Search Results (221)

Background/Objectives: The objective of this study was to validate a new parent-reported scale for tracking Pediatric Acute-onset Neuropsychiatric Syndrome (PANS). PANS is a condition characterized by a sudden and severe onset of neuropsychiatric symptoms. To meet diagnostic criteria, an individual must present with either obsessive–compulsive disorder (OCD) or severely restricted food intake, accompanied by at least two additional cognitive, behavioral, or emotional symptoms. These may include anxiety, emotional instability, depression, irritability, aggression, oppositional behaviors, developmental or behavioral regression, a decline in academic skills such as handwriting or math, sensory abnormalities, frequent urination, and enuresis. The onset of symptoms is usually triggered by an infection or an abnormal immune/inflammatory response. Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) is a subtype of PANS specifically linked to strep infections. Methods: We developed a 101-item PANS/PANDAS and Related Inflammatory Brain Disorders Treatment Evaluation Checklist (PTEC) designed to assess changes to a patient’s symptoms over time along 10 subscales: Behavior/Mood, OCD, Anxiety, Food intake, Tics, Cognitive/Developmental, Sensory, Other, Sleep, and Health. The psychometric quality of PTEC was tested with 225 participants. Results: The internal reliability of the PTEC was excellent (Cronbach’s alpha = 0.96). PTEC exhibited adequate test–retest reliability (r = 0.6) and excellent construct validity, supported by a strong correlation with the Health subscale of the Autism Treatment Evaluation Checklist (r = 0.8). Conclusions: We hope that PTEC will assist parents and clinicians in the monitoring and treatment of PANS. The PTEC questionnaire is freely available at neuroimmune.org/PTEC. Full article

In this research, a single composite-type stretchable triboelectric nanogenerator (TENG) is proposed for efficient energy harvesting and handwriting recognition. The composite TENGs were fabricated by blending dielectric barium titanate (BT) and conductive carbon nanotubes (CNTs) in varying amounts into a styrene–butadiene rubber matrix. The energy harvesting efficiency depends on the type and amount of fillers, as well as their dispersion within the matrix. Stearic acid modification of BT enables near-nanoscale filler distribution, resulting in high energy conversion efficiencies. The composite achieved power efficiency, power density, charge efficiency, and charge density values of 1.127 nW/N, 8.258 mW/m³, 0.146 nC/N, and 1.072 mC/m³, respectively, under only 2% cyclic compressive strain at 0.85 Hz. The material performs better at low stress–strain ranges, exhibiting higher charge efficiency. The generated charge in the TENG composite is well correlated with the compressive stress, which provides a minimum activation pressure of 0.144 kPa, making it suitable for low-pressure sensing applications. A flat composite with dimensions of 0.02 × 6 × 5 cm³ can produce a power density of 26.04 W/m³, a charge density of 0.205 mC/m³, and an output voltage of 10 V from a single hand pat. The rubber composite also demonstrates high accuracy in handwriting recognition across different individuals, with clear differences in sensitivity curves. Repeated attempts by the same person show minimal deviation (<5%) in writing time. Additionally, the presence of reinforcing fillers enhances mechanical strength and durability, making the composite suitable for long-term cyclic energy harvesting and wearable sensor applications. Full article

Parkinson’s disease (PD) is a progressive neurodegenerative disorder that impairs motor function, including the fine motor control required for handwriting. Traditional diagnostic methods often lack sensitivity and objectivity in the early stages, limiting opportunities for timely intervention. There is a growing need for non-invasive, accessible tools capable of capturing subtle motor changes that precede overt clinical symptoms. Among early PD manifestations, handwriting impairments such as micrographia have shown potential as digital biomarkers. However, conventional handwriting analysis remains subjective and limited in scope. Recent advances in artificial intelligence (AI) and machine learning (ML) enable automated analysis of handwriting dynamics, such as pressure, velocity, and fluency, collected via digital tablets and smartpens. These tools support the detection of early-stage PD, monitoring of disease progression, and assessment of therapeutic response. This paper highlights how AI-enhanced handwriting analysis provides a scalable, non-invasive method to support diagnosis, enable remote symptom tracking, and personalize treatment strategies in PD. This approach integrates clinical neurology with computer science and rehabilitation, offering practical applications in telemedicine, digital health, and personalized medicine. By capturing dynamic features often missed by traditional assessments, AI-based handwriting analysis contributes to a paradigm shift in the early detection and long-term management of PD, with broad relevance across neurology, digital diagnostics, and public health innovation. Full article

Depressive disorders significantly impact individuals worldwide, including children and adolescents. Despite their widespread occurrence, early and precise diagnosis of depressive disorders remains a complex and challenging task, particularly in younger populations. This study proposes a novel machine learning framework leveraging kinematic handwriting analysis to enhance the detection of psychomotor disturbances indicative of psychomotor retardation in youths with depression. The handwriting data were acquired from 20 youths with depression and 20 healthy controls. All participants completed a simple repetitive handwriting task: continuous writing of the small cursive Latin letter “l”. Segmentation of the handwriting data into individual “Letters” was conducted, and 177 kinematic features were extracted and analyzed. Statistical methods were used to identify significant features. After recursive feature elimination, classification was achieved through machine learning algorithms: logistic regression, support vector machine, and random forest. After the identification of 40 significant features, logistic regression, utilizing an optimal three-feature subset, achieved the highest accuracy in classifying individual letters of 76.7% and the highest accuracy in classifying subjects of 82.5%. The feature selection process revealed that velocity-related features were most effective in distinguishing patients with depression from controls, expectedly reflecting a slowdown in psychomotor functioning among the patients. The findings demonstrate that kinematic handwriting analysis, when combined with machine learning techniques, offers a promising tool to support objective recognition of psychomotor speed, providing insight into psychomotor retardation in youth with depression. Full article

Identifying the scriptwriter in historical manuscripts is crucial for historians, providing valuable insights into historical contexts and aiding in solving historical mysteries. This research presents a robust deep learning system designed for classifying historical manuscripts by writer, employing intelligent feature selection and vision transformers. Our methodology meticulously investigates the efficacy of both handcrafted techniques for feature identification and deep learning architectures for classification tasks in writer identification. The initial preprocessing phase involves thorough document refinement using bilateral filtering for denoising and Otsu thresholding for binarization, ensuring document clarity and consistency for subsequent feature detection. We utilize the FAST detector for feature detection, extracting keypoints representing handwriting styles, followed by clustering with the k-means algorithm to obtain meaningful patches of uniform size. This strategic clustering minimizes redundancy and creates a comprehensive dataset ideal for deep learning classification tasks. Leveraging vision transformer models, our methodology effectively learns complex patterns and features from extracted patches, enabling precise identification of writers across historical manuscripts. This study pioneers the application of vision transformers in historical document analysis, showcasing superior performance on the “ICDAR 2017” dataset compared to state-of-the-art methods and affirming our approach as a robust tool for historical manuscript analysis. Full article

Predicting the motion of handwritten digits in video sequences is challenging due to complex spatiotemporal dependencies, variable writing styles, and the need to preserve fine-grained visual details—all of which are essential for real-time handwriting recognition and digital learning applications. In this context, our study aims to develop a robust predictive framework that can accurately forecast digit trajectories while preserving structural integrity. To address these challenges, we propose a novel video prediction architecture integrating ConvCARU with a modified DCGAN to effectively separate the background from the foreground. This ensures the enhanced extraction and preservation of spatial and temporal features through convolution-based gating and adaptive fusion mechanisms. Based on extensive experiments conducted on the MNIST dataset, which comprises 70 K pixel images, our approach achieves an SSIM of 0.901 and a PSNR of 29.31 dB. This reflects a statistically significant improvement in PSNR of +0.20 dB (p < 0.05) compared to current state-of-the-art models, thus demonstrating its superior capability in maintaining consistent structural fidelity in predicted video frames. Furthermore, our framework performs better in terms of computational efficiency, with lower memory consumption compared to most other approaches. This underscores its practicality for deployment in real-time, resource-constrained applications. These promising results consequently validate the effectiveness of our integrated ConvCARU–DCGAN approach in capturing fine-grained spatiotemporal dependencies, positioning it as a compelling solution for enhancing video-based handwriting recognition and sequence forecasting. This paves the way for its adoption in diverse applications requiring high-resolution, efficient motion prediction. Full article

Cognitive impairment is common but often overlooked in patients with inflammatory demyelinating diseases such as multiple sclerosis and neuromyelitis optica spectrum disorder. The conventional assessments may fail to detect subtle deficits and require substantial time and expertise. We collected neuropsychological scores and real-time handwriting data across nine drawing tasks and tasks from the Symbol Digit Modalities Test in 93 patients. Temporal, pressure, and kinematic features were extracted, and machine learning classifiers were trained using five-fold cross-validation with bootstrap confidence intervals. The response timing and pen pressure metrics correlated significantly with global cognitive scores (|r| = 0.30–0.37, p < 0.01). A support vector machine using eight selected features achieved an area under the receiver-operating characteristic curve (AUC) of 0.910, and a streamlined five-feature variant maintained an equivalent performance (AUC = 0.921) while reducing the assessment time by 35%. These results indicate that digital handwriting metrics can complement the standard screening by capturing fine motor and temporal characteristics overlooked in conventional testing. Validation in larger, disease-balanced, and longitudinal cohorts is needed to confirm their clinical utility. Full article

Background/Objectives: Developmental dysgraphia, a graphomotor difficulty affecting handwriting, significantly impacts children’s academic performance, emotional well-being, and overall development. Over the past two decades, intervention strategies have transitioned from traditional task-oriented motor training to more innovative, technology-driven, and holistic approaches. This paper aims to synthesise key developments in dysgraphia interventions, categorising them into distinct thematic areas and evaluating their effectiveness in improving handwriting outcomes. Methods: A review of 12 key studies was conducted, classifying interventions into four primary categories: (1) task-oriented and sensorimotor-based interventions; (2) technology-assisted solutions; (3) self-regulated and individualised approaches; and (4) integrated methodologies. Each study was analysed based on its methodology, intervention design, target population, and reported outcomes to assess the effectiveness and feasibility of different approaches. Results: The findings indicate significant advancements in handwriting interventions, with technology-assisted and integrated approaches demonstrating promising results in engagement, accessibility, and skill development. However, challenges remain in terms of scalability, cultural adaptability, and long-term sustainability. While self-regulated and individualised approaches offer tailored support, their effectiveness depends on factors such as learner motivation and instructional design. Conclusions: Despite progress in intervention strategies for developmental dysgraphia, further research is needed to optimise hybrid models that combine the strengths of multiple approaches. A more inclusive and adaptable framework is required to ensure equitable access to effective handwriting interventions. This study highlights the need for continued collaboration among researchers, educators, and policymakers to advance evidence-based interventions, fostering equitable learning opportunities for all children with dysgraphia. Full article

This paper deals with biometric identification based on unique patterns and characteristics of an individual’s handwriting, focusing on the dynamic writing process on a touchscreen device. Related work in this domain indicates the dominance of specific research approaches. Namely, in most cases, only the signature is analyzed, verification methods are more prevalent than recognition methods, and the provided solutions are mainly based on using a particular device or specific sensor for collecting biometric data. In this context, our work aims to fill the identified research gap by introducing a new handwriting-based user recognition technique. The proposed approach implements the concept of sensor fusion and does not rely exclusively on signatures for recognition but also includes other forms of handwriting, such as short sentences, words, or individual letters. Additionally, two different ways of handwriting input, using a stylus and a finger, are introduced into the analysis. In order to collect data on the dynamics of handwriting and signing, a specially designed apparatus was used with various sensors integrated into common smart devices, along with additional external sensors and accessories. A total of 60 participants took part in a controlled experiment to form a handwriting biometrics dataset for further analysis. To classify participants’ handwriting, custom architecture CNN models were utilized for feature extraction and classification tasks. The obtained results showed that the proposed handwriting recognition system achieves accuracies of 0.982, 0.927, 0.884, and 0.661 for signatures, words, short sentences, and individual letters, respectively. We further investigated the main effects of the input modality and the train set’s size on the system’s accuracy. Finally, an ablation study was carried out to analyze the impact of individual sensors within the fusion-based setup. Full article

Alzheimer’s disease (AD) is a persistent neurologic disorder that has no cure. For a successful treatment to be implemented, it is essential to diagnose AD at an early stage, which may occur up to eight years before dementia manifests. In this regard, a new predictive machine learning model is proposed that works in two stages and takes advantage of both unsupervised and supervised learning approaches to provide a fast, affordable, yet accurate solution. The first stage involved fuzzy partitioning of a gold-standard dataset, DARWIN (Diagnosis AlzheimeR WIth haNdwriting). This dataset consists of clinical features and is designed to detect Alzheimer’s disease through handwriting analysis. To determine the optimal number of clusters, four Clustering Validity Indices (CVIs) were averaged, which we refer to as cognitive features. During the second stage, a predictive model was constructed exclusively from these cognitive features. In comparison to models relying on datasets featuring clinical attributes, models incorporating cognitive features showed substantial performance enhancements, ranging from 12% to 26%. Our proposed model surpassed all current state-of-the-art models, achieving a mean accuracy of 99%, mean sensitivity of 98%, mean specificity of 100%, mean precision of 100%, and mean MCC and Cohen’s Kappa of 98%, along with a mean AUC-ROC score of 99%. Hence, integrating the output of unsupervised learning into supervised machine learning models significantly improved their performance. In the process of crafting early interventions for individuals with a heightened risk of disease onset, our prognostic framework can aid in both the recruitment and advancement of clinical trials. Full article

Background: The advent of digital technology has significantly altered ways of writing. While typing has become the dominant mode of written communication, handwriting remains a fundamental human skill, and its profound impact on cognitive processes continues to be a topic of intense scientific scrutiny. Methods: This paper investigates the neural mechanisms underlying handwriting and typing, exploring the distinct cognitive and neurological benefits associated with each. By synthesizing findings from neuroimaging studies, we explore how handwriting and typing differentially activate brain regions associated with motor control, sensory perception, and higher-order cognitive functions. Results: Handwriting activates a broader network of brain regions involved in motor, sensory, and cognitive processing. Typing engages fewer neural circuits, resulting in more passive cognitive engagement. Despite the advantages of typing in terms of speed and convenience, handwriting remains an important tool for learning and memory retention, particularly in educational contexts. Conclusions: This review contributes to the ongoing debate about the role of technology in education and cognitive development. By understanding the neural differences between handwriting and typing, we can gain insights into optimal learning strategies and potential cognitive advantages, in order to optimize educational, cognitive, and psychological methodologies. Full article

A series of studies and research have shown the existence of a link between handwriting and a person’s personality traits. There are numerous fields that require a psychological assessment of individuals, where there is a need to determine personality traits in a faster and more efficient manner than that based on classic questionnaires or graphological analysis. The development of image processing and recognition algorithms based on machine learning and deep neural networks has led to a series of applications in the field of graphology. In the present study, a system for automatically extracting handwriting characteristics from written documents and correlating them with Myers–Briggs type indicator is implemented. The system has an architecture composed of three levels, the main level being formed by four convolutional neural networks. To train the networks, a database with different types of handwriting was created. The experimental results show an accuracy ranging between 89% and 96% for handwritten features’ recognition and results ranging between 83% and 91% in determining Myers–Briggs indicators. Full article

Background: Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder worldwide. People suffering from PD exhibit motor symptoms that affect the control of upper and lower limb movement. Among daily activities that depend on proper upper limb control is the handwriting process, which has been studied in state-of-the-art research, mainly considering non-semantic drawings like spirals, geometric figures, cursive lines, and others. Objectives: This paper analyzes the suitability of modeling the handwriting process of digits from 0 to 9 to automatically discriminate between PD patients and healthy control subjects. The main hypothesis is that modeling these numbers allows a more natural evaluation of upper limb control. Methods: Two approaches are considered: modeling of the images resulting from the strokes collected by the digital tablet and modeling of the time series yielded by the digital tablet while performing the strokes, i.e., time-dependent signals. The first approach is implemented by fine-tuning a CNN-based architecture, while the second approach is based on hand-crafted features measured upon the time series, namely pressure and kinematic measurements. Features extracted from time-dependent signals are represented following two strategies, one based on statistical functionals and the other one based on creating Gaussian Mixture Models (GMMs). Results: The experiments indicate that pressure-based features modeled with functionals are the ones that yield the highest accuracy, indicating that PD-related symptoms are better modeled with dynamic approaches than those based on images. Conclusions: The dynamic approach outperformed the image-based model, indicating that the writing process, modeled with signals collected over time, reveals motor symptoms more clearly than images resulting from handwriting. This finding is in line with previous results in the state-of-the-art research and constitutes a step forward to create more accurate and informative methods to detect and monitor PD symptoms. Full article

As an important kind of DNN (deep neural network), CNN (convolutional neural network) has made remarkable progress and been widely used in the vision and decision-making of autonomous robots. Nonetheless, in many scenarios, even a minor perturbation in input for CNNs may lead to serious errors, which means CNNs lack robustness. Formal verification is an effective method to guarantee the robustness of CNNs. Existing works predominantly concentrate on local robustness verification, which requires considerable time and space. Probabilistic robustness quantifies the robustness of CNNs, which is a practical mode of potential measurement. The state-of-the-art of probabilistic robustness verification is a test-driven approach, which is used to manually decide whether a DNN satisfies the probabilistic robustness and does not involve robustness repair. Robustness repair can improve the robustness of CNNs further. To address this issue, we propose a probabilistic model checking-driven robustness guarantee framework for CNNs, i.e., PRG4CNN. This is the first automated and complete framework for guaranteeing the probabilistic robustness of CNNs. It comprises four steps, as follows: (1) modeling a CNN as an MDP (Markov decision processes) by model learning, (2) specifying the probabilistic robustness of the CNN via the PCTL (Probabilistic Computational Tree Logic) formula, (3) verifying the probabilistic robustness with a probabilistic model checker, and (4) probabilistic robustness repair by counterexample-guided sensitivity analysis, if probabilistic robustness does not hold on the CNN. We here conduct experiments on various scales of CNNs trained on the handwriting dataset MNIST, and demonstrate the effectiveness of PRG4CNN. Full article