Search Results (125)

Line traps are critical components of power line carrier systems, enabling remote control signaling, voice communication, and inter-substation control within electrical transmission and distribution networks. Despite their importance, limited research has addressed their seismic performance, particularly under near-fault and far-fault ground motions. This study addresses this gap by experimentally and numerically evaluating a full-scale 170 kV line trap. Ambient Vibration Tests (AVTs), using Enhanced Frequency Domain Decomposition (EFDD), and shake table testing established its modal and seismic response characteristics. A finite element (FE) model was then developed and calibrated using the experimental results. Dynamic analyses were conducted to evaluate the structural response under both near-fault and far-fault ground motions. Experimental findings revealed that the seismic response of the line trap increased with height, with the upper segment experiencing over four times the base acceleration. Numerical analyses further demonstrated that near-fault ground motions induced significantly higher displacement and acceleration responses than far-fault records. These findings collectively constitute a detailed investigation into the seismic performance of a full-scale line trap, emphasizing the pivotal role of ground motion characteristics in the structural evaluation of substation apparatus. Full article

This study examines the global mobility of researchers in the smart city domain from 2000 to 2020, using inter-country and intercity affiliation data from the Web of Science. Employing network analysis and spatial econometric models, the paper maps the structural reconfiguration of scientific labor circulation. The results show that the international mobility network is dense yet asymmetric, dominated by a small set of high-frequency corridors such as China–United States, which intensified markedly over the two decades. While early networks were fragmented and polycentric, the later period reveals a multipolar configuration with significant growth in South–South and intra-European exchanges. At the city level, Beijing, Shanghai, Wuhan, and Nanjing emerged as central nodes, reflecting the consolidation of East Asian hubs within the global knowledge system. Mesoscale community detection highlights the coexistence of territorially embedded ecosystems and transregional corridors sustained by thematic and reputational affinities. Growth decomposition indicates that high-income countries benefit from both talent retention and international inflows, while upper-middle-income countries rely heavily on inbound mobility. Spatial regression and quantile models confirm that economic growth and baseline scientific visibility remain robust drivers of urban smart city performance. In contrast, mobility effects are context-dependent and heterogeneous across city positions. Together, these findings demonstrate that researcher mobility is not only a vector of knowledge exchange but also a mechanism that reinforces spatial hierarchies and reshapes the geography of global smart city innovation. Full article

The rapid proliferation of heterogeneous Internet of Things (IoT) devices has introduced a wide range of operational and security challenges, particularly in the domains of device identification and behavior profiling. Traditional fingerprinting methods, which rely primarily on time domain features, often fail to capture the complex, periodic, and often bursty nature of IoT communication—especially in environments characterized by sparse, irregular, or noisy traffic patterns. To address these limitations, two novel frequency-based fingerprinting techniques have been proposed: Spectral-Only Frequency Fingerprint (SFF) and Spectro-Correlative Frequency Fingerprint (SCFF). These approaches shift the analysis from the time domain to the frequency domain, enabling the extraction of richer and more robust behavioral signatures from network traffic. While SFF focuses on capturing the core spectral features of device traffic, SCFF extends this by incorporating inter-feature correlations, offering a more nuanced and comprehensive representation of device behavior. The effectiveness of SFF and SCFF is evaluated across multiple publicly available IoT datasets using a range of machine learning classifiers. Experimental results demonstrate that both fingerprinting methods significantly outperform traditional time domain approaches in terms of accuracy, precision, recall, and F1-score—across all tested classifiers and datasets. Full article

Background: Large language models (LLMs) such as ChatGPT, Google Gemini, and Microsoft Copilot are increasingly used by patients seeking medical information online. While these tools provide accessible and conversational explanations, their accuracy and safety in emotionally sensitive scenarios—such as an incidental cancer diagnosis—remain uncertain. Objective: To evaluate the quality, completeness, readability, and safety of responses generated by three state-of-the-art LLMs to common patient questions following the incidental discovery of a kidney tumor. Methods: A standardized use-case scenario was developed: a patient learns of a suspicious renal mass following a computed tomography (CT) scan for back pain. Ten plain-language prompts reflecting typical patient concerns were submitted to ChatGPT-4o, Microsoft Copilot, and Google Gemini 2.5 Pro without additional context. Responses were independently assessed by five board-certified urologists using a validated six-domain rubric (accuracy, completeness, clarity, currency, risk of harm, hallucinations), scored on a 1–5 Likert scale. Two statistical approaches were applied to calculate descriptive scores and inter-rater reliability (Fleiss’ Kappa). Readability was analyzed using the Flesch Reading Ease (FRE) and Flesch–Kincaid Grade Level (FKGL) metrics. Results: Google Gemini 2.5 Pro achieved the highest mean ratings across most domains, notably in accuracy (4.3), completeness (4.3), and low hallucination rate (4.6). Microsoft Copilot was noted for empathetic language and consistent disclaimers but showed slightly lower clarity and currency scores. ChatGPT-4o demonstrated strengths in conversational flow but displayed more variability in clinical precision. Overall, 14% of responses were flagged as potentially misleading or incomplete. Inter-rater agreement was substantial across all domains (κ = 0.68). Readability varied between models: ChatGPT responses were easiest to understand (FRE = 48.5; FKGL = 11.94), while Gemini’s were the most complex (FRE = 29.9; FKGL = 13.3). Conclusions: LLMs show promise in patient-facing communication but currently fall short of providing consistently accurate, complete, and guideline-conform information in high-stakes contexts such as incidental cancer diagnoses. While their tone and structure may support patient engagement, they should not be used autonomously for counseling. Further fine-tuning, clinical validation, and supervision are essential for safe integration into patient care. Full article

DIALOGUE (DIagnostic AI Learning through Objective Guided User Experience) is a generative artificial intelligence (GenAI)-based training program designed to enhance diagnostic communication skills in medical students. In this single-arm pre–post study, we evaluated whether DIALOGUE could improve students’ ability to disclose a type 2 diabetes mellitus (T2DM) diagnosis with clarity, structure, and empathy. Thirty clinical-phase students completed two pre-test virtual encounters with an AI-simulated patient (ChatGPT, GPT-4o), scored by blinded raters using an eight-domain rubric. Participants then engaged in ten asynchronous GenAI scenarios with automated natural-language feedback. Seven days later, they completed two post-test consultations with human standardized patients, again evaluated with the same rubric. Mean total performance increased by 36.7 points (95% CI: 31.4–42.1; p < 0.001), and the proportion of high-performing students rose from 0% to 70%. Gains were significant across all domains, most notably in opening the encounter, closure, and diabetes specific explanation. Multiple regression showed that lower baseline empathy (β = −0.41, p = 0.005) and higher digital self-efficacy (β = 0.35, p = 0.016) independently predicted greater improvement; gender had only a marginal effect. Cluster analysis revealed three learner profiles, with the highest-gain group characterized by low empathy and high digital self-efficacy. Inter-rater reliability was excellent (ICC ≈ 0.90). These findings provide empirical evidence that GenAI-mediated training can meaningfully enhance diagnostic communication and may serve as a scalable, individualized adjunct to conventional medical education. Full article

Background/Objectives: Evidence-based nursing practice (EBNP) is essential in high-acuity settings such as intensive care units (ICUs) and emergency departments (EDs), where nurses are frequently required to make time-critical, high-stakes clinical decisions that directly influence patient safety and outcomes. Despite its recognized importance, the implementation of EBNP remains inconsistent, with frontline nurses often facing barriers to accessing and applying current evidence. Methods: This descriptive, cross-sectional study systematically mapped and prioritized clinical questions generated by ICU and ED nurses at a tertiary hospital in South Korea. Using open-ended questionnaires, 204 clinical questions were collected from 112 nurses. Each question was coded and classified according to the Nursing Interventions Classification (NIC) taxonomy (8th edition) through a structured cross-mapping methodology. Inter-rater reliability was assessed using Cohen’s kappa coefficient. Results: The majority of clinical questions (56.9%) were mapped to the Physiological: Complex domain, with infection control, ventilator management, and tissue perfusion management identified as the most frequent areas of inquiry. Patient safety was the second most common domain (21.6%). Notably, no clinical questions were mapped to the Family or Community domains, highlighting a gap in holistic and transitional care considerations. The mapping process demonstrated high inter-rater reliability (κ = 0.85, 95% CI: 0.80–0.89). Conclusions: Frontline nurses in high-acuity environments predominantly seek evidence related to complex physiological interventions and patient safety, while holistic and community-oriented care remain underrepresented in clinical inquiry. Utilizing the NIC taxonomy for systematic mapping establishes a reliable framework to identify evidence gaps and support targeted interventions in nursing practice. Regular protocol evaluation, alignment of continuing education with empirically identified priorities, and the integration of concise evidence summaries into clinical workflows are recommended to enhance EBNP implementation. Future research should expand to multicenter and interdisciplinary settings, incorporate advanced technologies such as artificial intelligence for automated mapping, and assess the long-term impact of evidence-based interventions on patient outcomes. Full article

A systems-oriented review of machine learning (ML) over the entire flood management spectrum, encompassing fluvial flood control, pluvial flood management, and resiliency-risk characterization was undertaken. Deep learners like long short-term memory (LSTM) networks perform well in predicting reservoir inflows and outflows. Convolution neural networks (CNNs) and other object identification algorithms are being explored in assessing levee and flood wall failures. The use of ML methods in pump station operations is limited due to lack of public-domain datasets. Reinforcement learning (RL) has shown promise in controlling low-impact development (LID) systems for pluvial flood management. Resiliency is defined in terms of the vulnerability of a community to floods. Multi-criteria decision making (MCDM) and unsupervised ML methods are used to capture vulnerability. Supervised learning is used to model flooding hazards. Conventional approaches perform better than deep learners and ensemble methods for modeling flood hazards due to paucity of data and large inter-model predictive variability. Advances in satellite-based, drone-facilitated data collection and Internet of Things (IoT)-based low-cost sensors offer new research avenues to explore. Transfer learning at ungauged basins holds promise but is largely unexplored. Explainable artificial intelligence (XAI) is seeing increased use and helps the transition of ML models from black-box forecasters to knowledge-enhancing predictors. Full article

The rise in online communication platforms has significantly increased exposure to harmful discourse, presenting ongoing challenges for digital moderation and user well-being. This paper introduces the EsCorpiusBias corpus, designed to enhance the automated detection of sexism and racism within Spanish-language online dialogue, specifically sourced from the Mediavida forum. By means of a systematic, context-sensitive annotation protocol, approximately 1000 three-turn dialogue units per bias category are annotated, ensuring the nuanced recognition of pragmatic and conversational subtleties. Here, annotation guidelines are meticulously developed, covering explicit and implicit manifestations of sexism and racism. Annotations are performed using the Prodigy tool (v1. 16.0) resulting in moderate to substantial inter-annotator agreement (Cohen’s Kappa: 0.55 for sexism and 0.79 for racism). Models including logistic regression, SpaCy’s baseline n-gram bag-of-words model, and transformer-based BETO are trained and evaluated, demonstrating that contextualized transformer-based approaches significantly outperform baseline and general-purpose models. Notably, the single-turn BETO model achieves an ROC-AUC of 0.94 for racism detection, while the contextual BETO model reaches an ROC-AUC of 0.87 for sexism detection, highlighting BETO’s superior effectiveness in capturing nuanced bias in online dialogues. Additionally, lexical overlap analyses indicate a strong reliance on explicit lexical indicators, highlighting limitations in handling implicit biases. This research underscores the importance of contextually grounded, domain-specific fine-tuning for effective automated detection of toxicity, providing robust resources and methodologies to foster socially responsible NLP systems within Spanish-speaking online communities. Full article

Cold environments challenge the structural and functional integrity of membrane proteins, requiring specialized adaptations to maintain activity under low thermal energy. Here, we investigate the molecular basis of cold tolerance in the peptide transporter PepT1 from the Antarctic icefish (Chionodraco hamatus, ChPepT1) using molecular dynamics simulations, binding free energy calculations (MM/GBSA), and dynamic network analysis. We compare ChPepT1 to its human ortholog (hPepT1), a non-cold-adapted variant, to reveal key features enabling psychrophilic function. Our simulations show that ChPepT1 displays enhanced global flexibility, particularly in domains adjacent to the substrate-binding site and the C-terminal domain (CTD). While hPepT1 loses substrate binding affinity as temperature increases, ChPepT1 maintains stable peptide interactions across a broad thermal range. This thermodynamic buffering results from temperature-sensitive rearrangement of hydrogen bond networks and more dynamic lipid interactions. Importantly, we identify a temperature-responsive segment (TRS, residues 660–670) within the proximal CTD that undergoes an α-helix to coil transition, modulating long-range coupling with transmembrane helices. Dynamic cross-correlation analyses further suggest that ChPepT1, unlike hPepT1, reorganizes its interdomain communication in response to temperature shifts. Our findings suggest that cold tolerance in ChPepT1 arises from a combination of structural flexibility, resilient substrate binding, and temperature-sensitive interdomain dynamics. These results provide new mechanistic insight into thermal adaptation in membrane transporters and offer a framework for engineering proteins with enhanced functionality in extreme environments. Full article

Background: Psychological problems post-stroke can negatively impact stroke survivors. Although general psychological services exist (e.g., NHS Talking Therapies), access remains limited, particularly for individuals with post-stroke communication and cognitive impairments. Stroke service staff report low confidence in managing psychological distress. This study is the first to explore the barriers and facilitators to implementing a novel intervention package comprising a cross-service care pathway and staff training to enhance post-stroke psychological provision. Methods: Staff from stroke and mental health services in four UK regions, recruited through purposive sampling to ensure diversity of services and professional roles, participated in semi-structured interviews or focus groups, guided by the Theoretical Domains Framework (TDF), before and after implementation of the intervention package. Pre-implementation interviews/groups identified anticipated barriers and facilitators to implementation and training needs, informing the development of site-specific intervention packages; post-implementation interviews/groups explored experienced barriers, facilitators and perceptions of the intervention. Interviews underwent thematic analysis using the TDF. Results: Fifty-five staff participated pre-implementation and seventeen post-implementation, representing stroke (e.g., nurse, physiotherapist, consultant) and psychology (e.g., counsellor, psychological therapist) roles across acute, rehabilitation, community, and voluntary services. Challenges anticipated pre-implementation included: limited specialist post-stroke psychological support; low staff confidence; and fragmented service pathways. Post-implementation findings indicated increased staff knowledge and confidence, enhanced screening and referral processes, and stronger inter-service collaboration. Implementation success varied across sites (with some sites showing greater ownership and sustainability of the intervention) and across staff roles (with therapy staff more likely than nursing staff to have received training). Conclusions: Effective implementation of an intervention package to increase psychological provision post-stroke requires staff engagement at all levels across all services. Staff investment influenced ownership of the intervention package, beliefs about priorities and overall enhancement of service capability. Full article

In the context of the new developmental philosophy, this study aimed to address the bottleneck of regional sustainable development; it constructs a three-system evaluation indicator system for Industrial Structure Optimization (ISO), Ecological Environment Management (EEM), and Socio-economic Development (SED), based on panel data from 20 cities in the Western Taiwan Straits Economic Zone between 2011 and 2023. To reveal how the synergistic development of the three subsystems in different domains can achieve sustainable development through their interactions and to analyze the dynamic patterns of the three subsystems, this study employed the panel vector autoregression (PVAR) model to examine the interactions between subsystems. Additionally, drawing on the framework of evolutionary economics, the study quantified the temporal evolution and spatial characteristics of the coupling coordination level among the three subsystems based on the results of the degree of coupling coordination model. The results indicate the following: (1) ISO shows a significant upward trend, EEM slightly declines, and SED experiences minor fluctuations before accelerating. (2) ISO, EEM, and SED exhibited self-reinforcing effects. (3) The degree of coupling, coordination, and coupling coordination all exhibit a trend of “fluctuating and increasing initially, followed by steady growth”. The spatial patterns of the degree of coupling, coordination, and coupling coordination have shifted from “decentralized” to “centralized”, with clear signs of synergistic development. (4) The difference in the degree of coupling coordination along the north–south direction remained the primary factor contributing to inter-regional disparities. Regions with the higher degrees of coupling coordination were concentrated in the southeastern coastal areas, while those with the lower degrees of coupling coordination appeared in the northeastern mountainous areas and southwestern coastal areas. (5) The spatial connection in the strength of the degree of coupling coordination has gradually increased, with notable intra-provincial connections and weakened inter-city connections across the province. The study’s results provided decision-making references for the construction of a sustainable development community. Full article

Lyn is a multifunctional Src-family kinase (SFK) that regulates immune signaling and has been implicated in diverse types of cancer. Unlike other SFKs, its full-length structure and regulatory dynamics remain poorly characterized. In this study, we present the first long-timescale molecular dynamics analysis of full-length Lyn, including the SH3, SH2, and SH1 domains, across wildtype, ligand-bound, and cancer-associated mutant states. Using principal component analysis, dynamic cross-correlation matrices, and network-based methods, we show that ATP binding stabilizes the kinase core and promotes interdomain coordination, while the ATP-competitive inhibitor dasatinib and specific mutations (e.g., E290K, I364N) induce conformational decoupling and weaken long-range communication. We identify integration modules and develop an interface-weighted scoring scheme to rank dynamically central residues. This analysis reveals 44 allosteric hubs spanning SH3, SH2, SH1, and interdomain regions. Finally, a random forest classifier trained on 16 MD-derived features highlights key interdomain descriptors, distinguishing functional states with an AUC of 0.98. Our results offer a dynamic and network-level framework for understanding Lyn regulation and identify potential regulatory hotspots for structure-based drug design. More broadly, our approach demonstrates the value of integrating full-length MD simulations with network and machine learning techniques to probe allosteric control in multidomain kinases. Full article

Background and Objectives: Artificial intelligence (AI) chatbots are increasingly employed for the dissemination of health information; however, apprehensions regarding their accuracy and reliability remain. The intricacy of sarcoidosis may lead to misinformation and omissions that affect patient comprehension. This study assessed the usability of AI-generated information on sarcoidosis by evaluating the quality, reliability, readability, understandability, and actionability of chatbot responses to patient-centered queries. Methods: This cross-sectional evaluation included 11 AI chatbots comprising both general-purpose and retrieval-augmented tools. Four sarcoidosis-related queries derived from Google Trends were submitted to each chatbot under standardized conditions. Responses were independently evaluated by four blinded pulmonology experts using DISCERN, the Patient Education Materials Assessment Tool—Printable (PEMAT-P), and Flesch–Kincaid readability metrics. A Web Resource Rating (WRR) score was also calculated. Inter-rater reliability was assessed using intraclass correlation coefficients (ICCs). Results: Retrieval-augmented models such as ChatGPT-4o Deep Research, Perplexity Research, and Grok3 Deep Search outperformed general-purpose chatbots across the DISCERN, PEMAT-P, and WRR metrics. However, these high-performing models also produced text at significantly higher reading levels (Flesch–Kincaid Grade Level > 16), reducing accessibility. Actionability scores were consistently lower than understandability scores across all models. The ICCs exceeded 0.80 for all evaluation domains, indicating excellent inter-rater reliability. Conclusions: Although some AI chatbots can generate accurate and well-structured responses to sarcoidosis-related questions, their limited readability and low actionability present barriers for effective patient education. Optimization strategies, such as prompt refinement, health literacy adaptation, and domain-specific model development, are required to improve the utility of AI chatbots in complex disease communication. Full article

Over the past few years, wireless communication has grown dramatically, and the consumer demand for wireless services has seen a significant jump. One of the main challenges for beyond fifth generation (B5G) networks is the increased capacity of the network. The continuously increasing number of network users and the limited radio spectrum in wireless technologies have led to severe congestion in communication channels. This issue leads to traffic congestion at base stations and introduces interference in the network, thereby degrading system capability and quality of service. Interference reduction has thus become a major design challenge in wireless communication systems. This review paper comprehensively explores interference management (IM) strategies in B5G networks. We critically analyze and summarize existing research on interference issues related to device-to-device communication, heterogeneous networks, inter-cell interference, and artificial intelligence (AI)-based frameworks. The paper reviews a wide range of methodologies, highlights the strengths and limitations of state-of-the-art approaches, and discusses standardized techniques such as power control, resource allocation, spectrum separation and mode selection, carrier aggregation, load balancing and cell range expansion, enhanced inter-cell interference coordination, coordinated scheduling and beamforming, coordinated multipoint, and AI-based interference prediction methods. A structured taxonomy and comparative summary are introduced to help categorize these techniques. Several related works based on their methodologies, shortcomings, and future directions have been critically reviewed. In addition, the paper identifies open research challenges and outlines key trends that are shaping future B5G IM systems. A comparative visualization is also provided to highlight dominant and underexplored optimization objectives across IM domains. This review serves as a valuable reference for researchers aiming to understand and evaluate current and emerging solutions for interference mitigation in B5G wireless systems. Full article

Multi-hop inter-domain wireless networks play a vital role in future heterogeneous communication systems by improving data transmission efficiency and security assurance. Despite the advances in secure routing techniques in areas such as node authentication and encryption, they still suffer from the shortcomings of frequent key updates, high computational overhead, and poor adaptability to large-scale dynamic topologies. To address these limitations, we propose a new routing method—the Secure Cross-Layer Route—designed for multi-hop inter-domain wireless networks to achieve unified optimization of security, delay, and throughput. First, we construct a multi-objective optimization model that integrates authentication delay, link load, and resource states, enabling balanced trade-offs between security and transmission performance in dynamic conditions. Second, we introduce a cross-layer information fusion mechanism that allows nodes to adapt routing costs in real time under heterogeneous network conditions, thereby improving path reliability and load balancing. Furthermore, a risk-aware dynamic key update strategy is developed to handle behavioral uncertainty among nodes, reducing authentication overhead and enhancing attack resilience. Experimental evaluations conducted on four datasets with varying network scales demonstrate the superior performance of the proposed method. Experimental results demonstrated that the proposed method achieves at least 28% improvement in effective throughput, reduces average authentication delay by approximately 30%, and increases the secure link ratio by at least 10%, outperforming mainstream routing algorithms under multi-constraint conditions. Full article