Search Results (315)

Background: Fibromyalgia (FM) is a chronic condition characterized by widespread pain, fatigue, cognitive difficulties, and psychological symptoms. Patients often present distinct personality traits and psychopathological patterns associated with symptom severity. Objective: To examine psychopathological profiles in FM patients based on functional, physical–somatic, and emotional impairment domains, as well as on cumulative disease severity. Materials and Methods: A cross-sectional study was conducted with 70 women clinically diagnosed with FM at a specialized Fibromyalgia Unit. Psychological functioning was assessed using the Personality Assessment Inventory, and disease impact was measured with the Fibromyalgia Impact Questionnaire. Hierarchical cluster analyses were used to classify participants into mild and severe clusters across FIQ domains, and psychological profiles were compared. Results: Patients with severe functional impairment had more affective dysregulation (76.43 vs. 70.20, p < 0.01) and somatic complaints (85.57 vs. 79.76, p < 0.05) than those with mild impairment. The severe–physical cluster showed greater mood instability, somatization, and suicidal ideation (60.94 vs. 53.61, p < 0.05). The severe–emotional cluster had higher rates of major depression (85.71% vs. 64.28%) and persistent depressive disorder (76.19% vs. 70.61%, p < 0.05). Severe showed more emotional instability and somatization, distinguishing it from mild. Greater cumulative severity intensified depressive and somatic disorders. Discussion: Findings support FM’s biopsychosocial profile, where emotional distress may relate to psychological and physical symptoms, reinforcing the need for personalized, multidisciplinary care and comprehensive assessment. Full article

(1) Background: Physical activity (PA) plays a crucial role in preserving and enhancing mental health, particularly in the aftermath of major health crises such as the COVID-19 pandemic. However, the specific levels and domains of physical activity that have the greatest impact on alleviating symptoms of anxiety, depression, and stress in the post-COVID-19 period remain unclear. The aim of this study was to examine the influence of different levels and domains of PA on mental health parameters, specifically symptoms of anxiety, depression, and stress, in individuals who had recovered from COVID-19. (2) Methods: The study included initial measurements (2–4 weeks post-recovery) and final measurements (14–16 weeks post-recovery). The sample comprised 288 participants aged 20 to 60 years (M = 47.06; SD = 12.41), with 95 men and 193 women. PA was assessed using the long version of the IPAQ questionnaire, while mental health was evaluated using the long version of the DASS scale. (3) Results: Stepwise regression analysis revealed that low- (p = 0.010) and moderate-intensity (p = 0.022) PA was significantly associated with reductions in anxiety symptoms as well as lower stress levels (low PA: p = 0.014; moderate PA: p = 0.042). Total PA (p < 0.001) and vigorous-intensity PA (p = 0.008) emerged as significant predictors of reduced depression levels. Among the domains of PA, home-based activities had a statistically significant impact on all three mental health components: anxiety (p = 0.005), depression (p = 0.002), and stress (p = 0.041). Transport-related PA was significantly associated with anxiety (p = 0.011) and stress (p = 0.022), but not with depression. (4) Conclusions: The results suggest that a combined model incorporating different levels and domains of PA may represent an effective approach to improving mental health in individuals recovering from COVID-19. Further longitudinal studies are needed to establish more precise causal relationships. Full article

Background: Dyspeptic symptoms are very common in the general population, with an estimated prevalence of 14% to 41%, and the majority of patients experience symptoms without an organic cause for them (so-called functional dyspepsia). While the pathophysiology of functional dyspepsia remains elusive, the impact of functional dyspepsia on quality of life is detrimental. The treatment involves a change in lifestyle—a healthy diet and physical activity—in combination with pharmacological treatments. However, currently, there is no standard therapy for this condition, although a nutritional approach appears to be feasible and well accepted by patients. In this context, the intake of some mineral water types might be able to play an important role. Objective: The aim of the present study was to evaluate whether the regular intake of bicarbonate natural mineral water (Aqua Carpatica from source “F2 Păltiniș”) is able to positively influence the symptomatic process of dyspepsia, promoting digestion and improving the quality of life of patients. Methods: The patients enrolled in this open-label study had diagnosis of functional dyspepsia formulated in accordance with the Rome III criteria. During the 4-week study, patients had to ingest tap water at 1.5 L/day (wash-out period: 2 weeks), and in the 2-week subsequent period, they had to ingest alkaline natural mineral water at 1.5 L/day. The primary efficacy endpoint of this study includes a statistically significant improvement (p < 0.05) in the “heartburn”, “regurgitation”, and “dyspepsia” subscales and the total Reflux Disease Questionnaire’s (RDQ) score with respect to the effects of alkaline natural mineral water. As secondary endpoints, we considered statistically significant improvements (p < 0.05) in quality-of-life scores (Psychological General Well-Being Index—Short form; PGWB-S), the patient’s self-assessment of the state of efficiency of their digestion, and their sense of post-prandial fullness, as well as the use of antacids. Results: Forty-five patients were enrolled: all were Caucasian and mostly women (25, 55.6% vs. 20 men, 44.4%), and they were aged between 25 and 75 years (50.6 ± 13.5 years; mean ± SD). The results of this preliminary study show a significant improvement in functional dyspepsia symptoms—as assessed via the RDQ—and an improvement in quality of life—as assessed using the PGWB-S score—after the intake of alkaline natural mineral water. Conclusions: This preliminary study provides clinical evidence for a recommendation of alkaline natural mineral water as a symptomatic treatment of dyspepsia. Full article

Background: The World Health Organization defines myopia as a global epidemic. Its growing prevalence and the increasingly early age onset all raise a major concern for public health due to the elevated risk of loss and deterioration of visual function as a result of myopia-related ocular pathological complications. However, it remains unclear whether the vision-related quality of life of patients with myopia is the same as in healthy individuals. The aim of the present study is to assess the quality of life in children and adolescents with myopia between the ages of 8 and 16 years, who underwent observation at USBOBAL-Varna. Methods: This study prospectively included 190 patients with myopia between −1.00 and −5.50 D, corrected with different optical aids. After a thorough physical ocular examination and inquiry into the best visual acuity with and without distance correction, specially designed questionnaires were completed by the patients and their parents/guardians for the purpose of the study. The data from the questionnaires was statistically processed. The mean age of the patients in the study was 11.65 years, 101 were female and 89 were male. Of these, 83 wore monofocal glasses, 50 were monofocal and 47 were multifocal contact lenses, and 10 wore ortho-K lenses. Results: No significant difference in best corrected visual acuity (BCVA) was found among the three types of optical correction (p-value > 0.05). Cronbach’s alpha of the questionnaire for all 10 factors was higher than 0.6, indicating acceptable internal consistency. Significantly higher scores were reported for overall, near, and distance vision, symptoms, appearance, attitude, activities and hobbies, handling, and perception for soft contact lens wearers than for spectacle wearers (p-value < 0.05). Ortho-K wearers performed better than spectacle wearers in all aspects except for pronounced symptoms (p = 0.74). No significant difference was found between ortho-K wearers and soft contact lens wearers for any factor (p > 0.05). Conclusions: Patients wearing spectacles and with myopia above −5.00 D had the highest anxiety scores and lower quality of life among all myopic participants. The research on the quality of life in children with myopia with different refractive errors and optical correction devices is crucial for improving corrective devices and meeting the needs of patients. Full article

Fire events can impact physical and mental health through smoke exposure, evacuation, property loss, and/or other environmental stressors. In this study, we developed community-driven, cross-sectional online surveys to assess public attitudes, health impacts, and protective actions of residents affected by the Tustin hangar fire that burned for 24 days in southern California. Results showed the most frequently reported fire-related exposure concerns (93%) to be asbestos and general air pollution and the most commonly reported mental health impacts to be anxiety (41%), physical fatigue (37%), headaches (33%), and stress (26%). Nose/sinus irritation was the most commonly reported (26.0%) respiratory symptom, while skin- and eye-related conditions were reported by 63.0% and 72.2% of the survey population, respectively. The most commonly reported health-protective actions taken by residents included staying indoors and/or closing doors and windows (67%), followed by wearing face masks (37%) and the indoor use of air purifiers (35%). A higher proportion of low-income residents had to spend money on remediation or other health-protective actions compared to high-income residents. Participants overwhelmingly reported disapproval of their city’s and/or government’s response to the fire disaster. Findings from this study underscore the potential impacts of major pollution events on neighboring communities and offer critical insights to better position government agencies to respond during future disasters while effectively communicating with the public and addressing community needs. Full article

Stress urinary incontinence (SUI) is a common condition that can significantly impair a woman’s quality of life. While initial management includes conservative treatments, surgical options are recommended in refractory cases. Suburethral slings are currently one of the most widely recommended surgical treatments due to their high long-term efficacy. However, complications such as postoperative urinary retention can occur and may lead to chronic voiding dysfunction when not promptly diagnosed and managed. Background/Objectives: The aim of this study was to evaluate the long-term voiding function in women undergoing delayed sling removal or incision for neglected chronic voiding dysfunction. Methods: This retrospective study examined women with chronic voiding dysfunction occurring at least one year after suburethral sling placement for SUI. Preoperative evaluation included comprehensive history, physical examination, urethral ultrasound, uroflowmetry, and urodynamic studies. Surgical interventions consisted of partial or complete sling removal or sling incision (unilateral or bilateral). Postoperative follow-up was conducted at one month and then at 12 months, including clinical examination, ultrasound, and symptom assessment. Results: Sixteen patients were included in the study, all of whom presented with urodynamic confirmation of voiding dysfunction. Following surgical intervention, a significant improvement was observed in voiding symptoms and overall symptoms (p < 0.01). Notably, only one patient experienced persistent voiding difficulties, although complete symptom remission was achieved following sacral neuromodulation. Conclusions: Sling removal or incision has proven to be an effective approach in resolving the majority of cases of neglected chronic voiding dysfunction. These findings suggest that, when appropriately performed, surgical intervention can substantially alleviate symptoms and improve patient well-being, providing an effective therapeutic option for what is often a debilitating condition. Full article

Background: Breast cancer is the most common malignant neoplasm among women worldwide, and its early detection is crucial for improving survival rates. The aim of our research was to assess the knowledge of health science students regarding breast cancer, with a particular focus on risk factors and symptoms, and to examine their associations with demographic and lifestyle characteristics. Methods: A cross-sectional online survey was conducted among 251 female health science students at the University of Pécs. For statistical analysis, we used the Chi-square test, the Mann–Whitney U test, the Kruskal–Wallis test, and Spearman correlation. Results: Students were most familiar with the symptoms of breast cancer (59.0%), while knowledge of non-modifiable (44.1%) and lifestyle-related (49.8%) risk factors was found to be lower. Third-year students (H = 15.892; p < 0.001), those with better financial status (H = 11.091; p = 0.011), physically active individuals (U = 6535.0; p = 0.020), and those who regularly performed breast self-examinations (U = 5356.0; p = 0.027) achieved significantly higher scores. Knowledge levels also varied by field of study (H = 18.203; p = 0.033); students in dietetics and paramedicine stood out with higher results. The majority of students (57.8%) had a moderate level of knowledge, while only 21.9% reached a high level. Surprisingly, the frequency of breast self-examination showed a weak but significant negative correlation with overall knowledge (ρ = −0.155; p < 0.05). Conclusions: Students’ knowledge requires improvement, particularly regarding risk factors. Targeted education and encouragement of breast self-examination could enhance students’ preparedness, thereby contributing to more effective prevention and early detection. Full article

Background and Objectives: Rectal cancer is a major cause of morbidity and mortality worldwide, and although current therapeutic protocols have improved survival, treatment-related toxicities may significantly affect patients’ daily functioning and emotional well-being. This study aimed to prospectively assess the impact of radiotherapy with concurrent capecitabine on functional and symptomatic outcomes in patients with rectal cancer, with a particular focus on the presence of a stoma and treatment strategy. Materials and Methods: From 165 patients initially assessed, 64 were included in this study after applying eligibility criteria. All received pelvic radiotherapy (50.4 Gy in 28 fractions); 62.5% also received CAPOX chemotherapy. The quality of life was assessed using EORTC QLQ-C30 and QLQ-CR29 questionnaires administered at three time points: before treatment, mid-treatment (day 15), and post-treatment. Results: A statistically significant deterioration was observed in physical, emotional, social, and role functioning over the course of treatment, along with an increase in symptom scores for fatigue, pain, gastrointestinal, and urinary complaints. The presence of a stoma was significantly associated with worse gastrointestinal symptoms and emotional functioning. No significant differences were noted between patients with or without chemotherapy. Despite symptom worsening, global quality-of-life scores remained relatively stable. Conclusions: These findings highlight the complex interplay between treatment toxicity and patient adaptation. The presence of a stoma and other clinical or demographic factors significantly influence patients’ experience during therapy. Integrating routine assessment of functional and symptomatic burden into clinical practice could support individualized interventions aimed at maintaining daily functioning and psychological resilience during treatment. Full article

Introduction: The clinical syndrome of heart failure (HF) is progressive and disabling for patients who rely on their caregivers for help and support. The caregiving role is inducing major changes in the personal, social, and family life of caregivers and entails a heavy emotional and physical burden, which in turn negatively affects their quality of life (QoL). Purpose: The purpose of this study was to explore the QoL of caregivers of patients with HF as well as the associated caregivers’ and patients’ characteristics. Material and Methods: The sample of the study included 340 caregivers along with their hospitalized patients. Data collection was performed by the method of the interview using the questionnaire “SF-36 Health Survey (SF-36)” to assess caregivers’ QoL. Results: Τhe physical QoL component of caregivers was found to be statistically significantly associated with the type of relationship with their patient (p = 0.001), age (p = 0.001), level of education (p = 0.001), occupation (p = 0.001), information about HF patients (p = 0.001), worry about finances (p = 0.001), and insecurity about the future (p = 0.001). The mental QoL component of caregivers was found to be statistically significantly associated with the type of relationship with their patient (p = 0.001), gender (p = 0.009), age (p = 0.001), level of education (p = 0.001), occupation (p = 0.001), frequency of visits to hospitalized patient (p = 0.001), information about HF (p = 0.029), anxiety about patients’ self-care (p = 0.001), worry about finances (p = 0.001), and insecurity about the future (p = 0.001). In terms of HF patient’s characteristics, the physical QoL component of caregivers was found to be statistically significantly associated with the patients’ age (p = 0.001), patients’ education level (p = 0.001), patients’ occupation (p = 0.006), patients’ family history of cardiac disease (p = 0.006), and patients’ self-reported symptom management before hospital admission (p = 0.022). The mental QoL component of caregivers was found to be statistically significantly associated with the patients’ education level (p = 0.020), the patients’ NYHA stage (p = 0.001), prior hospitalization (p = 0.001), the patients’ family history of cardiac disease (p = 0.012), and the patients’ self-reported symptom management before admission (p = 0.001). Conclusions: In-depth understanding factors affecting QoL in caregivers with HF may enhance plans and actions to attain healthcare goals among societies globally. Full article

Background/Objectives: Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality worldwide, with transarterial chemoembolization (TACE) commonly used as a palliative approach for patients who are not candidates for surgical resection. Understanding the factors that influence health-related quality of life (HRQoL) after TACE is essential for improving patient-centered care. This systematic review seeks to consolidate current evidence on the variables that impact HRQoL in HCC patients post-TACE. Methods: In adherence to PRISMA guidelines, a comprehensive search was conducted across five English and Chinese databases—PubMed, Scopus, Web of Science, CNKI, and Wanfang—covering studies from database inception to May 2025. Eligible studies were observational and examined factors affecting HRQoL in post-TACE HCC patients. Two independent reviewers performed screening, data extraction, and quality assessment using the Joanna Briggs Institute (JBI) Critical Appraisal Tools. Results: Nine studies met the inclusion criteria, including six cohort studies and three cross-sectional studies. The quality assessment rated seven studies as high quality and two as moderate. A range of validated HRQoL assessment tools was used, with the EORTC QLQ-C30 and FACT-G being the most commonly employed. The factors influencing HRQoL were grouped into five categories: (1) demographic factors (e.g., age, gender, education level); (2) clinical indicators (e.g., liver function, tumor burden); (3) psychological factors (e.g., depression, anxiety, spiritual well-being); (4) social support (e.g., financial status, coping mechanisms); and (5) physical symptoms (e.g., fatigue, pain, appetite loss). Across studies, both symptom severity and psychological distress were consistently associated with lower HRQoL. Conclusions: The HRQoL of HCC patients following TACE is influenced by a complex interplay of demographic, clinical, psychological, social, and symptomatic factors. Tailored, multidimensional interventions addressing these diverse aspects are crucial to optimizing recovery and improving overall well-being. Full article

Background/Objectives: Long COVID-19 is characterized by persistent symptoms lasting three months or more following SARS-CoV-2 infection. Nutrition has emerged as a modifiable factor influencing recovery trajectories and symptom burden; however, existing evidence remains fragmented across diverse study designs and populations. This scoping review synthesized global evidence on the role of diet and nutrition in managing long COVID-19 symptoms and supporting recovery. Methods: Following PRISMA-ScR and Joanna Briggs Institute guidelines for scoping reviews, we searched major biomedical databases for studies published between 2020 and 2025. Eligible studies examined dietary intake, nutritional status, or nutrition-related interventions in adults with long COVID-19. Results: After duplicates were removed, 1808 records were screened, resulting in 50 studies that met the inclusion criteria—27 intervention studies and 23 observational studies. Nutritional exposures included micronutrients (e.g., vitamins D, K₂), amino acids (e.g., L-arginine), multinutrient formulations, microbiota-targeted therapies (e.g., probiotics, synbiotics), nutritional status, diet quality, and whole-diet patterns (e.g., the Mediterranean diet). Approximately 76% of studies reported improvements in long COVID-19-related symptoms such as fatigue, mood disturbances, physical function, and markers of inflammation. Conclusions: Diet and nutrition may support long COVID-19 recovery by targeting inflammation and the gut microbiome to alleviate symptoms and improve functional outcomes. Well-powered trials of whole-diet approaches, combined with targeted supplementation, are needed to confirm their potential as scalable, accessible tools for post-COVID-19 recovery and management. Full article

Background/Objectives: Major Depressive Disorder (MDD) is a neuropsychiatric disorder affecting nearly 200 million people worldwide. While it has broad health effects, relatively little is known about how these vary across MDD ‘subtypes’, which reflect distinct symptom profiles. This systematic review examined the methods used to define several MDD subtypes and their associations with physical, cognitive, social, and functional health outcomes. Methods: A systematic search of PubMed was conducted in accordance with PRISMA 2020 guidelines to identify peer-reviewed studies published in English between 2014 and 2025. The final search was conducted on 21 January 2025. Studies were included if they examined adults with MDD subtypes and reported health-related outcomes. Risk of bias was assessed using the Newcastle–Ottawa Scale. A narrative synthesis was conducted due to heterogeneity in the subtype definitions and outcome measures. Results: Sixteen studies were included. Atypical and melancholic depression were most consistently associated with metabolic dysfunction, higher BMI, and a greater waist circumference. Melancholic depression was frequently associated with cognitive deficits, though results varied. Cognitive impairments were also observed in DSM-defined atypical depression, particularly in attention, vigilance, and social cognition. Anxious and melancholic depression may be associated with more severe social and functional impairment compared to other subtypes. However, the findings were limited by inconsistent definitions and outcome measures. Conclusions: Some subtypes, particularly atypical, melancholic, and anxious depression, are differentially associated with specific patterns of impairment, though inconsistencies limit firm conclusions. Registration: This review was retrospectively registered with the Open Science Framework (OSF): No specific funding was received. Full article

Long COVID denotes the persistence of symptoms after acute SARS-CoV-2 infection lasting for at least two months without another identifiable cause. Affecting an estimated 15% of COVID-19 patients, long COVID manifests in a wide range of symptoms. Despite extensive research on its one-year effects, limited data exist beyond 12 months. Due to the different manifestations of long COVID, its diagnosis can be challenging. Identifying potential mechanistic contributors and biomarkers would be highly valuable. Recent studies have highlighted the potential of noncoding RNAs (ncRNAs) as biomarkers for disease stratification in COVID-19. Specifically, we have recently identified miR-144-3p and a subset of lncRNAs as candidates for assessing disease severity and outcomes in COVID-19. This nested case–control study extends such investigations to 98 long COVID patients recruited 18 months after hospitalization, exploring the relationship between circulating ncRNA expression and persistent symptoms. While miR-144-3p, HCG18, and lncCEACAM21 expression did not differ between symptomatic and asymptomatic patients, LEF1-AS1 was downregulated in the peripheral blood mononuclear cells (PBMCs) of symptomatic patients. Of note, multiple LEF1-AS1 isoforms and LEF1 sense transcript levels were reduced and negatively correlated with relevant clinical markers. While further studies are needed, our discoveries offer new perspectives on the diagnosis and management of persistent long COVID. Full article

Background: Pain is one of the major medical and public health challenges in the world, and its prevalence is unaffected by some ‘painful’ pandemics of the past, reflecting the deep-rooted causes of other origins. Surgical conditions accounting for one-third of the global burden of disease are associated with physical pain, either as a symptom or complication. For effective perioperative pain management of culturally diverse patients, it is imperative to understand how patients view and deal with pain. Therefore, this study explored study participants’ pain experience as well as their perception of the causes, consequences, and treatment options of surgical condition-related pain. Methods: With a subjectivist research paradigm, as well as relativist and interpretivist ontological and epistemological underpinnings, a qualitative description study design was used to interview 11 patients with abdominal surgical conditions and 12 family members taking care of those patients in three hospitals. Following inductive coding, thematic analysis was employed, which resulted in four themes. Findings: Patients and their families shared various experiences and perceptions of the meanings, causes, consequences, and treatment options of pain, summarized under four emergent themes: Perception of pain meaning, causes, and consequences; sustenance for pain relief; traditional pain relievers; and conventional pain medicine. Conclusions: This study highlighted that ethnoculturally diverse surgical patients and their families may have unique perceptions of pain and use various treatment approaches at home, which might have implications on perioperative pain management. Therefore, professionals at the participating hospitals and elsewhere with similar contexts should consider these cultural phenomena during surgical pain management. Full article

Background/Objectives: Multiple myeloma is a malignancy of plasma cells detected in the bone marrow, inducing symptoms like anemia, hypercalcemia, renal problems, and bone fractures in multiple myeloma patients, affecting their quality of life. The bone marrow microenvironment plays a crucial role in the prognosis and progression of the disease. The purpose of this study was to examine the relationship between the percentages of the major cell populations of the bone marrow, including immune cells, and physical function/quality of life in multiple myeloma patients after first-line treatment. Methods: Twenty-one multiple myeloma patients (N = 14 men, N = 7 women) participated in the study after completing first-line treatment. Bone marrow and blood samples were taken one hundred days after transplantation, while physical function (6 min walking test, handgrip test, maximal aerobic power, and isometric strength), health-related quality of life (QLQ-C30), and body composition (DXA) were assessed 2–5 days later. Flow cytometry was used to assess the percentages of plasma cells, mast cells, B cells (total, precursors, naïve, and memory), T cells (total, CD27− and CD27+), NK/NKT cells (total, CD27− and CD27+), eosinophils, monocytes, neutrophils, myeloid progenitors, erythroblasts, and erythroid progenitors, expressed as percentages of total nucleated cells of the bone marrow. Results: The percentage of CD27+ NK/NKT cells was correlated with five parameters of the quality of life questionnaire: physical function (r = 0.78, p = 0.005), role functioning (r = 0.69, p = 0.020), fatigue (r = −0.86, p = 0.000), pain (r = 0.68, p = 0.021), and dyspnea (r = −0.80, p = 0.003). Conclusions: In conclusion, stronger immune surveillance in the bone marrow from CD27+ NK/NKT cells is correlated with better quality of life in multiple myeloma patients. Full article