Search Results (67)

Background: Increased placental thickness has been associated with adverse perinatal outcomes and fetal functional and structural abnormalities. However, whether marked third-trimester placental thickening is associated with a distinct maternal clinical profile compared with pregnancies with normal placental thickness remains insufficiently characterized. This study aimed to compare maternal characteristics, comorbidities, medication exposure, infection history, and fetal findings between pregnancies with marked placental thickening, defined as placental thickness ≥70 mm, and gestational-age-matched control pregnancies with a placental thickness <70 mm and no documented maternal or fetal abnormalities. Methods: This retrospective matched case–control study included singleton pregnancies referred for fetal echocardiography to a tertiary referral center in Łódź, Poland, between 1 January 2022 and 14 March 2025. Placental thickness was measured sonographically in a perpendicular plane from the chorionic plate to the basal plate, excluding the umbilical cord insertion site. Only anterior and/or fundal placentas assessed at ≥28 weeks of gestation were included. Among pregnancies with recorded third-trimester placental thickness measurements, 99 cases with placental thickness ≥70 mm were identified as the thick-placenta group. A control group of 99 pregnancies with placental thickness <70 mm was selected and matched for gestational age. Control pregnancies had no documented maternal disease, no fetal structural or functional abnormalities, and no exposure to the medications analyzed in this study. Maternal demographic characteristics, body mass index, comorbidities, infection history, obstetric history, and medication use were compared between groups. Continuous variables were compared using Welch’s t-test and the Mann–Whitney U test, and categorical variables were compared using Fisher’s exact test. Results: The study included 99 pregnancies with marked placental thickening and 99 control pregnancies with normal placental thickness. Gestational age at examination was comparable between groups, with a mean of 35.5 weeks in controls and 35.0 weeks in the thick-placenta group (p = 0.662, Welch’s t-test). Median gestational age was also not significantly different between groups (35.4 vs. 36.43 weeks; p = 0.340, Mann–Whitney U test). Mean placental thickness was significantly greater in the thick-placenta group than in controls (81.4 mm vs. 46.9 mm; p < 0.0001). Maternal age and anthropometric characteristics were comparable between groups, whereas BMI > 25 kg/m² was more common in the thick-placenta group. In contrast to the clinically healthy control group, maternal infection was documented in 100.0% of thick-placenta cases, hormonal treatment in 97.0%, history of COVID-19 in 52.5%, hypothyroidism in 44.4%, prior miscarriage in 37.4%, aspirin or anticoagulant use in 32.3%, gestational diabetes mellitus in 25.3%, and pregnancy-induced hypertension in 7.1%. All evaluated maternal clinical factors were significantly more common in the thick-placenta group than in controls. Fetal cardiac or extracardiac dysfunction was present in 68.7% of thick-placenta pregnancies. Conclusions: In this gestational-age-matched case–control study, pregnancies with marked third-trimester placental thickening showed a distinct maternal profile compared with healthy controls with normal placental thickness. Despite comparable gestational age, maternal age, and maternal anthropometric characteristics, the thick-placenta group demonstrated a significantly higher infectious, hormonal, metabolic, and endocrine burden. These findings indicate that, in this selected tertiary referral cohort, placental thickness ≥70 mm was associated with a higher burden of maternal clinical abnormalities and fetal functional findings. Rather than representing an independent marker of placental maladaptation or maternal-fetal risk, marked placental thickening should be interpreted as a clinically relevant ultrasound finding that may prompt careful review of maternal history and targeted fetal assessment. Prospective studies are needed to determine which maternal factors are independently associated with placental thickening and to clarify their relationship with fetal function and perinatal outcomes. Full article

Background: Sleep disturbance and psychosocial stress are emerging contributors to hypertensive disorders of pregnancy. The present cohort was recruited during the COVID-19 period, a time marked by substantial changes in prenatal care delivery, social support, and daily routines, which may have influenced maternal sleep and stress burden. Objective: This study aimed to evaluate the independent and integrated associations between maternal sleep quality, psychological stress, and pregnancy outcomes in women at moderate to high risk for preeclampsia. Methods: In a single-center observational cohort of 170 pregnant women enrolled at 16 weeks’ gestation, sleep was assessed using the Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), and Fitbit Sense 2™ wearable data, while stress was measured through the Perceived Stress Scale (PSS-10), Generalized Anxiety Disorder-7 (GAD-7), and morning salivary cortisol. Associations with preeclampsia, birth weight, gestational age, and NICU admission were analyzed using multivariate regression and receiver operating characteristic (ROC) models. The COVID-19 period was treated as the contextual background of recruitment rather than as a directly compared exposure. Results: Poorer subjective sleep quality (higher PSQI) correlated negatively with birth weight (r = −0.34, p = 0.008) and gestational age (r = −0.28, p = 0.04). Elevated morning cortisol was significantly associated with NICU admission (r = 0.28, p = 0.002). The combined sleep + stress model predicted birth weight (R² = 0.26, p = 0.003) and preeclampsia (pseudo R² = 0.15, p = 0.015) more accurately than individual domains, achieving an ROC-AUC of 0.86 (95% CI: 0.78–0.92). Conclusions: In high-risk pregnancies, integrated evaluation of sleep and stress parameters may improve the prediction of fetal growth impairment and preeclampsia beyond single-domain models. These findings support the incorporation of psychosocial and behavioral markers into antenatal risk stratification. Because no pre-pandemic or post-pandemic comparator group was included, the COVID-19 period should be interpreted as the contextual background of the study rather than as an independently tested exposure. Full article

Pregnancy represents a distinct immunological and physiological state that modifies maternal susceptibility to SARS-CoV-2 and influences the clinical and biological course of COVID-19. Accumulating evidence indicates that the interaction between viral entry determinants, gestation-specific immune modulation, placental endocrine–angiogenic pathways, and systemic inflammatory responses underlies the characteristic manifestations of SARS-CoV-2 infection during pregnancy. This review consolidates current understanding of SARS-CoV-2 viral structure, receptor biology, and the gestational regulation of key entry cofactors, including ACE2, TMPRSS2, NRP1, CTSL and FURIN, within reproductive and placental tissues. The review further integrates documented mechanisms of cytokine-mediated immune dysregulation, endothelial injury, thrombo-inflammation, and steroidogenic alteration observed in affected pregnancies, and examines their contribution to placental malperfusion, preeclampsia-like presentations, fetal growth abnormalities and preterm birth. Published molecular and computational studies characterising trophoblast antiviral defenses, receptor expression patterns, and structural determinants of Spike–ACE2 affinity are synthesised to contextualise the biological basis of placental susceptibility and the rarity of confirmed transplacental transmission. Current evidence on maternal clinical outcomes, fetal and neonatal consequences, vaccination efficacy, therapeutic considerations and contemporary management guidelines is also critically reviewed. By integrating molecular, immunological, pathological and clinical insights, this article provides a comprehensive framework for understanding the interaction between SARS-CoV-2 infection and pregnancy-specific physiology, with implications for risk assessment, preventive strategies and maternal–fetal care. Full article

Pertussis, caused by Bordetella pertussis, remains a public health concern despite long-standing vaccination programs. After a marked decline during the COVID-19 pandemic, a resurgence was observed in Europe and Italy, with a sharp increase in 2024. This study describes pertussis epidemiological trends in the Tuscany Region (Italy) from 2019 to 2024 to identify high-risk groups and inform prevention strategies. A retrospective population-based analysis was conducted using cases reported to the national surveillance system (PREMAL). Incidence rates were calculated using ISTAT population data, and demographic, temporal, and clinical characteristics were analyzed. Overall, 669 cases were reported (mean annual incidence rate: 3.03/100,000 (IC 95% 2.47–3.59; period incidence rate: 18.2/100,000 (IC 95% 16.81–19.56)), with 89% occurring in 2024 (16.34/100,000 (IC 95% 15.03–17.65)). No sex differences were observed, and most cases were reported in Central Tuscany (64%). Children under 15 years accounted for 87% of cases. The highest incidence was observed among 10–14-year-olds, while infants < 1 year, particularly those under 4 months, showed the highest burden in narrower age strata. Hospitalizations occurred in 12.6% of cases, decreasing substantially in 2024. The 2024 resurgence likely reflects waning immunity, disruptions to routine vaccinations during the pandemic, and reduced pathogen circulation in previous years due to containment and isolation measures related to the pandemic. Strengthening surveillance and improving booster and maternal vaccination coverage are essential to protect vulnerable populations. Full article

Background: Readmission of newborns within the first 28 days after initial discharge represents a significant healthcare concern, causing distress to families and financial burden on healthcare systems. Understanding readmission patterns and risk factors is essential for implementing preventive strategies. Objective: This retrospective observational study aimed to evaluate the prevalence and characteristics of neonatal readmissions to a pediatric center in Ploiești, Romania, during a 12-month period (1 January 2024–31 December 2024). Methods: We reviewed medical records of all newborns aged 0–28 days admitted to the pediatric hospital after initial discharge from maternity wards. Clinical characteristics, diagnoses, paraclinical findings, and demographic data were analyzed. Results: A total of 131 newborns were readmitted, representing a 1.9% readmission rate, and only the first readmission for each patient was included in the analysis. The majority (60.9%) presented with preventable infectious pathology, including bronchiolitis (18.3%), rhinoconjunctivitis (16%), pyoderma (11.4%), infectious gastroenteritis (8.4%), and COVID-19 infection (6.8%). Males comprised 61.3% of cases, and 74.8% were born via cesarean section. Exclusive breastfeeding rate was 45.8%. Concerningly, two cases (1.5%) presented with measles, reflecting declining vaccination coverage in Romania (the lowest in the European Union at 62%). Conclusions: The predominance of preventable infectious conditions among neonatal readmissions highlights critical gaps in post-discharge care and infection prevention education. The presence of vaccine-preventable diseases underscores the urgent need to address declining immunization rates in Romania. Enhanced parental education on hygiene practices, infection prevention, and improved post-discharge follow-up systems are essential to reduce neonatal morbidity and readmission rates. Full article

Background: Postnatal bonding reflects the early emotional relationship between a mother and her infant and is shaped by psychological and perinatal factors. This study examined associations between postnatal bonding and maternal depressive symptoms, resilience, labor anxiety, and sociodemographic and health-related variables, as well as anxiety related to the COVID-19 pandemic, the war in Ukraine, and global events. Methods: This prospective cohort study included and followed 150 pregnant women in Poland from pregnancy to 12 months postpartum. Assessments were conducted during pregnancy and at 4–6 weeks, 6 months, and 12 months after delivery. Postnatal bonding was assessed using the PBQ, depressive symptoms with the EPDS, labor anxiety with the LAQ, resilience with the KOP-26, and anxiety related to external stressors with study-specific questionnaires. Non-parametric analyses were performed with a significance level of p < 0.05. Results: Postnatal bonding difficulties were most prevalent at 4–6 weeks postpartum (26.1%) and decreased over time. Maternal depressive symptoms showed the strongest and most consistent associations with bonding difficulties, whereas higher resilience, particularly in family relations and social competence, was associated with better bonding outcomes. Labor anxiety was weakly associated with bonding only in the early postpartum period, while no associations were found with sociodemographic characteristics or anxiety related to external societal stressors. Conclusions: Maternal depressive symptoms and resilience emerged as the key factors associated with postnatal bonding quality, highlighting their importance as targets for early identification and intervention. Full article

Background: Women are at increased risk of developing severe morbidity and mortality during pregnancy, childbirth, and the puerperium, especially in developing countries. In Mexico, during 2020, 27.5% of maternal deaths were attributed to COVID-19. The aim of this study was to describe the sociodemographic and clinical characteristics of maternal deaths among patients with and without COVID-19 in the state of Tamaulipas. Materials and Methods: A non-probabilistic sampling approach was used in this observational, cross-sectional, descriptive, retrospective study of obstetric patients. Results: One hundred and six obstetric patient records were evaluated. Eleven patients died directly from COVID-19 complications. The mean age of the population was 29.5 years, with 7.54% suffering from type 2 diabetes mellitus and 5.66% systemic arterial hypertension. Obstetric complications were late surgical puerperium (11.32%), physiological puerperium (9.43%), and obstetric hemorrhage (7.54%). Lung complications were community-acquired pneumonia (20.75%), of which 50% were due to COVID-19 (10.37%) and respiratory distress syndrome (15.09%). Systemic complications were hypovolemic shock (16.98%), septic shock (15.09%), and multiple organ failure (12.26%). Conclusions: Mortality from COVID-19 in obstetric patients was 10.37%, and 89.63% died from gynecological, lung, and systemic complications. Full article

Background/Objectives: Exclusive breastfeeding (EBF) during hospitalization is essential for infant health but remains suboptimal in many Gulf Cooperation Council (GCC) countries. Maternal factors and the COVID-19 pandemic may have influenced breastfeeding practices. Understanding these determinants is crucial for improving postnatal care. This study aimed to identify determinants of breastfeeding practices during hospitalization before and during the COVID-19 pandemic in Bahrain. Methods: This retrospective cohort study reviewed electronic records of 321 mothers and their newborns discharged between March 2019 and March 2021 from a larger pool of 4500 cases. A structured data collection form was used to capture maternal age, parity, nationality, mode of delivery, COVID-19 period of delivery (pre-pandemic vs. pandemic), breastfeeding method, and reasons for mixed feeding. Descriptive and inferential statistical analyses were conducted to identify associations between variables. Results: Multiparous mothers had significantly higher exclusive breastfeeding rates than primiparous mothers (p = 0.016). The mode of delivery showed a strong association with breastfeeding outcomes, with vaginal births linked to higher EBF rates (p < 0.01). A notable decline in EBF was observed during the COVID-19 pandemic period, from 40% pre-pandemic to 14% during the pandemic. Conclusions: Exclusive breastfeeding during hospitalization is significantly influenced by delivery method and maternal parity. Although the COVID-19 pandemic may have contributed to reduced EBF rates, further research is required to validate these trends. These findings emphasize the importance of supportive hospital policies, particularly for first-time and cesarean mothers, and stress the need to strengthen breastfeeding practices during public health emergencies. Full article

The effects of the COVID-19 pandemic restricted the availability of healthcare and social services. This retrospective study reports WIC enrollment rates and presents descriptive data on prenatal care access and selected maternal health conditions among pregnant women in Florida before and during the COVID-19 pandemic. Using birth data linking maternal and infant characteristics from the Florida Department of Health Bureau of Vital Statistics, we examined birth records from 1 January 2019 to 31 December 2020 related to women ranging from 11 to 59 years of age who received WIC. The descriptive results show that WIC recipients had higher rates of inadequate prenatal care and adverse maternal health outcomes during the pandemic. Logistic regression results show that the odds of receiving inadequate prenatal care increased by 24% (OR = 1.24, p < 0.001), the odds of experiencing gestational diabetes by 9% (OR = 1.09, p < 0.001), and the odds of experiencing gestational hypertension by 10% (OR = 1.10, p < 0.001). Further research is needed to evaluate how specific WIC services influence maternal outcomes, particularly during public health emergencies. Full article

Measles remains a major public health issue, particularly among paediatric populations who are unvaccinated or lack of maternal antibody transfer. Although the majority of cases manifest with moderate clinical forms, certain patient categories are at risk for severe disease progression. This study aims to describe the clinical and epidemiological characteristics of paediatric measles cases hospitalized in the Paediatric Departments of the “Prof. Dr. Matei Balș” National Institute of Infectious Diseases, Bucharest, Romania during two distinct epidemic waves: 2017–2019 and 2023–2024. A retrospective analysis evaluated mortality rates, distribution by age and sex, as well as clinical disease patterns. The 2023–2024 measles epidemic was marked by a higher number of paediatric cases (3.114 vs. 1.068), a lower mortality rate (0.32% vs. 3.74%), a shift towards older age groups, and a greater frequency of complications—particularly gastrointestinal, haematological, and ophthalmological—compared to the 2017–2019 wave. The findings underscore the urgent need for strengthened vaccination programs and targeted public health interventions, particularly among vulnerable groups and patients at risk of developing severe forms of the disease. Owing to a sustained decline in measles vaccination coverage among the paediatric population, Romania has experienced two major measles outbreaks within the past decade, interrupted by the COVID-19 pandemic. This study draws attention to the increasing incidence of measles in older children, suggesting a cumulative effect of reduced immunization rates over time. Full article

Early caregiving can evoke feelings of helplessness in mothers that are potentially associated with disintegrative responses, i.e., intrusive thoughts and dissociative experiences in the context of infant care. Given the associated increase in stress and exposure to life-threatening dangers, crises such as pandemics and wars may intensify these responses, but this has not previously been tested. Objectives: This cross-sectional study aimed to (1) examine maternal disintegrative responses across three contexts—a high-intensity phase of the COVID-19 pandemic, a subsequent low-intensity pandemic period, and the Israel–Hamas war—and (2) compare the two crisis periods in terms of trauma-related exposure, a damaged experience of childbirth and childcare, and their links to disintegrative responses. Method: This study had two parts and was conducted among Israeli mothers. Part 1 involved 1416 mothers across three groups: high-intensity pandemic (N = 637), low-intensity pandemic (N = 360), and war (N = 419). Part 2 involved a subsample from Part 1 comparing the 1056 mothers from the high-intensity pandemic and war groups. All the participants completed questionnaires assessing maternal disintegrative responses, trauma-related exposure, and a damaged experience of childbirth and childcare. The analyses included ANOVA and mediation models, controlling for maternal characteristics. Results: Intrusive thoughts and dissociative experiences were significantly higher during both the high-intensity pandemic and war periods compared to the low-intensity pandemic period. Trauma exposure indirectly predicted intrusive thoughts and dissociative experiences through a damaged experience of childbirth and childcare, particularly during war. Conclusions: The findings indicate that maternal disintegrative responses were higher during high-intensity crisis contexts, with the highest levels reported by mothers during the war. Trauma exposure and a damaged experience of childbirth and childcare were associated with more intrusive thoughts and dissociative experiences, underscoring the need for targeted support to protect maternal well-being and caregiving during crises. Full article

Objectives: The hospital organizational model can have an impact on people’s health. A critical lesson can be drawn from the pandemic. The possible negative sequelae of the practice of separation of maternal–infant dyads adopted during an infant’s first SARS-CoV-2 pandemic infection on infants have not been considered. Our purpose was to investigate the short- and long-term effects on neonates born to SARS-CoV-2 infected mothers of two different mother–infant dyad management strategies after birth (Separation vs. Rooming-In). Methods: This prospective cohort study enrolled 60 pregnant women who tested positive for SARS-CoV-2 infection and their newborns. We identified two cohorts of study based on mother–infant dyad management after delivery: Cohort A (Separation) and Cohort B (Rooming-In). Inclusion criteria were neonates born from mothers infected with SARS-CoV-2 during the pregnancy undergoing or not undergoing separation. Main Outcome: Rate of exclusive breastfeeding at 6 months of age was the primary outcome. The rate of mother–infant transmission of SARS-CoV-2 infection, growth, incidence of acute infections and neurodevelopment up to 12 months of life were also evaluated. Results: In total, 60 mother–infant dyads (maternal age 30.6 vs. 33.8 years, p = 0.335; gestational age 39.0 vs. 38.9 weeks, p = 0.451) were enrolled at delivery, and 53 dyads completed the study at the 6-month follow-up. Baseline clinical characteristics were similar between the two cohorts. At 6-month follow-up, the rate of breastfeeding was significantly decreased in Cohort A compared with Cohort B (4% vs. 46%, p < 0.001). The rate of SARS-CoV-2 infection was similar between the two cohorts of the study. Weight gain at 6 months of life was significantly higher in Cohort A compared to Cohort B (8129 g, 95% CI, 7562 to 8695; vs. 7393 g, 95% CI, 6912 to 7874; p = 0.005). No differences were detected in terms of rate of acute neonatal infections and neurodevelopment outcomes. Conclusions: The separation practice led to a reduction in the rate of breastfeeding after discharge and to a consequently increased implementation of formula milk, which might justify the alarming increased weight gain of newborns who did not undergo the Rooming-In practice. Given the potential of recurrent outbreaks of other viral pandemics, our results suggest more caution early in life towards the disruption of consolidated procedures that may have long-term consequences. However, the COVID-19 pandemic offered a unique context to observe the effects of temporary mother–infant separation; clinicians should be reassured that the temporary separation practice did not affect neurodevelopment and be aware that it could be considered an option, at least if Rooming-In cannot be carried out due to severe reasons such as lack of staff or adequate space. Full article

Background: COVID-19 is linked to multiple adverse pregnancy outcomes but with inconsistent evidence associating the disease with fetal growth restriction (FGR) and small for gestational age (SGA). There are limited data on the impact of COVID-19 on neonatal growth measurements, specifically microcephaly without SGA or low birth weight. We hypothesize that COVID-19 is associated with smaller neonatal head measurements without increasing the risk of small for gestational age. This relationship may be related to the timing of COVID-19 exposure in pregnancy. Methods: An Institutional Review Board (IRB) approved retrospective cohort study enrolled 140 COVID-19-infected and 136 COVID-19-uninfected patients. Inclusion criteria: (a) singleton birth between 28 April 2020 and 31 December 2022; and (b) maternal COVID-19 infection diagnosed via polymerase chain reaction (PCR). Exclusion criteria: Less than 12 years of maternal age, major fetal anomalies, and fetal loss < 15 weeks. The outcomes were a comparison of newborn growth measurements (length, weight, and head circumference (HC) at birth), Ponderal Index (PI), and development of SGA between SARS-CoV-2-infected and uninfected patients. Maternal and neonatal characteristics were descriptively summarized, and multivariate analyses and linear regression models were performed. Baseline maternal demographics did not differ amongst cohorts. Results: Compared to the uninfected cohort, COVID-19 diagnosed in the third trimester was associated with a lower neonatal HC compared to newborns of uninfected patients (β = −0.38 [0.38 SD lower], 95% CI −0.65 to −0.10, p = 0.024). There was no significant difference among cohorts in birth length, weight, or diagnosis of small for gestational age. Conclusions: We found that COVID-19 infection in the third trimester was associated with a lower neonatal head circumference without associated SGA. The cause underlying this association is unknown. Further research to determine the risk of neurotropic fetal infection by SARS-CoV-2, like ZIKA’s effect on the fetal immune system leading to microcephaly, is urgently needed. Full article

Background: The impact of the SARS-CoV-2 viral infection during pregnancy on the fetus can be direct—transmitted through the placenta—and indirect—creating unfavorable conditions for the development of the fetus because of inflammation, micro-thrombosis, and hypercoagulation. Our study aimed to determine the types and frequency of pathohistological changes in placental tissue in SARS-CoV-2-positive pregnant women and to examine the possible role of oxidative stress in the prognosis of the delivery and its maternal and fetal complications. Methods: This prospective clinical study included 50 pregnant women divided into two groups, SARS-CoV-2 positive (COVID-19 group) and SARS-CoV-2 negative (control group), from who we collected demographic, clinical, obstetric, biochemical and pathologic data. Data about the newborn characteristics were also collected, which included anamnestic, clinical, and biochemical data. Results: The values of the superoxide anion radical and index of lipid peroxidation were significantly different in mothers concerning the presence of the SARS-CoV-2 infection, while the levels of the nitric oxide, index of lipid peroxidation, reduced glutathione, and superoxide dismutase were significantly different in the newborns depending on the SARS-CoV-2 infection. Newborn characteristics were similar between groups except for concentrations of IgM antibody. The incidence of pathohistological changes of the FVM type in the COVID-19 group of pregnant women was 46%, while in the control group, the incidence was 18%. Conclusions: This study confirmed the significant impact of the SARS-CoV-2 viral infection on maternal and fetal biochemical parameters and oxidative stress-mediated placental dysfunction. Future studies should be performed with more participants and follow-up neonatal development. Full article

Background/Objectives: Venous thromboembolism (VTE) is related to maternal mortality, especially after the coronavirus disease (COVID-19) pandemic. The Royal College of Obstetricians and Gynecologists (RCOG) guidelines’ risk assessment score has been established to reduce thrombotic complications during pregnancy. Recently, it was found that the soluble fibrin monomer complex (SFMC) could be an alternative to D-dimer (DD), which has been used to assess the risk of VTE. This study aims to reveal the difference between FM and DD concentrations in low- and high-VTE-risk groups according to the RCOG’s guidelines. Method: This observational study was conducted at the Department of High-Risk Pregnancy, Tu Du Hospital, Vietnam between August 2023 and April 2024. This study enrolled 100 pregnant women beyond 28 weeks of gestation at low risk (≤2 points) and high risk (≥3 points) of VTE assessment following the RCOG guidelines’ score. Blood samples were collected for the SFMC and DD tests before delivery. Statistical tests were used to compare the difference in SFMC and DD concentrations between the two groups. A p-value < 0.05 is considered statistically significant. Results: We found no significant difference in DD and SFMC tests between low and high VTE risk (1.61 [1.30–2.30] vs. 1.51 [0.91–2.13]; 5.00 [1.36–9.78] vs. 3.74 [1.28–14.63], respectively; p > 0.05). The length of hospital stay in the high-risk group is longer than that of the low-risk group and involves postpartum infection. In addition, we found no significant correlation between the gestational age and SFMC or DD concentration. However, a moderate positive correlation between the two tests was found. Similarly, no significant correlation between the VTE score and SFMC or DD concentration was found in the present study. Conclusions: The soluble fibrin monomer complex and D-dimer tests are not significantly different between low-risk and high-risk groups determined through VTE evaluation before delivery according to the RCOG guidelines. The fibrin-linked tests need to be individualized and applied among pregnant women with higher scores of VTE risk based on maternal and pregnancy characteristics during antenatal care. Further studies with a larger number of participants are required to strengthen the findings. Full article