Search Results (1,182)

Per- or polyfluoroalkyl substances (PFASs) are man-made compounds involved in compositions of many industrial processes and consumer products. The largest-volume man-made PFAS are made up of refrigerants and fluoropolymers. Major concerns for our society related to these substances are their contribution to global warming as greenhouse gasses and the potential for adverse effects on living organisms, particularly by long-chain perfluoroalkyl acid derivatives. Restrictions on manufacturing and applications will increase in the near future. The full remediation of historical and current contaminations of air, soil and water remains problematic, especially for ultra-short PFASs, such as trifluoroacetic acid. Future monitoring of PFAS levels and their impact on ecosystems remains important. PFASs have become integrated in the lifestyle and infrastructures of our modern worldwide society and are likely to be part of that society for years to come in essential applications by closing the fluorine loop. Full article

Anthropogenic noise can have diverse effects on natural ecosystems, but less is known about the degree to which noise can alter organisms in comparison to other disturbances. A variety of frequencies are produced by man-made objects, ranging from high to low frequencies, and we studied infrasound (<20 Hz) produced by wind turbines and trains. We estimated the number, mass and viability of seeds produced by flowers of Plains pricklypear (Opuntia polyacantha Haw.) that were left open to pollinators, hand-pollinated or bagged to exclude pollinators. Each pollination treatment was applied to plants at varying distances from wind turbines and railways (≤25 km). Self-pollinated Opuntia polyacantha and plants within the wind facility produced ≥1.6 times more seeds in the bagged treatments compared to more distant sites. Seed mass and the percent of viable seeds decreased with distance from infrasound. Viability of seeds was >70% for most treatments and sites. If wind facilities, railways and other man-made structures produce infrasound that increases self-pollination, crops and native plants near sources may produce heavier seeds with higher viability in the absence of pollinators, but genetic diversity of plants may decline due to decreased cross-pollination. Full article

Sustainability in the construction sector has become a fundamental objective for mitigating escalating environmental challenges; given that concrete is the most widely used man-made material, extending its service life is therefore critical. Among durability concerns, magnesium sulfate (MgSO₄) attack is particularly deleterious to concrete structures. Therefore, this study investigates the short- and long-term performance of concrete produced with copper slag (CS)—a massive waste generated by copper mining activities worldwide—employed as a supplementary cementitious material (SCM), together with recycled coarse aggregate (RCA), obtained from concrete construction and demolition waste, when exposed to MgSO₄. CS was used as a 15 vol% cement replacement, while RCA was incorporated at 0%, 20%, 50%, and 100 vol%. Compressive strength, bulk density, water absorption, and porosity were measured after water curing (7–388 days) and following immersion in a 5 wt.% MgSO₄ solution for 180 and 360 days. Microstructural characteristics were assessed using scanning electron microscopy (SEM), X-ray diffraction (XRD), thermogravimetric analysis with its differential thermogravimetric derivative (TG-DTG), and Fourier transform infrared spectroscopy (FTIR) techniques. The results indicated that replacing 15% cement with CS reduced 7-day strength by ≤10%, yet parity with the reference mix was reached at 90 days. Strength losses increased monotonically with RCA content. Under MgSO₄ exposure, all mixtures experienced an initial compressive strength gain during the short-term exposures (28–100 days), attributed to the pore-filling effect of expansive sulfate phases. However, at long-term exposure (180–360 days), a clear strength decline was observed, mainly due to internal cracking, brucite formation, and the transformation of C–S–H into non-cementitious M–S–H gel. Based on these findings, the combined use of CS and RCA at low replacement levels shows potential for producing environmentally friendly concrete with mechanical and durability performance comparable to those of concrete made entirely with virgin materials. Full article

The COVID-19 pandemic’s rapid shift to working from home has fundamentally challenged residential acoustic design, which traditionally prioritises rest and relaxation rather than sustained concentration. However, a clear gap exists in understanding how acoustic needs and the subjective evaluation of soundscape appropriateness (SA) differ between these conflicting activities within the same domestic space. Addressing this gap, this study reveals critical differences in how people experience and evaluate home soundscapes during work versus relaxation activities in the same residential spaces. Through an online survey of 247 Chinese participants during lockdown, we assessed soundscape perception attributes, the perceived saliencies of various sound types, and soundscape appropriateness (SA) ratings while working and relaxing at home. Our findings demonstrate that working at home creates a more demanding acoustic context: participants perceived indoor soundscapes as significantly less comfortable and less full of content when working compared to relaxing (p < 0.001), with natural sounds becoming less noticeable (−13.3%) and distracting household sounds more prominent (+7.5%). Structural equation modelling revealed distinct influence mechanisms: while comfort significantly mediates SA enhancement in both activities, the effect is stronger during relaxation (R² = 0.18). Critically, outdoor man-made noise, building-service noise, and neighbour sounds all negatively impact SA during work, with neighbour sounds showing the largest detrimental effect (total effect size = −0.17), whereas only neighbour sounds and outdoor man-made noise significantly disrupt relaxation activities. Additionally, natural sounds act as a positive factor during relaxation. These results expose a fundamental mismatch: existing residential acoustic environments, designed primarily for rest, fail to support the cognitive demands of work activities. This study provides evidence-based insights for acoustic design interventions, emphasising the need for activity-specific soundscape considerations in residential spaces. As hybrid work arrangements become the norm post-pandemic, our findings highlight the urgency of reimagining residential acoustic design to accommodate both focused work and restorative relaxation within the same home. Full article

Fabric veneer panels were prepared using ethylene-vinyl acetate copolymer film (EVA) as the intermediate layer and poplar plywood as the substrate. Eight fabrics with different compositions were selected for evaluation to screen out fabric materials suitable for poplar plywood veneer. The fabrics were objectively analyzed by bending and draping, compression, and surface roughness, and subjectively evaluated by establishing seven levels of semantic differences. ESEM, surface adhesive properties, and peel resistance tests were used to characterize the microstructure and physical–mechanical properties of the composites. The results show that cotton and linen fabrics and corduroy fabrics are superior to other fabrics in performance, and they are suitable for decorative materials. Because the fibers of the doupioni silk fabric are too thin, and the fibers of felt fabric are randomly staggered, they are not suitable for the surface decoration materials of man-made panels. The acetate veneer surface gluing performance was 1.31 MPa, and the longitudinal peel resistance was 20.98 N, significantly exceeding that of other fabric veneers. Through the subjective and objective analysis of fabrics and gluing performance tests, it was concluded that, compared with fabrics made of natural fibers, man-made fiber fabrics are more suitable for use as surface finishing materials for wood-based panels. The results of this study provide a theoretical basis and process reference for the development of environmentally friendly decorative panels, which can be expanded and applied to furniture, interior decoration, and other fields. Full article

Introduction: Acute Myeloid Leukemia (AML) is a hematologic malignancy characterized by the clonal expansion of myeloid progenitors. While it primarily affects the bone marrow, extramedullary relapse occurs in 3–5% of cases, and it is linked to poor prognosis. Central nervous system (CNS) involvement presents diagnostic challenges due to nonspecific symptoms. CNS manifestations include leptomeningeal dissemination, nerve infiltration, parenchymal lesions, and myeloid sarcoma, occurring at any disease stage and frequently asymptomatic. Methods: A 62-year-old man with a recent history of AML in remission presented with diplopia and aching paresthesias in the left periorbital region spreading to the left frontal area. The diagnostic workup included neurological and hematological evaluation, lumbar puncture, brain CT, brain magnetic resonance imaging (MRI) with contrast, and dermatological evaluation with skin biopsy due to the appearance of nodular skin lesions on the abdomen and thorax. Results: Neurological evaluation showed hypoesthesia in the left mandibular region, consistent with left trigeminal nerve involvement, extending to the periorbital and frontal areas, and impaired adduction of the left eye with divergent strabismus in the primary position due to left oculomotor nerve palsy. Brain MRI showed an equivocal thickening of the left oculomotor nerve without enhancement. Cerebrospinal fluid (CSF) analysis initially showed elevated protein (47 mg/dL) with negative cytology; a repeat lumbar puncture one week later detected leukemic cells. Skin biopsy revealed cutaneous AML localization. A diagnosis of AML relapse with CNS and cutaneous localization was made. Salvage therapy with FLAG-IDA-VEN (fludarabine, cytarabine, idarubicin, venetoclax) and intrathecal methotrexate, cytarabine, and dexamethasone was started. Subsequent lumbar punctures were negative for leukemic cells. Due to high-risk status and extramedullary disease, the patient underwent allogeneic hematopoietic stem cell transplantation. Post-transplant aplasia was complicated by septic shock; the patient succumbed to an invasive fungal infection. Conclusions: This case illustrates the diagnostic complexity and poor prognosis of extramedullary AML relapse involving the CNS. Early recognition of neurological signs, including cranial nerve dysfunction, is crucial for timely diagnosis and management. Although initial investigations were negative, further analyses—including repeated CSF examinations and skin biopsy—led to the identification of leukemic involvement. Although neuroleukemiosis cannot be confirmed without nerve biopsy, the combination of clinical presentation, neuroimaging, and CSF data strongly supports the diagnosis of extramedullary relapse of AML. Multidisciplinary evaluation remains essential for detecting extramedullary relapse. Despite treatment achieving CSF clearance, the prognosis remains unfavorable, underscoring the need for vigilant clinical suspicion in hematologic patients presenting with neurological symptoms. Full article

The proliferation of telecommunication devices in recent decades has resulted in a substantial increase in exposure risk to manmade radiofrequency electromagnetic fields (RF-EMFs) for both animals and plants. The physiological effects of these exposures remain to be fully elucidated. In this study, we measured and analyzed the chlorophyll fluorescence rise kinetics of lettuce plants in the presence of RF-EMFs and after a short drought treatment. The analysis of the fluorescence data was conducted using two different strategies: a conventional JIP test and a novel machine learning-assisted anomaly-detection approach. Our results suggest that exposure to RF-EMFs weakens the plant’s hormetic responses induced by drought treatment, both in terms of the response’s magnitude and its extent. These findings provide further evidence supporting the hypothesis that RF-EMFs interfere with plant stress responses. Full article

The research presented in this paper focuses on the utilization of 3D printing technology in the design and manufacture of a prosthetic hand, equipped with a digit replicator. The subject of this study was a young man who had undergone the amputation of two fingers on his right hand. The electronic control of the movement of the finger copy was developed using Arduino language. A concept and outline drawings were developed in ProCreate. Three-dimensional scan of the hand and forearm was made using an EinScan PRO HD SHINING 3D scanner. Using CAD software—Autodesk Inventor and Autodesk Meshmixer, the prosthesis was designed. Printing was carried out on a 3D printer of the i3 MK3 and MK3+ series using a PLA (polylactic acid) filament. It was determined that PLA is an optimal material for printing, as it is considered to be safe for future patients’ skin. Work on the electronic circuitry started in Autodesk TinkerCad simulation software, allowing the code to be verified and ensuring the safety of the control system. The prosthesis’s design demonstrates the potential to reach as many people in need as possible by using readily available, low-cost, and easy-to-use components. Full article

The increasing number of natural and man-made disasters registered at the global level is causing a significant amount of damage. This represents one of the main sustainability challenges at the global level. The collapse of the Twin Towers, Hurricane Katrina, and the nuclear accident at the Fukushima power plant are some of the most representative disaster events that occurred at the beginning of the third millennium. These relevant disasters need an enhanced level of preparedness to reduce the gaps between the plan and its implementation. Among these actions, training and exercises play a relevant role because they increase the capability of planners, managers, and the people involved. By focusing on the exposure risk component, the general objective of the research is to obtain quantitative evaluations of the exercise’s contribution to risk reduction through evacuation. The paper aims to analyze serious games using a set of methods and models that simulate an urban risk reduction plan. In particular, the paper proposes a transparent framework that merges transport risk analysis (TRA) and transport system models (TSMs), developing serious game activities with the support of emerging information and communication technologies (e-ICT). Transparency is possible through the explicitation of reproducible analytical formulations and linked parameters. The core framework of serious games is constituted by a set of models that reproduce the effects of players’ choices, including planned actions of decisionmakers and travel users’ choices. The framework constitutes the prototype of a digital platform in a “non-stressful” context aimed at providing more insights about the effects of planned actions. The proposed framework is characterized by transparency, a feature that allows other analysts and planners to reproduce each risk scenario, by applying TRA and relative effects simulations in territorial contexts by means of TSMs and parameters updated by e-ICT. A basic experimentation is performed by using a game, presenting the main results of a prototype test based on a reproducible exercise. The prototype experiment demonstrates the efficacy of increasing preparedness levels and reducing exposure by designing and implementing a serious game. The paper’s methodology and results are useful for policymakers, emergency managers, and the community for increasing the preparedness level. Full article

Accurate multi-class semantic segmentation of disaster-affected areas is essential for rapid response and effective recovery planning. We present CSDNet, a context-aware segmentation model tailored to disaster scene scenarios, designed to improve segmentation of both large-scale disaster zones and small, underrepresented classes. The architecture combines a lightweight transformer module for global context modeling with depthwise separable convolutions (DWSCs) to enhance efficiency without compromising representational capacity. Additionally, we introduce a detection-guided feature fusion mechanism that integrates outputs from auxiliary detection tasks to mitigate class imbalance and improve discrimination of visually similar categories. Extensive experiments on several public datasets demonstrate that our model significantly improves segmentation of both man-made infrastructure and natural damage-related features, offering a robust and efficient solution for post-disaster analysis. Full article

Natural and man-made disasters are occurring more frequently, making household emergency preparedness essential for an effective response. Enrollees of the World Trade Center Health Registry have been found to be less prepared than the US national average despite their prior disaster exposure. The purpose of this study was to evaluate and compare the effectiveness of two interventions—a mailed brochure and a structured phone call—for increasing emergency preparedness knowledge among this population. We conducted a two-arm parallel group trial between February 2019 and August 2020. Participants were Registry enrollees who completed the Wave 4 Registry (2015–2016) survey, whose primary language was English or Spanish, who lived in New York City, and who did not report being a rescue and recovery worker affiliated with FDNY or NYPD. Enrollees were randomized to receive either a brochure by mail summarizing the components of emergency preparedness or a 15 min phone call describing the same. The primary outcome measure was the number of “yes” responses to the ten-item CDC CASPER emergency preparedness questionnaire, measured at baseline and post-intervention. Enrollees were sequentially alternatively assigned to either the brochure or phone call groups. In total, 705 enrollees were assigned to the brochure (n = 353) or phone call (n = 352) groups, and a total of 702 enrollees were analyzed. The Incident Rate Ratio (IRR) for the effect of time was 1.17 (95% CI = (1.14, 1.20)) and for intervention was 1.00 (95% CI = (0.95, 1.05)) Both the brochure and phone call interventions improved knowledge of emergency preparedness from baseline to post-intervention assessment, and to the same extent. Full article

Transportation is a major contributor to air pollution, with vehicles emitting around 65% of manmade hydrocarbons, 64% of carbon monoxide, and 40% of nitrogen oxides. These pollutants harm the environment, human health, and materials. With vehicle populations expected to reach 1.3 billion by 2030, emissions will only worsen. This project focuses on enhancing the efficiency of catalytic converters, which help convert harmful tailpipe emissions like unburned hydrocarbons and CO into less harmful substances (CO₂ and H₂O). Using a selective catalyst alongside a catalytic converter, the study aims to significantly reduce toxic emissions from traditional IC engine vehicles. Full article

Promoting environmental stewardship among youths is crucial for inspiring collaborative, multi-generational actions to tackle long-term environmental challenges. This research study explores the impact of an environmental education (EE) field trip, which highlighted wastewater management and renewable energy technology, on high school students using the revised new ecological paradigm (NEP) scale as a key metric in a pre-post survey, which uses traditionally pro (NEP) and anti (dominant social paradigm, DSP) conservationist statements to measure beliefs towards the environment. When applying the Wilcoxon signed-rank test (null hypothesis t = 0, no change) to the series of environmental stewardship action questions “___ is an extremely important part of protecting the environment”, we identified ten out of the thirteen scale questions to show significant change, all of which were positive. Additionally, the overall impact score was positive and significant (p ≤ 0.05). This finding demonstrates that respondents felt more strongly that these variables played a role in protecting the environment after experiencing the field trip. This suggests that exposure to environmental management intervention strategies utilizing man-made infrastructure and technology may enhance human capability to positively influence the environment and mitigate environmental threats, potentially alleviating concerns about environmental issues. These results suggest that environmental stewardship in youth needs to be reconceptualized in an increasingly STEM-focused world, and a new metric should be developed to assess environmental beliefs. Full article

This article aims to provide an account of the political thought of Archbishop John Carroll on the topic of religious liberty as a core principle of the American founding. It examines the relationship of Church and State through the lens of a developing self-understanding in the American and Roman Catholic identities. American Catholic colonists were accused of having a divided allegiance that made them dangerous to the social compact, divided between papal authority and the authority of the republic. Further, the place of the Catholic Church in a more pluralistic religious landscape following the Reformation demanded a reexamination of the traditional Catholic teaching on religious liberty. One man in particular stands out as a seminal figure in the development of a rapprochement between the American liberal understanding of religious liberty and that of the Catholic tradition. This man was Archbishop John Carroll, the first Roman Catholic Bishop in America. Carroll’s theoretical and practical approach to the highly contentious issue of religious liberty is a noteworthy example of simultaneous commitment to the Catholic faith and responsiveness to the exigencies of the moment and the perennial demands of political life. Carroll’s example is useful for Catholics and all others, as a model for Church–State separation. Full article

Plywood and particle boards, commonly used in construction and interior environments, are sources of indoor chemical emissions from synthetic adhesives, resins, and surface treatments. Among these, formaldehyde, classified as a group 1 carcinogen by the International Agency for Research on Cancer, and other compounds are associated with oxidative stress, inflammation, and organ toxicity. This study aimed to evaluate the toxicological and physiological effects of plywood and particleboard emissions in female C57BL/6 mice. The mice were exposed to formaldehyde, phytoncides, and untreated wood samples under short- (30–60 days) and long-term (120–180 days) conditions. Biological effects were assessed through histopathology of major organs, differential white blood cell counts, oxidative stress markers, antioxidant enzyme activities (catalase and glutathione peroxidase), liver and kidney function tests (alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen, and creatinine), and inflammatory cytokine profiling (interferon-gamma, tumor necrosis factor-α, interleukin (IL)-10, and IL-12p70). These findings revealed no significant pathological changes or systemic toxicity following long-term exposure. Minor elevations in hepatic and renal biomarkers were observed but remained within physiological limits. Antioxidant responses and cytokine fluctuations suggested mild adaptive and immunomodulatory effects. These results highlight the importance of reducing emissions from engineered wood products to improve indoor air quality and minimize potential health risks. Full article