Search Results (10)

Precise sculpturing of light empowers light with abundant phenomena across fundamental physics and practical applications. The emergence of metasurfaces provides a pivotal solution to the limitations of traditional optical components, which make it difficult to meet the integration requirements of diverse applications, and they are distinguished by their ultra-thin profiles, low optical losses, and high degree of controllability. In this paper, we elucidate the core physical principles to manipulate phase, amplitude, and polarization with meta-optic architecture, along with nonlocal effects. Specifically, we revisit the research progress and typical applications of meta-waveguides, meta-fibers, meta-lasers, meta-spectrometers, and meta-sensing. Finally, it looks forward to the future development direction of meta-optics in exploring the limits of light field control, chip-scale functional integration, and discovering new physical effects, providing theoretical and technical references for the development of metaphotonic devices. Full article

Background: Melanoma metastasis, driven by tumor microenvironment (TME)-mediated crosstalk facilitated by extracellular vesicles (EVs), remains a major therapeutic challenge. A critical barrier to clinical translation is the overlap in protein cargo between tumor-derived and healthy cell EVs. Objective: To address this, we developed Scaffold-free Functional Deconvolution (SFD), a novel computational approach that leverages a comprehensive healthy cell EV protein database to deconvolute non-oncogenic background signals. Methods: Beginning with 1915 proteins (identified by MS/MS analysis on an Orbitrap Fusion Lumos Mass Spectrometer using the IonStar workflow) from melanoma EVs isolated using REIUS, SFD applies four sequential filters: exclusion of normal melanocyte EV proteins, prioritization of metastasis-linked entries (HCMDB), refinement via melanocyte-specific databases, and validation against TCGA survival data. Results: This workflow identified 21 high-confidence targets implicated in metabolic-associated acidification, immune modulation, and oncogenesis, and were analyzed for reduced disease-free and overall survival. SFD’s versatility was further demonstrated by surfaceome profiling, confirming enrichment of H7-B3 (CD276), ICAM1, and MIC-1 (GDF-15) in metastatic melanoma EV via Western blot and flow cytometry. Meta-analysis using Vesiclepedia and STRING categorized these targets into metabolic, immune, and oncogenic drivers, revealing a dense interaction network. Conclusions: Our results highlight SFD as a powerful tool for identifying clinically relevant biomarkers and therapeutic targets within melanoma EVs, with potential applications in drug development and personalized medicine. Full article

The microwave spectrum of 3,5-dimethylanisole was recorded using a pulsed molecular jet Fourier transform microwave spectrometer, covering the frequency range from 2.0 to 26.5 GHz. Splittings from internal rotations of the syn-m and anti-m-methyl groups were observed, analyzed, and modeled using the XIAM and the ntop programs for a data set including 622 rotational lines. The torsional barriers of the syn-m and anti-m-methyl groups were determined to be 58.62367(53) cm⁻¹ and 36.28449(69) cm⁻¹, respectively. The low barriers to internal rotation of both methyl groups posed significant challenges for spectral analysis and modeling. The successful assignment was achieved using combination difference loops and separately fitting the five torsional components. Comparing the torsional barriers observed in various toluene derivatives with methyl groups at meta-positions supports the assumption that electrostatic effects contribute more significantly than steric effects in the low-barrier cases of aromatic molecules. Full article

In this paper, a design method of diffraction structure based on metasurface is proposed for light splitting and focusing simultaneously. In the method, firstly, the light field calculation model of the proposed structure is established based on Fresnel diffraction and the transmittance function is calculated. Then, the model structural parameter selection mechanism is determined, and the spectrum resolution equation of the structure is derived. Simulation results indicate that the proposed method can offer a broader working bandwidth and enhanced higher resolution compared to off-axis meta-lens. Moreover, this proposed method can be deployed in high-resolution, wide-band ultra-compact spectrometer systems potentially. Full article

Monomers of meta-fluorophenol (mFP) were trapped from the gas phase into cryogenic argon and nitrogen matrices. The estimated relative energies of the two conformers are very close, and in the gas phase they have nearly equal populations. Due to the similarity of their structures (they only differ in the orientation of the OH group), the two conformers have also similar predicted vibrational signatures, which makes the vibrational characterization of the individual rotamers challenging. In the present work, it has been established that in an argon matrix only the most stable trans conformer of mFP exists (the OH group pointing away from the fluorine atom). On the other hand, the IR spectrum of mFP in a nitrogen matrix testifies to the simultaneous presence in this matrix of both the trans conformer and of the higher-energy cis conformer (the OH group pointing toward the fluorine atom), which is stabilized by interaction with the matrix gas host. We found that the exposition of the cryogenic N₂ matrix to the Globar source of the infrared spectrometer affects the conformational populations. By collecting experimental spectra, either in the full mid-infrared range or only in the range below 2200 cm⁻¹, we were able to reliably distinguish two sets of experimental bands originating from individual conformers. A comparison of the two sets of experimental bands with computed infrared spectra of the conformers allowed, for the first time, the unequivocal vibrational identification of each of them. The joint implementation of computational vibrational spectroscopy and matrix-isolation infrared spectroscopy proved to be a very accurate method of structural analysis. Some mechanistic insights into conformational isomerism (the quantum tunneling of hydrogen atom and vibrationally-induced conformational transformations) have been addressed. Finally, we also subjected matrix-isolated mFP to irradiations with UV light, and the phototransformations observed in these experiments are also described. Full article

Metasurfaces have gained growing interest in recent years due to their simplicity in manufacturing and lower insertion losses. Meanwhile, they can provide unprecedented control over the spatial distribution of transmitted and reflected optical fields in a compact form. The metasurfaces are a kind of planar array of resonant subwavelength components that, depending on the intended optical wavefronts to be sculpted, can be strictly periodic or quasi-periodic, or even aperiodic. For instance, gradient metasurfaces, a subtype of metasurfaces, are designed to exhibit spatially changing optical responses, which result in spatially varying amplitudes of scattered fields and the associated polarization of these fields. This paper starts off by presenting concepts of anomalous reflection and refraction, followed by a brief discussion on the Pancharatanm–Berry Phase (PB) and Huygens’ metasurfaces. As an introduction to wavefront manipulation, we next present their key applications. These include planar metalens, cascaded meta-systems, tunable metasurfaces, spectrometer retroreflectors, vortex beams, and holography. The review concludes with a summary, preceded by a perspective outlining our expectations for potential future research work and applications. Full article

The Gaudeanmus area is located at the southern Central Zone of the Damara orogenic belt in south-western Africa. In this paper, we investigate the whole rock major and trace element compositions and Sr–Nd–Pb isotopic compositions of the biotite granite, and determine the age of the samples utilising U–Pb zircon dating methods. Our results provide an LA–collector inductively plasma mass spectrometer (ICP–MS) zircon U–Pb age for the biotite granite of 540 ± 4 Ma (i.e., earliest Cambrian). The biotite granites show the characteristics of metaluminous compositions belonging to high-K calc–alkaline to shoshonite series. The granites contain high alkali and rare earth elements (REE), are enriched in large-ion lithophile elements (Rb, K, Pb), and depleted in high field-strength elements (Nb, Ta, Ti). The REE patterns are characterised by enrichment of LREEs relative to HREEs and medium negative Eu anomalies in the chondrite-normalised REE diagram. These rocks have high initial ⁸⁷Sr/⁸⁶Sr ratios (0.71400–0.71768); low εNd(t) value (−12.0 to −7.1); Sm–Nd isotope crust model ages ranging from 1711 to 2235 Ma; and large variations in ²⁰⁶Pb/²⁰⁴Pb (18.0851–19.2757), ²⁰⁷Pb/²⁰⁴Pb (15.6258–15.7269), and ²⁰⁸Pb/²⁰⁴Pb ratios (38.7437–40.5607). Such geochemical signatures indicate that the biotite granite rocks derive mainly from partial melting of ancient crustal rocks resembling the local basement meta-sedimentary rocks. However, minor mantle-derived materials may have also been involved in the formation of these rocks. Combining with regional tectonic evolution, we consider that the biotite granite intrusions in the Gaudeanmus area formed in a transitional tectonic regime that went from compressional to extensional tectonics. Full article

As a high-temperature sorbent, kaolinite undergoes the flash calcination process in the furnace resulting in the dehydroxylation and structural distortion, which are closely related to its heavy metal/alkali metal adsorption characteristics. We investigated the flash calcination of kaolinite by the experiments using a drop tube furnace and by the characterization of flash-calcined products using thermogravimetric-differential scanning calorimeter (TG-DSC), X-ray diffraction (XRD), Fourier Transform Infrared Spectrometer (FTIR)and nuclear magnetic resonance (NMR). There were three kinds of hydroxyl groups in kaolinite during flash calcination at 800–1300 °C, E-type (~50%, easy), D-type (~40%, difficult) and U-type (~10%, unable) according to the removal difficulty. The hydroxyl groups activation was believed to be the first step of the removal of E-type and D-type hydroxyl groups. The kinetics model of dehydroxylation groups at 900–1200 °C was established following Arrhenius equation with the activation energy of 140 kJ/mol and the pre-exponential factor of 1.32 × 10⁶ s⁻¹. At 800 °C, the removal of E-type hydroxyl groups resulted in the conversion of a part of VI-coordinated Al in kaolinite to V-coordinated Al and the production of meta-kaolinite. When the temperature rose up to 1200 °C, mullite was produced and a part of V-coordinated Al converted to IV-coordinated Al and VI-coordinated Al. Finally, the adsorption characteristics of kaolinite was discussed according to the results of dehydroxylation and structural distortion. Full article

Ultra-compact spectrometers with high-resolution and/or broadband features have long been pursued for their wide application prospects. The off-axis meta-lens, a new species of planar optical instruments, provides a unique and feasible way to realize these goals. Here we give a detailed investigation of the influences of structural parameters of meta-lens-based spectrometers on the effective spectral range and the spectral resolution using both wave optics and geometrical optics methods. Aimed for different usages, two types of meta-lens based spectrometers are numerically proposed: one is a wideband spectrometer working at 800–1800 nm wavelengths with the spectral resolution of 2–5 nm and the other is a narrowband one working at the 780–920 nm band but with a much higher spectral resolution of 0.15–0.6 nm. The tolerance for fabrication errors is also discussed in the end. These provides a prominent way to design and integrate planar film-based spectrometers for various instrumental applications. Full article

In order to comprehensively utilize coal gangue, we present fluidized calcination as a new thermal technology for activating coal gangue and systematical study was conducted in comparison with static calcination. The calcined products obtained by different calcination methods under various temperatures were characterized by the means of X-ray diffraction (XRD), thermal gravimetry-differential scanning calorimeter (TG-DSC), Fourier transform-infrared spectroscopy (FT-IR) and scanning electron microscope-energy dispersive spectrometer (SEM-EDS). Chemical and physical characteristics such as aluminium leaching rate, chemical oxygen demand and whiteness of calcined products were also investigated. The results show that aluminium leaching rate could reach to the maximal value 74.42% at 500 °C by fluidized calcination, while the maximal value of 66.33% could be reached at 600 °C by static calcination. Products by fluidized calcination obtained higher whiteness and lower chemical oxygen demand (COD) under the same calcination temperature. The well-crystallized kaolinite transform to amorphous meta-kaolinite under 600 °C and mullite presence under 1000 °C according to phase transformation, chemical bond variation and microstructure evolution analysis. Fluidized calcination was more efficiently for combustion of carbon/organic matter and dehydroxylation of kaolinite, which might applied in coal gangue industry in future. Full article