Search Results (368)

Background/Objectives: Percutaneous transthoracic needle biopsy (PTNB) using advanced navigation techniques is increasingly performed; however, pulmonologists’ experience remains limited. This study reports an interventional pulmonologist’s initial experience with cone-beam computed tomography (CBCT) laser-guided PTNB and the diagnostic performance for lesions with diameters greater than or less than 20 mm. Methods: We retrospectively analysed the data of patients who underwent PTNB in a C-arm CBCT-equipped hybrid operating room between July 2020 and March 2024. All patients underwent the biopsy procedure under local anaesthesia. This was preceded by an initial 3D scan for planning of the needle route, followed by coaxial needle insertion. A post-procedural scan was also performed to identify complications. Results: Seventy-seven patients were enrolled in the study. The median distances of the needle path from the skin to the pleura and from the pleura to the lesion were 33.4 mm and 31.7 mm, respectively. The median number of tissue samplings was 4.9 ± 1.8. The median operating room duration was 51.5 ± 25.7 min, respectively. The median total dose area product was 8485.4 ± 5819.9 µGym². The sensitivity and specificity of our study findings were 93.3% (56/60) and 100%, while the accuracy was 94.8% (73/77). The overall complication rate was 13%. Conclusions: PTNB procedure by pulmonologists is a feasible and safe, single-operator workflow in a hybrid operating room. It can be performed under CBCT laser guidance with a similar diagnostic yield, acceptable radiation exposure and procedure duration, and minimal or manageable complications. Full article

Focusing on continuous action space methods for autonomous maneuvering decision making in 1v1 unmanned aerial vehicle scenarios, this paper first establishes a UAV kinematic model and a decision-making framework under the Markov Decision Process. Second, a continuous control strategy based on the Soft Actor-Critic (SAC) reinforcement learning algorithm is developed to generate precise maneuvering commands. Then, a multi-dimensional situation-coupled reward function is designed, introducing a Health Point (HP) metric to assess situational advantages and simulate cumulative effects quantitatively. Finally, extensive simulations in a custom Gym environment validate the effectiveness of the proposed method and its robustness under both ideal and noisy observation conditions. Full article

Recent advances in legged robotics have highlighted deep reinforcement learning (DRL)-based controllers for their robust adaptability to diverse, unstructured environments. While position-based DRL controllers achieve high tracking accuracy, they offer limited disturbance rejection, which degrades walking stability; torque-based DRL controllers can mitigate this issue but typically require extensive time and trial-and-error to converge. To address these challenges, we propose a Real-Time Motion Generator (RTMG). At each time step, RTMG kinematically synthesizes end-effector trajectories from target translational and angular velocities (yaw rate) and step length, then maps them to joint angles via inverse kinematics to produce imitation data. The RL agent uses this imitation data as a torque bias, which is gradually annealed during training to enable fully autonomous behavior. We further combine the RTMG-generated imitation data with a decaying action priors scheme to ensure both initial stability and motion diversity. The proposed training pipeline, implemented in NVIDIA Isaac Gym with Proximal Policy Optimization (PPO), reliably converges to the target gait pattern. The trained controller is Tensor RT-optimized and runs at 50 Hz on a Jetson Nano; relative to a position-based baseline, torso oscillation is reduced by 24.88% in simulation and 21.24% on hardware, demonstrating the effectiveness of the approach. Full article

Background: The Transformative, Resilient, and Youth-Led/Driven (TRY) Gym, a school-based co-creative mental health training programme, is grounded in the Positive Youth Development (PYD) approach. It seeks to improve adolescents’ mental health and well-being by strengthening their resilience and competence. Additionally, it prepares them to deliver peer-led mental health activities, promoting mental wellness and fostering a stigma-free, supportive environment. Methods: This study evaluated the programme using a mixed-method design. In total, 94 students from eight secondary schools in Hong Kong were recruited, with 80 participating in the evaluation. Results: Five outcomes showed significant improvements from baseline to the post-implementation phase, including social competence, cognitive competence, emotional competence, resilience, and mental well-being. Common features were identified across interviews, which may possibly account for the significant results and participants’ improved mental health. Conclusions: The TRY Gym programme’s fidelity was demonstrated by its completion, which included high participant responsiveness, and a co-creative and youth-driven approach in the project. In addition, the positive outcomes of the programme underscore its effectiveness in improving mental health among adolescents by imparting mental health knowledge and providing opportunities for participants to apply learnt techniques in everyday life situations. Full article

Redox imbalance and epigenetic dysregulation, which both contribute to tumor initiation, survival, and resistance to therapy, are intimately linked to the progression of cancer. Reactive oxygen species (ROS) have two contrasting effects: at moderate concentrations, they promote angiogenesis and oncogenic signaling, whereas at high concentrations, they trigger apoptosis. Oxidative stress alters histone modifications, DNA methylation, and non-coding RNA (ncRNA) expression, reshaping the epigenetic landscape and supporting malignant phenotypes. Plant-derived antioxidants, including flavonoids, polyphenols, alkaloids, and terpenoids, act as dual modulators of cancer biology. They scavenge or regulate reactive oxygen species (ROS), restore redox balance, activate tumor suppressor pathways, inhibit oncogenic mechanisms, and reverse abnormal epigenetic marks. Compounds such as resveratrol, curcumin, epigallocatechin gallate (EGCG), quercetin, and sulforaphane modulate DNA methyltransferases (DNMTs), histone deacetylases (HDACs), and non-coding RNA networks, and can enhance chemotherapy and radiation therapy. Despite promising mechanisms, challenges remain in translational efficacy, optimal dosing, and bioavailability. This review emphasizes the potential of plant-derived antioxidants as precision oncology adjuncts and highlights the need for biomarker-guided strategies, nano-delivery systems, and clinical validation to fully realize their therapeutic benefits. Plant-derived antioxidants mitigate ROS-induced oncogenic signaling, as evidenced by in vitro and clinical models. Full article

The benefits of physical activity on physical and mental health are well established. Exercise can be particularly advantageous in neurodegenerative disorders such as Parkinson’s disease (PD), where progressive loss of muscle mass and impaired motor performance are common. We report the case of a 58-year-old man with PD who underwent a structured, adapted physical activity program in preparation for a relay swim across the Strait of Messina (Sicily, Italy). The aim was to evaluate changes in body composition (fat mass, fat-free mass) and performance following four months of adapted swimming training, alongside adapted physical activity in the gym and Nordic walking. The patient swam 1300 m in 42 min and 38 s in the relay, which was a marked improvement from the baseline and subsequent assessments. In conclusion, while a longer follow-up period and a larger patient sample would be necessary, the findings from this case study suggest that the adapted exercise program improved both physical fitness and body composition. This generally supports the key role of physical activity in managing Parkinson’s disease and, in particular, the positive effects of adaptive sports training. Full article

This study presents the design and implementation of a compact data acquisition system for immersive ultrasonic inspection of small-diameter pipelines, targeting applications where conventional systems are impractical due to size constraints. The system integrates the Eclipse Z7 platform with a customized pulser-receiver module and a rotary pipeline inspection gauge (PIG) equipped with a 5 MHz immersion-type ultrasonic transducer. The PIG module is designed to scan pipelines with an 8.18 mm wall thickness and a 200 mm inner diameter. Before deployment, real-time system calibration is performed via a connected computer interface to ensure optimal performance. Once inside the pipeline, the PIG operates autonomously, with ultrasonic data being acquired and stored locally on a Raspberry Pi. Post-inspection, the recorded data is extracted and analyzed on the computer to assess pipeline integrity. The proposed system offers a compact alternative to commercial solutions, particularly in scenarios involving limited access and small-diameter pipelines. Full article

Gyms are indoor environments in which many people perform physical exercise and could potentially increase the risks of bacterial contamination and dissemination. Staphylococcus aureus (S. aureus) is one of the most prevalent bacteria in community-acquired infections; thus, the rapid detection and continuous monitoring of S. aureus are crucial for evaluating the hygienic status of gym environments. This work describes the fabrication of a nanochain-based biosensor for S. aureus detection using carboxyl-modified polystyrene (PS) nanoparticles functionalized with a specific antibody. When target bacteria bind to the nanochains, they yield distinct color changes which support the directly visualizable analysis of optical images, recorded using optical microscopy or even a smart mobile phone. In addition to high portability, this biosensor is also capable of the quantification and continuous monitoring of the bacterial load in a gym environment over a broad linear range (10⁰ CFU/mL~10⁵ CFU/mL), with a detection limit of 1 CFU/mL. In summary, this study validated the applicability of the biosensors for the rapid detection and real-time monitoring of gym environmental pathogens. Full article

This paper explores the café–gym symbiosis mode in Xi’an and its key influencing factors. Taking 63 sub-districts in the seven main urban districts of Xi’an as an example, based on the Dianping.com data of 753 cafés and 335 gyms and survey data from 492 questionnaires, this paper uses methods such as the symbiotic degree, symbiotic coefficient, and binary logistic regression model. On the basis of evaluating the symbiotic model between cafés and fitness centers, it explores the key factors influencing the symbiotic model of cafés and fitness centers. The results showed that cafés and gyms in Xi’an have a variety of characteristics, including agglomeration, correlation, complementarity, and combination, laying the foundation for a symbiosis between them. Among the subject symbiosis modes in Xi’an, point symbiosis was the main symbiotic organization mode. Simultaneously, the proportion of the point symbiosis mode was higher in the urban–rural transitional area than in other areas (traditional inner-city areas, mature built-up areas, emerging expansion areas). An asymmetric reciprocal symbiosis mode dominated the symbiotic behavior mode of entertainment industry objects in Xi’an. In terms of the total weekly entertainment consumer and the additional entertainment consumer dimensions, in the asymmetric reciprocal symbiosis mode, the proportion of cafés having a large impact on gyms was the highest: 60.00% and 62.86%, respectively. However, from the composite index dimension, in the asymmetric reciprocal symbiosis mode, the proportion of gyms having a large impact on cafés was the highest: 39.13%. From the symbiotic interface, the physical space within urban residential areas, office areas, commercial areas, and other main material spaces was the important basic support force for the symbiotic development of urban culture and the entertainment industry. The influence of the symbiosis mode of the culture and entertainment industry has stability. From the perspective of the symbiotic environment, cultural and creative elements, government policies, and consumer spending on entertainment foster the formation of an asymmetrical mutualistic symbiosis model between cafés and gyms. Conversely, factors such as marketization, globalization, and demographic factors inhibit its development. These findings offer valuable insights for urban planners and businesses, which help optimize the layout of the urban entertainment industry. Full article

Background: This study investigates how both jump-related (jump height and flight time) and ball-related parameters (release height, release angle, and velocity) influence shooting accuracy in basketball under different contextual constraints. Methods: Eighteen senior players competing in the national championship (11 females and 7 males; 22.0 ± 3.7 years) performed 90 shots each across three positions (left 45°, middle 90°, right 45°) and three shooting conditions (baseline, simulated gym audience noise, and simulated opposition). Jump variables were derived from force platforms, while ball kinematics were extracted using a high-speed Qualisys camera system. Results: A three-way ANOVA revealed no systematic effects of position or opposition, and only a small effect of noise on flight time (p = 0.019), which was not confirmed by the Linear Mixed Model. Comparisons between successful and missed shots indicated significantly higher flight time, jump height, and release height, and a tendency for higher release velocity in successful attempts, with no differences in release angle. Spearman correlation showed weak associations between biomechanical variables and shooting accuracy (R² = 0.005–0.012). Conclusions: These findings suggest that while adaptive biomechanical changes occur under contextual constraints, their isolated impact on shot success is limited. Successful performance appears to rely more strongly on release-related parameters, emphasizing the need for a holistic approach to training that integrates technical, perceptual, and psychological dimensions. Full article

Background: Climbing and strength training are among the most popular types of sports among recreational athletes. However, many newcomers quickly lose motivation and abandon training due to a lack of visible and athletic progress. Hence, we assessed whether a 6-week combined structured gym and climbing training could improve arm muscle strength and size. Methods: We recruited 25 healthy recreational athletes (14 [56.0%] females, age = 20.4 ± 1.7 years, BMI = 21.8 ± 1.7 kg·m⁻²). Most participants trained several times per week (N = 12, 48.0%), and training sessions lasted between 1 and 2 h (N = 11, 44.0%). Most athletes rated their current fitness level as “very good” (N = 15, 60.0%). Subjects performed two gym sessions and two climbing training sessions per week and avoided other training for 6 weeks. We measured the time of bar hang, handgrip strength, and forearm circumference before and after 6 weeks. Results: Hanging time increased from 55.3 ± 3.2 s to 60.9 ± 31.3 s (t(24) = 6.68, p < 0.001). Right handgrip strength increased from 31.6 ± 8.4 N to 34.3 ± 7.6 N (t(24) = 5.58, p < 0.001). Left handgrip strength increased from 29.4 ± 9.9 N to 31.0 ± 9.8 N (t(24) = 4.62, p < 0.001). Right forearm circumference increased from 24.6 ± 1.5 cm to 25.4 ± 1.7 cm (t(24) = 9.04, p < 0.001). Left forearm circumference increased from 24.6 ± 2.0 cm to 25.1 ± 2.1 cm (t(24) = 5.94, p < 0.001). All the relationships remained significant when stratified between males (p < 0.001–0.003) and females (p < 0.001–0.008). Conclusions: A 6-week training intervention consisting of structured climbing and strength training induces significant improvements in grip strength and the appearance of arm muscles in recreational athletes. Amateurs could benefit even from shorter training mesocycles, as a 6-week window to see visible progress. Full article

In reinforcement learning (RL), reward function design is critical to the learning efficiency and final performance of agents. However, in complex tasks such as humanoid motion tracking, traditional static weighted reward functions struggle to adapt to shifting learning priorities across training stages, and designing a suitable shaping reward is problematic. To address these challenges, this paper proposes a two-layered reward reinforcement learning framework. The framework decomposes the reward into two layers: an upper-level goal reward that measures task completion, and a lower-level optimizing reward that includes auxiliary objectives such as stability, energy consumption, and motion smoothness. The key innovation lies in the online optimization of the lower-level reward weights via an online meta-heuristic optimization algorithm. This online adaptivity enables goal-conditioned reward shaping, allowing the reward structure to evolve autonomously without requiring expert demonstrations, thereby improving learning robustness and interpretability. The framework is tested on a gymnastic motion tracking problem for the Unitree G1 humanoid robot in the Isaac Gym simulation environment. The experimental results show that, compared to a static reward baseline, the proposed framework achieves 7.58% and 10.30% improvements in upper-body and lower-body link tracking accuracy, respectively. The resulting motions also exhibit better synchronization and reduced latency. The simulation results demonstrate the effectiveness of the framework in promoting efficient exploration, accelerating convergence, and enhancing motion imitation quality. Full article

Background: Performance-enhancing drug (PED) use has become increasingly prevalent among adolescents and emerging adults, not solely for athletic advantage but as a psychological and sociocultural coping mechanism. In Türkiye, where Westernized body ideals intersect with traditional values, the emotional and symbolic meanings of PED use among youth remain underexplored. Methods: This qualitative study employed semi-structured interviews and reflexive thematic analysis to examine the subjective experiences of 26 Turkish adolescents and emerging adults (19 males, 7 females; ages 16–22) in Istanbul who reported non-medical use of steroids or other PEDs. Participants were recruited through snowball sampling in gym-adjacent communities across six urban districts. Interviews were conducted online, recorded, transcribed, and analyzed to identify emergent psychological themes. Results: Six interconnected themes were identified: (1) body-based insecurity and the fantasy of reinvention; (2) emotional regulation through bodily control; (3) secrecy as autonomy; (4) compulsive enhancement and dissatisfaction; (5) psychological dependency and regret; and (6) PED use as agency and protest. While male and female participants differed in aesthetic goals and social narratives, both groups framed PED use as a means of identity construction, emotional survival, and social validation. Participants did not perceive themselves as deviant but as strategic actors navigating a performance-driven culture. Conclusions: PED use among youth in urban Türkiye emerges as a psychologically embedded coping mechanism rooted in emotional regulation, self-concept, and perceived control. Rather than a deviant behavior, it reflects an adaptive but precarious strategy for managing insecurity and achieving recognition during a critical developmental stage. Full article

The COVID-19 pandemic imposed unprecedented restrictions on movement and daily life, testing the resilience and adaptability of existing housing stock, as families worldwide were forced to adapt their homes into multifunctional environments. In New Zealand, where lockdowns were among the most stringent globally, homes rapidly transformed into workplaces, schools, gyms, and places of refuge. Little is known about how these adaptations affected the sustainability of homes and occupants’ well-being, particularly in the context of future crises. This study examined the economic, environmental, and psychosocial impact of the COVID-19 lockdown on New Zealand households. A questionnaire survey was conducted, and a quantitative analysis method was employed using survey data from 92 valid responses from New Zealand respondents who experienced lockdowns in various types of housing. To find important patterns and connections, descriptive and inferential statistical analyses were conducted. Findings revealed that economic factors had the strongest influence on respondents’ perceived experience during the COVID-19 lockdown, with households reporting increased electricity and water use but reduced fuel costs. Environmental factors were also significant, with respondents noting the importance of fresh air, sunlight, acoustic privacy, and more spacious rooms, alongside the critical need for a dedicated workspace. Psychosocial effects included higher distraction levels, monotony, and heightened concern for health. Group differences highlighted the influence of age and the number of bedrooms on the perceived experience of lockdown. This pilot work offers a New Zealand perspective on the intersection of the pandemic with the sustainability of homes. The practical implications of this study highlight the need for sustainable housing retrofits, hybrid work policies that support ergonomic and acoustically adequate home offices, and demographic-sensitive interventions to enhance resilience and occupant well-being in future crises. Full article

Background: The high-intensity demands of CrossFit induce respiratory muscle fatigue, potentially impairing performance via the metaboreflex. Respiratory muscle training (RMT) may mitigate this effect, but evidence in female athletes remains limited. Objective: We aimed to investigate the effects of RMT on sport-specific performance and maximal inspiratory pressure (PIMAX) in recreational female CrossFit practitioners. Design: We conducted a parallel-group randomized controlled trial. Setting: The study was conducted in a CrossFit-affiliated gym. Participants: We recruited twenty-nine recreational female practitioners (age: 30.3 ± 7.9 years) with ≥1 year of uninterrupted training who were free from respiratory diseases. Interventions: Participants were randomized to a CrossFit-only group (n = 14) or CrossFit + RMT group (n = 15). Both trained 5 days/week for 6 weeks; the RMT group additionally performed 30 inspiratory efforts at 50% of PIMAX, 5 days/week, with weekly load adjustment. Main Outcome Measures: Primary: Sport-specific performance (total repetitions in a 10-min AMRAP [As Many Rounds As Possible] test). Secondary: PIMAX (cmH₂O). Measurements were taken pre- and post-intervention. Results: Baseline performance and PIMAX were similar between groups. After 6 weeks, the CrossFit + RMT group improved in performance more (Δ = +10.5 ± 10.7 reps, p = 0.03, ηp² = 0.168) than the CrossFit-only group (Δ = +2.3 ± 8.1). PIMAX gains were also greater with RMT (Δ = +19.6 ± 8.4 cmH₂O, p = 0.043, ηp² = 0.148) vs. control (Δ = +10.1 ± 9.7). No adverse events occurred. Conclusions: Adding RMT to CrossFit training enhanced sport-specific performance and inspiratory strength in recreational female practitioners more than CrossFit alone. RMT appears to be a safe and effective complementary strategy for high-intensity functional training. Full article