Search Results (394)

Adipose tissue expandability refers to the capacity of white adipose tissue to store excess energy safely while preserving metabolic homeostasis. This adaptive response takes place via both an increase in adipocyte number (hyperplasia) and size (hypertrophy). Healthy expansion requires coordinated angiogenesis, extracellular matrix remodeling, and functional adipose stem and progenitor cells. Within this conceptual framework, when expandability is limited—due to genetic factors, aging, or chronic overnutrition—adipocyte hypertrophy predominates, which is hypothesized to trigger hypoxia, endoplasmic reticulum stress, chronic low-grade inflammation, and fibrosis. These changes are proposed to form a physical and metabolic barrier that compromises further safe lipid storage, potentially driving the spillover of surplus lipids to ectopic sites: the liver (promoting steatosis and hepatic insulin resistance), skeletal muscle (intramyocellular lipid accumulation and impaired glucose uptake), and pancreas (β-cell dysfunction and reduced insulin secretion). Lipotoxic intermediates such as diacylglycerols and ceramides activate protein kinase C isoforms and may impair insulin receptor signaling, thereby contributing to systemic insulin resistance. The clinical correlate is a spectrum of metabolic disorders including type 2 diabetes, dyslipidemia, metabolic dysfunction-associated steatotic liver disease, and cardiovascular disease. Understanding the determinants of adipose tissue expandability—from adipose stem cell function and angiogenesis to fibrosis and immune cell infiltration—provides a framework for identifying individuals at risk despite normal body weight and for developing targeted therapies that restore healthy adipose tissue expansion. The aim of this narrative review is to analyze how nutritional factors shape adipose tissue expandability and how limitations in expandability drive obesity-related metabolic disease. To this end, we leverage bariatric surgery as a physiological model illustrating how weight loss reduces lipid overflow while intrinsic adipose tissue expandability may remain incompletely restored. Full article

Hydrogen-rich off-gas generated during nuclear fuel fabrication requires safe oxidation with limited nitric oxide (NO) formation. This study experimentally investigates the combustion of a simulated H₂/N₂ off-gas under open-air jet and CH₄ hot coflow-assisted conditions with MILD-like characteristics. One-dimensional premixed flame calculations are further employed to examine the intrinsic kinetics of H₂ oxidation and NO formation. Under the open-air baseline condition, the residual H₂ and NO concentrations measured at the flame tip were 244.8 and 158.1 ppm, respectively. Introducing hot coflow elongated the visible reaction zone from 13.0 cm to 15.0–22.0 cm and reduced the flame temperature from 783.6 °C to 405–517 °C. The residual H₂ concentration decreased to 30.7–104.3 ppm, while NO emissions decreased to 9.4–50.2 ppm. Kinetic analysis revealed that hydrogen oxidation was primarily governed by chain branching reactions involving H radicals and oxygen molecules. Increasing the hot coflow equivalence ratio altered the relative contributions of the Nitrogen–Nitrogen–Hydrogen (NNH) and Zeldovich-related NO formation pathways. Overall, the hot coflow was associated with an extended reaction zone as well as with reduced residual H₂ and NO concentrations under the investigated conditions. Full article

Behavioral malware analysis relies on dynamic-analysis logs—sequences of Windows API calls recorded by sandboxes such as CAPEv2—assumed to represent the malware’s effects faithfully. To the best of our knowledge, this assumption has never been tested by re-executing the recorded calls. We propose WinAPIReplay, which re-executes each recorded Win32 and NT-native call as a real operating-system call, without the malware binary, using a unified handle map for cross-layer handle chains and a three-tier sandbox confining every side effect to disposable places. Across 500 WinMET samples from five families, 74.04% of modeled Layer-1 behavior-domain calls are reproduced (95% bootstrap CI [71.02, 76.75]); the Layer-1 domain covers 57.98% of all recorded calls, and a conservative rate excluding substituted calls is 71.15%. An ablation attributes this causally to the per-category executors—handle-validity falls from 94.9% to 10.2% without them—and no side effect escapes the sandbox on the channels the tool models and monitors. A four-way taxonomy assigns most of the residual to intrinsic, environment-dependent behavior; re-execution is near-deterministic (98.90% stable). Under Sysmon, it safely generates family-labeled file/registry telemetry for the reproduced subset (46,150 events) from static logs alone—while its result record recovers the malware’s process arguments and network destinations—and a classifier over it reaches 92.0% leave-one-out accuracy on 100 samples, statistically indistinguishable from an API-category baseline. WinAPIReplay thus provides, to the best of our knowledge, the first quantitative measurement of dynamic-log reproducibility within a demonstrated safety envelope, and a safe route to labeled, environment-consistent endpoint telemetry. Full article

Accurate state-of-health (SOH) prediction is essential for the safe and cost-effective operation of lithium-ion battery systems. However, current data-driven methods still struggle to jointly extract multiscale degradation information, capture long-range dependencies, fuse heterogeneous health indicators, and provide transparent model decisions. This study proposes an interpretable multi-feature SOH prediction framework that integrates improved complete ensemble empirical mode decomposition with adaptive noise (ICEEMDAN), Autoformer, and a bidirectional temporal convolutional network (BiTCN). ICEEMDAN adaptively decomposes capacity-related sequences into intrinsic mode functions and residual components, thereby suppressing noise and representing degradation dynamics at multiple temporal scales. Autoformer captures long-term trends and periodic patterns through series decomposition and auto-correlation, whereas BiTCN models local dynamic fluctuations through bidirectional temporal convolutions. The decomposed components and health indicators are then fused for battery health-state prediction. Shapley additive explanations (SHAP) are used to quantify feature contributions, and interval prediction is introduced to evaluate predictive uncertainty. Experiments on CALCE lithium-ion battery datasets show that the proposed ICEEMDAN-Autoformer-BiTCN model outperforms the tested baseline combinations, achieving an MAE of 6.6646 and an R² of 0.9896 under ICEEMDAN decomposition. SHAP analysis further indicates that residual components, SOH-related information, cycle number, and internal resistance make consistent contributions across battery samples. These results suggest that the proposed framework improves prediction accuracy while providing a more interpretable and uncertainty-aware approach to battery health assessment. Full article

Gene therapy is undergoing continued clinical translation and technological development. This progress has been marked by regulatory approvals and broadened therapeutic indications across genetic, metabolic, and oncologic diseases and disorders. The field has evolved over decades from early viral-mediated gene addition to approaches capable of targeted editing, regulation, or replacement of genetic information. These systems include base and prime editors, epigenetic modulators, CRISPR-Cas, RNA therapeutics and programmable integration platforms. When paired with increasingly sophisticated viral and nonviral delivery strategies, these technologies enable greater control over tissue targeting, duration of activity, and therapeutic exposure. Recent clinical successes, including approved ex vivo CRISPR-based therapies for hemoglobinopathies, in vivo CRISPR editing for transthyretin amyloidosis, and emerging clinical applications of base and prime editing, provide growing clinical evidence for the feasibility of genetic medicines. However, technological advancement has also made platform selection increasingly complex. Therapeutic performance is determined not by editing efficiency alone, but by the interaction among genetic precision, temporal control, dosage tunability, delivery efficiency, durability, and disease-specific safety requirements. A molecularly efficient platform may still have limited therapeutic value if it cannot reach the disease-relevant cell population at sufficient and safe exposure. In this review, we examine recent technological and clinical advances in genetic medicine with particular emphasis on developments during the past approximately five years. We propose a multidimensional framework in which gene therapy platforms are evaluated according to three intrinsic properties—genetic precision, temporal control, and dosage tunability—while delivery, clinical maturity, and disease context act as major translational constraints. This framework highlights that no single platform is universally optimal; rather, successful therapeutic design depends on matching the biological characteristics of the intervention to the requirements of the disease and target tissue. Remaining challenges in extrahepatic delivery, genomic safety, immunogenicity, manufacturing, and long-term monitoring remain important determinants of broader clinical implementation. Full article

Enterococcus lactis KUST2812 is a halotolerant strain isolated from broad bean paste (BBP). It shows strong potential as a safe fermentation starter due to its high survival rate (98.32% in 18% NaCl), absence of hemolytic activity, and susceptibility to clinically relevant antibiotics, with resistance limited to intrinsic traits. Growth and metabolic dynamics suggest that salt stress decouples growth from tyrosine catabolism: while 6% NaCl significantly inhibited bacterial cell growth, tyrosine depletion occurred within 12 h under 6% NaCl, compared with the 96 h required under non-saline conditions. Multi-omics analyses suggest a molecular network associated with this tyrosine conversion under salt stress. Two tyrosine decarboxylase genes (tdc) were upregulated by 1.85- and 6.50-fold, respectively. The tyrosine-specific transporter gene tyrP was upregulated 4.99-fold, and the protein synthesis-associated gene tyrS was upregulated 4.93-fold. These changes collectively support a diversified tyrosine utilization strategy of E. lactis KUST2812. Moreover, coordinated responses involving the Na⁺/H⁺ antiporter system, compatible solute transporters, and oxidative stress markers contributed to the metabolic basis for salt adaptation of this strain. Evaluation in BBP fermentation suggested that E. lactis KUST2812 may reduce tyrosine accumulation without causing a significant increase in tyramine. These findings offer a potential microbial resource and a theoretical basis for managing tyrosine-related quality issues in fermented foods. Full article

Aeromonas hydrophila is a globally distributed aquatic pathogen. Antibiotic overuse in traditional management practices has intensified problems such as antimicrobial resistance and environmental pollution, creating an urgent need for safe alternatives. This study characterized a BLIS produced by Leuconostoc falkenbergense SBL-85-2, which shows potential as an antibiotic alternative in aquaculture. L. falkenbergense SBL-85-2 exhibited no hemolytic activity, lacked typical high-risk virulence factors, and only low-identity vancomycin-related intrinsic genes (vanT and vanY) were identified by the CARD database, which may preliminarily indicate its potential biosafety for aquatic applications. The BLIS exhibited marked activity against A. hydrophila, with an inhibition zone of 39.14 ± 0.65 mm, as well as other critical pathogens including Aeromonas rivipollensis, Aeromonas salmonicida, Escherichia coli, Salmonella Typhimurium, Staphylococcus aureus, and Vagococcus fluvialis. Furthermore, the BLIS exhibited remarkable thermal stability (retained 87.18 ± 0.14% activity after treatment at 100 °C for 10 min) and UV stability (92.67 ± 0.75% residual activity after 3 h exposure) coupled with sensitivity to proteases, confirming its proteinaceous nature. Molecular weight determination indicated that the BLIS is a low-molecular-weight peptide (<2.7 kDa). Mechanistically, the BLIS disrupted bacterial cell membrane integrity, ultimately resulting in the leakage of cellular contents and a time-dependent reduction in intracellular ATP levels (reduced by 69.16 ± 4.10% at 2 h), exerting its antimicrobial effect. Collectively, our results indicate that this BLIS combines potent antibacterial efficacy with a favorable biosafety profile, suggesting its significant potential for the biological control of A. hydrophila in aquaculture. Full article

Although natural biopolymers represent promising sustainable packaging alternatives, their weak mechanical and barrier properties limit industrial use. While previous reviews focus on descriptive aspects of enzymatic modification, this review fills a critical literature gap by systematically bridging molecular-level laccase-driven reactions with quantitative techno-economic and safety and regulatory frameworks. We evaluate the kinetic and topological differences between direct tyrosyl-coupled protein homopolymerisation and mediator-assisted ‘graft-then-link’ polysaccharide strategies. Crucially, we analyse how entrapment versus surface-immobilised architectures dictate mass-transfer regimes, establishing their specific functional fitness for active oxygen scavenging or intelligent time-temperature monitoring. Beyond physical performance, we critically assess the translational bottlenecks currently hindering industrial scaling. For the first time, we integrate a quantitative techno-economic analysis using the Technology Readiness Level (TRL) framework, demonstrating that active film fabrication costs (EUR 0.01–0.10/m²) are heavily offset by high-protein food waste savings (>EUR 2.00/kg). Finally, we navigate European and US regulatory landscapes for enzymatically active materials and evaluate safety risks via the Threshold of Toxicological Concern (TTC) model and deterministic migration modelling. This comprehensive analysis establishes a ‘Safe-by-Design’ paradigm, guiding the scalable development of intrinsically safe, high-performance biocatalytic packaging. Full article

The treatment of articular cartilage defects remains a significant clinical challenge due to the tissue’s limited intrinsic repair capacity. This paper presents a review of clinical experiences with the use of Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) as a novel therapeutic option for cartilage regeneration. WJ-MSCs offer key advantages, including high proliferative potential, strong immunomodulatory properties, and low immunogenicity, making them suitable for allogeneic applications. This review describes a single-step, dry-arthroscopic technique that was employed for the implantation of WJ-MSCs embedded in a scaffold directly into cartilage defects. Clinical follow-up, supported by MRI evaluation, demonstrated favorable outcomes with evidence of defect filling, improved cartilage surface quality, and sustained functional improvement in patients. These results suggest that WJ-MSC-based therapies, delivered through minimally invasive surgical techniques, represent a safe and effective strategy for cartilage repair, with the potential to become an important alternative to current standard treatments. Recent advances in artificial intelligence (AI) and multimodal bioprinting are opening new perspectives for standardizing regenerative therapies. Machine learning models can predict bioink performance, optimize scaffold design, and integrate real-time imaging feedback such as optical coherence tomography and photoacoustic imaging. These approaches allow closed-loop quality control and the creation of digital twins to ensure biomechanical fidelity of constructs. Incorporating AI-assisted bioprinting with Wharton’s jelly MSCs could accelerate the translation of laboratory findings into reproducible, patient-specific cartilage implants. This manuscript is structured as a translational review of WJ-MSC-based cartilage repair, with AI-assisted bioprinting presented as a prospective future manufacturing direction rather than current clinical practice. Full article

To explore the emerging role of natural ligands, specifically coumarin and curcumin, and their coordination with the transition metals ruthenium (Ru) and iridium (Ir) as photosensitizers (PSs) in photodynamic therapy (PDT) for cancer. This highlights the integration of natural compounds and transition metals to overcome limitations in photophysical properties, hypoxia tolerance, and clinical translation. Regarding PDT oncology, this examines an immunological effect on Ru/Ir complexes and natural ligand-metal hybrids. They induce immunogenic cell death (ICD) through reactive oxygen species (ROS) generation, calreticulin exposure, extracellular ATP release, and HMGB1 secretion. These damage-associated molecular patterns act as “danger signals” to recruit dendritic cells, prime CD8⁺ cytotoxic T-cells, and establish systemic antitumor immunity. This study compares natural ligand-metal complexes with conventional Ru(II)/Ir(III) complexes and clinical PSs to assess their translational potential as immune-activating agents in PDT oncology, as well as focusing on the integration of nanotechnology with natural ligand-metal complexes to enhance delivery, biocompatibility, and clinical translation. A narrative review was conducted of the literature published between 2010 and 2025 across multiple electronic databases, including WanFang Data, PubMed, ScienceDirect, Scopus, Web of Science, Springer Link, SciFinder, and CNKI, without language restrictions. Studies focusing on coumarin, curcumin, Ru(II), Ir(III), and PDT were analyzed. Extracted data included chemical structures, absorption and emission spectra, singlet oxygen yields, biological activities, and therapeutic outcomes. Comparative evaluation was performed between free natural ligands, their Ru(II)/Ir(III) complexes, and nanodelivery systems to assess efficacy, biocompatibility, and translational potential. Coumarin and curcumin exhibited intrinsic antioxidant, anti-inflammatory, and anticancer properties but were limited by short absorption/emission ranges, poor photostability, and low singlet oxygen yields, restricting preclinical application. Coordination with Ru(II) and Ir(III) significantly enhanced intersystem crossing, extended absorption into the near-infrared region, and improved singlet oxygen quantum yields (Φ_Δ up to ~0.78). These complexes demonstrated potent photocytotoxicity under normoxia and hypoxia, achieving IC₅₀ values in the nanomolar range, which indicated organelle-specific targeting (mitochondria, lysosomes, ER), induced ICD, and synergized with checkpoint blockade. Nanocarrier encapsulation further improved solubility and tumor selectivity, and reduced systemic toxicity. Coumarin- and curcumin-based Ru/Ir complexes represent promising next-generation or immune activating PDT agents by combining natural pharmacological activity with superior photophysical performance. The ability to generate reactive oxygen species under hypoxia and achieve multimodal therapeutic effects positions them as strong candidates for clinical translation. Clinical approval of natural ligand-Ru/Ir complexes depends on rigorous safety, pharmacokinetic, and nanodelivery validation, but these complexes clearly extend PDT beyond local cytotoxicity toward durable immune protection. Future research should prioritize ligand engineering, nanotechnology integration, and translational models to bridge preclinical promise with safe and effective clinical applications. Full article

A hard protein corona was engineered onto tannic acid-modified magnetic nanoparticles (SAMN@TA), a magnetic and luminescent core–shell nano-carrier, using bovine serum amine oxidase (BSAO), an enzyme catalyzing the oxidation of polyamines and producing the corresponding aldehydes and hydrogen peroxide. The absorption and intracellular bioactivity of the self-assembled multimodal SAMN@TA@BSAO were investigated on an intestinal barrier model built with human colorectal adenocarcinoma (Caco-2) cells. The tailored BSAO corona possessed fouling resistance and, at the same time, was able to activate the clathrin-mediated endocytosis (CME) mechanism. Despite its size and intrinsic complexity, the nano-vehicle was effectively transported across the cell layer, safely transiting across the cell cytoplasm and reaching the lumen. As a function of intracellular polyamine concentration, the system’s biological activity induced intracellular oxidative stress, leading to the activation of the Keap1/Nrf2 oxidative protection pathway. The SAMN@TA@BSAO effect was well described by a dose–response curve with an EC₅₀ of around 30 µg mL⁻¹ and a programmable killing efficiency (>50.0%), recalling the feasibility of a low molecular weight drug administration. The present study contributes to the nascent knowledge on engineering protein corona as a key to rationally design nanomaterials for biomedical applications. Full article

Effective thermal management is a cornerstone of safe, long-life lithium-ion battery operation, especially under high-rate charge–discharge and dynamic driving conditions. Conventional active cooling technologies face inherent trade-offs between heat dissipation efficiency, system complexity, and temperature uniformity, while phase change materials (PCMs) provide a promising passive alternative by absorbing latent heat during phase transition to buffer temperature spikes, improve temperature uniformity, and delay thermal runaway propagation. This paper presents a comprehensive review of recent advances in PCM-based lithium-ion battery thermal management, systematically covering the full scope from fundamental battery heat generation mechanisms to material synthesis optimization and hybrid system integration. At the material level, we analyze state-of-the-art strategies to address the intrinsic drawbacks of organic PCMs—low thermal conductivity, mismatched phase transition temperatures, and high flammability—including the construction of carbon/metal conductive skeletons, compositional tuning of phase change behavior, and flame-retardant modifications. These approaches have yielded composite PCMs with significantly improved heat transport capability and fire safety, while preserving high latent heat storage capacity. At the system level, we evaluate the thermal performance of pure passive PCM configurations, which excel at peak temperature suppression and inter-cell temperature uniformity, as well as hybrid designs that combine PCMs with air or liquid cooling to resolve heat accumulation issues and maintain stable performance under prolonged, demanding operating cycles. Despite these advances, key challenges remain: balancing high thermal conductivity with high latent heat capacity, developing climate-adaptable phase transition temperatures, and integrating multiple functionalities without compromising core thermal storage properties. Looking forward, future research directions include multifunctional integrated composites, smart adaptive PCMs, cost-effective scalable manufacturing, and precision structural engineering. This review also summarizes quantified performance trade-offs and provides actionable design guidelines for both material development and system-level integration. Full article

Strict monitoring of methane (CH₄) during underground coal mining is necessary, as the lower explosive limit (LEL) is 5 vol% in air. A conventional tin oxide (SnO₂)-based metal–oxide semiconductor (MOS) sensor has an operating temperature of 200–400 °C, which requires a prohibitive power demand and entails the risk of ignition within an intrinsically safe environment. The decoration of SnO₂ nanoarchitectures with palladium has been demonstrated to achieve room temperature (RT) detection of CH₄ due to the chemical sensitisation spillover mechanism and electronic sensitisation by Schottky barrier modulation. Moreover, palladisation of SnO₂ nanowires (NWs) is likely to be an effective route for achieving a more efficient detection of CH₄ aerosol at RT or near RT. The purpose of this mini-review is to provide a critical synthesis of advances that have been reported between 2020 and 2026. Because no published study to date has directly demonstrated room-temperature CH₄ detection using pure Pd-decorated SnO₂ nanowires, performance data from mechanistically analogous systems—namely H₂-sensing Pd–SnO₂ nanowires and CH₄-sensing non-nanowire Pd–SnO₂ nanostructures—are included in this review and are explicitly labelled as such throughout. This absence of direct RT CH₄ NW data constitutes the primary research gap motivating this review. The performance of Pd-containing SnO₂ nanostructures reported in the literature spans response values of 17.6 (300 ppm CH₄, 2.5 mol% Pd–SnO₂ nanoporous, 340 °C) to 21.3 (3000 ppm CH₄, bimetallic Pt–Pd–SnO₂ mesoporous, 400 °C), representing a 3–10× improvement over bare SnO₂ (response: 2–10 in the same concentration range). These benchmarks were obtained at elevated temperatures (340–400 °C); no equivalent room-temperature CH₄ detection data for Pd–SnO₂ nanowires currently exists in the published literature. Reported response times range from 3 to 9 s at elevated temperature (340–400 °C) to 74–78 s for room-temperature visible-light-activated systems, where photocatalytic oxygen activation is the rate-limiting step. The 30 s MSHA alarm threshold is met by elevated-temperature systems but remains a challenge for RT configurations. The LODs were 175.9 ppb (bimetallic PdxPt/SnO₂ mesoporous system). Two hybrid composites containing rGO exhibited an extended capability for RT operation. Bimetallic PdPt decoration and ML-augmented sensor arrays are identified as the most promising near-term pathways to bridge the selectivity and stability gaps for certified mining deployment. Full article

Taxilli Herba (Sangjisheng) is a hemi-parasitic medicinal plant whose quality is intrinsically linked to its host species. While previous reviews have extensively summarized its chemical constituents and pharmacological activities, a systematic understanding of how host trees dictate its quality and safety remains largely fragmented. This review bridges this gap by proposing a “host-governed quality paradigm.” By integrating historical records with modern scientific findings, we critically evaluate the molecular mechanisms underlying host–parasite interactions and their impact on medicinal quality. We highlight that host species influence Taxilli Herba across three critical dimensions: (i) chemical composition, comprising both intrinsic bioactive compounds and host-derived metabolites; (ii) toxicity profile, where even hosts lacking cardiac glycosides may pose potential safety hazards; and (iii) pharmacological activity, where host identity modulates therapeutic potency and traditional medicinal properties (e.g., “cold” vs. “warm” nature). Importantly, we highlight that the cardiac glycoside test specified in the current Chinese Pharmacopoeia is insufficient to ensure the safety of Sangjisheng derived from diverse hosts. To address these challenges, we propose a host-governed quality paradigm comprising four pillars: (1) mechanistic studies on host–parasite interactions; (2) revision of pharmacopeial standards to restrict approved sources; (3) promotion of standardized cultivation using safe host species (e.g., Morus alba); and (4) stringent quality control for edible and medicinal applications. This framework aims to ensure the safety, efficacy, and sustainable use of Sangjisheng in clinical practice. Full article

Aqueous zinc metal batteries are promising for safe and cost-effective energy storage. However, their practical application is limited by the intrinsic instability of the Zn/electrolyte interface, including water-induced hydrogen evolution, Zn corrosion, and dendrite-prone Zn deposition. Herein, glutaronitrile (GLN) is introduced as a multifunctional dinitrile additive to stabilize Zn metal anodes through coupled regulation of solvation chemistry and interfacial evolution. The polar C≡N groups of GLN can coordinate with Zn²⁺, to replace part of the water molecules in the primary solvation shell, thereby suppressing the activity of coordinated water. Meanwhile, uncoordinated C≡N groups act as hydrogen-bond acceptors to reorganize the surrounding water network, further suppressing free-water participation in hydrogen evolution and corrosion. This dual regulation optimizes the Zn/electrolyte interfacial environment, improves electrolyte wettability on Zn, homogenizes Zn²⁺ flux, and promotes compact, dendrite-suppressed Zn deposition. Additionally, GLN promotes the formation of a chemically heterogeneous interfacial structure enriched with ZnF₂ in the inner region, which further protects the Zn surface and stabilizes the Zn plating/stripping process. The optimized ZHG6 electrolyte enables Zn||Zn symmetric cells to cycle stably for over 900 h at 1 mA cm⁻² and 1 mAh cm⁻², while Zn||Cu cells maintain high Coulombic efficiency during long-term cycling. Furthermore, Zn||V₆O₁₃ full cells exhibit enhanced cycling stability and rate capability, achieving stable operation for 3200 cycles at 5 A g⁻¹. As evidenced in this work, dinitrile-based molecular additives provide an effective and scalable strategy to fabricate durable aqueous zinc metal batteries. Full article