Search Results (1,089)

Lightweight steel-framing (LSF) systems have become increasingly prominent in modern construction due to their structural efficiency, design flexibility, and sustainability. However, traditional facade materials such as stone are often cost-prohibitive, and brick veneers—despite their popularity—pose seismic performance concerns. This study introduces an innovative porcelain sheathing system for cold-formed steel (CFS) shear walls. Porcelain has no veins thus it offers integrated and reliable strength unlike granite. Four full-scale CFS shear walls incorporating screwed porcelain sheathing (SPS) were tested under combined cyclic lateral and constant gravity loading. The experimental program investigated key seismic characteristics, including lateral stiffness and strength, deformation capacity, failure modes, and energy dissipation, to calculate the system response modification factor (R). The test results showed that configurations with horizontal sheathing, double mid-studs, and three blocking rows improved performance, achieving up to 21.1 kN lateral resistance and 2.5% drift capacity. The average R-factor was 4.2, which exceeds the current design code values (AISI S213: R = 3; AS/NZS 4600: R = 2), suggesting the enhanced seismic resilience of the SPS-CFS system. This study also proposes design improvements to reduce the risk of brittle failure and enhance inelastic behavior. In addition, the results inform discussions on permissible building heights and contribute to the advancement of CFS design codes for seismic regions. Full article

Aluminum (Al) stress is an important factor that inhibits crop growth in acidic soils and poses a threat to pumpkin (Cucurbita moschata) production. In this study, we investigated the effect of endophyte (endophyte) strain J01 of blueberry (Vaccinium uliginosum) on the growth, development, and transcriptional regulatory mechanisms of pumpkin under aluminum stress. The results showed that the blueberry endophyte strain J01 significantly increased the root length of pumpkin under aluminum stress, promoted the growth of lateral roots, and increased root vigor; strain J01 reduced the content of MDA and the relative conductivity in the root system; strain J01 enhanced the activities of superoxide dismutase and catalase in the root system but inhibited ascorbate peroxidase activity. Transcriptome analysis further revealed that strain J01 significantly regulated the expression of key genes associated with aluminum tolerance, including the upregulation of transporter protein genes (aluminum-activated malate transporter and aquaporin), affecting the gene expression levels of genes encoding antioxidant enzymes (ascorbate peroxidase and glutathione S-transferase) and cell wall modification genes (xyloglucan endotransglucosylase/hydrolase and pectin methylesterase). This study provides a theoretical basis and practical guidance for using microbial resources to improve aluminum tolerance in cucurbit crops. Full article

The 2020 southern Puerto Rico earthquake sequence highlighted the severe seismic vulnerability of informally constructed two-story reinforced concrete (RC) houses. This study examines the failure mechanisms of these structures and assesses the effectiveness of first-floor RC shear-wall retrofitting. Nonlinear pushover and dynamic time–history analyses were performed using fiber-based distributed plasticity models for RC frames and nonlinear macro-elements for second-floor masonry infills, which introduced a significant inter-story stiffness imbalance. A bi-directional seismic input was applied using spectrally matched, near-fault pulse-like ground motions. The findings for the as-built structures showed that stiffness mismatches between stories, along with substantial strength and stiffness differences between orthogonal axes, resulted in concentrated plastic deformations and displacement-driven failures in the first story—consistent with damage observed during the 2020 earthquakes. Retrofitting the first floor with RC shear walls notably improved the performance, doubling the lateral load capacity and enhancing the overall stiffness. However, the retrofitted structures still exhibited a concentration of inelastic action—albeit with lower demands—shifted to the second floor, indicating potential for further optimization. Full article

The cecal microbiota is essential for intestinal health and performance. This study describes the succession patterns of the cecal microbiota in Japanese quail (Coturnix japonica) until 42 days of age. Sixty quails were raised using standard conditions and fed corn–soybean meal diets. Cecal contents were sampled from five birds weekly from 7 to 42 days of age and submitted to Illumina 16S rRNA sequencing for metabarcoding analysis. Diversity and functional prediction were carried out with QIIME2, PICRUSt2, STAMP and MicrobiomeAnalyst 2.0. Firmicutes increased from 50% at 7 days to more than 80% at 42 days, whereas Bacteroidota decreased from 45% to 12% in the same period. Alpha diversity progressively increased with age, indicating a richer and more balanced microbiota at later ages. Genera such as Bacteroides were predominant in the beginning and later were replaced by Lachnospiraceae, Ruminococcus and Faecalibacterium. These developmental taxonomic features aligned with significant shifts in ten metabolic pathways identified by prediction, revealing a transition from biosynthetic functions to complex carbohydrate metabolism and cell wall biosynthesis. The first seven days are considered a critical window for probiotics intervention, which may favor the establishment of a microbiota that is more stable and beneficial to quail performance. Full article

Background/Objectives: Posterior inferior cerebellar artery (PICA) aneurysms are one of the most difficult cerebrovascular lesions to treat and account for 0.5–3% of all intracranial aneurysms. They have deep anatomical locations, broad-neck configurations, high perforator density, and a close association with the brainstem, which creates considerable technical challenges for either microsurgical or endovascular treatment. Despite its acceptance as the standard of care for most posterior circulation aneurysms, PICA aneurysms are often associated with flow diversion using a coil or flow diversion due to incomplete occlusions, parent vessel compromise and high rate of recurrence. This case aims to describe the utility of microsurgical clipping as a durable and definitive option demonstrating the value of tailored surgical planning, preservation of anatomy and ancillary technologies for protecting a genuine outcome in ruptured PICA aneurysms. Methods: A 66-year-old male was evaluated for an acute subarachnoid hemorrhage from a ruptured and broad-necked fusiform left PICA aneurysm at the vertebra–PICA junction. Endovascular therapy was not an option due to morphology and the center of the recurrence; therefore, a microsurgical approach was essential. A far-lateral craniotomy with a partial C1 laminectomy was carried out for proximal vascular control, with careful dissection of the perforating arteries and precise clip application for the complete exclusion of the aneurysm whilst preserving distal PICA flow. Results: Post-operative imaging demonstrated the complete obliteration of the aneurysm with unchanged cerebrovascular flow dynamics. The patient had progressive neurological recovery with no new cranial nerve deficits or ischemic complications. Long-term follow-up demonstrated stable aneurysm exclusion and full functional independence emphasizing the sustainability of microsurgical intervention in challenging PICA aneurysms. Conclusions: This case intends to highlight the current and evolving role of microsurgical practice for treating posterior circulation aneurysms, particularly at a time when endovascular alternatives are limited by anatomy and hemodynamics. Advances in artificial intelligence cerebral aneurysm rupture prediction, high-resolution vessel wall imaging, robotic-assisted microsurgery and new generation flow-modifying implants have the potential to revolutionize treatment paradigms by embedding precision medicine principles into aneurysm management. While the discipline of cerebrovascular surgery is expanding, it can be combined together with microsurgery, endovascular technologies and computational knowledge to ensure individualized, durable, and minimally invasive treatment options for high-risk PICA aneurysms. Full article

Seed germination is a critical phase in the plant lifecycle of Camellia oleifera (oil tea), directly influencing seedling establishment and crop reproduction. In this study, we examined transcriptomic and physiological changes across five defined germination stages (G0–G4), from radicle dormancy to cotyledon emergence. Using RNA sequencing (RNA-seq), we assembled 169,652 unigenes and identified differentially expressed genes (DEGs) at each stage compared to G0, increasing from 1708 in G1 to 10,250 in G4. Functional enrichment analysis revealed upregulation of genes associated with cell wall organization, glucan metabolism, and Photosystem II assembly. Key genes involved in cell wall remodeling, including cellulose synthase (CESA), phenylalanine ammonia-lyase (PAL), 4-coumarate-CoA ligase (4CL), caffeoyl-CoA O-methyltransferase (COMT), and peroxidase (POD) showed progressive activation during germination. A Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis revealed dynamic regulation of phenylpropanoid and flavonoid biosynthesis, photosynthesis, carbohydrate metabolism, and hormone signaling pathways. Transcription factors such as indole-3-acetic acid (IAA), ABA-responsive element binding factor (ABF), and basic helix–loop–helix (bHLH) were upregulated, suggesting hormone-mediated regulation of dormancy release and seedling development. Physiologically, cytokinin (CTK) and IAA levels peaked in G4, antioxidant enzyme activities were highest in G2, and starch content increased toward later stages. These findings provide new insights into the molecular mechanisms underlying seed germination in C. oleifera and identify candidate genes relevant to rootstock breeding and nursery propagation. Full article

The Southern Lhasa Terrane, as the southernmost tectonic unit of the Eurasian continent, has long been a focal area in global geoscientific research due to its complex evolutionary history. The Yeba Formation exposed in this terrane comprises an Early–Middle Jurassic volcanic–sedimentary sequence that records multiphase tectonic deformation. This study applies structural analysis to identify three distinct phases of tectonic deformation in the Yeba Formation of the Southern Lhasa Terrane. The D₁ deformation is characterized by brittle–ductile shearing, as evidenced by the development of E-W-trending regional shear foliation (S₁). S₁ planes dip northward at angles of 27–87°, accompanied by steeply plunging stretching lineations (85–105°). Both south- and north-directed shear-rotated porphyroclasts are observed in the hanging wall. ⁴⁰Ar-³⁹Ar dating results suggest that the D₁ deformation occurred at ~79 Ma and may represent an extrusion-related structure formed under a back-arc compressional regime induced by the low-angle subduction of the Neo-Tethys Ocean plate. The D₂ deformation is marked by the folding of the pre-existing shear foliation (S₁), generating an axial planar cleavage (S₂). S₂ planes dip north or south with angles of 40–70° and fold hinges plunge westward or NWW. Based on regional tectonic evolution, it is inferred that the deformation may have resulted from sustained north–south compressional stress during the Late Cretaceous (79–70 Ma), which caused the overall upward extrusion of the southern Gangdese back-arc basin, leading to upper crustal shortening and thickening and subsequently initiating folding. The D₃ deformation is dominated by E-W-striking ductile shear zones. The regional shear foliation (S₃) exhibits a preferred orientation of 347°∠75°. Outcrop-scale ductile deformation indicators reveal a top-to-the-NW shear sense. Combined with regional tectonic evolution, the third-phase (D3) deformation is interpreted as a combined product of the transition from compression to lateral extension within the Lhasa terrane, associated with the activation of the Gangdese Central Thrust (GCT) and the uplift of the Gangdese batholith since ~25 Ma. Full article

Childhood obesity is a substantial health problem worldwide. The origin of obesity (increased adiposity) can be partly traced back to intrauterine life. However, the determinants of fetal fat deposition remain unclear. This study investigated the association between cord blood adipocytokines related to lipid metabolism (leptin, adiponectin, and insulin-like growth factor-1 [IGF-1]) and fetal adiposity during gestation. A prospective study was conducted in a cohort of 94 singleton pregnancies. Fetal ultrasonography was performed at 24, 30, and 36 weeks of gestation. Estimated fetal adiposity (EFA) was calculated by integrating measurements of cross-sectional arm and thigh fat area percentages and anterior abdominal wall thickness. Plasma cytokine levels and C-peptide immunoreactivity (as a proxy for fetal insulin resistance) were evaluated in cord blood samples obtained at delivery. The associations of cord blood leptin, adiponectin and IGF-1 levels with EFA at 24, 30, and 36 weeks were determined by multiple linear regression, adjusted for potential covariates. The multivariate analyses indicated that leptin was significantly correlated with EFA at 30 and 36 weeks. Leptin was also positively correlated with C-peptide immunoreactivity in the umbilical cord. Cord adiponectin levels were not associated with EFA across gestation. Cord IGF-1 levels were significantly correlated with EFA and estimated fetal body weight (EFW) at 36 weeks. In conclusion, cord leptin was associated with EFA at 30 and 36 weeks, and IGF-1 was associated with EFA at 36 and EFW at 36 weeks. In Conclusion, cord leptin was associated with EFA at 30 and 36 weeks, and IGF-1 was associated with EFA and EFW at 36 weeks. Considering the effects of leptin and IGF-1 on fetal insulin resistance and lipid metabolism, increased levels of leptin and IGF-1 are potential plasma biomarkers of increased fetal adiposity, which may predispose to infant obesity and metabolic dysfunction in later life. Full article

Background/Objectives: Childhood obesity represents a growing public health concern. It is closely associated with obstructive sleep apnoea (OSA), which impairs nocturnal breathing and significantly affects neurocognitive and cardiovascular health. This review aims to analyse differences in fat distribution, anthropometric parameters, and instrumental assessments of paediatric OSA compared to adult OSA to improve the diagnostic characterisation of obese children. Methods: narrative review. Results: While adenotonsillar hypertrophy (ATH) remains a primary cause of paediatric OSA, the increasing prevalence of obesity has introduced distinct pathophysiological mechanisms, including fat accumulation around the pharynx, reduced respiratory muscle tone, and systemic inflammation. Children exhibit different fat distribution patterns compared to adults, with a greater proportion of subcutaneous fat relative to visceral fat. Nevertheless, cervical and abdominal adiposity are crucial in increasing upper airway collapsibility. Recent evidence highlights the predictive value of anthropometric and body composition indicators such as neck circumference (NC), neck-to-height ratio (NHR), neck-to-waist ratio (NWR), fat-to-muscle ratio (FMR), and the neck-to-abdominal-fat percentage ratio (NAF%). In addition, ultrasound assessment of lateral pharyngeal wall (LPW) thickness and abdominal fat distribution provides clinically relevant information regarding anatomical contributions to OSA severity. Among imaging modalities, dual-energy X-ray absorptiometry (DXA), bioelectrical impedance analysis (BIA), and air displacement plethysmography (ADP) have proven valuable tools for evaluating body fat distribution. Conclusions: Despite advances in the topic, a validated predictive model that integrates these parameters is still lacking in clinical practice. Polysomnography (PSG) remains the gold standard for diagnosis; however, its limited accessibility underscores the need for complementary tools to prioritise the identification of children at high risk. A multimodal approach integrating clinical, anthropometric, and imaging data could support the early identification and personalised management of paediatric OSA in obesity. Full article

Adobe churches are representative of Andean architectural heritage, yet their structural vulnerability to seismic events remains a significant concern. This study evaluates the seismic performance of the 17th-century Church of Santo Tomás de Aquino in Rondocan, Peru, an adobe building that underwent conservation work in the late 1990s. The assessment combines in situ inspections and experimental testing with advanced nonlinear numerical modeling. A finite-element macro-model was developed and calibrated using sonic and ambient vibration tests to replicate the observed structural behavior. Nonlinear static (pushover) analyses were performed in the four principal directions to identify failure mechanisms and to evaluate seismic capacity using the Peruvian seismic code. Kinematic limit analyses were conducted to assess out-of-plane mechanisms using force- and displacement-based criteria. The results revealed critical vulnerabilities in the rear façade and lateral walls, particularly in terms of out-of-plane collapse, while the main façade exhibited a higher capacity but a brittle failure mode. This study illustrates the value of advanced numerical simulations, calibrated with field data, as effective tools for assessing seismic vulnerability in historic adobe buildings. The outcomes highlight the necessity of strengthening measures to balance life safety requirements with preservation goals. Full article

This study presents a comprehensive finite element investigation into the design optimization of an ultra-high temperature ceramic matrix composite thruster for green bipropellant systems. Focusing on ZrB₂–SiC–Cfiber composites, it explores their thermal and mechanical response under realistic transient combustion conditions. Two geometries, a simplified and a complex full-featured model, were evaluated to assess the impact of geometric fidelity on stress prediction. The complex thruster model (CTM) offered improved resolution of temperature gradients and stress concentrations, especially near flange and convergent regions, and was adopted for optimization. A parametric study with nine wall thickness profiles identified a 2 mm tapered configuration in both convergent and divergent sections that minimized mass while maintaining structural integrity. This optimized profile reduced peak thermal stress and overall mass without compromising safety margins. Transient thermal and strain analyses showed that thermal stress dominates initially (≤3 s), while thermal strain becomes critical later due to stiffness degradation. Damage risk was evaluated using temperature-dependent stress margins at four critical locations. Time-dependent failure maps revealed throat degradation for short burns and flange cracking for longer durations. All analyses were conducted under hot-fire conditions without cooling. The validated methodology supports durable, lightweight nozzle designs for future green propulsion missions. Full article

Preserving heritage sites is a complex challenge that requires multidisciplinary approaches, combining scientific accuracy with cultural and historical sensitivity. In alignment with UNESCO’s conservation guidelines, this study investigated the airflow dynamics and wind-induced structural effects within ancient architecture using advanced computational fluid dynamics (CFD). The study site was the Na Phra Meru Historical Temple in Ayutthaya, Thailand, where the shear stress transport $k-\omega$ turbulence model was applied to analyze distinctive airflow patterns. A high-precision 3D computational domain was developed using Faro focus laser scanning technology, with the CFD results being validated based on onsite experimental data. The findings provided critical insights into the temple’s ventilation behavior, revealing strong correlations between turbulence characteristics, wind speed, temperature, and relative humidity. Notably, the small slit windows generated complex flow mixing, producing a large internal recirculation zone spanning approximately 70% of the central interior space. In addition to airflow distribution, the study evaluated the aerodynamic forces and rotational moments acting on the structure based on five prevailing wind directions. Based on these results, winds from the east and northeast generated the highest aerodynamic loads and rotational stresses, particularly in the lateral and vertical directions. Overall, the findings highlighted the critical role of airflow and wind-induced forces in the deterioration and long-term stability of heritage buildings. The study demonstrated the value of integrating CFD, environmental data, and structural analysis to bridge the gap between conservation science and engineering practice. Future work will explore further the interactions between wall moisture and the multi-layered pigments in mural paintings to inform preservation practices. Full article

Current biodiesel production is costly, in part due to the catalysts added during transesterification and later washed out. We have previously shown that intact rapeseed shells can be ball-milled with an alcohol to produce biodiesel without an added catalyst. Here, we report on the activation and identity of the complexing agent within the shells of rapeseeds and sunflower seeds. Lignin, present in the cell walls of plant matter, complexes with iron and manganese within metallic media, such as in a ball mill, and acts as a catalyst support in a transesterification reaction with oil and methanol. When ball-milled with methanol, rapeseed and sunflower seeds produce up to 90% biodiesel, similar to yields produced by industrial methods. However, this new method for producing biodiesel is a greener alternative, as it requires fewer organic solvents, may reduce the time and energy required for synthesis, and may reduce the effort required for product purification. Full article

The growing application of soil–geosynthetic composites (SGCs) in geotechnical engineering has highlighted the critical role of reinforcement spacing in enhancing structural performance. This study presents a numerical investigation of the stress–deformation behavior of SGC masses under working stress and failure load conditions, considering both confining and unconfined pressure scenarios. A finite element (FE) model was developed to analyze stress distribution, reinforcement strain profiles at varying depths, and lateral displacement at open facings. Results revealed that vertical stresses in reinforced and unreinforced soil masses were nearly identical, while lateral stresses increased notably in reinforced masses, particularly near reinforcement layers and open facings. Closer reinforcement spacing (0.2 m) effectively reduced lateral displacement and enhanced structural stability compared with wider spacing (0.4 m). In some cases, strengthening reinforcement in the upper portion of the SGC mass proved more effective under failure loads in both confining and unconfined pressure conditions. These findings provide critical insights for optimizing reinforcement spacing in SGC systems, with implications for the design of retaining walls and bridge abutments. Full article

Introduction: Angiosarcomas arise from vascular or lymphatic endothelial cells and can develop at any site. Visceral angiosarcomas are aggressive high-grade tumors with a high risk of recurrence, metastasis, and poor survival. Nationwide studies with long-term follow-up are limited, but crucial for understanding this malignancy. This study aimed to describe a national cohort of patients with visceral angiosarcomas and estimate long-term survival, local recurrence, and metastases. Methods: We included all adult patients in Denmark diagnosed with histologically confirmed visceral angiosarcoma from 2000 to 2017. Data were obtained from the Danish Pathology Register and the Danish Sarcoma Database, both providing nationwide and comprehensive records. Additional information on demographics, comorbidities, symptoms, diagnosis, tumor location, treatment, recurrence, and survival were collected from registries and health records. Results: Eighteen patients with visceral angiosarcoma were identified, corresponding to an incidence of one per 5.5 million inhabitants per year. The median age was 56.5 years (IQR: 50–70), and 56% were female. Tumors were most commonly located in the kidney, liver, and thoracic wall. Metastases were present at diagnosis in 17% and developed later in 50%. Surgery was performed in 61%, with R0 resection in 55%. Median overall survival was 249 days (IQR: 121–858), and the 5-year survival rate was 11%. Only one patient (6%) remained alive at long-term follow-up. Conclusions: This Danish nationwide study confirms that visceral angiosarcomas are rare, highly aggressive tumors with a poor prognosis, consistent with international findings. Despite the small cohort, the disease demonstrated significant heterogeneity in anatomical location, metastatic pattern, and treatment approaches. Full article