Targeting of Tumor Dormancy Pathway
A special issue of Onco (ISSN 2673-7523).
Deadline for manuscript submissions: 30 May 2025 | Viewed by 2661
Special Issue Editors
Interests: DNA polymorphisms; RNA; miRNAs; carcinogenesis; bioinformatics; DNA damage; cell cycle; cancer
Interests: cancer immunology; cancer immunotherapy; biomarkers; precision oncology; immune resistance; cancer vaccines; immune escape; immune checkpoint inhibitors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Dormant tumor cells, also known as minimal residual disease, represent a population of cancer cells that have entered a state of growth arrest, typically after primary tumor removal or during periods of remission. This dormant state allows them to evade conventional cancer therapies, such as chemotherapy or radiation, which primarily target actively dividing cells. It is generally thought that dormant tumor cells have the potential to reactivate and give rise to metastatic tumors years or even decades after initial treatment. However, from another perspective, keeping tumor cells silent for decades can be regarded as tantamount to cure. From both perspectives, it is important to understand the mechanisms underlying dormancy. Keeping tumor cells dormant for indefinite periods of time could form a new strategy of cancer treatment. This Special Issue will highlight the current state of the knowledge in tumor dormancy, targeting of tumor dormancy pathways, and future prospects for exploiting tumor dormancy for cancer therapies.
Dr. Athanassios Kotsinas
Dr. Constantin N. Baxevanis
Guest Editors
Manuscript Submission Information
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Keywords
- dormant tumor cells
- conventional cancer therapies
- cancer therapies
- chemotherapy
- radiation
- tumor dormancy
- targeting of tumor dormancy pathways
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