(1) Background: Sequential landscape changes give people experiences of dynamic beauty, and the key to creating spatial sequences lies in the organization of spatial changes. The purpose of this study is to use a 3D point cloud model to achieve a ref...
Despite rising attention to pathways thinking in multiple domains such as climate adaptation, energy supply planning, and flood risk management, their spatial translation is so far understudied. We set out to study how spatial design based on pathway...
The Yuan River Basin in Hunan Province, known for its rich history and cultural heritage, is home to traditional village landscapes characterized by distinct cultural genes and regional features. This study focuses on 21 traditional villages in Xupu...
Can a replicase be found in the vast sequence space by random drift? We partially answer this question through a proof-of-concept study of the times of occurrence (hitting times) of some critical events in the origins of life for low-dimensional RNA...
In the modernization process since China’s reform and liberalization, urban and village space design is reflected in the characteristics of Western cultures. The idea of Western space design has a profound influence on China, but the piecemeal...
The water-town settlements in the East River Delta of China engage with the aquatic environment, establishing a comprehensive cultural–ecological system. However, rapid urbanization challenges the structural integrity of water-town settlements....
The objectives of this study were to evaluate spatial sampling and statistical aspects of landscape-level wildfire rate of spread (ROS) estimates derived from airborne thermal infrared imagery (ATIR). Wildfire progression maps and ROS estimates were...
Dispersed archaeological landscapes are often rich in heritage value but weakly integrated into regional tourism systems. This creates difficulties in visitor orientation, interpretive continuity, and conservation-sensitive tourism planning. In respo...
From 2016 to 2020, an investigation was carried out to identify the rate of Angiostrongylus spp. infections in European badgers in Hungary. During the study, the hearts and lungs of 50 animals were dissected in order to collect adult worms, the morph...
As a part of cultural landscapes, toponyms with abundant cultural connotations and a long history are valuable cultural heritage assets. Choronyms not only reflect natural and social phenomena but also help with relevant management and naming work. I...
The campus landscape contributes a lot to students’ mental and physical health. Students’ emotional attachment to landscape space is an important scientific basis for landscape design. This study used immersive virtual reality eye trackin...
Moving away from a static concept for the landscape that surrounds us, in this research article, we approach the visual landscape as a dynamic concept. Moreover, we attempt to provide an interconnection between the domains of landscape and cartograph...
While the transition to renewable energy becomes a main driver of landscape change, few publications discuss the historical transformation of landscapes for the development of energy—commonly referred to as energy landscape. The research report...
The forest landscape pattern evolution can reveal the intensity and mode of action of human–land relationships at different times and in different spaces, providing scientific support for regional ecological security, human settlement health, and sus...
Recent advances in nanomaterials have profoundly transformed the landscape of biomedical imaging and analytical detection. By leveraging unique physical, chemical, and optical properties at the nanoscale, these materials enable unprecedented sensitiv...
Heterogenous landscape features of the Himalayan region shape the genetic structure of animal populations by delimiting spatial patterns of dispersal and reproduction. Integrating population genetic analysis with landscape features could yield result...
This study explores the design characteristics of approach spaces in architect Yoshiji Takehara’s independent residential works, focusing on their spatial arrangement, sinuosity, and experiential qualities. Through the analysis of Takehara&rsqu...
A crucial feature of life is its spatial organization and compartmentalization on the molecular, cellular, and tissue levels. Spatial transcriptomics (ST) technology has opened a new chapter of the sequencing revolution, emerging rapidly with transfo...
Urban streams constitute a valuable form of multi-functional blue and green infrastructure (BGI) and can support urban development to generate ecosystem, social, and economic benefits. In global cities, planning for BGI enhancement contributes to cli...
The Linpan in western Sichuan is a composite rural landscape of “household-water-forest-field” on the Chengdu Plain. Under the interference of human activities, problems such as landscape fragmentation and ecological function degradation...
Habitat fragmentation caused by human activities threatens plant genetic diversity, but the mechanisms shaping gene flow and spatial genetic structure in epiphytic orchids remain poorly understood. Here, we investigated the genetic structure and gene...
Sui–Tang Luoyang represents a classic achievement in Chinese capital planning, yet research remains dominated by archaeological and historical–geographical approaches, lacking a unifying theoretical framework. This research addresses this...
This paper investigates the design of a coastal cycling route that integrates principles of sustainable mobility with the perceptual qualities of the urban landscape. In response to contemporary environmental challenges, the promotion of cycling as a...
Traditional villages face many difficulties in the era of globalization, especially in light of fast industrialization and urbanization. The breakdown of settlement patterns and the erosion of local characteristics and cultural identities pose critic...
Maintaining soil moisture conditions in the vadose zone is crucial to maintaining water availability in a semi-arid environment. However, understanding of biophysical factors related to soil moisture conditions in the Wallacea tectonic landscape rema...
While RNA sequencing and multi-omic approaches have significantly advanced cancer diagnosis and treatment, their limitation in preserving critical spatial information has been a notable drawback. This spatial context is essential for understanding ce...
Using Zhijiang City, Hubei Province as an example, this study constructed an ecological risk assessment model based on land use data from the three phases of 2000, 2010, and 2020. We then determined the ecological compensation priority sequence based...
Urban landscape lakes are increasingly at risk of nitrogen-induced eutrophication. Microbial nitrogen transformation plays a crucial role in reducing nitrogen levels in these lakes. However, the relationships between microbial communities, nitrogen f...
A data assimilation method to produce complete temporal sequences of synthetic medium-resolution images is presented. The method implements a Kalman filter recursive algorithm that integrates medium and moderate resolution imagery. To demonstrate the...
Mucosal immunity plays a critical role in the pathogenesis of inflammatory immune diseases. This study leverages single-cell RNA sequencing, spatial transcriptomics, and spatial proteomics to compare the cellular mechanisms involved in periodontitis...
Previous morphological studies have confirmed that Canton settlements maintain a stable cultural landscape sequence consisting of ponds, open spaces, ancestral halls, residences, and forests. Villages in the Dongjiang River Basin exhibit an inherent...
The repeated application of herbicides has led to the development of herbicide resistance. Models are useful for identifying key processes and understanding the evolution of resistance. This study developed a spatially explicit model at a landscape s...
The Sedongpu Valley has experienced repeated ice–rock avalanches, glacier detachments, and related hazards, but the long-term vegetation trajectory in this hazard-affected outlet landscape remains poorly documented. To document vegetation chang...
Incomplete datasets curtail the ability of archaeologists to investigate ancient landscapes, and there are archaeological sites whose locations remain unknown in many parts of the world. To address this problem, we need additional sources of site loc...
Ovarian clear cell carcinoma (OCCC) is a rare subtype of epithelial ovarian cancer characterised by a high frequency of loss-of-function ARID1A mutations and a poor response to chemotherapy. Despite their generally low mutational burden, an intratumo...
Remote sensing techniques provide crucial insights into ancient settlement patterns in various regions by uncovering previously unknown archaeological sites and clarifying the topological features of known ones. Meanwhile, in the northern part of the...
Alzheimer’s Disease (AD), the most common form of dementia, is pathologically defined by extracellular beta-amyloid (Aβ) plaques and intraneuronal neurofibrillary tangles (NFTs), accompanied by chronic neuroinflammation. Recent advances in...
Land capitalization has become one of the central issues in contemporary China’s economic development and land system reform. Existing scholarship has predominantly approached this topic from the perspectives of effects, governance, and propert...
Understanding the population genetic pattern and process of gene flow requires a detailed knowledge of how landscape characteristics structure populations. Although Cynodon dactylon (L.) Pers. (common bermudagrass) is widely distributed in the world,...
We investigate the feasibility of obtaining multiple spatially-separated biopsies from a single lesion to explore intratumor heterogeneity and identify actionable truncal mutations using whole exome sequencing (WES). A single-pass radiologically-guid...
Under rapid urbanization and watershed-scale spatial restructuring, urban green-space systems are often treated as residual indicators after construction land has been allocated, which limits the capacity of blue–green networks to act as leadin...
Glioblastoma is one of the most common and lethal primary neoplasms of the brain. Patient survival has not improved significantly over the past three decades and the patient median survival is just over one year. Tumor heterogeneity is thought to be...
This article reviews the impact of single-cell sequencing (SCS) on cancer biology research. SCS has revolutionized our understanding of cancer and tumor heterogeneity, clonal evolution, and the complex interplay between cancer cells and tumor microen...
Soil organic matter (SOM) plays pivotal roles in characterizing dryland structure and function; however, remotely sensed spatially-detailed SOM mapping in these regions remains a challenge. Various digital soil mapping approaches based on either sing...
In this paper, an approach through a Deep Learning architecture for the three-dimensional reconstruction of outdoor environments in challenging terrain conditions is presented. The architecture proposed is configured as an Autoencoder. However, inste...
The transcriptional co-activator with PDZ binding motif (TAZ) is a key effector of the Hippo signaling pathway. We and others previously reported that high expression levels of TAZ are positively associated with decreased survival rates and shorter t...
Incisive inquiry involving indicators of ecological and environmental integrity entails exploration of spatial structure at selected scales from landscape level to regional regimes. Conventional colorization of digital displays provides perspective b...
Background: Diabetic kidney disease (DKD) is a major complication of diabetes leading to kidney failure. Methods: This study investigates lipid metabolism profiles of long-standing DKD (LDKD, diabetes duration > 10 years) by integrative analysis o...
The Qinling Mountains, known for high forest cover and multiple ecosystem services (ES), present significant potential for advancing ecological management (EM) paradigms. However, existing studies on matching long-term ES sequences with governance un...
Extrachromosomal circular DNA (eccDNA) has emerged as a pivotal contributor to cancer progression, facilitating oncogene amplification, dysregulated gene expression, and tumor heterogeneity. Despite its significance in cancer, the interplay between e...
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