Search Results (2,058)

Background/Objectives: To critically evaluate the current scientific literature on the physiological and preventive functions of vitamin D, with special emphasis on its possible involvement in multi-organ pathologies, and to assess the effectiveness of supplementation strategies for maintaining homeostasis. Methods: A review of the literature was conducted following a methodological approach in accordance with the PRISMA 2020 statement for systematic reviews. The bibliographic search was carried out in the PubMed, Scopus, and Web of Science databases, using controlled terms and Boolean operators. Rigorous inclusion and exclusion criteria were applied in three phases: blind search, selection by title/abstract, and full-text evaluation. Articles published in first quartile journals (JCR 2023) were prioritized. The search was complemented with targeted strategies such as consulting ORCID profiles, using the Jábega tool, and tracking cross-references. Results: The selected studies reinforce that vitamin D acts as a transcriptional modulator with effects beyond the skeletal system, including immunomodulatory, neuroprotective, and antitumor functions. Associations were identified between low levels of 25(OH)D and a higher prevalence of autoimmune, neurodegenerative, and metabolic diseases, as well as certain types of cancer. However, evidence of causality is still limited, and clinical trials have shown mixed results regarding its preventive efficacy. Supplementation strategies are useful in vulnerable populations, although their indiscriminate use without a documented deficiency is not recommended. Conclusions: Vitamin D is emerging as a potentially relevant agent in preventive medicine. While its benefits extrapolated from bone metabolism still require robust clinical validation, current findings support its role in regulating key systemic functions. A balanced approach combining sun protection, health education, food fortification, and targeted supplementation, tailored to the clinical context of each individual, is recommended. Full article

Advancing toward sustainable higher education requires simultaneously addressing United Nations Sustainability Goals 4 (quality education) and 5 (gender equality). This mixed-methods case study analyzes how cultural stereotypes and gender expectations influence career choices in the field of computer science, which is highly masculinized in Chile. As a contextual and comparative contrast, the feminization of disciplines such as nursing is considered, illustrating the gender polarization across areas of knowledge. This comparison is not random, since in Chile the health sector stands at the opposite end of the spectrum from technology, as demonstrated by the study’s figures. As a theoretical basis, a simple systematic review of the literature published between 2013 and 2024 (in English and Spanish) was carried out, drawing on Scopus, Web of Science, SciELO, and ERIC databases, following some steps of the PRISMA protocol. Thematic analysis allowed mapping research by region, discipline, and type of intervention. The results confirm the persistence of stereotyped beliefs about skills and professional roles, even in contexts with formal equity policies. Strategies that foster empathy, belonging, and intercultural communication, implemented through mentoring, outreach activities, or curriculum redesign, emerge as key catalysts for more inclusive environments. The study presents a practical case applied to first-year computer engineering students at the Universidad de La Frontera (Chile), in which gendered perceptions embedded in vocational choice processes were identified. By situating this study in Chile’s context, we identify how local structures—school sector, regional labor markets, and gender norms—shape women’s participation in computing. Based on this experience, practical recommendations are proposed for integrating a gender perspective into technology education, including pedagogical strategies, gender-sensitive vocational guidance, and the visibility of role models. Full article

Background/Objectives: Pediatric asthma is the most prevalent chronic respiratory condition in children and adolescents worldwide and remains a major contributor to morbidity, school absenteeism, and the use of integrated healthcare services. The main goal of this systematic review is to synthesize the available evidence about the impact of biologic therapies on the quality of life in the pediatric population (children and adolescents) with asthma. Methods: This systematic review followed the PRISMA guidelines. A comprehensive search was performed across PubMed, Scopus, and Web of Science for articles published between 2015 and 2025 in English, Portuguese, or Spanish. Studies were eligible if they included pediatric patients (<18 years) with asthma receiving biologic therapies (e.g., omalizumab, mepolizumab, dupilumab) and reported health-related quality of life (HRQoL) outcomes using validated instruments. Article selection followed PICOS criteria and excluded reviews, case reports, and editorials. Risk of bias was assessed using the Mixed Methods Appraisal Tool. Results: A total of 576 articles were found and screened, and 8 studies were selected. The characteristics of the studies highlighted the involved countries, study design, number of participants, conditions, type of biologic intervention, duration, and follow-up. In addition, the importance of biologic therapies in patients’ HRQoL was presented. All eight included studies reported statistically significant improvements in HRQoL using appropriate scales. Conclusions: The studies reinforced the importance of biologic therapies to improve HRQoL in both patients and families/caregivers. Implications for health promotion, in particular, greater involvement of integrated healthcare comprising health professionals, family, school contexts, and the community, are discussed. Full article

Introduction: Aesthetic surgery addresses subjective desires for morphological enhancement and differs from reconstructive surgery due to its elective, non-therapeutic nature. This distinction introduces complex medico-legal challenges, particularly concerning informed consent, patient expectations, and the legal evaluation of aesthetic damage. Materials and Methods: A narrative review was conducted using national legislation, Italian and international clinical guidelines, peer-reviewed literature from PubMed, Scopus, and Web of Science, and Italian Supreme Court rulings. Eight commonly litigated aesthetic procedures were analyzed in terms of clinical indications, public reimbursement criteria, and medico-legal risk. Results: Findings revealed significant variability in medico-legal exposure among procedures. Fully elective interventions such as liposuction and breast augmentation carried the highest litigation risk. Common legal claims included inadequate informed consent, poor psychological assessment, and mismatched expectations. The review emphasizes the need for personalized consent processes and comprehensive preoperative evaluations. Discussion: Italian case law increasingly adopts a “mixed obligation” model for aesthetic surgery, requiring not only technical skill but also a prognostic and relational evaluation of the intervention. Informed consent must be detailed, individualized, and well-documented, as it holds greater legal weight than in therapeutic procedures. Predictive medico-legal tools such as psychological profiling and structured consent protocols are essential for risk mitigation. Conclusions: Modern aesthetic surgery requires a redefined approach to damage assessment that incorporates psychological, relational, and identity factors. In both clinical and surgical practice, an approach tailored to the patient’s psychological profile must be increasingly taken into consideration, both when proposing and carrying out treatments and in medical-legal assessments. A legally and ethically sound practice depends on transparency, documentation, and patient-centered care, especially in the absence of therapeutic indications. Full article

Diabetes is a global and local epidemic, with an exponential growth trend in prevalence rates. This article presents data collected through a survey administered to a probabilistic sample of patients enrolled in a diabetes control program within a network of health institutions in Cali, Colombia. The purpose of the survey was to explore knowledge, attitudes, and practices related to diabetes. The survey was designed as part of the quantitative component of a mixed methods macroproject, and the questionnaire was developed based on a review of the literature and the research team’s expertise in the field. The results of the article correspond to the description of the database and combine raw survey data with additional analytical variables derived from grouped response options or recoded items. The data provides a valuable source of information for further research and for decision-makers interested in diabetes risk management. In conclusion, this database enables other broader studies on factors related to adherence to conventional treatments and the use of nonconventional treatments for type 2 diabetes. Full article

Background/Objectives: The application of manure introduces antibiotic resistance genes (ARGs) into farmland, posing a significant public health risk. While tillage and fertilization practices are known to influence soil ecosystems, a systematic synthesis of how tillage patterns specifically regulate the fate of manure-derived ARGs is lacking. Methods: This review bridges this critical knowledge gap by systematically analyzing the interactions between conventional/conservation tillage and the distribution, persistence, and transmission of these ARGs. Results: It is observed that conservation tillage (e.g., no tillage), while beneficial for soil health, can lead to ARG accumulation at the soil surface, potentially increasing runoff risks, whereas conventional tillage promotes vertical mixing and dilution. A key unique contribution of this review is the systematic comparison of conventional versus conservation tillage, revealing quantitative reductions in ARG abundance. under practices like no till or deep plowing. Conclusions: We further con-solidate and propose integrated management strategies, combining precision agriculture, optimized fertilization, and scientific soil management, to mitigate ARG pollution. This work provides a targeted framework for developing more effective intervention measures to ensure agricultural sustainability and safeguard human health. Full article

Background: Depression is a significant complication of the peripartum period that can result in profound long-term detrimental implications for the affected woman, her child, and her family. It is possible that micronutrient imbalances could contribute to the development of perinatal depression through their roles in neurotransmitter synthesis and neuroendocrine and neuroimmune pathways. Micronutrient imbalances are more likely during the perinatal period due to the additional physiological demands on the body during this time. The objective of this systematic review was to review and summarise the existing evidence regarding the association between micronutrient levels and perinatal depression. Methods: MEDLINE, EMBASE, PsycINFO, CINAHL, Scopus, and Web of Science were searched for studies examining blood levels of micronutrients and assessment of depression within the peripartum period using validated rating tools. Results: A total of 58 studies met the eligibility criteria and were included in this review. Of these, 31 studies reported a significant inverse association between perinatal depression and at least one of the following: vitamin D, iron status, vitamin B12, folate, or zinc. Vitamin D was the most frequently investigated nutrient, examined in 28 of the 58 articles. The remaining 27 did not demonstrate a significant association. Conclusion: This review found that vitamin D deficiency has the greatest evidence of an association with perinatal depression. The evidence for other micronutrients is mixed, inconclusive, or limited. Further research is required to determine the significance of these micronutrients in the development of perinatal depression. Full article

Background and Objective: Zanubrutinib, a next-generation Bruton’s tyrosine kinase inhibitor (BTKi), has demonstrated promising efficacy in chronic lymphocytic leukemia (CLL), including treatment-naïve (TN) and relapsed/refractory (R/R) patients. However, evidence synthesis across clinical trials remains limited. We conducted a systematic review and single-arm meta-analysis to evaluate the efficacy of zanubrutinib in CLL. Methods: This study was performed in accordance with PRISMA guidelines and Cochrane recommendations. PubMed, Medline, Scopus, and Web of Science were searched up to August 2025 using terms related to zanubrutinib and CLL/SLL. Eligible studies included clinical trials of zanubrutinib in TN or R/R CLL/SLL patients. Risk of bias was assessed using the JBI tool for non-randomized studies and for RCTs. Pooled estimates of efficacy outcomes were calculated using a random-effects model. Pooled estimates were calculated using the DerSimonian–Laird random-effects model, which accounts for both within- and between-study variability. Results: Seven studies (n > 1000) were included, enrolling both TN and R/R patients across diverse global populations. The pooled overall response rate (ORR) was 93.3% (95% CI, 86.7–99.8%) in mixed TN and R/R populations, 94.4% (95% CI, 91.6–97.3%) in TN patients, and 83.9% (95% CI, 75.0–92.8%) in R/R patients. Complete response (CR) rates were 12.2% (95% CI, 0.3–24.2%) overall, 13.8% (95% CI, 1.5–26.2%) in TN patients, and 5.0% (95% CI, 0.3–9.8%) in R/R patients. Partial response (PR) rates reached 86.0% (95% CI, 82.6–89.5%) in TN and 63.2% (95% CI, 53.5–73.0%) in R/R patients. Progressive disease was rare (≤1% in R/R cohorts). Heterogeneity was moderate to high across several outcomes. Conclusions: Zanubrutinib demonstrates favorable efficacy in CLL, achieving high ORR in both TN and R/R patients, with particularly durable responses in TN populations. Although complete response rates remain modest, especially among R/R patients, overall disease control appears consistent. These findings support zanubrutinib as an effective treatment option across CLL settings; however, variability among studies and the modest CR rates highlight the need for longer follow-up and direct comparative trials to further define its clinical role. Full article

Background/Objectives: Residual symptoms—such as persistent negative or cognitive symptoms—and relapse remain common in schizophrenia (SCZ) despite the proven efficacy of antipsychotics. As a result, add-on medications are frequently prescribed in real-world clinical practice. Although these agents are often used chronically, most evidence supporting their benefits comes from short-term trials. This systematic review aimed to assess the effect of adjunctive medication on long-term clinical outcomes and relapse prevention. Methods: Following PRISMA guidelines, we searched PubMed and Scopus (2000–2025) for trials of add-on agents administered for ≥24 weeks in SCZ spectrum disorders. Eligible studies compared antipsychotic treatment as usual with and without an add-on pharmacological agent (or with an added placebo). The primary outcome was long-term symptom change evaluated via established clinical scales, while relapse was the secondary outcome. Risk of bias was assessed with the Cochrane RoB 2 tool (PROSPERO registration: CRD420251075647). Results: The 22 of 4101 selected studies were classified into a group of frequently used add-on agents in clinical practice (antidepressants, mood stabilizers) and a group of less common agents, encompassing cognitive enhancers, antibiotics and antioxidants/anti-inflammatory agents. Results regarding clinical efficacy were mixed for both groups and respective subcategories. Overall, no drug class produced robust benefits. Relapse was systematically reported in only one study, with low overall relapse rates (2.5%). Risk-of-bias assessment did not reveal significant methodological concerns, apart from high attrition (average 29.5%). Conclusions: Evidence for the long-term efficacy of add-on pharmacological treatments in SCZ is inconsistent, with no agent demonstrating reliable benefits. These findings raise concerns regarding long-term polypharmacy and also highlight the need for further investigations. Future studies should prioritize longer follow-up, relapse outcomes and realistic treatment patterns. Full article

Background: Faculty burnout in allied healthcare education institutions represents a significant challenge with implications for educational quality, organizational effectiveness, and healthcare workforce development. This scoping review aims to map the existing literature on the relationships between leadership approaches, faculty personality factors, and burnout within allied healthcare education, while examining digital competence as a potential moderating factor. Methods: This scoping review followed the PRISMA-ScR guidelines. Five electronic databases (MEDLINE, CINAHL, ERIC, PsycINFO, and Web of Science) were searched for relevant studies published between 2010 and 2024. Studies examining burnout among allied healthcare educators in relation to leadership, personality traits, or digital competence were included. Data extraction captured study characteristics, methodological approaches, key findings, and theoretical frameworks. Quality assessment was conducted using the Mixed Methods Appraisal Tool. Results: Sixteen studies met the inclusion criteria. Existing research indicates significant relationships between leadership styles and faculty burnout rates, with transformational leadership consistently associated with lower burnout scores. The literature reveals that individual personality traits demonstrate significant relationships with burnout vulnerability, with emotional stability and extraversion showing the strongest protective effects. Limited research has examined digital competence in relation to burnout, though emerging evidence suggests it may function as a moderating factor. Significant gaps exist in non-Western contexts and in understanding interaction effects between leadership, personality, and digital competence. Conclusions: The current literature supports the importance of leadership approaches that emphasize collaboration, faculty autonomy, recognition, and professional development opportunities in protecting against burnout in allied healthcare education settings. Digital competence represents a promising but understudied job resource that may mitigate burnout effects. Future research should explore cross-cultural variations, interaction effects between personal and organizational factors, and the effectiveness of interventions in reducing faculty burnout. Full article

Background: Within the framework of social cognition, conservatism can be conceptualized as a strategy for addressing fundamental psychological needs. Therefore, it is hypothesized that individuals with conservative orientations exhibit stronger reactions to perceived threats compared to their less conservative counterparts. Aim: To perform an exploratory scoping systematic review of existing literature examining behavioral, physiological, neurophysiological, and emotional responses associated with the relationship between conservatism and threat perception. Method: Following PRISMA guidelines, a systematic search was conducted using PubMed and Google Scholar primary databases, resulting in the inclusion of 19 relevant articles. Results: Approximately three-fifths (11 of 19 studies; 57.9%) provided empirical support for the hypothesis that conservatism is positively associated with threat sensitivity. These findings reveal a complex and nuanced relationship between conservatism and threat perception, with recent evidence—including large-scale longitudinal data and experimental manipulations of COVID-19–related threats—indicating weak or context-dependent associations. The overall pattern highlights substantial heterogeneity across methodological approaches, with mixed results particularly among physiological and priming studies. Conclusions: While the majority of evidence supports a relationship between political conservatism and threat sensitivity, the magnitude of this association appears modest, emphasizing the importance of considering moderating variables such as cultural context, the type of threat, and methodological variations in measurement in future research. Full article

Background/Objectives: According to recent literature, the prevalence and incidence of long-term illnesses such as asthma and diabetes in young people have substantially risen over the past 13 years. Recent figures indicate that, in England, 4.10% of all prescriptions were prescribed for young people. The aim of this study was to investigate young people’s perspectives of pharmaceutical services provided by primary care pharmacists relating to medication. Methods: A cross-sectional survey using both online and paper-based tools was conducted from March to November 2019. The population for this survey was young people from 18 to 24 years old registered as students at one of the universities in England. The survey consisted of twenty-four questions, and they were a mix of closed-ended questions, such as multiple-choice and Likert scales, and open-ended questions. Results: A total of 210 out of 800 survey responses were completed from different recruitment sources, achieving a response rate of 26.25%. Most participants were female (62.38%), and the most frequent age was 18 years (35.24%). Among participants, 15.70% were diagnosed with long-term illnesses, of which 33.33% were reported as the respiratory disease, asthma. Pharmacists were not utilised as a source of information for young people, with the majority (60.60%) obtaining information from their doctors. Most of the participants (96.97%) had not taken part in a Medicines Use Review (MUR) or New Medicine Service (NMS), and 78.79% were not aware of any services or support groups by their pharmacist. Among different healthcare professionals, GPs and hospital doctors were the most frequently reported to discuss with young people about their illnesses. Conclusions: There is an opportunity to further develop pharmaceutical services and support by primary care pharmacists for young people with long-term illnesses. Policymakers and primary care pharmacists in the future could utilise the perceptions and opinions of young people found in the current study to inform the development of primary care pharmacy services to meet young people’s needs and perceptions. These results are of benefit to policymakers in assisting in the development of pharmacy services. Further research will enhance understanding of the perceptions of young people about the pharmaceutical services offered by primary care pharmacists with respect to medications. Full article

Introduction: As the prevalence of Parkinson’s disease (PD) increases, care homes face growing challenges in managing residents’ complex mental health needs. Residents may experience low mood, anxiety, and hallucinations. Methods: A scoping review (ScR) was conducted following the methodological framework of Arksey and O’Malley and reported according to the PRISMA-ScR checklist. Four databases (CINAHL, Embase, PsycINFO, and Scopus) and grey literature sources were searched up to June 2025, alongside grey literature (European Public Health Association (EUPHA), the UK Department of Health and Social Care, the National Institute for Health and Care Excellence (NICE), and the World Health Organisation (WHO), with the aim of mapping the existing evidence on the mental health and well-being of people living with Parkinson’s disease in care homes, in order to identify gaps in the literature. Screening and data extraction were conducted independently by two reviewers using Covidence software, with discrepancies resolved through discussion. Results: Eleven studies met the inclusion criteria, encompassing quantitative, qualitative, and mixed-methods designs. The findings indicate that mental health disorders are common and severe among care home residents with PD; 61% of individuals experienced at least one, contributing to reduced quality of life, increased care dependency, emotional distress, and social isolation. Caregivers report significant burden associated with managing symptoms associated with mental health disorders and residents frequently experience a decline in psychosocial well-being. Conclusions: Although few studies evaluated interventions, the findings highlight the need for both pharmacological and non-pharmacological approaches. Specialised staff training and adherence to international care guidelines are needed to improve recognition and management of mental health needs in residents living with PD. Full article

Available reviews of the literature have failed to adequately address research on non-suicidal self-injury (NSSI) that has been conducted in developing countries, with the aim of this study being to systematically review empirical research on NSSI that has been conducted among adolescents and young adults living in countries located on the African continent. Guided by the Joanna Briggs Institute methodology for mixed methods systematic reviews, searches were conducted in six databases—PubMed, Scopus, PsychINFO, African Journals Online, African Index Medicus, and Sabinet African Journals—with searches being conducted from inception to 31 December 2024. These searches identified 33 unique records published in peer-reviewed journals or presented in postgraduate theses during the period 1985 to 2024; with the process of data synthesis identifying three broad analytic themes: the nature of NSSI, risk/protective factors associated with NSSI engagement, and the functions of NSSI. Key findings in relation to these themes: (1) highlight the value of an ethnomedical perspective in cross-cultural research on NSSI, and (2) suggest that the conventional focus on intrapersonal and proximal interpersonal influences on NSSI (in relation to both risk/resilience and NSSI functions) could usefully be extended to include influences emanating from the broader sociocultural context in which individuals are embedded. These findings are discussed in terms of their implications for future research. Full article

Background: Childhood Obesity is a significant and growing Public Health threat among Aboriginal and Torres Strait Islander (ATSI) children and adolescents in Australia. Health sectors in Australia have been focusing on health intervention programs across various states to prevent childhood obesity. This review aims to analyse the impact of obesity intervention programs conducted among children and adolescents of ATSI communities across Australia and report on the best practices for conducting future research. Objectives: This scoping review synthesised existing literature on the obesity prevention interventions programs among ATSI Children and Adolescents in Australia and examined their scope, implementation, and outcomes; evaluated their cultural appropriateness; and highlighted critical enablers and barriers. Methods: This scoping review analysed scholarly journal articles that reported on the findings of obesity intervention programs delivered across ATSI children and adolescents. Only Quasi-experimental and Randomized Control Trials (RCTs) were selected for the review. A full search has been carried out in Health databases such as Cochrane Library, Medline, PubMed, and ProQuest Central for the past 15 years. The framework of the Joanna Briggs Institute (JBI) for Scoping reviews was followed throughout this review. Results: Eleven studies met inclusion criteria. Findings were clustered into five themes: (i) community-led, systems-based interventions improved health behaviours and anthropometry; (ii) culturally tailored, community-embedded programs enhanced engagement and health literacy; (iii) early childhood and family-focused approaches showed promise; (iv) community or policy initiatives yielded mixed results; and (v) behavioural interventions were ineffective without addressing social and structural determinants. The most effective programs were community-delivered, multi-stakeholder, and centred on empowerment and capacity building. Conclusions: Obesity prevention efforts targeting Aboriginal and Torres Strait Islander children and adolescents are most successful when community-led, culturally grounded, and supported by multiple stakeholders. These findings underscore the necessity of culturally sensitive, participatory approaches. Further research is needed to strengthen the evidence base and inform sustainable, policy-relevant strategies for childhood obesity. Full article