Search Results (3,124)

Adapting low-viscosity liquids for individuals with dysphagia presents persistent challenges in both texture modification and patient compliance. This exploratory study assessed the flow characteristics and nutritional contributions of 30 beverages (22 plant-based and 8 dairy-based) across different thickener concentrations and syringe models, following the International Dysphagia Diet Standardization Initiative (IDDSI) flow test. Flow measurements were obtained using four available 10 mL syringes that differed from the IDDSI-specified model, intending to evaluate their potential impact on results and inform strategies for situations where standard syringes are unavailable. Findings show that flow performance and IDDSI classification are strongly influenced by syringe design, thickener type, and beverage composition. The use of alternative syringes introduced variability in consistency measurements, highlighting the importance of equipment standardization. Interpretation of flow levels was further complicated by transitional IDDSI thresholds and subjective assessments. Nutritionally, the study reinforces the role of hydration in dysphagia management and explores the potential of plant-based beverages to enhance both fluid intake and fiber contribution. Several samples provided meaningful contributions to daily fiber and micronutrient requirements. Importantly, the study found that half the manufacturer’s recommended thickener dose was often sufficient to achieve IDDSI compliance. These findings support the practical use of non-standard syringes in IDDSI testing, inform more efficient thickening strategies, and highlight plant-based beverages as promising alternatives to dairy in dysphagia diets. Together, they offer actionable insights for improving consistency control and nutritional quality in dysphagia care. Full article

Metal anodes promise improvements in energy density and cost; however, their performance is determined within the first several nanometers at the interface. This review reports on how polymer-based artificial solid electrolyte interphases (SEIs) are engineered to stabilize Li and aqueous-Zn anodes, and how these designs are now evaluated against operando readouts rather than post-mortem snapshots. We group the related molecular strategies into three classes: (i) side-chain/ionomer chemistry (salt-philic, fluorinated, zwitterionic) to increase cation selectivity and manage local solvation; (ii) dynamic or covalently cross-linked networks to absorb microcracks and maintain coverage during plating/stripping; and (iii) polymer–ceramic hybrids that balance modulus, wetting, and ionic transport characteristics. We then benchmark these choices against metal-specific constraints—high reductive potential and inactive Li accumulation for Li, and pH, water activity, corrosion, and hydrogen evolution reaction (HER) for Zn—showing why a universal preparation method is unlikely. A central element is a system of design parameters and operando metrics that links material parameters to readouts collected under bias, including the nucleation overpotential (η_nuc), interfacial impedance (charge transfer resistance (R_ct)/SEI resistance (R_SEI)), morphology/roughness statistics from liquid-cell or cryogenic electron microscopy (Cryo-EM), stack swelling, and (for Li) inactive-Li inventory. By contrast, planar plating/stripping and HER suppression are primary success metrics for Zn. Finally, we outline parameters affecting these systems, including the use of lean electrolytes, the N/P ratio, high areal capacity/current density, and pouch-cell pressure uniformity, and discuss closed-loop workflows that couple molecular design with multimodal operando diagnostics. In this view, polymer artificial SEIs evolve from curated “recipes” into predictive, transferable interfaces, paving a path from coin-cell to prototype-level Li- and Zn-metal batteries. Full article

Background: Glioblastoma (GBM) remains refractory to chemoradiotherapy. Glial populations—microglia/monocyte-derived macrophages, reactive astrocytes, and the oligodendrocyte lineage—shape both treatment resistance and radiation-related brain injury. Scope: We synthesize how myeloid ontogeny and plasticity, astrocytic hubs (IL-6/STAT3, TGF-β, connexin-43/gap junctions), and oligodendrocyte precursor cells (OPCs)–linked programs intersect with DNA-damage responses, hypoxia-driven metabolism, and extracellular vesicle signaling to support tumor fitness while predisposing normal brain to radiotoxicity. Translational implications: Convergent, targetable pathways (IL-6/JAK–STAT3, TGF-β, chemokine trafficking, DDR/senescence) enable co-design of radiosensitization and neuroprotection. Pragmatic levers include myeloid reprogramming (CSF-1R, CCR2), astrocyte-axis modulation (STAT3, TGF-β, Cx43), and brain-penetrant DDR inhibition (e.g., ATM inhibitors), paired with delivery strategies that raise intratumoral exposure while sparing healthy tissue (focused-ultrasound blood–brain barrier opening, myeloid-targeted dendrimers; Tumor Treating Fields as an approved adjunct therapy). Biomarker frameworks (TSPO-PET, macrophage-oriented MRI radiomics, extracellular vesicle liquid biopsy) can support selection and pharmacodynamic readouts alongside neurocognitive endpoints. Outlook: Timing-aware combinations around radiotherapy and hippocampal/white-matter sparing offer a near-term roadmap for “glia-informed” precision radiotherapy. Full article

Compressed carbon dioxide energy storage (CCES) has emerged as a promising solution for long-duration energy storage owing to its high energy density, adaptability to diverse environments, and compatibility with carbon capture technologies. This study develops a dynamic MATLAB 2024a/Simscape model for a 10 MW × 8 h gas–liquid CCES (GL-CCES) system featuring two-stage compression and two-stage expansion. Constant-pressure operation is maintained by check and throttle valves at the boundaries of the high-pressure tank. After startup, all system variables except those associated with the storage tank stabilize rapidly. The analysis reveals several critical dynamic phenomena: (1) a persistent mass-flow imbalance between charging and discharging processes under constant-pressure operation; (2) distinct phase transitions within the high-pressure tank that produce inflection points in thermodynamic evolution; and (3) strong ambient-temperature sensitivity that dictates system stability and efficiency boundaries. The system achieves a round-trip efficiency of 70.52% at 25 °C, which decreases to 67.01% at 21 °C. More importantly, the dynamic energy density (5.15 kWh m⁻³) is only 12.7% of the steady-state reference value. These results demonstrate the feasibility of GL-CCES for large-scale, long-duration energy storage, while also highlighting its pronounced sensitivity to ambient conditions, underscoring the need for optimized design and adaptive operational strategies. Full article

This study examines the determinants of financial sustainability in Turkish maritime industry by analyzing firm-level panel data from 190 ship and boat maintenance firms and 208 coastal shipping companies for the 2010–2022 period, comprising 5174 firm-year observations. Fixed-effects models with Driscoll–Kraay robust standard errors are employed to evaluate how asset structure, liquidity, and energy efficiency jointly affect firm profitability across subsectors, using the Operating Return on Assets (OROA) as the principal indicator of operational performance. The empirical results indicate substantial heterogeneity between maintenance and shipping firms. For maintenance firms, OROA shows a positive association with the Non-Current Assets to Total Assets ratio (NCATA) and the Economic Efficiency Ratio (EER) but a negative association with the Current Ratio (CR), suggesting that capital deepening and operational efficiency tend to correlate with stronger performance, whereas excess liquidity is associated with weaker outcomes. For shipping firms, OROA is positively associated with EER and Total Asset Turnover (TATR) but negatively associated with Fixed Asset Turnover (FATR) and CR, indicating relationships consistent with efficiency gains from energy management and asset utilization but linkages suggesting challenges from fleet aging and liquidity mismanagement. Overall, the findings suggest that the drivers of financial sustainability are associated with different structural conditions across maritime subsectors, highlighting the importance of targeted modernization, port efficiency, and energy-transition investment strategies. Full article

The traditional role of banks as intermediaries has been transferred to a vast array of businesses, creating many sources of income. The present study examines the impact of income diversification on bank risk. A total of 565 commercial banks from 50 countries were examined. A dynamic panel data analysis using Maximum Likelihood with Structural Equation Modelling was performed. The study found that income diversification has no significant effect on risk-weighted assets, while it reduces the insolvency risk and liquidity risk of the bank. Multiple proxies were utilized to measure bank risk to increase the robustness of the study. The study stressed the importance of income diversification and efficient capital allocation across various investment projects to survive in a highly competitive environment. Overall, this study provides new insights into the contradictory relationship between income diversification and bank risk in the global context. This would assist in developing strategies and policies to reduce risk and increase stability in the banking sector. Full article

The COVID-19 pandemic caused by the SARS-CoV-2 virus has exposed the urgency of research on rapid and efficient virus detection and strategies to inhibit its replication. Previous studies have mostly focused on traditional immunoassay or optical methods, but they have limitations in terms of sensitivity, timeliness, and in-depth analysis of molecular interaction mechanisms. Solid-state nanopore single-molecule detection methods, which can monitor molecular conditions in real time at the single-molecule level, bring new opportunities to solve this problem. The nucleocapsid protein (N protein) of SARS-CoV-2 was systematically investigated under different conditions, such as external drive voltage, pH, nanopore size, and N protein concentration. The translocation of the N protein through the nanopore was then analyzed. Subsequently, we analyzed the translocation characteristics of the N protein, RNA, and N protein–RNA complexes. With the aid of EMSA experiments, we conclusively confirmed that RNA binds to the N protein. Building on this finding, we further explored small molecules that could affect the nanopore translocation of N protein–RNA complexes, such as gallocatechin gallate (GCG), epigallocatechin gallate (EGCG), and the influenza A viral inhibitor Nucleozin. The results show that GCG can disrupt the liquid-phase condensation of the N protein–RNA complex and inhibit the replication of the N protein. Meanwhile, the structural isomer EGCG of GCG and the small molecule Nucleozin can also block RNA-triggered N protein liquid–liquid phase separation (LLPS). Our results confirmed that GCG, EGCG, and Nucleozin exhibit antagonistic effects on the N protein, with differences in their effective concentrations and the potency of their antagonism. Herein, using solid-state nanopore single-molecule detection technology, we developed an experimental method that can effectively detect RNA-induced changes in N protein properties and the regulatory effects of small molecules on the LLPS of N protein–RNA complexes. These findings not only provide highly valuable insights for in-depth research on the molecular interactions involved in viral replication, but also open up promising new avenues for future responses to similar viral outbreaks, the development of a rapid and effective detection method based on solid-state nanopores and single-molecule detection, and antiviral therapies targeting N protein–RNA interactions. Full article

Peptides are notable cosmetic ingredients owing to their diverse biological activities and beneficial effects on skin health. Therefore, multifunctional peptides capable of simultaneously exerting antioxidant, whitening, and anti-wrinkle effects are highly desirable. In this study, a scalable and cost-effective chemical synthesis strategy was used for the rapid design and synthesis of linear peptide sequences with skin bioactivity using solid-phase peptide synthesis. Subsequently, liquid-phase peptide synthesis was used to enhance the proteolytic stability and develop a cyclic peptide, cyclic CYGSR (CR5), which was subjected to in vitro biological evaluation. CR5 showed high biocompatibility in water-soluble tetrazolium salt-1 (WST-1) assays, maintaining over 90% cell viability at concentrations up to 400 μg/mL. In the 2,2-Diphenyl-1-picrylhydrazy (DPPH) assay, CR5 exhibited strong antioxidant activity with 83.18% radical scavenging at 200 μg/mL. It also showed 97.79% tyrosinase inhibition at 800 μg/mL, confirming significant whitening potential. Moreover, CR5 inhibited matrix metalloproteinase-1 (MMP-1) expression by 73.55% and increased type I procollagen expression by 44.68% at 400 μg/mL, demonstrating its anti-wrinkle potential. Additionally, molecular docking and dynamic simulation demonstrated stable binding of the peptide to tyrosinase and MMP-1. Collectively, CR5 possesses multifunctional properties with excellent biocompatibility, highlighting its potential as a novel cosmetic active ingredient. Full article

Late spring frosts and transient cold spells constrain tomato productivity. This study presents a comparative analysis of the chilling response of two Solanum lycopersicum cultivars, MoneyMaker (MM) and Micro-Tom (MT), and the wild relative S. lycopersicoides. The assessment integrated physiological parameters, such as electrolyte leakage and PSII efficiency, expression levels of CBF1–3 genes (via qPCR), and fatty acid composition dynamics of membrane lipids (via gas-liquid chromatography-mass spectrometry). The results revealed distinct response strategies. S. lycopersicoides exhibited comprehensive tolerance and was coordinated across biological levels. Its key mechanisms include superior membrane integrity, sustained PSII photochemical efficiency, stable upregulation of CBF genes (with predominant CBF3 induction), and consistently high α-linolenic acid content. This integration prevented membrane damage and sustained photosynthesis. Conversely, the MM cultivar displayed high sensitivity, characterized by transient CBF1 upregulation, an absence of adaptive lipid remodelling, rapid membrane damage, and severe photoinhibition, explaining its poor recovery. The MT genotype demonstrated an intermediate phenotype, featuring delayed but persistent CBF activation, and the partial lipid profile shifted toward the wild-type pattern, indicating a partial adaptive capacity for membrane adjustment. These findings establish S. lycopersicoides as a vital genetic resource for breeding cold-tolerant tomatoes, while MT provides a model for studying adaptation mechanisms in cultivated varieties. Full article

Alzheimer’s disease is driven by multiple molecular drivers, including the pathological behavior of two intrinsically disordered proteins, amyloid-β (Aβ) and tau, whose aggregation is regulated by sequence-encoded ensembles and liquid–liquid phase separation (LLPS). This review integrates recent advances in biophysics, structural biology, and computational modeling to provide a multiscale perspective on how sequence determinants, post-translational modifications, and protein dynamics regulate the conformational landscapes of Aβ and tau. We discuss sequence-to-ensemble principles, from charge patterning and aromatic binders to familial mutations that reprogram structural ensembles and modulate LLPS. Structural studies, including NMR, SAXS, cryo-EM, and cryo-electron tomography, trace transitions from disordered monomers to fibrils and tissue-level structures. We highlight experimental challenges in LLPS assays, emerging standards for reproducibility, e.g., LLPSDB, PhaSePro, and FUS benchmarks, and computational strategies to refine and condensate modeling. Finally, we explore the therapeutic implications, including condensate-aware medicinal chemistry, ensemble-driven docking, and novel insights from clinical trials of anti-Aβ antibodies. Together, these perspectives underscore a paradigm shift toward environment- and ensemble-aware therapeutic design for Alzheimer’s and related protein condensation disorders. Full article

The rising amount of food industry waste has sparked interest in its valorization as a source of bioactive compounds. This study combines bibliometric analysis and a systematic review to map the scientific literature on the recovery of bioactive compounds from food byproducts, focusing on green extraction strategies and their alignment with the principles of the circular economy. A total of 176 documents, published between 2015 and 2025, were analyzed. The analysis shows significant growth after 2020 and highlights bioactive compounds, extraction, and the circular economy as the primary research themes. Italy, Spain, and Brazil emerged as the leading countries in scientific production. The systematic review covers green extraction techniques, including ultrasound-assisted extraction (UAE), microwave-assisted extraction (MAE), pressurized liquid extraction (PLE), supercritical fluid extraction (SFE), enzyme-assisted extraction (EAE), and natural deep eutectic solvent extraction (NADES). UAE- and NADES-based processes were the most frequently applied extraction techniques, mainly targeting phenolic compounds and flavonoids. Significant progress has been observed, particularly in the advancement of extraction technologies, in the recovery of key bioactive compounds, and in their industrial applications. These methods recover phenolics, flavonoids, anthocyanins, and other compounds with antioxidant, antimicrobial, and cardioprotective properties, which have potential applications in functional foods, nutraceuticals, pharmaceuticals, cosmetics, and biodegradable packaging. Nutraceuticals and functional foods represent the main application areas, followed by cosmetics and pharmaceuticals. Despite progress, challenges remain, including scalability, equipment costs, solvent recovery, and process standardization. The green extraction of bioactive compounds from food byproducts shows promise and can support the goals of the 2030 Agenda. Full article

A tiered approach is presented for evaluating occupational risks during liquid deposition modelling (LDM) using ceramic materials for manufacturing complex geometries in construction. The ceramic paste is comprised of kaolin/zeolite powders mixed with deionised water at a specific ratio. The tiered occupational risk analysis covered (i) the material evaluation and information gathering, (ii) on-site exposure measurements to ultrafine and micro-size particles, and (iii) morphological and toxicological analyses of raw and collected air samples. Results indicated an increase in PM4 (particle diameter < 4 μm) concentrations during powder preparation, reaching up to 1 mg/m³ during powder preparation, although below the corresponding substance-specific and general dust occupational exposure limit and with no increased exposure to ultrafine particles, as supported by morphological analysis. In toxicity assessment, reactive oxygen species production (ROS) reached approximately 300% for 50 μg/mL raw kaolin powder, while inducing high upregulation of TNF-α and IL-6 mRNA expression genes, indicating activation of pro-inflammatory pathways. Airborne samples resulted in cell viability reduction by ~50% at 40 μg/mL, showing significance (p-value < 0.001). Translating these findings to human risk remains difficult, yet the findings highlight an urgent requirement for continuous exposure surveillance, tailored toxicity evaluations, and robust protective strategies throughout ceramic manufacturing. Full article

The recovery of rare earth elements (REEs) from the spent NdFeB magnets has great strategic significance for ensuring the security of critical mineral resources. This process requires scientifically designed separation technologies to ensure high output and purity of the obtained rare earths. Hydrometallurgy has been widely applied to extract REEs from spent permanent magnets. This paper summarizes and reviews hydrometallurgical technologies, mechanisms, and applications for the separation and recovery of REEs and iron (Fe) from the spent permanent magnets. Key methods include: The hydrochloric acid total solution method, where the spent NdFeB is completely dissolved in hydrochloric acid, iron is precipitated and removed, and then REEs are extracted. The hydrochloric acid preferential dissolution method, where spent NdFeB magnets are first fully oxidized by oxidative roasting, converting Fe²⁺ to Fe³⁺, which hydrolyzes to Fe(OH)₃, and is precipitated and removed, allowing for the subsequent extraction of REEs to obtain rare earth oxides. Acid baking and water leaching, where spent NdFeB is calcined with acidification reagents, and the calcined products are dissolved in water to leach out REEs. At the same time, Fe is retained in the leaching residue. Electrolysis in aqueous solution, where Fe is electrolyzed at the anode or deposited at the cathode to separate it from REES. Organic acids leaching, where organic acids dissolve metals through acidolysis and complexation. Bioleaching, which utilizes microorganisms to recover metal through biological oxidation and complexation. Ionic liquid systems, where Fe or REEs are extracted using ionic liquid or leached by deep eutectic solvents. This paper provides an in-depth discussion on the challenges, advantages, and disadvantages of these strategies for recycling spent NdFeB magnets, as well as the leaching and extraction behavior of REEs. It focuses on environmental impact assessment, improving recovery efficiency, and decreasing reagent consumption. The future development direction for recycling spent NdFeB magnets is proposed, and a research idea of proposing a combined process to avoid the drawbacks of a single recycling method is introduced. Full article

It is known that the addition of SrO heterogeneous nucleation site particles can refine the microstructure of SUS316L stainless steel additively manufactured (AMed) by powder bed fusion (PBF). In this study, this idea was confirmed by directed energy deposition (DED). However, there are several types of DED machines, and the energy system and the material supply system of these machines are different depending on each machine. In this study, the grain refinement behavior and the formability of AMed SUS316L stainless steel with the addition of SrO heterogeneous nucleation site particles are evaluated using a single-beam type LAMDA 200 machine and a multi-beam type ALPION Series machine. The size of the melt pool made by the ALPION Series machine is smaller than that of the LAMDA 200 machine, which results in a shorter residence time in the liquid state of the melt pool for the ALPION Series machine. The grains formed in the inoculated sample manufactured by the ALPION Series machine under the unidirectional scanning strategy are found to be refined compared to those in the uninoculated sample. On the other hand, it is found that the formation of defects and the crystallographic texture observed in the samples manufactured by the LAMDA 200 machine is suppressed by the addition of SrO heterogeneous nucleation site particles. These differences between the ALPION Series and LAMDA 200 machines would come from the differences in the melting state, including temperature, cooling conditions, and re-heating. Full article

Sinomenine (SIN) is a promising candidate for the treatment of rheumatoid arthritis (RA). Although it possesses the advantage of being non-addictive, its poor aqueous solubility and low oral bioavailability have limited its clinical application. To address these issues, SIN was encapsulated into lipid cubic liquid crystal nanoparticles (LCNPs) and systematically characterized. Molecular dynamics (MD) simulations were first employed to screen suitable excipients for formulation development. Combined with single-factor optimization and Box–Behnken response surface design, the optimal composition and preparation process were determined. The resulting SIN-LCNPs exhibited a particle size of 149.7 ± 0.9 nm, a polydispersity index (PDI) of 0.223 ± 0.01, a zeta potential of −18.9 mV, and an encapsulation efficiency (EE%) of 92.2%. Spectroscopic analyses confirmed successful incorporation of SIN into the lipid matrix. Pharmacodynamic studies revealed that SIN-LCNPs enhanced targeted drug delivery to inflamed joints, significantly alleviating inflammation and suppressing disease progression in rats. In vivo single-pass intestinal perfusion (SPIP) experiments further demonstrated that SIN was primarily absorbed through the small intestine and that the LCNP carrier effectively improved its intestinal permeability. Collectively, this study provides a novel strategy and theoretical foundation for developing efficient formulations of poorly water-soluble drugs, highlighting the potential clinical application of SIN-LCNPs in RA therapy. Full article