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Search Results (562)

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17 pages, 18446 KiB  
Article
Spatial Forecasting and Social Acceptance of Human-Wildlife Conflicts Involving Semi-Aquatic Species in Romania
by Alexandru Gridan, Claudiu Pașca, Georgeta Ionescu, George Sîrbu, Cezar Spătaru, Ovidiu Ionescu and Darius Hardalau
Diversity 2025, 17(8), 559; https://doi.org/10.3390/d17080559 - 7 Aug 2025
Abstract
Human-Wildlife conflict (HWC) presents a growing challenge for wildlife conservation, especially as species recover and reoccupy human-dominated landscapes, creating tensions between ecological goals and local livelihoods. Such conflicts are increasingly reported across Europe, including Romania, involving semi-aquatic species like the Eurasian beaver ( [...] Read more.
Human-Wildlife conflict (HWC) presents a growing challenge for wildlife conservation, especially as species recover and reoccupy human-dominated landscapes, creating tensions between ecological goals and local livelihoods. Such conflicts are increasingly reported across Europe, including Romania, involving semi-aquatic species like the Eurasian beaver (Castor fiber L.) and Eurasian otter (Lutra lutra L.). Enhancing coexistence with wildlife through the integration of conflict mapping, stakeholder engagement, and spatial analysis into conservation planning is therefore essential for ensuring the long-term protection of conflict species. A mixed-methods approach was used, including structured surveys among stakeholders, standardized damage report collection from institutions, and expert field assessments of species activity. The results indicate that while most respondents recognize the legal protection of both species, a minority have experienced direct conflict, primarily with beavers through flooding and crop damage. Tolerance varied markedly among demographic groups: researchers and environmental agency staff were most accepting, whereas farmers and fish farm owners were the least accepting; respondents with no personal damage experience and those with university or post-secondary education also displayed significantly higher acceptance toward both species. Institutional reports confirmed multiple beaver-related damage sites, and through field validation, conflict forecast zones with spatial clustering in Harghita, Brașov, Covasna, and Sibiu counties were developed. These findings underscore the importance of conflict forecasting maps, understanding the coexistence dynamics and drivers of acceptance, and the need to maintain high acceptance levels toward the studied species. The developed maps can serve as a basis for targeted interventions, helping to balance ecological benefits with socioeconomic concerns. Full article
(This article belongs to the Special Issue Restoring and Conserving Biodiversity: A Global Perspective)
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56 pages, 1426 KiB  
Review
A Holistic Review of Cannabis and Its Potential Risks and Benefits in Mental Health
by Alejandro Borrego-Ruiz and Juan J. Borrego
Psychiatry Int. 2025, 6(3), 92; https://doi.org/10.3390/psychiatryint6030092 - 4 Aug 2025
Viewed by 446
Abstract
Background: The dual nature of cannabis, as both a promising therapeutic tool and a widely used recreational substance with potential risks, raises important societal controversies, including its unclear impacts regarding mental health. This narrative review provides a comprehensive overview of cannabis, addressing (i) [...] Read more.
Background: The dual nature of cannabis, as both a promising therapeutic tool and a widely used recreational substance with potential risks, raises important societal controversies, including its unclear impacts regarding mental health. This narrative review provides a comprehensive overview of cannabis, addressing (i) its historical context; (ii) its chemical composition and pharmacokinetics; (iii) its pharmacological effects; (iv) its negative impacts on physiological and mental health; (v) its potential use as a drug for the treatment of neurological and psychiatric disorders; (vi) its relationship with the gut microbiome and how this interaction might influence mental functioning; (vii) the pathophysiology, prevalence, comorbidities, and treatment strategies of cannabis use disorder; and (viii) social perspectives on its legalization. Results: Cannabis presents a complex chemical profile and pharmacokinetics that show promise in treating numerous neurological, psychiatric, and psychological conditions. However, its use carries risks, which depend on factors such as compound concentration, dosage, consumption method, frequency of use, and individual vulnerability. Cannabis use disorder seems to be less severe than other substance use disorders, but it still constitutes a significant concern, as its manifestation is not uniform across all users. Conclusions: Cannabis demands a thorough understanding that goes beyond simplistic explanations and prejudices, standing as a plant of substantial clinical significance and highlighting the importance of personalized approaches to its use and increased awareness of how individuals respond to its effects. Full article
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16 pages, 513 KiB  
Article
Dismantling the Myths of Urban Informality for the Inclusion of the Climate Displaced in Cities of the Global South
by Susana Herrero Olarte and Angela María Díaz-Márquez
World 2025, 6(3), 109; https://doi.org/10.3390/world6030109 - 1 Aug 2025
Viewed by 234
Abstract
By 2050, it is estimated that approximately 200 million people will be displaced due to the impacts of climate change. Vulnerability to climate change is shaped not only by environmental factors but fundamentally by systemic power relations and structural conditions present at both [...] Read more.
By 2050, it is estimated that approximately 200 million people will be displaced due to the impacts of climate change. Vulnerability to climate change is shaped not only by environmental factors but fundamentally by systemic power relations and structural conditions present at both the places of origin and destination. In Latin America, climate-displaced persons predominantly settle in marginalised neighbourhoods, where widely accepted informality facilitates their rapid arrival but obstructs genuine progress and full integration as urban citizens. This paper critically examines the prevailing myths that justify the persistence of informality, revealing the socioeconomic challenges faced by climate migrants in the region. These four dominant myths are (1) Latin America’s inherently low productivity levels; (2) concessions by the ruling class enabling excluded groups to merely survive; (3) the perceived privilege of marginalised neighbourhoods to generate income outside formal legal frameworks, which supports their social capital; and (4) the limited benefits associated with formalisation. Debunking these myths is essential for developing effective public policies aimed at reducing informality and promoting inclusive urban integration, ultimately benefiting both climate migrants and host communities. Full article
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18 pages, 255 KiB  
Article
Making the Invisible Visible: Addressing the Sexuality Education Needs of Persons with Disabilities Who Identify as Queer in Kenya
by Amani Karisa, Mchungwani Rashid, Zakayo Wanjihia, Fridah Kiambati, Lydia Namatende-Sakwa, Emmy Kageha Igonya, Anthony Idowu Ajayi, Benta Abuya, Caroline W. Kabiru and Moses Ngware
Disabilities 2025, 5(3), 69; https://doi.org/10.3390/disabilities5030069 - 31 Jul 2025
Viewed by 172
Abstract
Persons with disabilities face barriers to accessing sexuality education. For those who identify as queer, these challenges are compounded by stigma, ableism, and heteronormativity, resulting in distinct and overlooked experiences. This study explored the sexuality education needs of persons with disabilities who identify [...] Read more.
Persons with disabilities face barriers to accessing sexuality education. For those who identify as queer, these challenges are compounded by stigma, ableism, and heteronormativity, resulting in distinct and overlooked experiences. This study explored the sexuality education needs of persons with disabilities who identify as queer in Kenya—a neglected demographic—using a phenomenological approach. Data were collected through a focus group discussion with six participants and analyzed thematically. Three themes emerged: invisibility and erasure; unprepared institutions and constrained support networks; and agency and everyday resistance. Educational institutions often overlook the intersectional needs of persons with disabilities who identify as queer, leaving them without adequate tools to navigate relationships, sexuality, and rights. Support systems are often unprepared or unwilling to address these needs. Societal attitudes that desexualize disability and marginalize queerness intersect to produce compounded exclusion. Despite these challenges, participants demonstrated agency by using digital spaces and informal networks to resist exclusion. This calls for policy reforms that move beyond tokenism to address the lived realities of multiply marginalized groups. Policy reform means not only a legal or governmental shift but also a broader cultural and institutional process that creates space for recognition, protection, and participation. Full article
15 pages, 226 KiB  
Article
From Legal Commentaries to Common Instruction: Joseph Story’s Abridgments to His Commentaries on the Constitution of the United States
by Brigid Flaherty Staab
Laws 2025, 14(4), 53; https://doi.org/10.3390/laws14040053 - 31 Jul 2025
Viewed by 149
Abstract
Justice Joseph Story’s Commentaries on the Constitution of the United States (1833) have long been regarded as the scholarly source for a nationalist account of the U.S. Constitution in Antebellum America. Yet recent scholarship has questioned whether the Commentaries should be viewed exclusively [...] Read more.
Justice Joseph Story’s Commentaries on the Constitution of the United States (1833) have long been regarded as the scholarly source for a nationalist account of the U.S. Constitution in Antebellum America. Yet recent scholarship has questioned whether the Commentaries should be viewed exclusively as a work of legal scholarship. This article reinterprets Justice Story’s three-volume work as a project of civic education during a period of political and constitutional uncertainty. Written during the Nullification Crisis and in the wake of codification efforts, Justice Story presents his Commentaries for the use of the American public, providing them, and not exclusively lawyers and judges, with a source to support a popular conception of American constitutionalism. Story’s project of civic education is clearly shown by his personal efforts to abridge his Commentaries on three separate occasions to ensure the wide distribution of the work to Americans of different ages, groups, localities, and levels of education. As such, this article offers Justice Story as a guide to contemporary judges who seek to engage in civic education projects. Full article
16 pages, 236 KiB  
Article
Disability Certification in Colombia: An Analysis from the Perspective of Inclusive Social Protection
by Monica Pinilla-Roncancio and Nicolas Rodriguez Caicedo
Disabilities 2025, 5(3), 66; https://doi.org/10.3390/disabilities5030066 - 25 Jul 2025
Viewed by 507
Abstract
Disability Certification is an instrument that can contribute to the identification of persons with disabilities who are potential beneficiaries of social protection programmes. In Colombia, the disability certification process was changed in 2020 to include a human rights perspective. However, little information exists [...] Read more.
Disability Certification is an instrument that can contribute to the identification of persons with disabilities who are potential beneficiaries of social protection programmes. In Colombia, the disability certification process was changed in 2020 to include a human rights perspective. However, little information exists on how far the process aligns with the recommendations made by the Convention on the Rights of Persons with Disabilities or to what extent it provides useful information for the operation of the country’s social protection system. This study aims to analyse how the changes implemented in 2020 have contributed to the identification and determination of persons with disabilities in social protection programmes in Colombia. This research uses an analytical-descriptive design, in which legal documents related to the social protection programme and disability certification were analysed. In addition, we conducted semi-structured interviews in Colombia with people with disabilities, professionals conducting the certification, and with key stakeholders, and we analysed the information using thematic analysis. Colombia changed its certification process in 2020, moving from a capacity-to-work assessment to a process of assessing functioning capacity and participation limitations following the International Classification of Functional Disability and Health. However, the new certification process has not provided an instrument to contribute to determining persons with disabilities who should be prioritised or receive social benefits in Colombia. The certification does not establish the support needs of people with disabilities, does not recommend reasonable adjustments to support their participation in society, and has not been used systematically in social protection programmes. Finally, individuals with disabilities commented that the disability certification is a process that does not open up opportunities to receive social benefits and social transfers, and in most cases, it is an expensive and lengthy process. Disability certification in Colombia is not an instrument that determines the needs of people with disabilities, nor the reasonable accommodations that they require in order to participate in society. Full article
13 pages, 203 KiB  
Article
Accessibility of Dutch Public Space: Regulations and Local Actions by Pedestrians with Disabilities
by Dick Houtzager and Edwin Luitzen De Vos
Laws 2025, 14(4), 51; https://doi.org/10.3390/laws14040051 - 24 Jul 2025
Viewed by 374
Abstract
This article examines the accessibility of public space for individuals with disabilities in the Netherlands, as well as the relevant legal frameworks intended to promote accessibility. It discusses the Convention on the Rights of Persons with Disabilities (UN CRPD) and efforts to implement [...] Read more.
This article examines the accessibility of public space for individuals with disabilities in the Netherlands, as well as the relevant legal frameworks intended to promote accessibility. It discusses the Convention on the Rights of Persons with Disabilities (UN CRPD) and efforts to implement its provisions at the local level. The article first provides an overview of Dutch legislation and regulations concerning accessibility in public spaces. It then presents an analysis of the experiences of individuals with disabilities in navigating streets and pavements in two Dutch cities, Utrecht and Almere. The central question is to what extent equal participation in public space has been realised. The findings indicate that national legislation remains inadequate in addressing the accessibility of streets and pavements. Despite the constitutional amendment in January 2023, which prohibits discrimination on the grounds of disability, substantive equality is largely dependent on the individual policies and bylaws of the 342 municipalities. The involvement of individuals with disabilities in shaping the inclusive use of public space is therefore crucial at the local level. This article highlights local initiatives that have successfully drawn the attention of municipal policymakers and civil servants to the importance of accessible streets. Full article
19 pages, 909 KiB  
Viewpoint
The Big Minority View: Do Prescientific Beliefs Underpin Criminal Justice Cruelty, and Is the Public Health Quarantine Model a Remedy?
by Alan C. Logan and Susan L. Prescott
Int. J. Environ. Res. Public Health 2025, 22(8), 1170; https://doi.org/10.3390/ijerph22081170 - 24 Jul 2025
Viewed by 834
Abstract
Famed lawyer Clarence Darrow (1857–1938) argued strongly for an early-life public health approach to crime prevention, one that focused on education, poverty reduction, and equity of resources. Due to his defense of marginalized persons and his positions that were often at odds with [...] Read more.
Famed lawyer Clarence Darrow (1857–1938) argued strongly for an early-life public health approach to crime prevention, one that focused on education, poverty reduction, and equity of resources. Due to his defense of marginalized persons and his positions that were often at odds with his legal colleagues and public opinion, he was known as the Big Minority Man. He argued that the assumption of free will—humans as free moral agents—justifies systems of inequity, retributive punishment, and “unadulterated brutality.” Here, the authors revisit Darrow’s views and expand upon them via contemporary research. We examine increasingly louder argumentation—from scholars across multiple disciplines—contending that prescientific notions of willpower, free will, blameworthiness, and moral responsibility, are contributing to social harms. We draw from biopsychosocial perspectives and recent scientific consensus papers calling for the dismantling of folk psychology ideas of willpower and blameworthiness in obesity. We scrutinize how the status quo of the legal system is justified and argue that outdated notions of ‘moral fiber’ need to be addressed at the root. The authors examine recent arguments for one of Darrow’s ideas—a public health quarantine model of public safety and carceral care that considers the ‘causes of the causes’ and risk assessments through a public health lens. In our view, public health needs to vigorously scrutinize the prescientific “normative” underpinnings of the criminal justice system. Full article
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19 pages, 298 KiB  
Article
Determinants of Refugee Children’s Self-Perceived Educational Performance: A Comparative Study of Lebanon, Turkey, and Australia
by Maha Shuayb and Mohammad Hammoud
Soc. Sci. 2025, 14(7), 440; https://doi.org/10.3390/socsci14070440 - 18 Jul 2025
Viewed by 551
Abstract
This study investigates how differing educational frameworks across Lebanon, Turkey, and Australia influence the perceived educational performance of Syrian refugee children. The legal status granted to refugees in each country fundamentally shapes their respective education systems’ responses. In Lebanon, refugees are generally classified [...] Read more.
This study investigates how differing educational frameworks across Lebanon, Turkey, and Australia influence the perceived educational performance of Syrian refugee children. The legal status granted to refugees in each country fundamentally shapes their respective education systems’ responses. In Lebanon, refugees are generally classified as temporarily displaced persons, resulting in an emergency-based approach to education for the approximately 500,000 Syrian children present. By contrast, Australia has offered permanent resettlement opportunities to selected Syrian refugees, integrating them directly into mainstream schools. Turkey, meanwhile, has progressively shifted from emergency-based measures to policies oriented toward long-term integration. This research is based on survey data from 1298 Syrian refugee children across the three contexts. Findings from ordered probit regression analyses indicate that, beyond the legal duration of residency and the prevailing educational policy model (emergency versus long-term integration), variables such as the extent of educational segregation, the availability of preparatory and language support programmes, and the socioeconomic status of families are also pivotal in shaping students’ self-perceived academic performance. Full article
(This article belongs to the Section International Migration)
13 pages, 217 KiB  
Article
“To Live or Not to Live”: The Silent Voices of Adolescents with Disabilities in Ghana
by Florence Naab, Mary A. Asirifi, Charles Ampong Adjei, Josephine M. Kyei, William Menkah, Hellen Gateri, Emilene Riesdorfer, Reyna Parikh and Elizabeth Burgess-Pinto
Disabilities 2025, 5(3), 64; https://doi.org/10.3390/disabilities5030064 - 16 Jul 2025
Viewed by 361
Abstract
About 8% of Ghanaians, including adolescents, have various types of disabilities. Although many legal and constitutional protections for people with disabilities, including adolescents, exist in Ghana, it is widely known that these persons face a variety of psychosocial issues. Several factors have been [...] Read more.
About 8% of Ghanaians, including adolescents, have various types of disabilities. Although many legal and constitutional protections for people with disabilities, including adolescents, exist in Ghana, it is widely known that these persons face a variety of psychosocial issues. Several factors have been identified as contributing to the unremitting marginalisation of people with disabilities in general, but the extent to which these can be generalised to adolescents with disabilities is unknown. This study, therefore, sought to document the determinants, manifestations, and consequences of disability-related stigma among differently abled adolescents in three special schools in northern, middle, and southern Ghana. An exploratory descriptive qualitative design was used. Overall, 54 participants were purposively selected for a semi-structured interview and focus group discussions. Braun and Clarke’s procedure for thematic analysis was followed. The findings showed a variety of stigmatising experiences by adolescents with disabilities in their sociocultural context. More broadly, the cause of disability was linked to the ramifications of parental sins against the gods, being a descendant of river gods, and the consequences of bewitchment/curses by family members. Others included the perceived transmissibility of the disability and disability as a visible condition. Stigma manifested in the form of pejorative labelling, ableism, and social exclusion. The consequences of this stigma included negative psychological and emotional effects (i.e., depression, low self-esteem, and a lack of confidence) and suicidal ideation. There is an urgent need for stigma reduction interventions for adolescents with disabilities in Ghana as part of an effort to improve their wellbeing. Full article
17 pages, 1599 KiB  
Article
Trends in Antidepressant, Anxiolytic, and Cannabinoid Use Among Italian Elite Athletes (2011–2023): A Longitudinal Anti-Doping Analysis
by Mario Ruggiero, Leopoldo Ferrante, Domenico Tafuri, Rosaria Meccariello and Filomena Mazzeo
Sports 2025, 13(7), 233; https://doi.org/10.3390/sports13070233 - 16 Jul 2025
Viewed by 464
Abstract
Mental health disorders, particularly depression and anxiety, have become increasingly prevalent among elite athletes, exacerbated by factors such as competitive pressure and the Coronavirus Disease 19 (COVID-19) pandemic. This study analyzes trends in the use of antidepressants, anxiolytics, and cannabinoids (delta-9-tetrahydrocannabinol (THC)/cannabidiol (CBD)) [...] Read more.
Mental health disorders, particularly depression and anxiety, have become increasingly prevalent among elite athletes, exacerbated by factors such as competitive pressure and the Coronavirus Disease 19 (COVID-19) pandemic. This study analyzes trends in the use of antidepressants, anxiolytics, and cannabinoids (delta-9-tetrahydrocannabinol (THC)/cannabidiol (CBD)) among Italian athletes from 2011 to the first half of 2023 (FH2023), referring to anti-doping reports published by the Italian Ministry of Health. Data from 13,079 athletes were examined, with a focus on non-prohibited medications, banned substances, and regulatory impacts, including threshold adjustments for THC since 2013 and the legalization of CBD. The results show fluctuating use of antidepressants/anxiolytics, with peaks in 2021 and the FH2023, coinciding with post-pandemic awareness. Positive THC cases rose following regulatory changes, reflecting socio-cultural trends. Gender disparities emerged, with THC use predominantly among males (e.g., nine males vs. one female in 2013), though female athletes were underrepresented in testing. This study highlights the need for personalized, evidence-based strategies that balance therapeutic efficacy and anti-doping compliance. Clinicians should carefully consider prescribing selective serotonin reuptake inhibitors (SSRIs) and benzodiazepines to address depression and anxiety and should monitor the risks of CBD contamination. Future research should adopt longitudinal, gender-sensitive approaches to refining guidelines and combating stigma in professional sports. Full article
(This article belongs to the Topic Recent Advances in Physical Education and Sports)
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21 pages, 664 KiB  
Article
Trust, Privacy Fatigue, and the Informed Consent Dilemma in Mobile App Privacy Pop-Ups: A Grounded Theory Approach
by Ming Chen and Meimei Chen
J. Theor. Appl. Electron. Commer. Res. 2025, 20(3), 179; https://doi.org/10.3390/jtaer20030179 - 14 Jul 2025
Viewed by 512
Abstract
As data becomes a core driver of modern business innovation, mobile applications increasingly collect and process users’ personal information, posing significant challenges to the effectiveness of informed consent and the legitimacy of user authorization. Existing research on privacy informed consent mechanisms has predominantly [...] Read more.
As data becomes a core driver of modern business innovation, mobile applications increasingly collect and process users’ personal information, posing significant challenges to the effectiveness of informed consent and the legitimacy of user authorization. Existing research on privacy informed consent mechanisms has predominantly focused on privacy policy texts and normative legal discussions, often overlooking a critical touchpoint—the launch-time privacy pop-up window. Moreover, empirical investigations from the user’s perspective remain limited. To address these issues, this study employs a two-stage approach combining compliance audit and grounded theory. The preliminary audit of 21 mobile apps assesses the compliance of privacy pop-ups, and the formal study uses thematic analysis of interviews with 19 participants to construct a dual-path explanatory framework. Key findings reveal that: (1) while the reviewed apps partially safeguarded users’ right to be informed, compliance deficiencies still persist; (2) trust and privacy fatigue emerge as dual motivations driving user consent. Trust plays a critical role in amplifying the impact of positive messages within privacy pop-ups by enhancing the consistency among users’ cognition, affect, and behavior, thereby reducing resistance to privacy consent and improving the effectiveness of the current informed consent framework. Conversely, privacy fatigue increases the inconsistency among these factors, undermining consent effectiveness and exacerbating the challenges associated with informed consent. This study offers a user-centered framework to explain the dynamics of informed consent in mobile privacy pop-ups and provides actionable insights for regulators, developers, and privacy advocates seeking to enhance transparency and user autonomy. Full article
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16 pages, 268 KiB  
Article
Queer Migration in Catholic Countries of Central and Eastern Europe: An Unexplored Topic
by Milda Ališauskienė, Halina Grzymala-Mosczynska, Jacek Prusak and Siniša Zrinščak
Religions 2025, 16(7), 881; https://doi.org/10.3390/rel16070881 - 9 Jul 2025
Viewed by 771
Abstract
This paper explores the under-researched phenomenon of queer migration in Croatia, Lithuania, and Poland—three post-communist, Catholic-majority countries. Drawing on existing studies in the literature and empirical data, it examines how prevailing social conservatism—shaped by the influence of Catholicism and the distinct developmental trajectories [...] Read more.
This paper explores the under-researched phenomenon of queer migration in Croatia, Lithuania, and Poland—three post-communist, Catholic-majority countries. Drawing on existing studies in the literature and empirical data, it examines how prevailing social conservatism—shaped by the influence of Catholicism and the distinct developmental trajectories of these countries—is reflected in research on queer migration. Although limited, the current body of knowledge confirms that concerns over LGBTQIA+ rights are a factor motivating emigration. The three examples illustrate how queer migration must be analyzed within the complex interplay between Europeanization and liberalization, and the backlash against these processes. This backlash, prominently supported by the Catholic Church, includes resistance to gender equality and LGBTQIA+ rights. By critically engaging with existing research, the paper underscores the need for future studies—particularly those investigating the gap between legal protections and prevailing social attitudes toward LGBTQIA+ individuals, the relationship between human rights backlashes and queer migration, the intersections between spatial context and personal biographies, and the connection between the queer migration and recent immigration waves in these countries. Full article
32 pages, 1126 KiB  
Review
Exploring the Role of Artificial Intelligence in Smart Healthcare: A Capability and Function-Oriented Review
by Syed Raza Abbas, Huiseung Seol, Zeeshan Abbas and Seung Won Lee
Healthcare 2025, 13(14), 1642; https://doi.org/10.3390/healthcare13141642 - 8 Jul 2025
Viewed by 1278
Abstract
Artificial Intelligence (AI) is transforming smart healthcare by enhancing diagnostic precision, automating clinical workflows, and enabling personalized treatment strategies. This review explores the current landscape of AI in healthcare from two key perspectives: capability types (e.g., Narrow AI and AGI) and functional architectures [...] Read more.
Artificial Intelligence (AI) is transforming smart healthcare by enhancing diagnostic precision, automating clinical workflows, and enabling personalized treatment strategies. This review explores the current landscape of AI in healthcare from two key perspectives: capability types (e.g., Narrow AI and AGI) and functional architectures (e.g., Limited Memory and Theory of Mind). Based on capabilities, most AI systems today are categorized as Narrow AI, performing specific tasks such as medical image analysis and risk prediction with high accuracy. More advanced forms like General Artificial Intelligence (AGI) and Superintelligent AI remain theoretical but hold transformative potential. From a functional standpoint, Limited Memory AI dominates clinical applications by learning from historical patient data to inform decision-making. Reactive systems are used in rule-based alerts, while Theory of Mind (ToM) and Self-Aware AI remain conceptual stages for future development. This dual perspective provides a comprehensive framework to assess the maturity, impact, and future direction of AI in healthcare. It also highlights the need for ethical design, transparency, and regulation as AI systems grow more complex and autonomous, by incorporating cross-domain AI insights. Moreover, we evaluate the viability of developing AGI in regionally specific legal and regulatory frameworks, using South Korea as a case study to emphasize the limitations imposed by infrastructural preparedness and medical data governance regulations. Full article
(This article belongs to the Special Issue The Role of AI in Predictive and Prescriptive Healthcare)
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28 pages, 2586 KiB  
Review
Diagnostic, Therapeutic, and Prognostic Applications of Artificial Intelligence (AI) in the Clinical Management of Brain Metastases (BMs)
by Kyriacos Evangelou, Panagiotis Zemperligkos, Anastasios Politis, Evgenia Lani, Enrique Gutierrez-Valencia, Ioannis Kotsantis, Georgios Velonakis, Efstathios Boviatsis, Lampis C. Stavrinou and Aristotelis Kalyvas
Brain Sci. 2025, 15(7), 730; https://doi.org/10.3390/brainsci15070730 - 8 Jul 2025
Viewed by 703
Abstract
Brain metastases (BMs) are the most common intracranial tumors in adults. Their heterogeneity, potential multifocality, and complex biomolecular behavior pose significant diagnostic and therapeutic challenges. Artificial intelligence (AI) has the potential to revolutionize BM diagnosis by facilitating early lesion detection, precise imaging segmentation, [...] Read more.
Brain metastases (BMs) are the most common intracranial tumors in adults. Their heterogeneity, potential multifocality, and complex biomolecular behavior pose significant diagnostic and therapeutic challenges. Artificial intelligence (AI) has the potential to revolutionize BM diagnosis by facilitating early lesion detection, precise imaging segmentation, and non-invasive molecular characterization. Machine learning (ML) and deep learning (DL) models have shown promising results in differentiating BMs from other intracranial tumors with similar imaging characteristics—such as gliomas and primary central nervous system lymphomas (PCNSLs)—and predicting tumor features (e.g., genetic mutations) that can guide individualized and targeted therapies. Intraoperatively, AI-driven systems can enable optimal tumor resection by integrating functional brain maps into preoperative imaging, thus facilitating the identification and safeguarding of eloquent brain regions through augmented reality (AR)-assisted neuronavigation. Even postoperatively, AI can be instrumental for radiotherapy planning personalization through the optimization of dose distribution, maximizing disease control while minimizing adjacent healthy tissue damage. Applications in systemic chemo- and immunotherapy include predictive insights into treatment responses; AI can analyze genomic and radiomic features to facilitate the selection of the most suitable, patient-specific treatment regimen, especially for those whose disease demonstrates specific genetic profiles such as epidermal growth factor receptor mutations (e.g., EGFR, HER2). Moreover, AI-based prognostic models can significantly ameliorate survival and recurrence risk prediction, further contributing to follow-up strategy personalization. Despite these advancements and the promising landscape, multiple challenges—including data availability and variability, decision-making interpretability, and ethical, legal, and regulatory concerns—limit the broader implementation of AI into the everyday clinical management of BMs. Future endeavors should thus prioritize the development of generalized AI models, the combination of large and diverse datasets, and the integration of clinical and molecular data into imaging, in an effort to maximally enhance the clinical application of AI in BM care and optimize patient outcomes. Full article
(This article belongs to the Section Neuro-oncology)
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