Search Results (43)

Cardiovascular disease remains the leading cause of death worldwide, yet despite massive investment in drug discovery, the progress of cardiovascular drugs from lab to clinic remains slow. It is a complex, costly pathway from drug discovery to the clinic and failure becomes more expensive as a drug progresses along this pathway. The focus has begun to shift to optimisation of in vitro culture methodologies, not only because these must be undertaken are earlier on in the drug discovery pathway, but also because the principles of the 3Rs have become embedded in national and international legislation and regulation. Numerous studies have shown myocyte cell behaviour to be much more physiologically relevant in 3D culture compared to 2D culture, highlighting the advantages of using 3D-based models, whether microfluidic or otherwise, for preclinical drug screening. This review aims to provide an overview of the challenges in cardiovascular drug discovery, the limitations of traditional routes, and the successes in the field of preclinical models for cardiovascular drug discovery. It focuses on the particular role biomimicry can play, but also the challenges around implementation within commercial drug discovery. Full article

This study investigates how an increase in the quality of business ventures, measured as their success probability, affects trust and return on investment (ROI) in situations where the investor–entrepreneur interaction is affected by moral hazard and asymmetric information. We model a repeated trust problem between investors and entrepreneurs, featuring moral hazard and adverse selection. Hidden Markov techniques and computer simulations are used to derive the main results. We find that trust and ROI may decline as quality improves. Although lenders tend to reduce the requirements for granting initial credit, they nevertheless become less tolerant of current borrowers who fail to pay back. Additionally, we demonstrate a novel substitution effect, where lenders prefer new borrowers over existing borrowers that experienced early failures. The main conclusions of our study are that while impressing early on is effective in gaining first access to credit, it may nevertheless hurt the cause of getting credit in subsequent periods, following an early failure. In business environments plagued with ex post moral hazard, entrepreneurs might do better by gaining trust first and impressing later. Furthermore, our results imply that in a thriving economy, not only are bad loans made, but good loans are lost as well. Full article

Meeting renewable energy targets is one of the most significant global challenges to achieving SDG 7—Ensure access to affordable, reliable, sustainable, and modern energy for all. This study focuses on the global energy transition to understand the factors that influence success or failure in achieving targets. First, the gap between the stated targets and our predictions was calculated. Next, the roles of economic, political, and environmental variables in determining this gap were analyzed. Data were collected from 63 countries from 2000 to 2022, ensuring the global representativeness and robustness of the results. Many countries may struggle to meet their renewable energy targets. Political stability, regulatory quality, and investment freedom play a remarkable role in helping countries get closer to achieving their targets. More industrialized countries with large populations face greater challenges due to high energy intensity. This paper aims to predict the propensity of countries to meet their energy targets by integrating the forecasting and analysis of the economic, political, and geographical factors that influence a green transition. The results provide new insights into how socioeconomic and geopolitical differences influence the energy transition, offering insights for more effective policies. It is argued that accelerated administrative procedures are needed to reduce investment uncertainty and improve energy systems’ flexibility. In addition, involving local communities in the decision-making process is important to ensure the acceptance of RE projects. Finally, introducing energy markets that reflect the characteristics of renewable sources is recommended to facilitate a more rapid and sustainable transition. Full article

Cities—being places where both growth at large and human activity concentrate to the maximum extent, as well as being places of creation, innovation, and development—have been facing the challenge of adaptation to changing climate conditions. Successive greening of urban spaces is becoming an indicator of civilisational progress and one of the most important aspects of sustainable urban development and quality of life of city dwellers. It also represents a part of the sustainable management of natural resources and energy in the urban environment. This article addresses the subject of urban space greening, perceived as one of the ways of mitigating the effects of climate change. The study focuses on a comparative analysis of various planning and implementing activities related to green areas, as well as on available quantitative data on the greening and climate change adaptation of 44 Polish cities with urban adaptation plans (UAPs) in place. The research, covering the years 2017–2023, identifies the variety of urban greening methods, initiatives, and tools used in the process of urban planning and urban design. The results of the study showed that measures planned by local authorities lacked detailed tools as well as a long-term and systemic approach to greenery, energy, and space management. On the other hand, what was observed in the implementation was an apparent prevalence of urban acupuncture spots and a failure to make the most of all the benefits of the adaptive, social, and ecosystem-forming role of urban greening. The authors imply that their research can be used to formulate conclusions and guidelines for urban development policies which highlight the role and raise the importance of the greening of Polish cities under all urban investments, particularly in the process of adaptation of urban areas to climate change. Full article

Energy infrastructure connectivity is a key implementation area for the success of the Belt and Road Initiative. In the current complex international environment, China’s energy infrastructure investment in the countries along the Belt and Road is often restricted due to varying degrees of heated disputes with the host countries, thus facing the political risk of investment loss or even failure. This paper used the Heckman two-stage selection model to overcome the sample selection problem in traditional literature and systematically studied the political risks to China’s energy infrastructure investment in countries along the Belt and Road within a unified framework. The results showed that Chinese energy infrastructure investments exhibited market-seeking and energy resource-seeking features; while political risks had a significant impact on choosing the locations of energy infrastructure investments, socio-environmental factors were not given sufficient attention. At the national level, the implementation of the Belt and Road Initiative was beneficial to China’s foreign energy infrastructure investments under certain regulatory levels and environmental policy performance. Full article

As a model for delivering infrastructure initiatives, public–private partnerships (PPPs) have gained significant popularity in recent years. The globalization of PPP has exposed them to elevated risks emanating from the international real economy and financial market, which can ultimately result in project cancellations or distress. This study analyzes risk factors affecting the sustainable outcomes of global PPP projects from a stakeholder perspective. After identifying the interests of key stakeholders and examining how various risks influence stakeholders’ interests, a two-step binomial probit model is used to investigate domestic and international risk factors in PPP arrangements based on the World Bank PPI database. The empirical results indicate that inflation has a substantially positive effect on project failure, while factors such as PPP experience, central government involvement, exchange rate fluctuations, etc., significantly contribute to PPP success. In addition, the study demonstrates that trade openness and net foreign direct investment (FDI) inflow are crucial for the transmission of global risks. The study also provides policy implications and recommendations from a risk allocation–stakeholder relationship perspective to enhance the resilience of PPP initiatives based on these findings. Full article

Today, the world is experiencing a major cycle of investment in infrastructure, which is essential for the development and prosperity of countries and societies. Management failures in infrastructure projects are widely known, and some of them involve the weak engagement of project stakeholders. The importance of stakeholder involvement as a key factor in the success of infrastructure projects is widely recognized. However, the literature provides few answers to the question of how this process manifests itself in projects. Some scholars have concluded that it is a complex and under-researched management process. The research questions aim to find out how practitioners perceive stakeholder engagement, who conducts activities and processes related to stakeholder engagement and in what ways, what organizational aspects influence the process, and how success is achieved in infrastructure projects. Initially, eight experienced experts involved in a whole range of (complex) infrastructure projects were interviewed, and later, four additional interviews were conducted for verification purposes. During the interviews, all aspects of stakeholder engagement were discussed in detail and a thematic analysis was conducted. Based on the analysis, success and failure factors related to the stakeholder engagement process were defined. As a result, a framework model for stakeholder engagement and infrastructure project success is presented based on three levels of management and three levels of project success. Full article

Human capital is considered the most important resource in any organization. However, most companies are concerned with external customer satisfaction, without devoting much attention to the satisfaction of their employees. Indisputably, employee satisfaction is fundamental and determines the success or failure of what the customer experiences. Technological developments have changed our lives and habits, and even the way we relate to others, so the online increasingly influences the offline. The purpose of this manuscript was to examine the relationship between the Digital Communication of companies and their Employer Branding, with a special focus on the close relationship that employees feel with the company. To perform this analysis, a case study was carried out using a qualitative approach. Interviews with seven managers from three different companies, two of whom are responsible for the Digital Communication of their organizations, were performed. With the analysis of the data obtained, it is concluded that the Employer Branding perceived by the employees is of a positive image of the company, but they do not feel emotionally more connected with the organization through the Digital Communication practiced by it. With this study, it is expected that organizations recognize the importance that an online presence has in the image of their brand as a whole, and that it is important to invest in Digital Communication, but it has to be performed with an action plan to achieve the objectives intended. From an interdisciplinary perspective, the manuscript presents insights for marketing (digital marketing and employer branding) and for socially responsible behavior by organizations (in a Portuguese context). Full article

Optimizing the hydrogen value chain is essential to ensure hydrogen market uptake in replacing traditional fossil fuel energy and to achieve energy system decarbonization in the next years. The design of new plants and infrastructures will be the first step. However, wrong decisions would result in temporal, economic losses and, in the worst case, failures. Because huge investments are expected, decision makers have to be assisted for its success. Because no tools are available for the optimum design and geographical location of power to gas (P2G) and power to hydrogen (P2H) plants, the geographic information system (GIS) and mathematical optimization approaches were combined into a new tool developed by CNR-ITAE and the University of Bologna in the SuperP2G project, aiming to support the interested stakeholders in the investigation and selection of the optimum size, location, and operations of P2H and P2G industrial plants while minimizing the levelized cost of hydrogen (LCOH). In the present study, the tool has been applied to hydrogen mobility, specifically to investigate the conversion of the existing refuelling stations on Italian highways to hydrogen refuelling stations (HRSs). Middle-term (2030) and long-term (2050) scenarios were investigated. In 2030, a potential demand of between 7000 and 10,000 tons/year was estimated in Italy, increasing to between 32,600 and 72,500 tons/year in 2050. The optimum P2H plant configuration to supply the HRS was calculated in different scenarios. Despite the optimization, even if the levelized cost of hydrogen (LCOH) reduces from 7.0–7.5 €/kg in 2030 to 5.6–6.2 €/kg in 2050, the results demonstrate that the replacement of the traditional fuels, i.e., gasoline, diesel, and liquefied petroleum gases (LPGs), will be disadvantaged without incentives or any other economic supporting schemes. Full article

The inseparability of the production and consumption of services without quality control makes it difficult to fully meet the diverse needs of customers. Despite a company’s continuous efforts to satisfy customers with perceived quality aimed at service success, if the customers’ expectations are not met, the customers will not be satisfied. This study empirically analyzed the effects of customer tolerance and relationship commitment as psychological variables on the relationship between customer participation and repurchase intentions. According to the results of the analysis, relationship benefits, which are a motivation factor for customer participation, had significant effects on customer participation. In addition, customer participation showed significant effects on customer tolerance and relationship commitment. Furthermore, both customer participation and tolerance had significant effects on repurchase intentions; however, relationship commitment was found to have no significant effect on repurchase intentions. The results of this study indicate that customer tolerance formed through customer participation behavior improves customers’ satisfaction with perceived service quality thanks to the shared sense of responsibility that makes customers tolerate a failure of the final service after the service encounter process, thereby increasing repurchase intentions, which prevents the consumptive expenses invested into to recovering services after the company’s service failure. As such, the results of this study provide meaningful implications for sustainable management. Full article

As globalization continues, overseas arable land investment is becoming a viable option for China to alleviate its agricultural growth constraints, and the “Belt and Road” initiative offers plenty of opportunities for China to invest in overseas arable land. This study used data from the Land Matrix, KOF, World Bank, CEPII, UNCTAD and other databases to analyze the spatial distribution characteristics and factors influencing the success or failure of China’s overseas farmland investment projects in countries along the “Belt and Road” project through spatial analysis and the Logit model. The results show that North America has the largest share of production versus contracted acreage in current acreage investment cases, and Asian projects have the highest success rate. Both successful and failed projects in China regarding arable land investment are highly correlated spatially and characterized by a strong concentration and low uniformity of distribution, with differences in the degree of concentration in Asia, Africa and other regions. The contracted area, host country participation and host country resource endowment, business environment and institutional quality have significant, inverted “U-shaped”, negative and positive effects on project success, respectively. In addition, the involvement of the host country has a significant negative impact on the success of investment projects in Africa, and the length of investment and the type of investment purpose have a significant positive and negative impact on the success of investment projects in Asian countries. Therefore, China’s overseas arable land investment should be based on a full examination of existing investment projects in each country, the selection of host countries with abundant resource endowments and a good business environment and institutional environment and the adoption of a model suitable for each location to carry out investments according to local conditions. Full article

COVID-19 has impeded the internationalization of enterprises and sustainable digital economic growth. This situation has led to enterprises adopting divestment strategies to deal with multiple risks. However, the successful implementation of strategies depends on understanding the perceptible risks. Due to risk management failures or unexpected risks, strategic management has attributed withdrawal to production costs or marketing, but risk management has never addressed it. Moreover, small enterprises are more vulnerable to risks than large ones. For the first time, this study fills a gap in the literature by combining Dunning’s investment motives theory with the COSO risk management process theory to examine small enterprise risk perception in China. China has seen a growing number of foreign direct investment (FDI) withdraw. Different risks should have been faced and managed if these were determined to be efficiency-seekers or market-seekers. This research context led to a survey of 498 FDIs, including market-seeking or efficiency-seeking types, to identify perceived risk, managed risk, and value risk outcomes. The Statistical Package for the Social Sciences (SPSS) 18.0 program was used for frequency analysis of general characteristics and exploration of factor analysis, whereas, Analysis of Moment Structures (AMOS) 18.0 was used to perform a confirmatory factor analysis and develop a structural equation model. The obtained results indicate that market efficiency-oriented enterprises can modify their strategies by implementing digital transformation and localization strategies. In contrast, production efficiency-oriented enterprises will divest because of risks, without finding a better strategy. Full article

This research is an assessment of existing liquid waste disposal systems in West Africa and their performances over the years, using systems in Ghana and Nigeria as a case study. The main purpose of the study was to improve upon the sustainability of the systems, which according to earlier research activities, have been failing and resulting in health hazards. Ghana and Nigeria were selected because, from occurrences, especially in the West African sub-region, the two countries dictate the pace in contributions to the body of knowledge. Many portable liquid waste disposal systems were identified as part of the research process, as earlier researchers called for a paradigm shift from the practice of Europeanized systems that had not been successful in the entire sub-region. Many reasons have been attributed to the failures, and more worryingly, the systems continue to be operational despite their states of malfunctioning. Frequent power cuts and ineffective revenue generation contribute to numerous problems. West Africans have been enduring these occurrences for a long time with no solution in place. In a few instances, raw sewage is piped into a central biogas system for the future generation of electrical power; this system was found to be right on point because it was determined from the initial stages of development that by-products could be used to mitigate the high costs of maintenance. Another system that combines a biofil digester with its treated wastewater being channeled into a saturation pond was found to be a success because the outflow from the biofil was not meant to be channeled into main drains, as it did not wholly meet EPA approvals. The centralized sewage treatment systems have been functioning well in advanced countries; however, they are found to be ineffective in developing countries. The reasons included lack of availability for spare parts and coagulants, etc., which were normally imported. Additionally, when a larger community is targeted, revenue generation becomes a problem, thereby affecting return on investments (ROI) and operating and maintenance (O&M). None of the available central sewerage systems harvest by-products, making revenue generation a difficult task. The portable systems have been discussed in this research study, with examples and a record of performance over the years that could contribute to the body of knowledge in the field of sustainability for sewage treatment processes suitable for West Africa and for the whole of sub-Saharan Africa. Full article

Not all dog adoptions are successful. This two-year retrospective study used survival (i.e., time-to-event) analyses to investigate readmissions for dogs adopted from RSPCA Queensland shelters between 1 January 2019 and 31 December 2020. A better understanding of temporal patterns and risk factors associated with readmission may help RSPCA Queensland shelters better target and tailor resources to improve retention by adopters. The failure function (the cumulative percentage of adoptions that were readmitted by day of the adoption period) increased rapidly during the first 14 days of the adoption period. Approximately two-thirds of all returns occurred in this period. This readmission rate may have been influenced by the RSPCA Queensland adoption-fee refund policy. The cumulative percentage of adoptions that were readmitted plateaued at just under 15%. Dog size, age, coat colour, breed, and spending time in foster before adoption were factors associated with the risk of readmission. Failure functions for a low and a high-risk adoption example demonstrated the large degree of difference in hazard of readmission between covariate patterns, with estimated percentages of adoptions being returned by 90 days for those examples being 2% and 17%, respectively. Spending time in foster care before adoption appears to be protective against readmission, presumably because it supports a successful transition to the new home environment. Behaviour support and training provided for dogs during foster care may contribute to improve their outcomes. These findings highlight the profile of the higher-risk dogs potentially providing shelters with an opportunity to examine where and how resources could be allocated to maximize outcomes for the overall cohort. Population attributable 90-day failure estimates were calculated for each of bodyweight and age at adoption, coat colour, spending time in foster care before adoption, and breed. This calculation shows the expected reduction in the cumulative percentage of dogs readmitted by day 90 if the hazards of readmission for higher risk categories were reduced to those of a lower risk category. Expected reductions for individual factors ranged from 1.8% to 3.6% with one additional estimate of 6.8%. Risk of readmission could be reduced through increased development of foster capacity and capability, targeted interventions, improved adopter-dog matching processes, and more effective targeting of support for higher risk dogs, such as older or larger dogs. Population impact analyses provide a macro view that could assist shelters in strategically assessing the return on investment for various strategies aiming to improve adoption outcomes and potentially reduce readmissions. Full article

Entrepreneurship and innovation are the fuel of economic growth. Understanding the motivational factors that lead to the success of entrepreneurs in agribusiness can be useful in affecting the degree of successful investment that accelerates development and economic growth in the agriculture sector. In this study, we investigated the factors affecting the success of entrepreneurs in the agribusiness sector in Mashhad, Iran, using a two-stage Heckman approach. Factors affecting the success or failure of agribusiness entrepreneurship have received less attention in the literature. In this study, the aim was to determine the factors affecting agricultural entrepreneurship success and entrepreneurs’ profits. We generated the data for this study by designing a questionnaire and conducting a survey of active entrepreneurs in Mashhad in 2020. The results showed that entrepreneurship experience, risk-taking behavior, interest rates, and initial capital have a significant impact on the probability of entrepreneurship success and entrepreneur’s profits. Policies that could improve the skills of entrepreneurs, provision of initial capital requirements, and financial market efficiency had an effective role in increasing entrepreneurship and innovation in the agribusiness sector. Entrepreneurs in the field of agriculture could consider these factors to have better choices while entering or continuing with their agribusinesses. Our recommendation to policymakers and agribusiness leaders is to establish a friendlier and more stable environment for entrepreneurship and employ policies that help reduce the risk of entrepreneurs’ initial investment returns. Full article