Search Results (143)

Background: The genomic era has transformed not only the tools of medicine but the very logic by which we understand health and disease. Whole Exome Sequencing (WES), Clinical Exome Sequencing (CES), and Whole Genome Sequencing (WGS) have catalyzed a shift from Mendelian simplicity to polygenic complexity, from genetic determinism to probabilistic interpretation. This epistemological evolution calls into question long-standing notions of causality, certainty, and identity in clinical genomics. Yet, as the promise of precision medicine grows, so too do the tensions it generates: fragmented data, interpretative opacity, and the ethical puzzles of Variants of Uncertain Significance (VUSs) and unsolicited secondary findings. Results: Despite technological refinement, the diagnostic yield of Next-Generation Sequencing (NGS) remains inconsistent, hindered by the inherent intricacy of gene–environment interactions and constrained by rigid classificatory systems like OMIM and HPO. VUSs (neither definitively benign nor pathogenic) occupy a liminal space that resists closure, burdening both patients and clinicians with uncertainty. Meanwhile, secondary findings, though potentially life-altering, challenge the boundaries of consent, privacy, and responsibility. In both adult and pediatric contexts, genomic knowledge reshapes notions of autonomy, risk, and even personhood. Conclusions: Genomic medicine has to develop into a flexible, morally sensitive paradigm that neither celebrates certainty nor ignores ambiguity. Open infrastructures, dynamic variant reclassification, and a renewed focus on interdisciplinary and humanistic approaches are essential. Only by embracing the uncertainty intrinsic to our biology can precision medicine fulfill its promise, not as a deterministic science, but as a nuanced dialogue between genes, environments, and lived experience. Full article

This article closely examines the Georgian folk tale Master and Pupil, focusing on the intermedial transformation of its sequential narrative structure as an instance of oral storytelling. The tale is analyzed within the broader discourses of performativity, voice, and narrative subjectivity through the lenses of performance theory, media formalism, and the Aarne–Thompson–Uther (ATU) classification system (Type 325). The study reveals a transition in the tale from silence to vocal authority; here, voice functions not only as a means of communication but also as a vehicle for resistance, transformation, and the negotiation of identity. Master and Pupil emerges, beyond a magical apprenticeship narrative, as a multilayered performance of disembodiment and symbolic transmission through an intermedial perspective; in this context, musicality and vocality operate as liminal forces. The pupil’s acquisition of voice signifies both a narrative rupture and a restructuring of hierarchical relations. Furthermore, the article situates the tale within the broader matrix of the Georgian oral storytelling tradition, demonstrating how recurring motifs surrounding the transformation of voice reflect culturally embedded patterns of media convergence and embodied knowledge. By foregrounding the tale’s intermedial dynamics, this study reframes folk tales as a fluid site of aesthetic, cultural, and epistemic negotiations. Full article

This article investigates the role of space in the fiction of Jeffrey Eugenides, focusing on The Virgin Suicides (1993) and Middlesex (2002) through the lens of spatial theory. Drawing on key thinkers such as Henri Lefebvre, Michel Foucault, Edward Soja, Yi-Fu Tuan, and Doreen Massey, the study explores how Eugenides constructs spatial environments that not only frame but actively shape the identities, desires, and traumas of his characters. In The Virgin Suicides, suburban domestic spaces are shown to function as heterotopias—sites of surveillance, repression, and mythologized femininity—while Middlesex engages with transnational and urban spaces to narrate diasporic and intersex identity as dynamic, embodied, and liminal. The analysis reveals that Eugenides uses space as both a narrative device and a thematic concern to interrogate gender, memory, and power. Rather than passive backdrops, the novelistic spaces become charged arenas of conflict and transformation, reflecting and resisting dominant socio-cultural discourses. This study argues that space in Eugenides’ fiction operates as a critical register for understanding the politics of belonging and the production of subjectivity. By situating Eugenides within the broader field of literary spatiality, this article contributes to contemporary debates in literary geography, gender studies, and American fiction. Full article

Henri Lefebvre’s “right to the city” has rarely been examined through an intersectional feminist lens, leaving unnoticed the uneven burdens that urban design and policy place on women. This article bridges that gap by combining constitutional analysis, survey data (n = 736), in-depth interviews, and participatory observation to assess how Quito’s public spaces affect women’s safety and mobility. Quantitative results show that 81% of respondents endured sexual or offensive remarks, 69.8% endured obscene gestures, and 38% endured severe harassment in the month before the survey; 43% of these incidents occurred only days or weeks beforehand, underscoring their routine nature. Qualitative narratives reveal behavioral adaptations—altered routes, self-policing dress codes, and distrust of authorities—and identify poorly lit corridors and weak institutional presence as spatial amplifiers of violence. Analysis of Quito’s “Safe City” program exposes a gulf between its ambitious rhetoric and its narrow, transport-centered implementation. We conclude that constitutional guarantees of participation, appropriation, and urban life will remain aspirational until urban planning mainstreams gender-sensitive design, secures intersectoral resources, and embeds women’s substantive participation throughout policy cycles. A feminist reimagining of Quito’s public realm is therefore indispensable to transform the right to the city from legal principle into lived reality. Full article

This article offers a critical reading of the fishing neighbourhood of Paramos, located on the northern coast of Portugal, through a methodological approach that combines documentary photography and cognitive cartography. The study investigates the relationships between identity, landscape, and power within a territory marked by spatial fragmentation, symbolic exclusion, and functional indeterminacy. By means of a structured visual essay supported by field observation and interpretive maps, Paramos is examined as a liminal urban enclave whose ambiguities reveal tensions between memory, informal appropriation, and control devices. Drawing on authors such as Lefebvre, Augé, Hayden, Domingues, Foucault, and Latour, the article argues that the photographic image, used as a critical tool, can unveil hidden territorial logics and contribute to a more inclusive and situated spatial discourse. Full article

Black crusts and biological colonisation are among the most common types of ‘diseases’, with diverse aetiologies and presentations, affecting masonry architectural heritage. Over the past decades, there has been an increase in the incidence of this degradation phenomena due to the increase in pollution and climate change, especially on the urban walls of ancient cities. In particular, the present research examines the state of conservation of the city walls of Perugia, which are divided into two main city walls dating back to the Etruscan and Medieval periods and are recognised as historical heritage of high identity and cultural value. The degradation reflects, in the mentioned cases, on the liminal public and green areas. A view is also reflected in local journalism and social media, where residents and visitors have framed the spontaneous growth of herbs and medicinal shrubs within the stone joints of historic walls as an apparently benign and aesthetically pleasing occurrence. This misleading interpretation, while rooted in a superficial aesthetic appreciation, nevertheless draws attention to a real and urgent issue: the pressing need for systematic maintenance and intervention strategies—coordinated between academics, students, designers and stakeholders—which are able to reposition the city walls as central agents of urban and cultural regeneration, rather than peripheral remnants of the past. Full article

This study explores the spatial and social implications of urban food systems in Quito, Ecuador, focusing on how food access inequalities reflect and reinforce broader urban disparities. The research addresses a critical problem in contemporary urbanization: the disconnection between food provisioning and spatial equity in rapidly growing cities. The objective is to assess and map disparities in food accessibility using a mixed-methods approach that includes field observation, participatory mapping, value chain analysis, and statistical modeling. Five traditional and emerging food markets were studied in diverse districts across the city. A synthetic accessibility function F(x) was constructed to model food access levels, integrating variables such as income, infrastructure, transport availability, and travel time. These variables were subjected to Principal Component Analysis (PCA) and hierarchical clustering to generate three typologies of territorial vulnerability. The results reveal that peripheral areas exhibit lower F(x) values and weaker integration with the formal food system, leading to higher consumer costs and limited fresh food options. In contrast, central districts benefit from multimodal infrastructure and greater diversity of supply. This study concludes that food systems should be treated as critical urban infrastructure. Integrating food equity into land use and mobility planning is essential to promote inclusive, sustainable, and resilient urban development. Full article

Descola describes western culture, influenced by the Christian worldview, as “naturalist”. However, semiotic and ethnographic research shows that different perspectives about the relationship between humans and animals coexist with mainstream naturalism. In particular, the introduction of animals in churches is not rare in Italy today, even though it fuels an ongoing debate. The relationship with animals is central in Saint Anthony’s figure and feast, which includes the blessing of animals. This article first focuses on the figure of Saint Anthony, finding in its first sources the seeds of a worldview based on love for creation that fully flourishes centuries later with Saint Francis, then it contextualizes the blessing of animals in the context of a changing sensitivity towards animals, which are often considered from an affective perspective and as part of an ecological standpoint that is also expressed in the institutional discourse of the Catholic Church. Then, the patronal feast of Saint Anthony and the blessing of animals in two different urban communities of Turin (Italy) are the subject of an ethnosemiotic analysis highlighting the animals’ position (inside or at the border of the sacred space), the rite’s structure and the relation between the verbal discourse and the performance of celebrants and worshipers. The position of the animals is thus considered as the expression plane of semantic values about their status in relation to the family. Full article

The Religious Workforce Project is a Lilly Endowment-funded effort to map the nation’s changing Christian religious landscape. A quantitative component identifies broad US trends, while our qualitative work focuses on Christian congregations in the Washington, DC metro area and surrounding counties, to understand how congregations staff to fulfill their missions, and to learn how congregational leaders understand the nature of their ministry today. In 2019–2022, we conducted case studies in 40 congregations in a variety of Christian traditions and contexts. For our analysis, we used a framework based on three societal trends that have impacted congregations: long-term member loss in churches, a skewed distribution in church attendance in which most people attend large churches while most churches are small, and a pandemic-induced movement from brick-and-mortar spaces to online spaces. This analysis revealed the consequential impacts of these three trends on congregations and their leaders, and some of the essential skills needed for effective church operation during this “wilderness moment,” a liminal time in the life of the church. We see these impacts not only as responses to external pressures but also as signs of internal reimagining. Understanding these dynamics is crucial for developing effective strategies for church staffing and for preparing future congregational leaders that can adapt to the future needs of ministry. Full article

This paper aims to advance sociological theory by systematizing the concept of “limit situation”, a term that Berger employs throughout his work, though only in a hinted and unsystematic manner. To achieve this objective, the paper develops a theoretical framework that incorporates different contributions and perspectives. Within this framework, the concept of “limit situation” translates into an analytical tool for the sociological study of vulnerability, particularly in relation to engaged spirituality. The concept is tested through an empirical study based on in-depth interviews with founders, workers, and volunteers from organizations that provide care for individuals facing vulnerability. The analysis shows that encounters with vulnerability, under specific circumstances, create a liminal situation that promotes spirituality at both existential and operational levels. This process informs the value systems of the involved actors and activates specific social practices and relationships. Full article

In the context of globalization and rapid societal changes, preserving sacred landscapes is vital for cultural identity and resilience. This study investigates the concept of liminality within the cultural landscape of Neira Island, emphasizing the significance of the Buka Kampung ritual and keramat (sacred objects) as integral components of Neira landscape identity. Through qualitative analysis and case studies, the study explores how these rituals serve as liminal practices that mediate between continuity and transformation. The findings highlight that the act of making offerings at keramat during the Buka Kampung ritual fosters social cohesion and reinforces collective identity. This research contributes to a deeper understanding of the interplay between sacredness, rituals, and identity, demonstrating how these elements shape place attachment, collective memory, and the lived experiences of local communities. It highlights the importance of sacred landscapes in fostering community resilience and cultural continuity, offering insights into the role of ritual practices in heritage preservation. Full article

This article engages the concept of death as a revolutionary transformation within the contexts of mind uploading (MU) and Pierre Teilhard de Chardin’s theology of the Omega Point. The focus is not on the Omega Point itself as a conceptual endpoint, nor on what becomes of consciousness once it has been successfully uploaded into a digital substrate. To grasp the meaning of “death” within the context of MU, the article employs the notion of liminal speculative imagination to analyze death amid the liminality of biological mortality and digital immortality. It argues that death is more than just the end of life but rather as a transitional phase between different states of being. It contends that this liminal gap between life forms is an inherent aspect of existence that cannot be eliminated at a fundamental level. Instead of seeking to overcome death, the article suggests embracing the transformative nature of this liminality. In this view, death is seen as a natural and unavoidable part of life, serving as a mediator or catalyst for transitions into new forms of existence. Rather than focusing solely on achieving immortality, the article advocates for utilizing technology to facilitate evolution and advancement. By acknowledging the role of death in the process of transformation, particularly within the context of transhumanism, the article proposes that embracing liminality can lead to new possibilities for human evolution. This includes the potential emergence of transhuman life forms, such as those enabled by MU technologies. Full article

The return roadway in Limin Coal Mine experiences strong mine pressure during the mining work of the I030902 working face, which poses potential safety hazards to production and management. Therefore, hydraulic fracturing is used to relieve pressure on the free coal pillar roof. Hydraulic fracture simulation tests using gelatin materials were conducted, and the propagation of the hydraulic fracturing cracks in gelatin simulating different key strata was obtained, which led to the design of the hydraulic fracturing used in the I030902 working face at Limin Coal Mine. According to the analysis of the on-site tests, after fracturing, the roof pressure decreased by 17.8%, the average pressure step distance reduced by 18.0%, the average daily rate of the roof and floor convergence decreased by 63.86%, and the average daily rate of the roof and floor convergence was reduced by 72.4%. Therefore, the feasibility of the hydraulic fracturing in weak structure formation in hard roof strata and roadway deformation control has been verified, providing a theoretical foundation and on-site date for the relief of free roadway roof pressure. Full article

This article investigates the transformative impacts of regular nature-based adventure activity engagement and its long-lasting effects on eudaimonic well-being (EWB), specifically mental health. Although extant research highlights a wide range of well-being and mental health benefits from participation in such pursuits, less is known about experienced outdoor adventure enthusiasts for whom adventure is a fundamental and transformational part of their lives. The study builds on an existing conceptual framework that synthesizes pertinent research concepts on nature-based activity engagement and subjective well-being benefits. It presents key findings from 40 semi-structured in-depth online interviews with respondents from the UK, Germany, and Serbia. Interview data were collated and analyzed using a thematic framework approach. The findings highlight the importance of outdoor adventure activity engagement for respondents’ mental and physical health and long-term well-being. Regular activity participation can be transformational in reducing feelings of ill-being and enhancing EWB. It can improve self-efficacy and identity development and promote the fulfilment of psychological needs, facilitated by key transformational catalyzers. Continually entering a liminal state, experiencing emotions, and overcoming challenges and risks during engagement are crucial to “successful” long-lasting transformation. Further research should continue to explore adventure’s transformational and EWB benefits to develop long-term data. Full article

Post-Theoretical “creative–critical” research recently emerged in the discipline of Creative Writing as a collapse of the binaries between practice and Theory. This article shows that using this interdisciplinary methodology in the study of mysticism is a natural fit, illustrating its efficacy in a case study with the reflexive writing of the medieval Christian mystic Julian of Norwich. As a creative–critical writer and researcher, I explored the junctures where Julian’s poetics intersect with trauma-informed theology. Writing through these intersections formed a literary trauma-informed framework for the holding and processing of loss and grief through Julian’s nuanced modelling of mystical union with God. This case study shows how the framework came together critically and its application to contemporary ecological grief in the writing of a performative long poem, Blue: a lament for the sea. The “theopoetic” making process with two images from Julian’s texts, Christ’s “wounds” and “one-ing”, developed new language for liminal and spiritual experience. Insights from creative–critical research can be shared in artistic performance and publication in the academy and beyond in public impact. Bringing the whole self through theopoetics to the scholarly research of mysticism has the potential to form fresh insights, revealing new dimensions. Full article