Search Results (8)

Vernacular housing in the Andean region embodies long-standing building knowledge, environmental adaptation, and forms of social organization rooted in rural life. Over recent decades, these dwellings have undergone visible transformations linked to migration, changing aspirations, and the growing presence of industrialized construction materials. Rather than disappearing, vernacular forms have increasingly merged with contemporary solutions, producing hybrid architectural landscapes whose local dynamics are still insufficiently documented. This study analyzes the material, typological, and functional transformation of rural housing in Las Lagunas and Quisquinchir, two Indigenous communities located in Saraguro, Loja, Ecuador. A total of 192 houses were recorded through field observation and a structured digital survey implemented with KoBoCollect. The information was processed in R using descriptive statistics, contingency tables, chi-square tests, Cramér’s V, and standardized residual analysis. The findings show that architectural change in both communities does not occur through a simple replacement of traditional housing by modern models. Instead, vernacular, hybrid, and modern/eclectic typologies coexist within the same rural setting, revealing uneven and locally specific processes of transformation. The clearest differences emerge in construction materiality. Las Lagunas preserves a stronger presence of traditional wall systems, especially adobe and bahareque, while Quisquinchir shows a broader incorporation of industrialized materials, particularly concrete block. Statistical analysis confirmed significant associations between community and wall material, as well as between typology and wall material, whereas the relationship between community and architectural typology was comparatively weaker. Functional changes were also identified through the reduction or reconfiguration of intermediate spaces such as portals, patios, and corridors, suggesting a gradual shift toward more enclosed and specialized domestic environments. These results contribute empirical evidence for understanding architectural hybridization in Indigenous rural territories and support conservation and planning approaches capable of recognizing continuity, adaptation, and change within evolving Andean built landscapes. Full article

The brain is the central organ of adaptation to stress because it perceives and determines threats that induce behavioral, physiological, and molecular responses. In humans, chronic stress manifests as an enduring consistent feeling of pressure and being overwhelmed for an extended duration. This can result in a persistent proinflammatory response in the peripheral and central nervous system (CNS), resulting in cellular, physiological, and behavioral effects. Compounding stressors may increase the risk of chronic-stress-induced inflammation, which can yield serious health consequences, including mental health disorders. This review summarizes the current knowledge surrounding the neuroinflammatory response in rodent models of chronic stress—a relationship that is continually being defined. Many studies investigating the effects of chronic stress on neuroinflammation in rodent models have identified significant changes in inflammatory modulators, including nuclear factor-κB (NF-κB) and toll-like receptors (TLRs), and cytokines, including tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, and IL-6. This suggests that these are key inflammatory factors in the chronic stress response, which may contribute to the establishment of anxiety and depression-like symptoms. The behavioral and neurological effects of modulating inflammatory factors through gene knockdown (KD) and knockout (KO), and conventional and alternative medicine approaches, are discussed. Full article

IoT has seen remarkable growth, particularly in healthcare, leading to the rise of IoMT. IoMT integrates medical devices for real-time data analysis and transmission but faces challenges in data security and interoperability. This research identifies a significant gap in the existing literature regarding a comprehensive ontology for vulnerabilities in medical IoT devices. This paper proposes a fundamental domain ontology named MIoT (Medical Internet of Things) ontology, focusing on cybersecurity in IoMT (Internet of Medical Things), particularly in remote patient monitoring settings. This research will refer to similar-looking acronyms, IoMT and MIoT ontology. It is important to distinguish between the two. IoMT is a collection of various medical devices and their applications within the research domain. On the other hand, MIoT ontology refers to the proposed ontology that defines various concepts, roles, and individuals. MIoT ontology utilizes the knowledge engineering methodology outlined in Ontology Development 101, along with the structured life cycle, and establishes semantic interoperability among medical devices to secure IoMT assets from vulnerabilities and cyberattacks. By defining key concepts and relationships, it becomes easier to understand and analyze the complex network of information within the IoMT. The MIoT ontology captures essential key terms and security-related entities for future extensions. A conceptual model is derived from the MIoT ontology and validated through a case study. Furthermore, this paper outlines a roadmap for future research, highlighting potential impacts on security automation in healthcare applications. Full article

Modern Artificial Intelligence (AI) methods can produce a large quantity of accurate and richly described data, in domains such as surveillance or automation. As a result, the need to organize data at a large scale in a semantic structure has arisen for long-term data maintenance and consumption. Ontologies and graph databases have gained popularity as mechanisms to satisfy this need. Ontologies provide the means to formally structure descriptive and semantic relations of a domain. Graph databases allow efficient and well-adapted storage, manipulation, and consumption of these linked data resources. However, at present, there is no a universally defined strategy for building AI-oriented ontologies for the automotive sector. One of the key challenges is the lack of a global standardized vocabulary. Most private initiatives and large open datasets for Advanced Driver Assistance Systems (ADASs) and Autonomous Driving (AD) development include their own definitions of terms, with incompatible taxonomies and structures, thus resulting in a well-known lack of interoperability. This paper presents the Automotive Global Ontology (AGO) as a Knowledge Organization System (KOS) using a graph database (Neo4j). Two different use cases for the AGO domain ontology are presented to showcase its capabilities in terms of semantic labeling and scenario-based testing. The ontology and related material have been made public for their subsequent use by the industry and academic communities. Full article

Information retrieval (IR) is about making systems for finding documents or information. Knowledge organization (KO) is the field concerned with indexing, classification, and representing documents for IR, browsing, and related processes, whether performed by humans or computers. The field of IR is today dominated by search engines like Google. An important difference between KO and IR as research fields is that KO attempts to reflect knowledge as depicted by contemporary scholarship, in contrast to IR, which is based on, for example, “match” techniques, popularity measures or personalization principles. The classification of documents in KO mostly aims at reflecting the classification of knowledge in the sciences. Books about birds, for example, mostly reflect (or aim at reflecting) how birds are classified in ornithology. KO therefore requires access to the adequate subject knowledge; however, this is often characterized by disagreements. At the deepest layer, such disagreements are based on philosophical issues best characterized as “paradigms”. No IR technology and no system of knowledge organization can ever be neutral in relation to paradigmatic conflicts, and therefore such philosophical problems represent the basis for the study of IR and KO. Full article

Within the knowledge organization systems (KOS) set, the term “ontology” is paradigmatic of the terminological ambiguity in different typologies. Contributing to this situation is the indiscriminate association of the term “ontology”, both as a specific type of KOS and as a process of categorization, due to the interdisciplinary use of the term with different meanings. We present a systematization of the perspectives of different authors of ontologies, as representational artifacts, seeking to contribute to terminological clarification. Focusing the analysis on the intention, semantics and modulation of ontologies, it was possible to notice two broad perspectives regarding ontologies as artifacts that coexist in the knowledge organization systems spectrum. We have ontologies viewed, on the one hand, as an evolution in terms of complexity of traditional conceptual systems, and on the other hand, as a system that organizes ontological rather than epistemological knowledge. The focus of ontological analysis is the item to model and not the intentions that motivate the construction of the system. Full article

Endoderm-derived organs as liver and pancreas are potential targets for regenerative therapies, and thus, there is great interest in understanding the pathways that regulate the induction and specification of this germ layer. Currently, the knowledge of molecular mechanisms that guide the in vivo endoderm specification is restricted by the lack of early endoderm specific markers. Nephrocan (Nepn) is a gene whose expression characterizes the early stages of murine endoderm specification (E7.5–11.5) and encodes a secreted N-glycosylated protein. In the present study, we report the identification of a new transcript variant that is generated through alternative splicing. The new variant was found to have differential and tissue specific expression in the adult mouse. In order to better understand Nepn role during endoderm specification, we generated Nepn knock-out (KO) mice. Nepn^−/− mice were born at Mendelian ratios and displayed no evident phenotype compared to WT mice. In addition, we produced nullizygous mouse embryonic stem cell (mESC) line lacking Nepn by applying (CRISPR)/CRISPR-associated systems 9 (Cas9) and employed a differentiation protocol toward endoderm lineage. Our in vitro results revealed that Nepn loss affects the endoderm differentiation impairing the expression of posterior foregut-associated markers. Full article

This paper proposes a new collaborative and inclusive model for Knowledge Organization Systems (KOS) for sustaining cultural heritage and language diversity. It is based on contributions of end-users as well as scientific and scholarly communities from across borders, languages, nations, continents, and disciplines. It consists in collecting knowledge about all worldwide translations of one original work and sharing that data through a digital and interactive global knowledge map. Collected translations are processed in order to build multilingual parallel corpora for a large number of under-resourced languages as well as to highlight the transnational circulation of knowledge. Building such corpora is vital in preserving and expanding linguistic and traditional diversity. Our first experiment was conducted on the world-famous and well-traveled American novel Adventures of Huckleberry Finn by the American author Mark Twain. This paper reports on 10 parallel corpora that are now sentence-aligned pairs of English with Basque (an European under-resourced language), Bulgarian, Dutch, Finnish, German, Hungarian, Polish, Portuguese, Russian, and Ukrainian, processed out of 30 collected translations. Full article