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Keywords = high-dimensional data

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17 pages, 10069 KB  
Article
Geoelectric Response Characteristics of Leakage in Earth-Rock Dams Considering Reservoir Water Level Fluctuations: Numerical Simulation and In Situ Validation
by Xiaoyi Jiang, Shuhai Jiang, Binyang Sun, Lei Tan, Qimeng Li and Hu Xu
Processes 2026, 14(8), 1198; https://doi.org/10.3390/pr14081198 - 9 Apr 2026
Abstract
Reservoir water level fluctuations alter the saturation line in earth-rock dams, thereby affecting the accuracy of electrical leakage detection. To quantitatively investigate this influence, a three-dimensional (3D) geoelectric model of a concentrated leakage pathway was constructed using COMSOL Multiphysics based on parameters from [...] Read more.
Reservoir water level fluctuations alter the saturation line in earth-rock dams, thereby affecting the accuracy of electrical leakage detection. To quantitatively investigate this influence, a three-dimensional (3D) geoelectric model of a concentrated leakage pathway was constructed using COMSOL Multiphysics based on parameters from a reservoir in Zhejiang Province. Numerical simulations were performed under unsaturated, partially saturated, and fully saturated conditions with respect to the leakage zone, and a fixed-electrode monitoring system was deployed for in situ validation. The results show that 3D resistivity slices can approximately delineate the leakage hazard center. Under fully saturated conditions, the low-resistivity anomaly center shifts upward by 0.7 m. Under unsaturated conditions, the high-resistivity anomaly center shifts upward by 1.7 m. Under partially saturated conditions, the high-resistivity anomaly center exhibits the most pronounced upward shift (3.0 m). Notably, under partially saturated conditions, the boundary point between the high- and low-resistivity anomalies is located close to the central depth of the leakage pathway (deviation of approximately 0.7 m above the center), serving as a useful diagnostic indicator. In situ tests corroborate these findings, with identified anomaly zones matching the actual leakage points. This study provides a quantitative framework for interpreting geoelectrical data in earth-rock dams under fluctuating reservoir levels. Full article
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25 pages, 8514 KB  
Article
Fatigue Life Evaluation and Structural Optimization of Rubber Damping Components in Metro Resilient Wheels
by Qiang Zhang, Zhiming Liu, Yiliang Shu, Guangxue Yang and Wenhan Deng
Polymers 2026, 18(8), 915; https://doi.org/10.3390/polym18080915 - 9 Apr 2026
Abstract
Resilient wheels are widely employed in metro vehicles to mitigate vibration and noise, in which rubber damping components play a critical role in load transmission and fatigue resistance. However, stress concentration and cyclic loading can significantly compromise their durability and service life. In [...] Read more.
Resilient wheels are widely employed in metro vehicles to mitigate vibration and noise, in which rubber damping components play a critical role in load transmission and fatigue resistance. However, stress concentration and cyclic loading can significantly compromise their durability and service life. In this study, the structural optimization and fatigue life of rubber damping components in resilient wheels are systematically investigated based on finite element analysis and in-service metro operational data. A three-dimensional finite element model incorporating hyperelastic material behavior is developed to evaluate stress distributions under three representative conditions: press-fit assembly, straight-line operation, and curved-track operation. Based on the resulting stress fields, critical high-stress regions within the rubber component are identified and selected as targets for structural optimization. The Design of Experiments (DOE) methodology, integrated with the Isight 2022 optimization platform, is employed to determine the optimal geometric parameters that minimize the von Mises equivalent stress. Furthermore, a fatigue life prediction framework is established using actual metro service mileage data. Fatigue performance is assessed using Fe-safe 2022 software in conjunction with rubber fatigue crack propagation theory, and the results before and after optimization are systematically compared. This study demonstrates that stress concentrations in resilient wheel rubber damping components predominantly occur at fillet transition regions, governed by load transfer characteristics under press-fitting and service conditions. Through DOE-based structural optimization, the critical geometric parameters are effectively refined, leading to a significant reduction in stress levels in key regions. As a result, the proposed approach markedly improves fatigue performance, extending the minimum fatigue life from 1300 days to 24,322 days, thereby substantially enhancing the durability and reliability of the resilient wheel system. Full article
(This article belongs to the Section Polymer Processing and Engineering)
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26 pages, 7879 KB  
Article
Analysis of Vertical-Axis Wind Turbine Clusters Using Condensed Two-Dimensional Velocity Data Obtained from Three-Dimensional Computational Fluid Dynamics
by Md. Shameem Moral, Hiroto Inai, Yutaka Hara, Yoshifumi Jodai and Hongzhong Zhu
Energies 2026, 19(8), 1835; https://doi.org/10.3390/en19081835 - 8 Apr 2026
Abstract
Vertical-axis wind turbine (VAWT) clusters have been extensively investigated owing to their positive aerodynamic interactions. However, accurate predictions of the flow field and power output of each rotor in VAWT clusters using high-fidelity computational fluid dynamics (CFD) remain computationally expensive. In this study, [...] Read more.
Vertical-axis wind turbine (VAWT) clusters have been extensively investigated owing to their positive aerodynamic interactions. However, accurate predictions of the flow field and power output of each rotor in VAWT clusters using high-fidelity computational fluid dynamics (CFD) remain computationally expensive. In this study, we propose a fast computation method for the flow field and operating state of each rotor of VAWT clusters using temporally and spatially averaged velocity data compressed from an unsteady velocity field obtained via a 3D-CFD simulation of an isolated rotor. First, the unsteady 3D flow field in the 3D-CFD simulation is time-averaged over several revolutions. Next, the temporally averaged velocity is spatially averaged in the vertical direction to obtain spatially compressed data. Based on a previously developed fast computation framework, a wind-farm flow field is constructed using condensed two-dimensional velocity data obtained from a single turbine. The proposed method is applied to three-rotor configurations, and the rotational speeds of the turbines are compared with the wind-tunnel measurements. The results show that the proposed method substantially improved the prediction accuracy while maintaining a low computational cost. In addition, it can be used to efficiently design and optimize turbine layouts in VAWT wind farms. Full article
(This article belongs to the Special Issue Progress and Challenges in Wind Farm Optimization)
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40 pages, 4527 KB  
Article
Automatic Scoring of Laboratory Reports Using Multi-Dimensional Feature Engineering and Ensemble Learning with Dynamic Threshold Control
by Chang Wang and Jingzhuo Shi
Appl. Sci. 2026, 16(8), 3649; https://doi.org/10.3390/app16083649 - 8 Apr 2026
Abstract
In the field of engineering, the advancement of automated scoring systems for laboratory reports has been significantly hampered by three persistent challenges: scarcity of high-quality annotated data, high domain-specific complexity, and insufficient model interpretability. To address these limitations, this study proposes an AdaBoost [...] Read more.
In the field of engineering, the advancement of automated scoring systems for laboratory reports has been significantly hampered by three persistent challenges: scarcity of high-quality annotated data, high domain-specific complexity, and insufficient model interpretability. To address these limitations, this study proposes an AdaBoost regression model based on multi-level feature engineering and threshold control, denoted as MFTC-ABR. This method constructs a multi-dimensional feature set using a lightweight neural network, which evaluates laboratory reports across four core dimensions: comprehension of experimental principles, completion of experimental procedures, depth of result analysis, and plagiarism detection. At the scoring algorithm level, a dynamic threshold adjustment mechanism is integrated into the AdaBoostReg ensemble learning framework. By redesigning the sample weight update rule, the prediction errors of samples are divided into three intervals: the acceptable region, the stable learning range, and the focus range. Accordingly, a differentiated weight update strategy is implemented, and a history-aware mechanism is introduced to further regulate the attention allocated to individual samples. Finally, experimental results on the power electronics laboratory report dataset show that MFTC-ABR model achieves a mean absolute error (MAE) of 3.09 and a scoring consistency rate of 82% within a five-point error tolerance. These findings validate the effectiveness and practicability of the proposed method for automatic assessment in specialized domains with limited data availability. Full article
(This article belongs to the Section Computing and Artificial Intelligence)
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20 pages, 456 KB  
Article
A Perceptual Gap Analysis of Service Quality Perceptions in Home-Based Long-Term Care Service Centers
by Jui-Ying Hung
Healthcare 2026, 14(8), 980; https://doi.org/10.3390/healthcare14080980 - 8 Apr 2026
Abstract
Background: As Taiwan transitions into a super-aging society, the government has launched “Long-term Care (LTC) 3.0,” a policy initiative that marks a strategic shift from service expansion to integrated quality verification, digital oversight, and social resilience. This transition demands a robust quality verification [...] Read more.
Background: As Taiwan transitions into a super-aging society, the government has launched “Long-term Care (LTC) 3.0,” a policy initiative that marks a strategic shift from service expansion to integrated quality verification, digital oversight, and social resilience. This transition demands a robust quality verification mechanism. Ensuring perceptual consistency between service providers and external evaluators is critical for systemic fairness and sustainable service quality. Objective: This study utilized a two-dimensional gap analysis to examine the discrepancy in service quality benchmarks between home-based LTC center managers and assessment committee members, identifying critical divergence zones for institutional improvement. Methods: A cross-sectional evaluative study was conducted, involving center managers (evaluatees, n = 50) and external experts (evaluators, n = 28). The data were collected via a structured instrument covering 20 consensus benchmarks. Results: Significant perceptual gaps were identified across all dimensions (p < 0.001), with “Professional Care Quality” exhibiting the largest effect size (Cohen’s d > 1.5). Benchmarks with low external scores but high internal ratings were categorized into the “Overestimation (Management Blind Spot)” quadrant, signaling a systemic overestimation bias in administrative and clinical risk management. Conclusions: This study provides empirical evidence for the refinement of LTC 3.0 assessment systems. The results offer a strategic roadmap for policymakers to enhance organizational resilience by transitioning from subjective self-perception to objective, data-driven quality management through the two-dimensional gap model. Full article
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27 pages, 1999 KB  
Article
Uncertainty-Driven Risk Evaluation for Safety-Critical Software Under Conflicting Evidence Judgments: A Dual-Dimensional Evidence Fusion Approach
by Wenguang Xie, Wuhan Yang and Kenian Wang
Symmetry 2026, 18(4), 625; https://doi.org/10.3390/sym18040625 - 8 Apr 2026
Abstract
Risk assessment of safety-critical software relies heavily on expert reviews prone to high epistemic uncertainty and conflicting judgments. While evidence theory is widely used for information fusion, classical rules often yield counter-intuitive results in high-conflict scenarios. To address this, we propose an uncertainty-driven [...] Read more.
Risk assessment of safety-critical software relies heavily on expert reviews prone to high epistemic uncertainty and conflicting judgments. While evidence theory is widely used for information fusion, classical rules often yield counter-intuitive results in high-conflict scenarios. To address this, we propose an uncertainty-driven risk evaluation model based on a dual-dimensional evidence fusion approach. The framework integrates an improved Belief Entropy (BE) and an Evidence Conflict Coefficient (ECC) to quantify reliability from two perspectives: (1) Internal Dimension, using BE to measure inherent uncertainty within individual judgments; and (2) External Dimension, using ECC to measure divergence among multiple sources. By adaptively modifying Basic Probability Assignments (BPAs) with these dual-dimensional weights, the model effectively harmonizes data prior to fusion. Validated through an avionics software airworthiness case study, the methodology significantly enhances fusion stability and accuracy. Results confirm it effectively suppresses extreme deviations and raises the performance floor, providing a robust decision-support tool for safety-critical engineering. Full article
(This article belongs to the Section Computer)
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41 pages, 84120 KB  
Article
DDS-over-TSN Framework for Time-Critical Applications in Industrial Metaverses
by Taemin Nam, Seongjin Yun and Won-Tae Kim
Appl. Sci. 2026, 16(8), 3641; https://doi.org/10.3390/app16083641 - 8 Apr 2026
Abstract
The industrial metaverse is a digital twin space that integrates the real world with virtual environments through bidirectional synchronization. It supports critical services, such as time-sensitive machine control and large-scale collaboration, which require Time-Sensitive Networking and scalable Data Distribution Services. DDS, developed by [...] Read more.
The industrial metaverse is a digital twin space that integrates the real world with virtual environments through bidirectional synchronization. It supports critical services, such as time-sensitive machine control and large-scale collaboration, which require Time-Sensitive Networking and scalable Data Distribution Services. DDS, developed by the Object Management Group, provides excellent scalability and diverse QoS policies but struggles to guarantee transmission delay and jitter for time-critical applications. TSN, based on IEEE 802.1 standards, addresses these challenges by ensuring time-criticality. However, current research lacks comprehensive integration mechanisms for DDS and TSN, particularly from the viewpoints of semantics and system framework. Additionally, there is no adaptive QoS mapping converting the abstract DDS QoS policies to the sophisticated TSN QoS parameters. This paper presents a novel DDS-over-TSN framework that incorporates three key functions to address these challenges. First, Cross-layer QoS Mapping automates correspondences between DDS and TSN parameters, deriving technical constraints from standard documentation through retrieval-augmented generation. Second, Semantic Priority Estimation extracts substantial priority levels by utilizing language model embedding vectors as high-dimensional feature extractors. Third, Adaptive Resource Allocation performs dynamic bandwidth distribution for each priority level through reinforcement learning. Simulation results reveal over 99% mapping accuracy and 97% consistency in priority extraction. The applied Deep Reinforcement Learning paradigm allocated 99% of required resources to high-priority classes and reduced resource wastage by 15% compared to conventional methods. This methodology meets industrial requirements by ensuring both deterministic real-time performance and efficient resource isolation. Full article
(This article belongs to the Special Issue Digital Twin and IoT, 2nd Edition)
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20 pages, 7761 KB  
Article
A Microchannel Liquid Cold Plate for Cooling Prismatic Lithium-Ion Batteries with High Discharging Rate: Full Numerical Model and Thermal Flows
by Chuang Liu, Deng-Wei Yang, Cheng-Peng Ma, Shang-Xian Zhao, Yu-Xuan Zhou and Fu-Yun Zhao
World Electr. Veh. J. 2026, 17(4), 196; https://doi.org/10.3390/wevj17040196 - 8 Apr 2026
Abstract
The thermal safety and longevity of lithium-ion batteries are critically constrained by excessive temperature rise and spatial thermal non-uniformity, particularly during high-rate discharges. Most existing numerical investigations rely on simplified heat generation models that fail to capture the spatiotemporal heterogeneity of electrochemical heat [...] Read more.
The thermal safety and longevity of lithium-ion batteries are critically constrained by excessive temperature rise and spatial thermal non-uniformity, particularly during high-rate discharges. Most existing numerical investigations rely on simplified heat generation models that fail to capture the spatiotemporal heterogeneity of electrochemical heat sources, leading to compromised predictive accuracy. To address this deficiency, this study develops a comprehensive three-dimensional electrochemical–thermal coupled framework, integrating the Newman pseudo-two-dimensional (P2D) electrochemical model with conjugate heat transfer and laminar flow dynamics. The predictive robustness of this framework is rigorously validated against experimental data across multiple discharge rates (3 C and 5 C). The validated model is then deployed to evaluate a water-cooled microchannel cold plate designed for prismatic LiMn2O4/graphite cells under a demanding 5 C discharge. A systematic parametric investigation is conducted to quantify the effects of ambient temperature (293–343 K), microchannel number (2–6), and coolant inlet velocity (0.1–0.6 m/s) on the maximum battery temperature (Tmax) and temperature difference (ΔT). Results demonstrate that the proposed system exhibits exceptional environmental robustness: over a 50 K ambient temperature span, Tmax increases by merely 2.0 K, remaining safely below the 323 K industry limit. Densifying the channel count from 2 to 6 further reduces Tmax by 1.55 K and narrows ΔT to 4.25 K, successfully satisfying the strict 5 K temperature uniformity standard. Furthermore, the thermal benefit of elevating inlet velocity exhibits a pronounced diminishing-return trend governed by the asymptotic reduction in bulk coolant temperature rise, dictating a critical trade-off against the quadratically escalating pumping power. Ultimately, these findings provide robust theoretical guidelines for the rational design of safe and energy-efficient battery thermal management systems. Full article
(This article belongs to the Section Storage Systems)
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19 pages, 3349 KB  
Article
Collaborative Support Optimization for Constrained Foundation Pit Excavation Adjacent to Urban Rail Transit: A Case Study of Shangdi Station on Beijing Subway, China
by Haitao Wang, Anqi Zhang, Haoyu Wang, Wenming Wang, Junhu Yue and Jinqing Jia
Appl. Sci. 2026, 16(8), 3631; https://doi.org/10.3390/app16083631 - 8 Apr 2026
Abstract
Excavation adjacent to operating urban rail transit faces formidable deformation control challenges. To address this, a parametric collaborative optimization framework integrating micro steel pipe pile isolation and temporary intermediate partition wall reinforcement is proposed. Taking a foundation pit project at Shangdi Station of [...] Read more.
Excavation adjacent to operating urban rail transit faces formidable deformation control challenges. To address this, a parametric collaborative optimization framework integrating micro steel pipe pile isolation and temporary intermediate partition wall reinforcement is proposed. Taking a foundation pit project at Shangdi Station of Beijing Metro Line 13 as a case study, a three-dimensional finite element model was established using the Hardening Soil constitutive model and calibrated with field monitoring data. Optimization analysis reveals that micro-pile spacing is the dominant factor controlling local rail settlement, while intermediate partition wall thickness primarily dictates global surface settlement. By balancing stringent safety limits with construction economy through a multi-objective evaluation, the preferred support configuration was calculated to be 273 mm diameter micro-piles at 500 mm spacing, combined with a 300 mm-thick partition wall. This collaborative configuration successfully truncates lateral soil displacement, reducing maximum rail settlement by over 55% and surface settlement by 53.6% compared to the baseline. Field monitoring results show high consistency with the numerical predictions (RMSE = 0.1438 mm), confirming the reliability of the proposed parametric collaborative optimization framework. Ultimately, this framework provides a validated, quantitative design methodology and a practical reference for support design in constrained excavations adjacent to existing sensitive infrastructure. Full article
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25 pages, 3968 KB  
Article
Explainable Data-Driven Approach for Smart Crop Yield Prediction in Sub-Saharan Africa: Performance and Interpretability Analysis
by Damilola D. Olatinwo, Herman C. Myburgh, Allan De Freitas and Adnan Abu-Mahfouz
Agriculture 2026, 16(8), 826; https://doi.org/10.3390/agriculture16080826 - 8 Apr 2026
Abstract
The increasing demand for innovative strategies in sustainable food production—driven by rapid global population growth, particularly in sub-Saharan Africa (SSA)—necessitates urgent attention to agricultural resilience. Recent technological advancements have enhanced crop productivity, post-harvest preservation, and environmentally sustainable farming practices. However, three critical bottlenecks [...] Read more.
The increasing demand for innovative strategies in sustainable food production—driven by rapid global population growth, particularly in sub-Saharan Africa (SSA)—necessitates urgent attention to agricultural resilience. Recent technological advancements have enhanced crop productivity, post-harvest preservation, and environmentally sustainable farming practices. However, three critical bottlenecks remain: (i) the lack of accurate, maize-specific yield prediction methods tailored to SSA; (ii) limited multimodal modeling approaches capable of capturing complex, nonlinear interactions among heterogeneous data sources; and (iii) a lack of explainability mechanisms, which render high-performing models “black boxes” and hinder stakeholder trust. To address these gaps, this study presents an explainable machine learning framework for smart maize yield prediction. We integrate multimodal SSA-specific soil, crop, and weather data to capture the multi-dimensional drivers of maize productivity. Six diverse algorithms—including extreme gradient boosting (XGBoost), light gradient boosting machine (LGBM), categorical boosting (CatBoost), support vector machine (SVM), random forest (RF), and an artificial neural network (ANN) combined with a k-nearest neighbors (kNN)—were benchmarked to evaluate predictive performance. To ensure robustness against spatial heterogeneity, we employed a Leave-One-Plot-Out (LOPO) cross-validation strategy. Empirical results on unseen test data identify CatBoost as the best-performing model, achieving a coefficient of determination of (R2 =~76%), demonstrating its ability to capture complex, nonlinear relationships in agricultural data. To enhance transparency and stakeholder trust, we integrated Local Interpretable Model-agnostic Explanations (LIME), providing plot-level insights into the physiological and environmental drivers of maize yield. Together, these contributions establish a scalable and interpretable modeling framework capable of supporting data-driven agricultural decision-making in SSA. Full article
(This article belongs to the Section Artificial Intelligence and Digital Agriculture)
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26 pages, 7110 KB  
Article
Research on an Automatic Detection Method for Response Keypoints of Three-Dimensional Targets in Directional Borehole Radar Profiles
by Xiaosong Tang, Maoxuan Xu, Feng Yang, Jialin Liu, Suping Peng and Xu Qiao
Remote Sens. 2026, 18(7), 1102; https://doi.org/10.3390/rs18071102 - 7 Apr 2026
Abstract
During the interpretation of Borehole Radar (BHR) B-scan profiles, the accurate determination of the azimuth of geological targets in three-dimensional space is a critical issue for achieving precise anomaly localization and spatial structure inversion. However, existing directional BHR anomaly localization methods exhibit limited [...] Read more.
During the interpretation of Borehole Radar (BHR) B-scan profiles, the accurate determination of the azimuth of geological targets in three-dimensional space is a critical issue for achieving precise anomaly localization and spatial structure inversion. However, existing directional BHR anomaly localization methods exhibit limited intelligence, insufficient adaptability to multi-site data, and weak generalization capability, rendering them inadequate for engineering applications under complex geological conditions. To address these challenges, a robust deep learning model, termed BSS-Pose-BHR, is developed based on YOLOv11n-pose for keypoint detection in directional BHR profiles. The model incorporates three key optimizations: Bi-Level Routing Attention (BRA) replaces Multi-Head Self-Attention (MHSA) in the backbone to improve computational efficiency; Conv_SAMWS enhances keypoint-related feature weighting in the backbone and neck; and Spatial and Channel Reconstruction Convolution (SCConv) is integrated into the detection head to reduce redundancy and strengthen local feature extraction, thereby improving suitability for keypoint detection tasks. In addition, a three-dimensional electromagnetic model of limestone containing a certain density of clay particles is established to construct a simulation dataset. On the simulated test set, compared with current mainstream deep learning approaches and conventional directional borehole radar anomaly localization algorithms, BSS-Pose-BHR achieves superior performance, with an mAP50(B) of 0.9686, an mAP50–95(B) of 0.7712, an mAP50(P) of 0.9951, and an mAP50–95(P) of 0.9952. Ablation experiments demonstrate that each proposed module contributes significantly to performance improvement. Compared with the baseline, BSS-Pose-BHR improves mAP50(B) by 5.39% and mAP50(P) by 0.86%, while increasing model weight by only 1.05 MB, thereby achieving a reasonable trade-off between detection accuracy and complexity. Furthermore, indoor physical model experiments validate the effectiveness of the method on measured data. Robustness experiments under different Peak Signal-to-Noise Ratio (PSNR) conditions and varying missing-trace rates indicate that BSS-Pose-BHR maintains high detection accuracy under moderate noise and data loss, demonstrating strong engineering applicability and practical value. Full article
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25 pages, 2876 KB  
Article
High-Performance Computing Optimization of the Maxwell–Stefan Diffusion Model in OpenFOAM
by Zixin Chi, Xin Hui and Bosen Wang
Appl. Sci. 2026, 16(7), 3611; https://doi.org/10.3390/app16073611 - 7 Apr 2026
Abstract
Multicomponent diffusion modeling based on the Maxwell–Stefan formulation is widely used in high-fidelity combustion simulations due to its superior physical accuracy compared with simplified diffusion models. However, the computational complexity of the Maxwell–Stefan model, which arises from the solution of coupled multicomponent transport [...] Read more.
Multicomponent diffusion modeling based on the Maxwell–Stefan formulation is widely used in high-fidelity combustion simulations due to its superior physical accuracy compared with simplified diffusion models. However, the computational complexity of the Maxwell–Stefan model, which arises from the solution of coupled multicomponent transport equations, becomes a major performance bottleneck in large-scale CFD simulations. In this work, a high-performance computing optimization strategy for the Maxwell–Stefan diffusion model is developed within the OpenFOAM framework. The proposed method improves computational efficiency through block-based computation and vectorization-oriented data organization to better exploit modern CPU architectures and SIMD instruction capabilities. The optimized implementation enhances memory locality, increases data reuse efficiency, and reduces cache miss penalties. Numerical validation is performed using two-dimensional laminar counterflow flame cases and ammonia–hydrogen turbulent combustion cases, including both premixed and non-premixed jet flames. Results demonstrate that the optimized Maxwell–Stefan implementation preserves numerical accuracy while significantly improving computational performance. Speedups of 2.5×–4.5× are achieved depending on the number of chemical species. The developed approach provides an efficient solution for detailed combustion simulations involving large chemical mechanisms. The test cases and source code are openly shared. Full article
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23 pages, 1741 KB  
Article
Fixed-Bed Bioreactor Culture Enhances Yield and Reparative Properties of hTERT Mesenchymal Stem Cell Extracellular Vesicles
by Zachary Cuba, Lenny Godinho, Sujata Choudhury, Kajal Patil, Anastasia Williams, Weidong Zhou, Marissa Howard, Surya P. Aryal, Kevin A. Clayton, David A. Routenberg, Lance A. Liotta, Heather Couch, Fatah Kashanchi and Heather Branscome
Cells 2026, 15(7), 654; https://doi.org/10.3390/cells15070654 - 7 Apr 2026
Abstract
Mesenchymal stem cells (MSCs) are multipotent cells that have the ability to mediate cellular repair through a combination of soluble paracrine factors, as well as bioactive cargo packaged within extracellular vesicles (EVs). Although MSC-derived EVs have been widely investigated for their regenerative potential, [...] Read more.
Mesenchymal stem cells (MSCs) are multipotent cells that have the ability to mediate cellular repair through a combination of soluble paracrine factors, as well as bioactive cargo packaged within extracellular vesicles (EVs). Although MSC-derived EVs have been widely investigated for their regenerative potential, progress toward translational evaluation has been limited in part by challenges in scalable and reproducible manufacturing. We recently reported that human telomerase reverse transcriptase (hTERT)-immortalized MSCs reproducibly produce EVs that retain key characteristics of EVs derived from primary MSCs. Building on this work, three-dimensional (3D) culture systems have emerged as promising platforms for large-scale manufacturing. In this study, we compared the yield, molecular composition, and functional activity of EVs produced from hTERT-immortalized MSCs cultured in either a fixed-bed bioreactor or conventional two-dimensional (2D) flasks. Our data demonstrate that bioreactor culture results in increased EV yield as compared to an equivalent production from 2D cultures. Molecular analyses indicated that bioreactor-derived EVs were associated with a broader spectrum of cargo and were enriched with molecules that may contribute to enhanced reparative function. Importantly, bioreactor-derived EVs also exerted a more pronounced effect in cellular repair assays in vitro. Collectively, these results highlight the potential of fixed-bed bioreactors as scalable platforms for EV production, offering higher yields while preserving molecular composition and functional activity. This approach represents an important step toward achieving the reproducible, high-quality EV production required for research and future translational applications. Full article
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24 pages, 67497 KB  
Article
A Physics-Guided Dual-Stream Vibration Feature Fusion Network for Chatter-Induced Surface Mark Diagnosis in Wafer Thinning
by Heng Li, Hua Liu, Liang Zhu, Xiangyu Zhao, Lemiao Qiu and Shuyou Zhang
Machines 2026, 14(4), 404; https://doi.org/10.3390/machines14040404 - 7 Apr 2026
Abstract
Ultra-precision thinning of hard and brittle materials like monocrystalline silicon demands high dynamic stability in thinning spindle. To address the challenge of accurately detecting subtle spindle chatter anomalies in industrial environments characterized by high noise and limited data, this paper proposes a physics-guided [...] Read more.
Ultra-precision thinning of hard and brittle materials like monocrystalline silicon demands high dynamic stability in thinning spindle. To address the challenge of accurately detecting subtle spindle chatter anomalies in industrial environments characterized by high noise and limited data, this paper proposes a physics-guided dual-stream attention fusion transfer network (PG-AFNet). First, a physics-guided signal preprocessing method was developed. Using variational mode decomposition (VMD) and continuous wavelet transform (CWT) masking, one-dimensional dynamic features and high-frequency regions of interest (ROIs) rich in transient impact features were extracted. Second, the PG-AFNet architecture was designed. By introducing an attention mechanism, it achieves deep integration of one-dimensional purely dynamic sequences with two-dimensional spatiotemporal visual textures to capture surface damage features caused by subtle vibrations. Finally, systematic validations were conducted using a real silicon wafer thinning dataset with 197 real samples. By overcoming small-sample limitations via physical augmentation, PG-AFNet achieved an 82.45% (86.64% after data augmentation) diagnostic accuracy, significantly outperforming traditional baselines. Furthermore, a large-scale cross-load validation on the diverse CWRU dataset yielded an exceptional 99.68% accuracy under mixed-load conditions, conclusively verifying the model’s robust domain generalization. Lastly, a rigorous ablation study explicitly quantified the indispensable contributions of the physics-guided dual-stream architecture and attention fusion. This research provides a feasible theoretical foundation for intelligent surface quality monitoring in semiconductor hard-brittle material processing. Full article
(This article belongs to the Special Issue Monitoring and Control of Machining Processes)
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13 pages, 2283 KB  
Article
Study on RF Parameter Extraction Method for Novel Heterogeneous Integrated GaN Schottky Rectifiers Based on Hierarchical Reinforcement Learning
by Yi Wei, Li Huang, Ce Wang, Xiong Yin and Ce Wang
Electronics 2026, 15(7), 1537; https://doi.org/10.3390/electronics15071537 - 7 Apr 2026
Abstract
This study presents a heterogeneous integration micro-assembly process and circuit board packaging solution for GaN Schottky Barrier Diode (SBD) rectifiers, and innovatively constructs a hierarchical reinforcement learning strategy for optimizing SBD RF parameters. By establishing an optimization framework with the goal of efficiency [...] Read more.
This study presents a heterogeneous integration micro-assembly process and circuit board packaging solution for GaN Schottky Barrier Diode (SBD) rectifiers, and innovatively constructs a hierarchical reinforcement learning strategy for optimizing SBD RF parameters. By establishing an optimization framework with the goal of efficiency in the load-input power two-dimensional space, a dual-layer optimization mechanism is employed: the high-level strategy dynamically selects optimization regions and parameter combinations, while the low-level strategy implements specific parameter adjustments. This approach effectively addresses the challenges of device parameter modeling and circuit design. Experimental data shows that the efficiency error for the SBD1 rectifier remains stable within 2%, and the average error for SBD2 is reduced to 1.5%. This method enables efficient and accurate optimization of RF parameters, providing a reliable technical pathway for the engineering application of Wireless Power Transmission systems. Full article
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