Search Results (17)

Magnetic iron oxide (II,III) nanoparticles (MNPs) are highly interested in biomedicine. However, their application is limited by oxidation, aggregation, rapid clearance from the body, and poor biodistribution. Coating by human serum albumin (HSA), the predominant blood plasma protein, can significantly influence properties, prolong circulation half-life, and enhance tumor capture efficiency. Here, we report the synthesis of oleic acid and Tween20-coated MNPs and their interaction with HSA. The influence of albumin coating on MNP size, zeta potential, aggregation ability, and toxicity was studied. The particles were characterized by dynamic light scattering, transmission electron microscopy, and Fourier transform infrared spectroscopy methods. The nanoparticles’ relaxivities (r₁ and r₂) were assessed under a magnetic field of 1.88 T to evaluate their performance in MRI applications. The anticancer drug doxorubicin (DOX) loading capacity of up to 725 µg/mg for albumin-coated MNPs was determined. DOX-loaded MNPs displayed pH-sensitive drug release during acidic conditions. The series of DOX-loaded nanocomposites indicated inhibition of A549 cell lines, and the IC₅₀ values were evaluated. This research underscores the utility of HSA-coated MNPs in enhancing the efficacy and stability of drug delivery systems in biomedicine. Full article

High-voltage transmission lines face significant challenges due to environmental exposure, including corona discharge, ice accretion, and corrosion, which impact their durability and operational efficiency. This study investigates the performance of hydrophilic and superhydrophilic organosilane coatings applied to high-voltage wires to address these issues. Using a combination of experimental setups simulating real-world conditions, we evaluated corona discharge losses, ice adhesion, and corrosion resistance on coated and uncoated wires. The results reveal that hydrophilic and superhydrophilic organosilane coatings offer a substantial reduction in corona discharge power losses, with a 25–60% decrease compared to bare wires. Additionally, the proposed hydrophilic coating exhibits ice adhesion characteristics similar to bare wires, in contrast to the higher ice adhesion observed for superhydrophilic samples. Corrosion tests further highlight the performance of the hydrophilic coating, which reduces corrosion currents by approximately threefold compared to bare wires, demonstrating enhanced protection and long-term stability. While superhydrophilic coatings offer some advantages in corona discharge reduction, their increased ice adhesion and higher corrosion rates limit their applicability. The hydrophilic organosilane coating thus emerges as the optimal tradeoff, balancing effective corona discharge mitigation, moderating ice adhesion, and enhancing corrosion resistance, making it a promising solution for improving the performance and longevity of high-voltage transmission lines. Full article

Severe ice accretion on transmission lines can disrupt electrical grids and compromise the stability of power systems. Consequently, precise prediction of ice coating on transmission lines is vital for guiding their operation and maintenance. Traditional single-model icing prediction methods often exhibit limited accuracy under varying environmental conditions and fail to yield highly accurate predictions. We propose a multi-scenario, two-stage adaptive ensemble strategy (MTAES) for ice coating prediction to address this issue. A combined clustering approach is employed to refine the division of ice weather scenarios, segmenting historical samples into multiple scenarios. Within each scenario, the bagging approach generates multiple training subsets, with the extreme learning machine (ELM) used to build diverse models. Subsequently, a two-stage adaptive weight allocation mechanism is introduced. This mechanism calculates the distance from the scenario cluster centers and the prediction error of similar samples in the validation set for each test sample. Weights are dynamically allocated based on these data, leading to the final output results through an adaptive ensemble from the base model repository. The experimental results show that the model is significantly better than traditional models in predicting ice thickness. Key indicators of RMSE, MAE, and ${\mathrm{R}}^2$ reach 0.675, 0.522, and 83.2%, respectively, verifying the effectiveness of multi-scene partitioning and adaptive weighting methods in improving the accuracy of ice cover prediction. Full article

The icing on power transmission lines, as a major hazard affecting the safety of electricity usage in China during winter, poses a significant challenge in systematically evaluating the weather conditions and their distribution characteristics during the icing period. Understanding the interaction between the microterrain and micrometeorology and achieving a refined analysis of the physical mechanisms during the icing process remain difficult tasks in this field. These are crucial aspects for the development of more accurate icing prediction models across southern China. Therefore, this study provides a comprehensive review and summary of the current research state and progress in the study of power transmission line icing in southern China from three perspectives: (1) large-scale circulation characteristics; (2) microphysical process, terrain–atmosphere interaction, microtopography and local micrometeorological conditions for the occurrence of icing events; and (3) numerical icing event modeling and forecasting. This study also looks ahead to the scientific issues and technological bottlenecks that need to be overcome for the prediction of ice coating on power transmission lines in southern China. The goal is to provide guidance for the causal analysis and forecasting warnings of power transmission line icing in the complex microterrain of the southern region. Full article

Ice accretion on transmission lines can cause operational difficulties and disastrous events. In this study, a micro/nano-structured epoxy resin/polydimethylsiloxane (EP/PDMS) film on glass, with water droplet contact angles (CA) observed as high as 160° and the water droplet sliding angle (SA) < 1° was fabricated by aerosol-assisted chemical vapor deposition (AACVD). The glaze icing performance of the superhydrophobic EP/PDMS films have been investigated by comparing the bare glass and room temperature vulcanized (RTV) silicon rubber-coated glass substrate representing the glass insulators and silicone rubber insulators, respectively. Compared with the bare glass and the RTV silicon rubber coating, the EP/PDMS superhydrophobic coating showed excellent performance in delaying glaze icing, especially in the early stages of icing. After 20 min of glaze icing with tilting angle of 90° at −5 and −10 °C, 38.9% and 85.7% of the RTV silicon rubber coating were covered, respectively, and less than 3% of the EP/PDMS coating was covered by ice when the blank glass sheet was completely covered. The EP/PDMS films also showed good mechanical robustness and long-term stability, which are important considerations in their widespread real-world adoption. Full article

Piperine (PIP), a compound found in Piper longum, has shown promise as a potential chemotherapeutic agent for breast cancer. However, its inherent toxicity has limited its application. To overcome this challenge, researchers have developed PIP@MIL-100(Fe), an organic metal–organic framework (MOF) that encapsulates PIP for breast cancer treatment. Nanotechnology offers further treatment options, including the modification of nanostructures with macrophage membranes (MM) to enhance the evasion of the immune system. In this study, the researchers aimed to evaluate the potential of MM-coated MOFs encapsulated with PIP for breast cancer treatment. They successfully synthesized MM@PIP@MIL-100(Fe) through impregnation synthesis. The presence of MM coating on the MOF surface was confirmed through SDS-PAGE analysis, which revealed distinct protein bands. Transmission electron microscopy (TEM) images demonstrated the existence of a PIP@MIL-100(Fe) core with a diameter of around 50 nm, surrounded by an outer lipid bilayer layer measuring approximately 10 nm in thickness. Furthermore, the researchers evaluated the cytotoxicity indices of the nanoparticles against various breast cancer cell lines, including MCF-7, BT-549, SKBR-3, and MDA. The results demonstrated that the MOFs exhibited between 4 and 17 times higher cytotoxicity (IC₅₀) in all four cell lines compared to free PIP (IC₅₀ = 193.67 ± 0.30 µM). These findings suggest that MM@PIP@MIL-100(Fe) holds potential as an effective treatment for breast cancer. The study’s outcomes highlight the potential of utilizing MM-coated MOFs encapsulated with PIP as an innovative approach for breast cancer therapy, offering improved cytotoxicity compared to free PIP alone. Further research and development are warranted to explore the clinical translation and optimize the efficacy and safety of this treatment strategy. Full article

Nanoplatforms used for the loading of anticancer drugs constitute a promising approach to cancer treatment and reducing the side effects of these drugs. Among the cutting-edge systems used in this area are magnetic nanocomposites (MNCs) and nanocapsules (NCs). MNCs are considered to constitute a smart tool for magnetic-field-guided targeted drug delivery, magnetic resonance imaging, and hyperthermia therapy. Nanocapsules offer great potential due to their ability to control drug-loading capacity, their release efficiency, their stability, and the ease with which their surfaces can be modified. This study proposes a method for the development of nylon-6-coated MNCs and nylon-6 polymeric membrane NCs. A biocompatible nylon-6 polymer was first used for NC synthesis. Oleic-acid-modified and non-modified Fe₃O₄ nanoparticles were synthesized for the production of nylon-coated MNCs. Dynamic light scattering (DLS), transmission electron microscopy (TEM), and ζ-potential measurements were used to perform size, morphology, and charge analyses. The above-mentioned two types of MNCs were considered templates for the manufacture of nylon nanocapsules, leading to NCs with different charges and structures. The developed oleic-acid-coated nylon-6 MNCs and NCs showed excellent loading values of the chemotherapy drug doxorubicin (DOX) of up to 732 and 943 µg/mg (DOX/MNC or NC), respectively. On the contrary, the capacity of the nano-construction that was not modified with oleic acid did not exceed 140 µg/mg. The DOX-loaded nanosystems displayed pH-sensitive drug release properties, for which the highest efficiency was observed at an acidic pH. The series of DOX-loaded MNCs and NCs inhibited A549 and HEK 293FT cell lines, with the lowest IC50 value of 0.31 µM observed for the nanocapsules, which is a 1.5-fold lower concentration than the free DOX. Therefore, the presented nanoscale systems offer great potential for cancer treatment. Full article

A magnetic nanocomposite (MNC) is an integrated nanoplatform that combines a set of functions of two types of materials. A successful combination can give rise to a completely new material with unique physical, chemical, and biological properties. The magnetic core of MNC provides the possibility of magnetic resonance or magnetic particle imaging, magnetic field-influenced targeted delivery, hyperthermia, and other outstanding applications. Recently, MNC gained attention for external magnetic field-guided specific delivery to cancer tissue. Further, drug loading enhancement, construction stability, and biocompatibility improvement may lead to high progress in the area. Herein, the novel method for nanoscale Fe₃O₄@CaCO₃ composites synthesis was proposed. For the procedure, oleic acid-modified Fe₃O₄ nanoparticles were coated with porous CaCO₃ using an ion coprecipitation technique. PEG-2000, Tween 20, and DMEM cell media was successfully used as a stabilization agent and template for Fe₃O₄@CaCO₃ synthesis. Transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy, and dynamic light scattering (DLS) data were used for the Fe₃O₄@CaCO₃ MNC’s characterization. To improve the nanocomposite properties, the concentration of the magnetic core was varied, yielding optimal size, polydispersity, and aggregation ability. The resulting Fe₃O₄@CaCO₃ had a size of 135 nm with narrow size distributions, which is suitable for biomedical applications. The stability experiment in various pH, cell media, and fetal bovine serum was also evaluated. The material showed low cytotoxicity and high biocompatibility. An excellent anticancer drug doxorubicin (DOX) loading of up to 1900 µg/mg (DOX/MNC) was demonstrated. The Fe₃O₄@CaCO₃/DOX displayed high stability at neutral pH and efficient acid-responsive drug release. The series of DOX-loaded Fe₃O₄@CaCO₃ MNCs indicated effective inhibition of Hela and MCF-7 cell lines, and the IC 50 values were calculated. Moreover, 1.5 μg of the DOX-loaded Fe₃O₄@CaCO₃ nanocomposite is sufficient to inhibit 50% of Hela cells, which shows a high prospect for cancer treatment. The stability experiments for DOX-loaded Fe₃O₄@CaCO₃ in human serum albumin solution indicated the drug release due to the formation of a protein corona. The presented experiment showed the “pitfalls” of DOX-loaded nanocomposites and provided step-by-step guidance on efficient, smart, anticancer nanoconstruction fabrication. Thus, the Fe₃O₄@CaCO₃ nanoplatform exhibits good performance in the cancer treatment area. Full article

Silica nanoparticles (SiNPs) are a promising material for nanomedicine technology. SiNPs are considered a powerful tool for drug delivery, functional coatings and films, and biomolecule separation due to their stability, biocompatibility, and accessible surface modification. Herein, the synthesis of SiNPs and SiNPs nylon 6 (SiNPs-Nylon) coated nanocomposites was proposed. Transmission electron microscopy (TEM) and dynamic light scattering (DLS) were used for morphology, size, and stability analysis. Anticancer drug doxorubicin (DOX) loading to the nanocomposites and pH-dependent release experiments are presented. DOX-loaded nanocomposites with high drug capacities of up to 258 μg/mg (DOX/SiNPs) and 493 μg/mg (DOX/SiNPs-Nylon) show effective inhibition of A549 and HEK 293FT cell lines. The IC50 values were 0.08 ± 0.01 µM in terms of DOX amount and recalculated as 0.31 ± 0.04 µg/mL in terms of the concentration of SiNPs for the HEK 293FT cells. Therefore, silica nanocomposites have a high potential for cancer treatment. Full article

The icing on overhead transmission lines is one of the largest threats to the safe operation of electric power systems. Compared with other security accidents in the electric industry, a sudden ice disaster could cause the most serious losses to electric power grids. Among the numerous de-icing and anti-icing techniques for application, direct current ice-melting and mechanical de-icing schemes require power cuts and other restrictive conditions. Superhydrophobic coating technology has been widely focused for good anti-icing properties, low cost and wide application range. However, the special structure of curved transmission lines, complicated service environments, and variated electric performance could significantly limit the application of superhydrophobic anti-icing coatings on overhead transmission lines. In particular, superhydrophobic surfaces can be achieved by combining the rough micro-nano structure and modification agents with low surface energy. Compared with superhydrophobic coatings, superhydrophobic surfaces will not increase the weight of the substrate and have good durability and stability in maintaining the robust structure to repeatedly resist aging, abrasion, corrosion and corona damages, etc. Therefore, this review summarizes the theoretical basis of anti-icing behavior and mechanisms, influencing factors of anti-icing properties, potential techniques of superhydrophobic surfaces on transmission lines, and, finally, presents future development challenges and prospects of superhydrophobic surfaces in the anti-icing protection of overhead transmission lines. Full article

This paper reviews the application of various advanced anti-icing and de-icing technologies in transmission lines. Introduces the influence of snowing and icing disasters on transmission lines, including a mechanical overload of steel towers, uneven icing or de-icing at different times, Ice-covered conductors galloping and icing flashover of insulators, as well as the icing disasters of transmission lines around the world in recent years. The formation of various icing categories on transmission lines, as well as the effect of meteorological factors, topography, altitude, line direction, suspension height, shape, and electric field on ice-covered transmission lines, are all discussed in this study. The application of various advanced anti/de-icing technologies and their advantages and disadvantages in power transmission lines are summarized. The anti/de-icing of traditional mechanical force, AC/DC short-circuit ice melting, and corona effect is introduced. Torque pendulum and diameter-expanded conductor (DEC) have remarkable anti-icing effects, and the early investment resources are less, the cost is low, and the later maintenance is not needed. In view of some deficiencies of AC and DC ice melting, the current transfer intelligent ice melting device (CTIIMD) can solve the problem well. The gadget has a good effect and high reliability for de-icing conductors in addition to being compact and inexpensive. The application of hydrophobic materials and heating coatings on insulators has a certain anti-icing effect, but the service life needs further research. Optimizing the shed’s construction and arranging several string kinds on the insulators is advisable to prevent icing and the anti-icing flashover effect. In building an insulator, only a different shed layout uses non-consumption energy. Full article

In order to study the galloping mechanism of ice-covered four-split transmission lines in oblique flows, the aerodynamic forces and aero-elastic response characteristics of the crescent-shaped four-split ice-covered transmission lines are investigated through wind tunnel tests on rigid and aero-elastic models. According to Den Hartog and Nigel’s galloping theories, the damping coefficients are calculated based on the experimental data. The results show that the crescent-shaped ice-covered four-split transmission lines usually suffer from torsional galloping. Furthermore, based on the aero-elastic wind tunnel data, the galloping is characterized by an elliptical trajectory, negative damping ratio, and a negative strain at hanging position. In addition, the galloping appears to be more prone to occur under oblique flows, with a larger galloping amplitude and a lower critical wind speed. This might be because an out-of-plane vibration of the third-order mode is excited at a lower wind speed, leading to a coupled resonance between in-plane and out-of-plane vibrations at the third-order mode with a frequency ratio of 1:1. The experimental results in this paper can also be used to verify the fluid-structure interaction simulation method of ice-covered transmission lines. Full article

Magnetic nanoparticles (MNPs) have great potential in the drug delivery area. Iron oxide (Fe₃O₄) MNPs have demonstrated a promising effect due to their ferrimagnetic properties, large surface area, stability, low cost, easy synthesis, and functionalization. Some coating procedures are required to improve stability, biocompatibility, and decrease toxicity for medical applications. Herein, the co-precipitation synthesis of iron oxide MNPs coated with four types of primary surfactants, polyethylene glycol 2000 (PEG 2000), oleic acid (OA), Tween 20 (Tw20), and Tween 80 (Tw80), were investigated. Dynamic light scattering (DLS), ζ-potential, and transmission electron microscopy (TEM) techniques were used for morphology, size, charge, and stability analysis. Methylene blue reactive oxygen species (ROS) detection assay and the toxicity experiment on the lung adenocarcinoma A549 cell line were conducted. Two loading conditions for anticancer drug doxorubicin (DOX) on MNPs were proposed. The first one provides high loading efficiency (~90%) with up to 870 μg/mg (DOX/MNPs) drug capacity. The second is perspective for extremely high capacity 1757 μg/mg with drug wasting (DOX loading efficiency ~24%). For the most perspective MNP_OA and MNP_OA_DOX in cell media, pH 7.4, 5, and 3, the stability experiments are also presented. MNP_OA_DOX shows DOX pH-dependent release in the acidic pH and effective inhibition of A549 cancer cell growth. The IC50 values were calculated as 1.13 ± 0.02 mM in terms of doxorubicin and 0.4 ± 0.03 µg/mL in terms of the amount of the nanoparticles. Considering this, the MNP_OA_DOX nano theranostics agent is a highly potential candidate for cancer treatment. Full article

According to the engineering phenomenon of the galloping of ice-coated transmission lines at certain wind speeds, this paper proposes a novel type of energy harvester based on the galloping of a flexible structure. It uses the tension generated by the galloping structure to cause periodic strain on the piezoelectric cantilever beam, which is highly efficient for converting wind energy into electricity. On this basis, a physical model of fluid–structure interaction is established, and the Reynolds-averaged Navier–Stokes equation and SST K -ω turbulent model based on ANSYS Fluent are used to carry out a two-dimensional steady computational fluid dynamics (CFD) numerical simulation. First, the CFD technology under different grid densities and time steps is verified. CFD numerical simulation technology is used to simulate the physical model of the energy harvester, and the effect of wind speed on the lateral displacement and aerodynamic force of the flexible structure is analyzed. In addition, this paper also carries out a parameterized study on the influence of the harvester’s behavior, through the wind tunnel test, focusing on the voltage and electric power output efficiency. The harvester has a maximum output power of 119.7 μW/mm³ at the optimal resistance value of 200 KΩ at a wind speed of 10 m/s. The research results provide certain guidance for the design of a high-efficiency harvester with a square aerodynamic shape and a flexible bluff body. Full article

The aim of the work is to improve the release properties of curcumin onto human breast cancer cell lines using coated halloysite nanotubes (HNTs) with chitosan as a polycation. A loading efficiency of 70.2% (w/w) was attained for loading 4.9 mg of the drug into 0.204 g bed volume of HNTs using the vacuum suction method. Results acquired from Brunauer-Emmett-Teller (BET), Fourier-transform infrared (FTIR) spectroscopy, transmission electron microscopy (TEM), scanning electron spectroscopy (SEM), zeta potential, and thermogravimetric analysis (TGA) indicated the presence of the drug and the biopolymer in and around the nanotubes. The release properties of drug-loaded HNTs (DLHNTs) and chitosan-coated drug-loaded HNTs (DLHNTs-CH) were evaluated. The release percentages of DLHNTs and DLHNTs-CH after 6 h were 50.7 and 37%, respectively. Based on the correlation coefficients obtained by fitting the release nature of curcumin from the two samples, the Korsmeyer-Peppas model was found to be the best-fitted model. In vitro cell viability studies were carried out on the human breast cancer cell line MCF-7, using the MTT and trypan blue exclusion assays. Prior to the Trypan blue assay, the IC₅₀ of curcumin was determined to be $~$30 µM. After 24 h of incubation, the recorded cell viability values were 94, 68, 57, and 51% for HNTs, DLHNTs-CH, DLHNTs, and curcumin, respectively. In comparison to the release studies, it could be deducted that sustained lethal doses of curcumin were released from the DLHNTs-CH within the same time. It is concluded from this work that the “burst release” of naked drugs could be slowly administered using chitosan-coated HNTs as potential drug carriers. Full article