 0.5% (v/v) and increased lactic acid production, resulting in a decrease in pH of 0.3 units; however, L. thermotolerans in monoculture failed to implant properly in UHPH-treated must. In addition, wines from UHPH-treated musts exhibited 20% lower redox potential, suggesting that treatment with UHPH was effective in inactivating oxidative enzymes, as did those fermented with M. pulcherrima. Regarding volatile compounds, UHPH wines showed a 30% reduction in higher alcohols and carbonyl compounds, resulting in a characteristic aromatic profile that was positively evaluated in sensory analysis. In conclusion, the combination of UHPH and non-Saccharomyces yeasts represents an effective strategy for improving wine quality and reducing the use of sulfites. Full article
(This article belongs to the Special Issue Factors Affecting Wine Quality and Flavor)
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28 pages, 2349 KB  
Article
Analytical Modeling and Acoustic Optimization of Sound Insulation Performance of Finite-Sized Insulated Concrete Sandwich Panels
by Zhiwei Zhang, Bin Liu, An Chen, Zhibao Cheng and Jing Sun
Buildings 2026, 16(13), 2506; https://doi.org/10.3390/buildings16132506 (registering DOI) - 24 Jun 2026
Abstract
Insulated concrete sandwich panels (ICSPs) are widely utilized in modern building structures due to their excellent combination of energy efficiency and structural load-bearing capacity. However, compared to their mechanical and thermal properties, the sound insulation characteristics of ICSPs remain insufficiently studied, presenting a [...] Read more.
Insulated concrete sandwich panels (ICSPs) are widely utilized in modern building structures due to their excellent combination of energy efficiency and structural load-bearing capacity. However, compared to their mechanical and thermal properties, the sound insulation characteristics of ICSPs remain insufficiently studied, presenting a scientific deficit. In practical engineering, insufficient consideration of these acoustic properties—particularly the “acoustic bridging” induced by connectors—often leads to unpredictable noise transmission, making it difficult for building envelopes to meet stringent modern acoustic codes. To further investigate their acoustic characteristics, this paper extends existing theories on infinite periodic ICSPs to study the airborne sound insulation performance of finite-sized ICSPs. First, analytical models for ICSPs under simply supported on all edges (SS) and clamped on all edges (CC) boundary conditions are derived, wherein the connectors are equivalently modeled as elastic media and discrete elastic springs, respectively. Subsequently, the accuracy and applicability of the analytical models are verified through finite element (FE) models and an airborne sound insulation experiment. Finally, based on the analytical models, a parametric study is conducted to explore the effects of the stiffness of connectors, boundary conditions, and the thickness of the core layer on the sound insulation performance of the ICSPs. The results indicate that connector stiffness has a non-monotonic influence on the sound insulation performance of ICSPs. As the connector stiffness increases, the Rw first decreases and then increases, and the sound insulation performance gradually stabilizes when the connector stiffness becomes sufficiently high. Boundary conditions have a significant effect on the acoustic response. For the reference ICSPs, changing the boundary condition from SS to CC increases the Rw from 49 dB to 62 dB, corresponding to an increment of 13 dB and an approximately 95.0% reduction in the equivalent sound transmission coefficient. When the total panel thickness is kept constant, reducing the core layer thickness from 80 mm to 40 mm increases the Rw from 49 dB to 55 dB under SS boundary conditions and from 62 dB to 66 dB under CC boundary conditions, corresponding to increments of 6 dB and 4 dB, respectively. These improvements are equivalent to reductions of approximately 74.9% and 60.2% in the sound transmission coefficient, though this must be weighed against the inevitable reduction in thermal insulation capacity. Although the sound insulation performance of ICSPs is inferior to that of solid concrete panels (SCPs) of equivalent thickness, with reasonable parameter optimization, their sound insulation indices can significantly exceed the latest requirements of current building codes. By fully accounting for boundary effects in practical engineering, this study provides an analytical basis for the acoustic performance prediction and engineering-oriented optimization of finite-sized ICSPs. Full article
(This article belongs to the Section Building Structures)
40 pages, 1357 KB  
Review
Tumour Localisation Technologies in Colorectal Cancer Surgery: A Scoping Review of Marking and Detection Methods
by Mircea Fulea, Mihaela Mocan, Mircea Murar, Bogdan Mocan and Vasile Bințințan
Diagnostics 2026, 16(13), 1952; https://doi.org/10.3390/diagnostics16131952 (registering DOI) - 23 Jun 2026
Viewed by 152
Abstract
Background: Precise intraoperative localisation of small colorectal tumours during laparoscopic surgery remains challenging due to absent tactile feedback and subserosal tumour location. Current standard methods, particularly India ink tattooing, demonstrate 15–30% failure rates for lesions less than 10 mm, leading to prolonged [...] Read more.
Background: Precise intraoperative localisation of small colorectal tumours during laparoscopic surgery remains challenging due to absent tactile feedback and subserosal tumour location. Current standard methods, particularly India ink tattooing, demonstrate 15–30% failure rates for lesions less than 10 mm, leading to prolonged operative times, incomplete resections, and re-operations. Multiple emerging technologies promise improved localisation, yet comparative evidence remains fragmented. Objective: To map and characterise the current landscape of intraoperative marking and identification technologies for small colorectal tumour localisation during laparoscopic surgery, with emphasis on radiofrequency-based methods and alternative approaches, and to identify evidence gaps guiding future research. Methods: Following PRISMA-ScR guidelines, we systematically searched PubMed, Web of Science, and Scopus databases from January 2000 through December 2025 for studies evaluating tumour localisation technologies in colorectal cancer surgery, including primary tumour localisation during laparoscopic colectomy and localisation of colorectal liver metastases during hepatic surgery, or transferable anatomical applications with documented translational potential to colorectal surgery. Two independent reviewers screened all records, with discrepancies resolved through discussion and a third senior reviewer consulted for unresolved disagreements; data were extracted on technical performance, safety, feasibility, cost-effectiveness, usability, innovation potential, and evidence quality. Results: We included 89 studies comprising 18 colorectal-specific articles and 71 transferable/GI-adjacent studies. Detection success rates ranged from 71% to 100% across modalities. Near-infrared fluorescence with indocyanine green demonstrated the strongest clinical evidence with 75–100% detection across eight colorectal studies encompassing 2134 procedures and seamless workflow integration. Radiofrequency identification systems achieved 91.9–99% detection in feasibility studies with promising tissue penetration of 15–35 mm but limited colorectal validation. Electromagnetic navigation excelled in rigid organs with 85–98% success but showed degraded performance in mobile bowel at 71–75%. Critical evidence gaps included absent head-to-head comparative trials, non-standardised outcome metrics limiting cross-study comparability, and limited long-term safety data with only 14 studies providing follow-up exceeding six months. Conclusions: ICG fluorescence represents the most clinically mature technology identified, representing a priority candidate for colorectal-specific validation in challenging localisation scenarios. RFID systems demonstrate promising characteristics justifying prioritised research investment through adequately powered comparative trials. Future research must emphasise consortium-based comparative effectiveness studies, standardised outcome metrics, and integration with robotic and AI-assisted surgical platforms to accelerate clinical translation. Full article
(This article belongs to the Section Clinical Diagnosis and Prognosis)
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18 pages, 5064 KB  
Article
Spatial Calibration of Weigh-In-Motion Systems—Evaluation of Metrological Properties
by Janusz Gajda, Ryszard Sroka, Piotr Burnos and Mateusz Daniol
Sensors 2026, 26(13), 3978; https://doi.org/10.3390/s26133978 (registering DOI) - 23 Jun 2026
Viewed by 215
Abstract
This article presents a method for calibration of dynamic vehicle weighing systems (WIM—Weigh-In-Motion) involving the calibration of all WIM stations operating within a given road network segment as a single process. A key assumption of the method is the presence of at least [...] Read more.
This article presents a method for calibration of dynamic vehicle weighing systems (WIM—Weigh-In-Motion) involving the calibration of all WIM stations operating within a given road network segment as a single process. A key assumption of the method is the presence of at least one scale with significantly higher accuracy than the calibrated systems in this part of road network. This reference scale function may be played by a static scale, slow-pass scale (LS-WIM—Low-Speed WIM) for measurement of vehicle axle load or by a selected WIM system with heightened accuracy. Both the reference scale and all systems undergoing calibration must be equipped with a system for the automatic recognition of vehicle registration number plates. The reference scale makes it possible to determine axle load values considered as benchmark values. Then, for each vehicle weighed on the reference scale and subsequently on any WIM system operating within the analysed area, the relative difference between the reference result and the WIM system measurement is calculated with respect to the reference value. This difference forms the basis for the operation of the algorithm estimating the coefficients of the static characteristic of the calibrated WIM system (so-called calibration coefficients), which are then used to determine corrected weighing results. The estimation of the coefficients is updated after each identified vehicle that has previously been weighed on the reference scale is considered. The article presents both the results of simulations and experimental studies concerning the proposed spatial method of calibration. The results obtained allow for an assessment of the effectiveness of the proposed solution. As can be seen from the analyses conducted, this method leads to a significant reduction in systematic error of vehicle weight measurement. Unfortunately, it does not eliminate random errors. The spatial calibration approach described in this paper has certain limitations. The main ones include the impact of ANPR system errors on calibration effectiveness, cases where a vehicle is unloaded or loaded between WIM stations, and the propagation of systematic errors from the reference systems to the other WIM systems. A significant advantage of the proposed spatial calibration method is that it can operate effectively using weighing data from a single reference WIM system and does not require heavy traffic volumes. Full article
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16 pages, 312 KB  
Review
Machine Milking in Small Ruminants: Milking Systems and Association with Milk Quality Produced in the Farms
by Dimitra V. Liagka, George C. Fthenakis, Vasia S. Mavrogianni, Dafni T. Lianou, Vassiliki Spyrou and Natalia G. C. Vasileiou
Dairy 2026, 7(3), 46; https://doi.org/10.3390/dairy7030046 (registering DOI) - 22 Jun 2026
Viewed by 89
Abstract
The intensification and continuous evolution of dairy sheep and goat farming have played an essential role in the development and implementation of milking equipment. The increasing demand for time-efficient milking procedures, reduced labour costs, sustained milk production, and optimal mammary health have driven [...] Read more.
The intensification and continuous evolution of dairy sheep and goat farming have played an essential role in the development and implementation of milking equipment. The increasing demand for time-efficient milking procedures, reduced labour costs, sustained milk production, and optimal mammary health have driven the widespread adoption and optimisation of machine milking technologies. The objectives of this article are (i) the review of milking systems and relevant technological developments in milking equipment and (ii) the evaluation and description of their impact on udder health, as applied on dairy small ruminant farms. Milking systems used on farms depend on the available space and number of animals on the farms. Appropriate settings in milking systems are important for ensuring good milk quality; among them, vacuum level, pulsation rate and ratio are important characteristics that must be monitored regularly. Further, use of appropriate teatcups specific to the animal species to be milked is significant. An important aspect of proper maintenance of the milking system is the cleaning procedure after completion of milking. Points for consideration are quality and temperature of the water used for cleaning, use of detergents and disinfectants, and maintenance schedule and teatcup replacement. Some technological features that are part of milking systems include automatic vacuum shut off, electronic milk recording, electronic identification of animals, automatic flushing of milking clusters and automatic pre-stimulators. Farms will benefit from applying precision technologies, which will use data from tools related to animal genetic background, animal behavioural indicators, environmental conditions and disease-related functions for more holistic and cost-effective farm management. In this context, integration of sensor-based technologies in milking systems will be able to provide real-time information regarding quality of milk produced at individual and farm levels. Moreover, the introduction of automatic system flushing in-between animals during the milking procedure can contribute to breaking chains of potential bacterial transfer and reducing animal infections during milking. Overall, although machine milking has certainly contributed to improved efficiency, milk quality and labour conditions, flaws in system function may adversely affect mammary health. Full article
(This article belongs to the Special Issue Farm Management Practices to Improve Milk Quality and Yield)
17 pages, 3685 KB  
Article
Biodynamics and Discomfort of the Human Body in a Seated Posture with a Large Backrest Inclination Angle
by Zefeng Lin, Zhixin Su, Weitan Yin, Xu Zheng and Yi Qiu
Appl. Sci. 2026, 16(12), 6269; https://doi.org/10.3390/app16126269 (registering DOI) - 22 Jun 2026
Viewed by 175
Abstract
Large-reclined seating has emerged as a favored configuration in the luxury transport sector. While the static advantages are evident, the effect of this posture on dynamic comfort is not clear. This study investigated the objective biodynamics and subjective discomfort of the human body [...] Read more.
Large-reclined seating has emerged as a favored configuration in the luxury transport sector. While the static advantages are evident, the effect of this posture on dynamic comfort is not clear. This study investigated the objective biodynamics and subjective discomfort of the human body sitting in a large-reclined posture (58° from the vertical) under single axis vertical and lateral vibration excitations. The transmissibility of the human–seat system and apparent mass of the human body were measured respectively. The results revealed a critical transition between static and dynamic comfort: while the 58° posture offers superior static relaxation, dynamic discomfort dominates the overall perception when the excitation intensity exceeds a threshold of 0.249 m/s2 r.m.s. Objective measurements indicated that dynamic comfort degradation in large-reclined postures is primarily driven by altered inherent biodynamic characteristics. These findings highlight that future luxury vehicle seating must incorporate targeted dynamic isolation to compensate for posture-induced comfort degradation and ensure premium ride quality. Full article
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12 pages, 649 KB  
Article
Botulinum Toxin Treatment for Uncommon Phenotypes of Laryngeal Adductor Breathing Dystonia
by Domenico Antonio Restivo, Angelo Alito, Demetrio Milardi, Mario Stampanoni Bassi, Sara Lanza, Angelo Quartarone and Rosario Marchese-Ragona
Toxins 2026, 18(6), 272; https://doi.org/10.3390/toxins18060272 (registering DOI) - 20 Jun 2026
Viewed by 154
Abstract
Laryngeal adductor breathing dystonia (LABD) is a rare form of focal, task-specific respiratory dystonia affecting the laryngeal muscles of unknown aetiology. Unlike classical laryngeal dystonia (spasmodic dysphonia), LABD is not primarily characterised by impaired speech, but rather by dysfunction of respiratory laryngeal control. [...] Read more.
Laryngeal adductor breathing dystonia (LABD) is a rare form of focal, task-specific respiratory dystonia affecting the laryngeal muscles of unknown aetiology. Unlike classical laryngeal dystonia (spasmodic dysphonia), LABD is not primarily characterised by impaired speech, but rather by dysfunction of respiratory laryngeal control. The hallmark pathophysiological alteration consists of involuntary, action-induced adductor spasms of the laryngeal muscles during respiration, particularly during inspiration. LABD must be distinguished from inducible laryngeal obstruction (ILO), a broader, heterogeneous condition encompassing episodic, stimulus-triggered supraglottic or glottic closure, associated with asthma, reflux, or psychological triggers, that is generally not task-specific and lacks the neurological substrate characteristic of dystonia. In contrast, LABD is a persistent, effort-dependent, neurologically driven dystonia, demonstrable by paradoxical adductor spasms on fibreoptic laryngoscopy during normal inspiration and confirmed electromyographically by paradoxical thyroarytenoid muscle activation instead of the expected inspiratory relaxation. Traditional treatments, including respiratory retraining, speech therapy, biofeedback, psychotherapy, benzodiazepines, dopamine-blocking agents, and anticholinergic drugs, have proved largely ineffective. Tracheostomy may be required in cases of severe respiratory compromise. Botulinum toxin type A (BoNT/A) injections have been reported to successfully reduce inspiratory stridor in selected patients. Here, we present three cases of LABD displaying distinct phenotypes, in which typical features were associated with involvement of extra-laryngeal cranial districts, further expanding the known phenotypic spectrum of this condition. Full article
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22 pages, 412 KB  
Article
On a Biparametric Appell Extension: Analytical Properties and Structural Analysis
by Hany Mostafa Ahmed
Axioms 2026, 15(6), 455; https://doi.org/10.3390/axioms15060455 - 17 Jun 2026
Viewed by 137
Abstract
This paper introduces and investigates a novel two-parameter sequence, termed the biparametric Appell extension (B-App-Ex) and denoted by Bn(x;λ,α). Standard classical Appell sequences often lack sufficient structural parameters, which can limit their operational flexibility [...] Read more.
This paper introduces and investigates a novel two-parameter sequence, termed the biparametric Appell extension (B-App-Ex) and denoted by Bn(x;λ,α). Standard classical Appell sequences often lack sufficient structural parameters, which can limit their operational flexibility in certain advanced spectral schemes. To address this limitation, we construct an enhanced operational framework by integrating a binomial structural kernel (1+w)λ with a linear exponential scaling eαxw entirely within the Appell class. We provide a rigorous logical deduction of the fundamental properties of this sequence, including its explicit power series representation, a characteristic three-term recurrence relation, and a governing second-order differential equation (DEq.). A significant contribution of this work is the establishment of analytically exact connection and inverse connection formulas between the B-App-Ex basis and various classical orthogonal polynomial (COP) families. Numerical verification via a collocation-based projection framework demonstrates that these algebraic kernels achieve near-machine epsilon precision (≈1015), remaining stable even for high-order approximations. Furthermore, by isolating the dilation factor α, we establish an O(N) computational complexity that offers a reduction in latency by approximately two orders of magnitude compared to classical matrix-based transformations. The results demonstrate that the proposed biparametric (Bip.) extension offers a versatile and highly optimized analytical template for modeling complex dynamic systems where structural shifting and spatial scaling must be tuned simultaneously. Full article
(This article belongs to the Section Mathematical Analysis)
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28 pages, 6366 KB  
Article
Edge-Optimized Deep and Transfer Learning for Efficient DDoS Detection in IIoT Networks
by Mikiyas Alemayehu, Mohamed Chahine Ghanem and Hamza Kheddar
Mach. Learn. Knowl. Extr. 2026, 8(6), 166; https://doi.org/10.3390/make8060166 - 16 Jun 2026
Viewed by 257
Abstract
The increasing convergence of Operational Technology (OT) and Information Technology (IT) within the Industrial Internet of Things (IIoT) brings about remarkable improvements in monitoring and automation. However, it also exposes industrial systems to large-scale Distributed Denial of Service (DDoS) attacks. Edge-based defences are [...] Read more.
The increasing convergence of Operational Technology (OT) and Information Technology (IT) within the Industrial Internet of Things (IIoT) brings about remarkable improvements in monitoring and automation. However, it also exposes industrial systems to large-scale Distributed Denial of Service (DDoS) attacks. Edge-based defences are essential in satisfying low-latency demands and data sovereignty rules, yet they must function under severe resource limitations and adapt to shifting traffic characteristics without cloud assistance. In this work, we introduce a lightweight hybrid deep learning architecture that fuses a Convolutional Neural Network (CNN) with a Convolutional Block Attention Module (CBAM) and a Multi-Layer Perceptron (MLP) in a single detector. A sequential transfer learning scheme is adopted, including a feature projection layer that handles differences in input dimensionality. The model is pre-trained on the CIC-DDoS2019 dataset, then adapted to the more recent CICIoT23 dataset. Evaluations are performed on both datasets while preserving their natural class imbalance. We provide extensive ablation and variance analysis under identical experimental conditions. The proposed method achieves 99.52% accuracy on CICIoT23 while maintaining 99.65% recall, which is a crucial property for critical systems. Real-time measurements on a CPU-only testbed show an average inference latency of 0.013 ms, inference-only throughput exceeding 93,000 packets/s, and end-to-end batch throughput of approximately 38,000 packets/s. The solution demonstrates effective domain adaptation, sub-millisecond latency, and suitability for resource-constrained IIoT edge gateways. Full article
(This article belongs to the Section Safety, Security, Privacy, and Cyber Resilience)
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30 pages, 4306 KB  
Review
Physicochemical Aspects of Mixed Micelle Formation Between Amphiphilic Drugs and Surfactants
by Ádám Juhász, Bianka Torma, Egon F. Várkonyi, László Seres, Norbert Varga, Árpád Turcsányi and Edit Csapó
Int. J. Mol. Sci. 2026, 27(12), 5400; https://doi.org/10.3390/ijms27125400 - 15 Jun 2026
Viewed by 176
Abstract
The rational design of mixed micellar systems has emerged as a cornerstone of modern nanomedicine, offering unprecedented control over the solubility and bioavailability of challenging therapeutic agents. This review provides a comprehensive analysis of the physicochemical principles governing the assembly of amphiphilic drugs [...] Read more.
The rational design of mixed micellar systems has emerged as a cornerstone of modern nanomedicine, offering unprecedented control over the solubility and bioavailability of challenging therapeutic agents. This review provides a comprehensive analysis of the physicochemical principles governing the assembly of amphiphilic drugs and surfactants into synergistic nanostructures. By articulating the transition from traditional guest/host solubilization to “drug-as-component” models, we highlight the critical role of molecular interactions in achieving therapeutic precision. It further outlines the experimental methodologies used to investigate these systems and elucidates how they enhance the solubility, stability, and bioavailability of poorly water-soluble drugs. Special emphasis is placed on the practical applications of synergy in reducing systemic toxicity and optimizing drug release kinetics, providing a roadmap for the development of next-generation nano-pharmaceuticals. The functionality of these systems is significantly influenced by the molecular interactions among their constituents; thus, quantitative analysis of these interactions might enhance the formulation of more effective pharmaceuticals. This review outlines the key physicochemical principles of mixed micelle formation, including thermodynamics and synergistic interactions of amphiphiles, while emphasizing their relevance in current research and practical pharmaceutical applications. Various experimental methods, such as surface tension measurement, conductometric and calorimetric tests, and spectroscopic techniques, are compared in terms of their conditions of application and performance in understanding micelle formation and micelle structure. We clearly point out that the interpretation and evaluation of the properties of colloidal systems containing drug molecules solubilized by mixed micelles and an amphiphilic drug incorporated into micelles must be discussed and evaluated separately. Understanding the limitations and characteristics of the physical/chemical principles applied is essential for the rational design of mixed micelle carriers tailored to specific therapeutic needs. Full article
(This article belongs to the Special Issue Nanotechnology in Drug Delivery: Applications and Perspectives)
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26 pages, 10483 KB  
Article
Polymer-Gated Bilayer Buccoadhesive Tablets for Biphasic Release of Indomethacin: Balancing Dissolution and Mucoadhesion
by Linhan Li, Jie Wang, Jie Xu, Jiaxin Li and Gang Jin
Pharmaceuticals 2026, 19(6), 944; https://doi.org/10.3390/ph19060944 - 15 Jun 2026
Viewed by 285
Abstract
Objectives: To address the critical limitations of current formulations that fail to simultaneously resolve indomethacin’s poor water solubility, susceptibility to gastric acid hydrolysis, and difficulty in balancing rapid onset with long-term sustained release, this study prepared solid dispersions via anti-solvent freeze-drying to [...] Read more.
Objectives: To address the critical limitations of current formulations that fail to simultaneously resolve indomethacin’s poor water solubility, susceptibility to gastric acid hydrolysis, and difficulty in balancing rapid onset with long-term sustained release, this study prepared solid dispersions via anti-solvent freeze-drying to improve drug dissolution, constructed oral buccoadhesive bilayer controlled-release tablets using direct powder compression, and elucidated the intrinsic relationships among polymer gel properties, swelling-erosion behavior, tablet integrity maintenance, and drug release mechanisms. Methods: Solid dispersions (SDs) were prepared by anti-solvent freeze-drying. Bilayer tablets (25 mg IND/tablet, 12.5 mg/layer) were fabricated via direct powder compression after optimizing disintegrants and polymer matrices. In vitro dissolution, surface pH, adhesion time, and adhesion strength were evaluated. Results: SDs enhanced dissolution by at least 30-fold in water and 2.4-fold at pH 6.8 within 2 h versus pure drug. Optimized bilayer tablets achieved 45% drug release at 20 min and 80% sustained release over 8 h, with surface pH of 6.8 ± 0.1, adhesion time of 8.3 ± 0.1 h, and adhesion strength of 57 ± 0.13 g. Conclusions: The physicochemical properties of polymeric excipients are critical for balancing drug release and mucoadhesion in buccal tablets. To achieve ideal controlled-release effects, in addition to focusing on the swelling and erosion characteristics of matrix-based tablets, the ability to maintain tablet integrity during dynamic dissolution must be further investigated, which is an essential factor for ensuring precisely modulated drug release. Meanwhile, when employing solid dispersions as solubilizing intermediates to prepare controlled-release formulations, the gelling properties of polymers in each formulation component should be fully considered to avoid incomplete disintegration and insufficient release at the initial dissolution stage. Full article
(This article belongs to the Section Pharmaceutical Technology)
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29 pages, 13112 KB  
Article
An Integrated AHP–Kano–Walkability Framework for Evaluating and Optimizing Campus Pedestrian Systems: A Case Study of Huaqiao University
by Xiangning Zhang, Nanxin Zhang, Xueyan Ding and Ying Zhu
Buildings 2026, 16(12), 2359; https://doi.org/10.3390/buildings16122359 - 12 Jun 2026
Viewed by 233
Abstract
Increasing attention has been directed toward walkability evaluation because pedestrian environments are closely associated with mobility patterns, environmental quality, and everyday spatial experience. However, most existing walkability studies either emphasize objective spatial indicators or rely on subjective satisfaction surveys, while the relationship between [...] Read more.
Increasing attention has been directed toward walkability evaluation because pedestrian environments are closely associated with mobility patterns, environmental quality, and everyday spatial experience. However, most existing walkability studies either emphasize objective spatial indicators or rely on subjective satisfaction surveys, while the relationship between expert evaluation and user satisfaction has received relatively limited attention, particularly regarding its nonlinear characteristics. In addition, walkability frameworks developed for urban public environments are often directly applied to university campuses without adequately considering the distinctive behavioral characteristics of campus pedestrian activities. To address these limitations, this study proposes an integrated AHP–Kano walkability evaluation framework for campus pedestrian systems. The framework combines the Analytic Hierarchy Process (AHP) with the Kano model to establish a perception-sensitive and behavior-oriented evaluation structure. AHP is employed to determine the relative importance of environmental indicators through expert judgment, while the Kano model is introduced to capture the asymmetric effects of different environmental attributes on user satisfaction. GIS analysis and field investigation were employed as supplementary spatial diagnostic tools to support the interpretation of pedestrian–environment characteristics. Using the Xiamen campus of Huaqiao University as a case study, this research constructs a multidimensional evaluation system covering accessibility, safety, comfort, landscape quality, and service functionality. Questionnaire surveys and expert evaluations were conducted to analyze the relationship between objective environmental importance and subjective perceptual response. The results indicate that safety- and accessibility-related attributes primarily function as must-be requirements that prevent dissatisfaction, whereas environmental cleanliness and selected experiential elements exhibit stronger satisfaction-enhancing effects. Several landscape-related indicators, commonly emphasized in urban walkability studies, demonstrate relatively weak perceptual sensitivity in campus contexts, reflecting the task-oriented and time-constrained nature of campus pedestrian behavior. The present study extends existing walkability research in several important respects. Rather than relying on conventional linear assumptions, the proposed framework incorporates nonlinear perceptual responses into walkability evaluation. The findings further demonstrate that pedestrian perception is highly context-dependent in campus environments, while the integrated framework further provides a behavior-sensitive basis for prioritizing spatial interventions. Full article
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73 pages, 2707 KB  
Systematic Review
Neurophysiology of Sleep-Deprivation Part 1: Effects of Sleep-Deprivation on Event-Related Potentials (ERPs)—Systematic and Mechanistic Review
by James Chmiel and Jarosław Nadobnik
J. Clin. Med. 2026, 15(12), 4576; https://doi.org/10.3390/jcm15124576 - 12 Jun 2026
Viewed by 134
Abstract
Background: Sleep deprivation is one of the major public health and performance risk factors, with documented effects on vigilance, executive function, emotional regulation, and safety-critical behaviour. This review examines how event-related potentials (ERPs)—which provide millisecond-level resolution of cognitive processing stages—can clarify which neural [...] Read more.
Background: Sleep deprivation is one of the major public health and performance risk factors, with documented effects on vigilance, executive function, emotional regulation, and safety-critical behaviour. This review examines how event-related potentials (ERPs)—which provide millisecond-level resolution of cognitive processing stages—can clarify which neural processes are most affected by sleep loss, from early sensory encoding to later evaluative and control-related stages. Materials and Methods: This study was conducted as a systematic review of human studies on sleep deprivation and ERPs. Eligible studies included human participants, focused primarily on acute/total sleep deprivation, and reported ERP outcomes (e.g., amplitude, latency, topography, or related event-locked EEG measures). Searches were performed in major biomedical/psychology databases using sleep deprivation and ERP terms, with additional forward/backward citation searching. Data was extracted in a structured format (participant characteristics, deprivation protocol, ERP methods, behavioural outcomes, ERP findings, and recovery/countermeasure effects). Due to substantial heterogeneity in paradigms, protocols, and ERP methods, findings were synthesised narratively rather than meta-analysed. Risk of bias was assessed with RoB 2 and ROBINS-I. Results: The search identified 854 records, of which 82 studies were included following deduplication, screening, full-text review, and citation chasing. Samples were typically small, highly selected, and dominated by healthy young adults, with frequent attrition related to prolonged wakefulness and EEG data-quality constraints. Across studies, sleep deprivation produced stage-specific and task-dependent ERP effects rather than a single uniform pattern. The most consistent findings involved mid-to-late components. These components typically showed prolonged latency and reduced amplitude. In some cases, amplitude increases were observed and interpreted as compensatory recruitment. Early sensory/pre-attentive components (e.g., P1/N1/MMN/P50) were often relatively preserved, but showed selective vulnerability, including latency slowing, reduced filtering/gating, or decreased phase locking. A recurring observation was a behaviour–ERP dissociation, where ERP abnormalities were detectable even when behavioural impairment was modest, indicating covert neural inefficiency or compensation. Recovery sleep, naps, and countermeasures (e.g., modafinil, caffeine) produced partial, component-specific recovery, with amplitude and latency often recovering at different rates. Conclusions: The evidence indicates that sleep deprivation primarily disrupts higher-order, late-stage, and temporally coordinated neural processing, while earlier sensory processing is often preserved but becomes slower and less stable. Among ERP markers, the P300/P3 family is the most robust and informative signature of sleep loss effects and recovery. ERPs are therefore a sensitive tool for detecting neural dysfunction and compensation under sleep deprivation, including changes that may precede overt behavioural decline. Future research must improve the generalisability and reproducibility of ERP findings by employing larger, more diverse samples, alongside more standardised methodological, recording, and reporting practices. Full article
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