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Keywords = global assessment

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12 pages, 1187 KB  
Article
Assessment of Sunshine Duration for Various Time Resolutions Based on Pyranometric Data (An Example from Temperate Transition Climate of Central Europe)
by Krzysztof Błażejczyk, Jarosław Baranowski and Anna Błażejczyk
Atmosphere 2026, 17(1), 83; https://doi.org/10.3390/atmos17010083 - 14 Jan 2026
Abstract
Sunshine duration (SD) is one of the essential meteorological variables. It represents the sum of time for which direct solar radiation with an intensity above 120 W∙m−2 reaches the Earth’s surface. In the contemporary observational routine, automatic electronic devices are [...] Read more.
Sunshine duration (SD) is one of the essential meteorological variables. It represents the sum of time for which direct solar radiation with an intensity above 120 W∙m−2 reaches the Earth’s surface. In the contemporary observational routine, automatic electronic devices are in use. The pyranometric method based on the measurements of global solar radiation measurements (Kglob) is also proposed by WMO to assess SD. The aim of the paper is to study the accuracy of the Slob–Monna method (SD-WMO), recommended by WMO to calculate sunshine duration. Alternatively, the author’s method, which is based on the Ångström clearness index (SD-ACI), was used to approximate SD. In this purpose, two years series of SD and Kglob observations at four locations in Poland (well representing Central European transitional climate zone) were analyzed. The result shows that, for SD-WMO, sunshine duration values are on average 16% higher than observed ones. For the SD-ACI method, they are only 5% higher. When verifying the accuracy of SD-WMO and SD-ACI approximations, we have found that both for daily and monthly periods the calculated SD sums are closer to the observed ones in the case of SD-ACI than for the SD-WMO method. The correlation coefficients are, respectively, 0.98 and 0.82 (for daily sums) as well as 0.99 and 0.88 for monthly sums. Full article
(This article belongs to the Section Meteorology)
17 pages, 1325 KB  
Article
Shifts in Composition, Origin, and Distribution of Invasive Alien Plants in Guangxi, China, over 50 Years
by Jia Kong, Cong Hu, Yadong Qie, Chaohao Xu, Aihua Wang, Zhonghua Zhang and Gang Hu
Diversity 2026, 18(1), 44; https://doi.org/10.3390/d18010044 - 14 Jan 2026
Abstract
Invasions by alien plants are major global drivers of ecosystem changes and loss of biodiversity. Guangxi is an ecological barrier in southern China that is increasingly being affected by invasive alien plant species. We comprehensively reviewed the literature, compiling and analyzing the long-term [...] Read more.
Invasions by alien plants are major global drivers of ecosystem changes and loss of biodiversity. Guangxi is an ecological barrier in southern China that is increasingly being affected by invasive alien plant species. We comprehensively reviewed the literature, compiling and analyzing the long-term changes in species composition, native range, life forms, municipal-scale patterns, and correlates of invasive alien plant richness in Guangxi at three time points (1973, 2010, and 2023). Over the 50-year period, the number of invasive alien plant species markedly increased from 31 species in 1973 to 84 in 2010 and 158 in 2023; the number of families, genera, and species increased 2.05-, 3.75-, and 5.10-fold, respectively. Species native to North America consistently dominated the invasive flora, followed by those native to Africa. The number of species native to South America and Asia increased in the records from 2010 to 2023. Annual herbaceous plants accounted for the largest proportion of invasive species throughout the study period and showed the largest absolute increase in species number. However, no substantial temporal shifts in the overall life-form composition were detected. At the municipal scale, the invasive alien plant richness exhibited pronounced spatial heterogeneity. The invasive alien plant richness was highest in Guilin and Baise in 1973, in Guilin in 2023, followed by Nanning and Baise. Correlation analyses based on 2023 data revealed a significant positive association between invasive alien plant richness and tourism intensity, whereas relationships between population size, gross domestic product, and climatic variables were weak or nonsignificant. Overall, our results document the continued expansion and the spatial differentiation of invasive alien plants in Guangxi over the 50-year period of 1973–2023. These patterns primarily reflect the accumulation in the number of recorded invasive species under a consistent classification framework and should be interpreted with caution given the potential variation in survey effort among periods and cities. The results provide a descriptive baseline for the provincial-scale monitoring, risk assessment, and management of invasive alien plants. Full article
(This article belongs to the Special Issue Ecology, Distribution, Impacts, and Management of Invasive Plants)
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41 pages, 2683 KB  
Article
Multilevel Governance of Urban Climate Adaptation in the European Union: An Overview
by Grazia Brunetta and Martina Caputo
Urban Sci. 2026, 10(1), 50; https://doi.org/10.3390/urbansci10010050 - 14 Jan 2026
Abstract
Europe is warming faster than the global average, making climate change adaptation a central concern for urban policy and planning. This article develops and applies an analytical framework to assess the maturity of multilevel adaptation governance across European Union Member States as of [...] Read more.
Europe is warming faster than the global average, making climate change adaptation a central concern for urban policy and planning. This article develops and applies an analytical framework to assess the maturity of multilevel adaptation governance across European Union Member States as of 2025. Governance is operationalised through eight dimensions: (i) National Adaptation Strategies/Plans; (ii) Regional Adaptation Plans; (iii) Local Adaptation Plans; (iv) Sectoral Adaptation Plans; (v) integration in National Urban Policies; (vi) adaptive content in Long-Term Strategies; (vii) adaptation relevance in climate laws; and (viii) participation in the Covenant of Mayors. The results reveal pronounced heterogeneity: many Member States have up-to-date national strategies but display incomplete territorial diffusion, weak legal anchoring, or limited urban policy standards. By linking auditable rules to urban-facing instruments, this study offers a practical tool for benchmarking governance capacities, prioritising reforms, and tracking progress towards integrated, multilevel adaptation systems that support resilient urban development across the European Union. Full article
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19 pages, 2175 KB  
Article
Hydrological Changes Drive the Seasonal Vegetation Carbon Storage of the Poyang Lake Floodplain Wetland
by Zili Yang, Shaoxia Xia, Houlang Duan and Xiubo Yu
Remote Sens. 2026, 18(2), 276; https://doi.org/10.3390/rs18020276 - 14 Jan 2026
Abstract
Wetlands are a critical component of the global biogeochemical cycle and have great potential for carbon sequestration under the changing climate. However, previous studies have mainly focused on the dynamics of soil organic carbon while paying little attention to the vegetation carbon storage [...] Read more.
Wetlands are a critical component of the global biogeochemical cycle and have great potential for carbon sequestration under the changing climate. However, previous studies have mainly focused on the dynamics of soil organic carbon while paying little attention to the vegetation carbon storage in wetlands. Poyang Lake is the largest freshwater lake in China, where intra-annual and inter-annual variations in water levels significantly affect the vegetation carbon storage in the floodplain wetland. Therefore, we assessed the seasonal distribution and carbon storage of six typical plant communities (Arundinella hirta, Carex cinerascens, Miscanthus lutarioriparius, Persicaria hydropiper, Phalaris arundinacea, and Phragmites australis) in Poyang Lake wetlands from 2019 to 2024 based on field surveys, the literature, and remote sensing data. Then, we used 16 preseason meteorological and hydrological variables for two growing seasons to investigate the impacts of environmental factors on vegetation carbon storage based on four correlation and regression methods (including Pearson and partial correlation, ridge, and elastic net regression). The results show that the C. cinerascens community was the most dominant contributor to vegetation carbon storage, occupying 12.68% to 44.22% of the Poyang Lake wetland area. The vegetation carbon storage in the Poyang Lake wetland was significantly (p < 0.01) higher in spring (87.75 × 104 t to 239.10 × 104 t) than in autumn (77.32 × 104 t to 154.78 × 104 t). Water body area emerged as a key explanatory factor, as it directly constrains the spatial extent available for vegetation colonization and growth by alternating inundation and exposure. In addition, an earlier start or end to floods could both enhance vegetation carbon storage in spring or autumn. However, preseason precipitation and temperature are negative to carbon storage in spring but exhibited opposite effects in autumn. These results assessed the seasonal dynamics of dominant vegetation communities and helped understand the response of the wetland carbon cycle under the changing climate. Full article
14 pages, 2186 KB  
Article
An LMDI-Based Analysis of Carbon Emission Changes in China’s Fishery and Aquatic Processing Sector: Implications for Sustainable Risk Assessment and Hazard Mitigation
by Tong Li, Sikai Xie, N.A.K. Nandasena, Junming Chen and Cheng Chen
Sustainability 2026, 18(2), 860; https://doi.org/10.3390/su18020860 - 14 Jan 2026
Abstract
To align with disaster monitoring and sustainable risk assessment, the low-carbon transition of fisheries necessitates comprehensive carbon emission management throughout the supply chain. As China advances supply-side structural reform, transitioning from traditional to low-carbon fisheries is vital for the green development of the [...] Read more.
To align with disaster monitoring and sustainable risk assessment, the low-carbon transition of fisheries necessitates comprehensive carbon emission management throughout the supply chain. As China advances supply-side structural reform, transitioning from traditional to low-carbon fisheries is vital for the green development of the industry and its associated sectors. This study employs input–output models and LMDI decomposition to examine the trends and drivers of embodied carbon emissions within China’s fishery production system from 2010 to 2019. By constructing a cross-sectoral full-emission accounting system, the research calculates total direct and indirect emissions, exploring how accounting scopes influence regional responsibility and reduction strategies. Empirical results indicate that while China’s aquatic trade and processing have steadily developed, the sector remains dominated by low-value-added primary products. This structure highlights vast potential for deep processing development amidst shifting global dietary habits. Factor decomposition reveals that economic and technological development are the primary drivers of carbon emissions. Notably, technological progress within fisheries emerges as the most significant factor, playing a pivotal role in both driving and potentially mitigating emissions. Consequently, to effectively lower carbon intensity, the study concludes that restructuring the fishery industry is crucial. Promoting low-carbon development and enhancing the R&D of green technologies are essential strategies to navigate the dual challenges of industrial upgrading and environmental protection. Full article
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19 pages, 813 KB  
Review
Maca (Lepidium meyenii) as a Functional Food and Dietary Supplement: A Review on Analytical Studies
by Andreas Wasilewicz and Ulrike Grienke
Foods 2026, 15(2), 306; https://doi.org/10.3390/foods15020306 - 14 Jan 2026
Abstract
Maca (Lepidium meyenii Walp.), a Brassicaceae species native to the high Andes of Peru, has gained global attention as a functional food and herbal medicinal product due to its endocrine-modulating, fertility-enhancing, and neuroprotective properties. Although numerous studies have addressed its biological effects, [...] Read more.
Maca (Lepidium meyenii Walp.), a Brassicaceae species native to the high Andes of Peru, has gained global attention as a functional food and herbal medicinal product due to its endocrine-modulating, fertility-enhancing, and neuroprotective properties. Although numerous studies have addressed its biological effects, a systematic and up-to-date summary of its chemical constituents and analytical methodologies is lacking. This review aims to provide a critical overview of the chemical constituents of L. meyenii and to evaluate analytical studies published between 2000 and 2025, focusing on recent advances in extraction strategies and qualitative and quantitative analytical techniques for quality control. Major compound classes include macamides, macaenes, glucosinolates, and alkaloids, each contributing to maca’s multifaceted activity. Ultra-(high-)performance liquid chromatography (U(H)PLC), often coupled with ultraviolet, diode array, or mass spectrometric detection, is the primary and most robust analytical platform due to its sensitivity, selectivity, and throughput, while ultrasound-assisted extraction improves efficiency and reproducibility. Emerging techniques such as metabolomics and chemometric approaches enhance quality control by enabling holistic, multivariate assessment of complex systems and early detection of variations not captured by traditional univariate methods. As such, they provide complementary, predictive, and more representative insights into maca’s phytochemical complexity. The novelty of this review lies in its integration of conventional targeted analysis with emerging approaches, comprehensive comparison of analytical workflows, and critical discussion of variability related to phenotype, geographic origin, and post-harvest processing. By emphasizing analytical standardization and quality assessment rather than biological activity alone, this review provides a framework for quality control, authentication, and safety evaluation of L. meyenii as a functional food and dietary supplement. Full article
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22 pages, 1376 KB  
Article
Stability-Driven Osteoporosis Screening: Multi-View Consensus Feature Selection with External Validation and Sensitivity Analysis
by Waragunt Woratamrongpatai, Watcharaporn Cholamjiak, Nontawat Eiamniran and Phatcharapon Udomluck
J. Clin. Med. 2026, 15(2), 677; https://doi.org/10.3390/jcm15020677 - 14 Jan 2026
Abstract
Background/Objectives: Osteoporosis is a major global health concern, and early risk assessment plays a crucial role in fracture prevention. Although demographic, clinical, and lifestyle factors are commonly incorporated into screening tools, their relative importance within data-driven prediction frameworks can vary substantially across datasets. [...] Read more.
Background/Objectives: Osteoporosis is a major global health concern, and early risk assessment plays a crucial role in fracture prevention. Although demographic, clinical, and lifestyle factors are commonly incorporated into screening tools, their relative importance within data-driven prediction frameworks can vary substantially across datasets. Rather than aiming to identify novel predictors, this study evaluates the stability and behavior of established osteoporosis risk factors using statistical inference and machine learning-based feature selection methods across heterogeneous data sources. We further examine whether simplified and near-minimal models can achieve predictive performances comparable to that of full-feature configurations. Methods: An open-access Kaggle dataset (n = 1958) and a retrospective clinical dataset from the University of Phayao Hospital (n = 176) were analyzed. Feature relevance was assessed using logistic regression, likelihood ratio testing, MRMR, ReliefF, and unified importance scoring. Multiple predictor configurations, ranging from full-feature to minimal and near-minimal models, were evaluated using decision tree, support vector machine, k-nearest neighbor, naïve Bayes, and efficient linear classifiers. External validation was performed using hospital-based records. Results: Across all analyses, age consistently emerged as the dominant predictor, followed by corticosteroid use, while other variables showed limited incremental predictive contributions. Simplified models based on age alone or age combined with medication-related variables achieved performances comparable to full-feature models (accuracy ≈91% and AUC ≈ 0.95). In addition, near-minimal models incorporating gender alongside age and medications demonstrated a favorable balance between discrimination and computational efficiency under external validation. Although overall performance declined under distributional shift, naïve Bayes and efficient linear classifiers showed the most stable external behavior (AUC = 0.728–0.787). Conclusions: These findings indicate that stability-driven feature selection primarily reproduces well-established epidemiological risk patterns rather than identifying novel predictors. Minimal and near-minimal models—including those incorporating gender—retain acceptable performances under external validation and are methodologically efficient. Given the limited size and single-center nature of the external cohort, the results should be interpreted as preliminary methodological evidence rather than definitive support for clinical screening deployment. Further multi-center studies are required to assess generalizability and clinical relevance. Full article
(This article belongs to the Special Issue Accelerating Fracture Healing: Clinical Diagnosis and Treatment)
22 pages, 3418 KB  
Article
LGSTA-GNN: A Local-Global Spatiotemporal Attention Graph Neural Network for Bridge Structural Damage Detection
by Die Liu, Jianxi Yang, Jianming Li, Jingyuan Shen, Youjia Zhang, Lihua Chen and Lei Zhou
Buildings 2026, 16(2), 348; https://doi.org/10.3390/buildings16020348 - 14 Jan 2026
Abstract
Accurate detection of structural damage is essential for ensuring the safety and reliability of bridges. However, traditional vibration-based approaches often struggle to capture rich feature representations and adequately model spatial dependencies among sensors. This study proposes a novel bridge damage detection framework, LGSTA-GNN, [...] Read more.
Accurate detection of structural damage is essential for ensuring the safety and reliability of bridges. However, traditional vibration-based approaches often struggle to capture rich feature representations and adequately model spatial dependencies among sensors. This study proposes a novel bridge damage detection framework, LGSTA-GNN, which integrates local–global spatiotemporal learning with graph neural networks. The framework first extracts multi-scale temporal–frequency features using a multi-scale feature extraction module. A local graph feature extraction module then models intrinsic spatial relationships through graph convolutions, while a global graph attention module adaptively captures inter-sensor dependencies by emphasizing structurally informative nodes. A benchmark dataset generated from a scaled bridge model under progressive damage states is used to evaluate the proposed method. Extensive experiments demonstrate that LGSTA-GNN outperforms multiple graph neural network variants and conventional deep learning techniques, achieving superior accuracy, precision, recall, and F1-score. The confusion matrix and t-SNE visualization further verify its enhanced discriminative capability and robustness. Ablation studies confirm the contribution of each module, highlighting the effectiveness of global attention in identifying subtle structural deterioration. Overall, LGSTA-GNN provides an effective and interpretable solution for intelligent bridge damage detection, with strong potential for practical structural health monitoring and real-time safety assessment. Full article
(This article belongs to the Special Issue Research in Structural Control and Monitoring)
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13 pages, 639 KB  
Article
Fracture Occurrence Within FRAX-Defined High-Risk Myasthenia Gravis: An Exploratory Stratification by Age and Activities of Daily Living
by Takafumi Uchi and Shingo Konno
J. Clin. Med. 2026, 15(2), 672; https://doi.org/10.3390/jcm15020672 - 14 Jan 2026
Abstract
Background/Objectives: Patients with myasthenia gravis (MG) are at increased risk of osteoporotic fractures due to long-term oral corticosteroid use and disease-related muscle weakness. FRAX® estimates 10-year fracture probability but does not incorporate falls or MG-specific functional impairment. To explore heterogeneity of [...] Read more.
Background/Objectives: Patients with myasthenia gravis (MG) are at increased risk of osteoporotic fractures due to long-term oral corticosteroid use and disease-related muscle weakness. FRAX® estimates 10-year fracture probability but does not incorporate falls or MG-specific functional impairment. To explore heterogeneity of fracture occurrence within MG patients classified as high risk by FRAX major osteoporotic fracture (MOF) probability. Methods: In a single-center retrospective cohort of 68 MG patients assessed in 2012, FRAX MOF with femoral neck BMD was calculable in 54 patients; the 29 patients with FRAX MOF ≥ 9.0% (the median of these 54 patients) comprised the high-FRAX cohort. Patients were stratified by the cohort medians of age (67 years) and MG-ADL (2 points) into four strata (HH, HL, LH, LL). This median-based stratification was exploratory and not intended as a clinically meaningful threshold. The primary outcome was time to first MOF (up to 10 years). We compared fracture occurrence using both proportions and Kaplan–Meier analyses (log-rank test) and performed exploratory univariable Cox models for selected predictors. No multivariable confounder adjustment was performed. Results: Eight of twenty-nine patients (27.6%) experienced an MOF. The proportions with MOF were HH 25.0%, HL 40.0%, LH 57.1%, and LL 0.0% (global p = 0.068). Kaplan–Meier curves differed across strata (log-rank p = 0.03), with separation most evident between LH and LL. For univariable Cox analyses, age was associated with shorter time to MOF (hazard ratio [HR] 1.13 per year, p = 0.041), and baseline difficulty rising from a chair (MG-ADL item) was associated with higher hazard rates (HR 3.45, p = 0.048). Conclusions: In this small, selected high-FRAX MG cohort, fracture events appeared to cluster in patients with impaired ADL and fall-related MG-ADL abnormalities, whereas FRAX values remained strongly age-driven. These findings are exploratory and hypothesis-generating and should not be interpreted as evidence of FRAX miscalibration; confirmation in larger, prospectively followed cohorts is needed. Full article
(This article belongs to the Section Clinical Neurology)
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31 pages, 3908 KB  
Article
A Multi-Temporal Sentinel-2 and Machine Learning Approach for Precision Burned Area Mapping: The Sardinia Case Study
by Claudia Collu, Dario Simonetti, Francesco Dessì, Marco Casu, Costantino Pala and Maria Teresa Melis
Remote Sens. 2026, 18(2), 267; https://doi.org/10.3390/rs18020267 - 14 Jan 2026
Abstract
The escalating threat of wildfires under global climate change necessitates rigorous monitoring to mitigate environmental and socio-economic risks. Burned area (BA) mapping is crucial for understanding fire dynamics, assessing ecosystem impacts, and supporting sustainable land management under increasing fire frequency. This study aims [...] Read more.
The escalating threat of wildfires under global climate change necessitates rigorous monitoring to mitigate environmental and socio-economic risks. Burned area (BA) mapping is crucial for understanding fire dynamics, assessing ecosystem impacts, and supporting sustainable land management under increasing fire frequency. This study aims to develop a high-resolution detection framework specifically calibrated for Mediterranean environmental conditions, ensuring the production of consistent and accurate annual BA maps. Using Sentinel-2 MSI time series over Sardinia (Italy), the research objectives were to: (i) integrate field surveys with high-resolution photointerpretation to build a robust, locally tuned training dataset; (ii) evaluate the discriminative power of multi-temporal spectral indices; and (iii) implement a Random Forest classifier capable of providing higher spatial precision than current operational products. Validation results show a Dice Coefficient (DC) of 91.8%, significantly outperforming the EFFIS Burnt Area product (DC = 79.9%). The approach proved particularly effective in detecting small and rapidly recovering fires, often underrepresented in existing datasets. While inaccuracies persist due to cloud cover and landscape heterogeneity, this study demonstrates the effectiveness of a machine learning approach for long-term monitoring, for generating multi-year wildfire inventories, offering a vital tool for data-driven forest policy, vegetation recovery assessment and land-use change analysis in fire-prone regions. Full article
24 pages, 617 KB  
Systematic Review
Effects of Pulmonary Rehabilitation on Dyspnea, Quality of Life and Cognitive Function in COPD: A Systematic Review
by Alessandro Vatrella, Angelantonio Maglio, Maria Pia Di Palo, Elisa Anna Contursi, Angelo Francesco Buscetto, Noemi Cafà, Marina Garofano, Rosaria Del Sorbo, Placido Bramanti, Colomba Pessolano, Andrea Marino, Mariaconsiglia Calabrese and Alessia Bramanti
J. Clin. Med. 2026, 15(2), 670; https://doi.org/10.3390/jcm15020670 - 14 Jan 2026
Abstract
Background/Objectives: Chronic Obstructive Pulmonary Disease (COPD) is frequently associated with dyspnea, impaired health-related quality of life (HRQoL), and cognitive dysfunction. Although pulmonary rehabilitation (PR) is considered a core therapeutic strategy, its specific effects on cognitive function, dyspnea, and dysphonia remain unclear. This systematic [...] Read more.
Background/Objectives: Chronic Obstructive Pulmonary Disease (COPD) is frequently associated with dyspnea, impaired health-related quality of life (HRQoL), and cognitive dysfunction. Although pulmonary rehabilitation (PR) is considered a core therapeutic strategy, its specific effects on cognitive function, dyspnea, and dysphonia remain unclear. This systematic review aimed to evaluate the impact of PR and respiratory or cognitive-focused rehabilitative interventions on dyspnea, quality of life, cognitive performance, and voice outcomes in adults with COPD. Methods: This review was conducted in accordance with PRISMA 2020 guidelines and registered in PROSPERO (CRD420251131325). A systematic search of PubMed, Scopus and Web of Science identified studies published between 2010 and 21 August 2025. Eligible designs included randomized and non-randomized controlled studies, cohort, and mixed-method studies involving adults with COPD undergoing rehabilitative interventions targeting dyspnea, cognition, dysphonia, or swallowing. Outcomes included cognitive measures, dyspnea scales, voice parameters, and HRQoL indices. Results: Twelve studies (n ≈ 810 participants) met inclusion criteria. Most PR and exercise-based programs showed improvements in global cognition and executive functions, particularly when combined with cognitive training or high-intensity exercise modalities. Dyspnea improved consistently following short- to medium-term PR or respiratory muscle training, whereas low-frequency long-term programs yielded limited benefit. HRQoL improved across structured PR programs, especially in multidimensional interventions. Only one study assessed dysphonia, reporting transient improvements in maximum phonation time following inspiratory muscle training. No included study evaluated dysphagia-related outcomes. Conclusions: PR and respiratory muscle training can enhance cognition, dyspnea, and HRQoL in COPD, although evidence for dysphonia remains scarce and dysphagia is entirely unaddressed. Future high-quality trials should adopt standardized outcome measures, include long-term follow-up, and integrate voice and swallowing assessments within PR pathways. Full article
(This article belongs to the Section Respiratory Medicine)
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24 pages, 8070 KB  
Article
Research on Ecological Compensation in the Yangtze River Economic Belt Based on Water-Energy-Food Service Flows and XGBoost-SHAP Analysis
by Hao Wang, Jianshen Qu, Weidong Zhang, Peizhen Zhu, Ruoqing Zhu, Yuexia Han, Yong Cao and Bin Dong
Sustainability 2026, 18(2), 839; https://doi.org/10.3390/su18020839 - 14 Jan 2026
Abstract
Under the combined influence of global climate change and intensified human activities, quantifying ecological compensation (EC) amounts between regions and formulating scientifically sound and rational policies have become critical strategies for addressing the imbalance between economic development and ecological conservation. This study focuses [...] Read more.
Under the combined influence of global climate change and intensified human activities, quantifying ecological compensation (EC) amounts between regions and formulating scientifically sound and rational policies have become critical strategies for addressing the imbalance between economic development and ecological conservation. This study focuses on the Yangtze River Economic Belt (YREB) as the research subject, assesses ecosystem service supply and demand (ESSD) in the years 2000, 2010, and 2020 from the perspective of the water-energy-food nexus (WEF-Nexus), identifies ecosystem service flows (ESF) between supply and demand areas, develops an integrated EC model incorporating ecological, economic, and social dimensions to estimate EC amounts, and ultimately employs the XGBoost-SHAP model to analyze the underlying driving mechanisms. The results indicate the following: (1) From 2000 to 2020, the spatio-temporal variations in the three ESSDs in the YREB were substantial. Additionally, imbalances in ESSDs were observed, predominantly in economically advanced regions. (2) A total of 183 ESFs were identified among cities within the YREB, reflecting relatively active exchanges of ecosystem services (ESs). (3) Over the past two decades, the average annual total EC of the YREB amounted to 46,866.35 million yuan, with EC capital flows occurring in 117 cities. The proportion of water area in each city constitutes the primary driver of the EC amount. The EC model based on the “water-energy-food” ecosystem service flow (WEF-ESF) proposed in this study provides a valuable reference and scientific basis for formulating EC policies among YREB cities. Full article
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15 pages, 3927 KB  
Article
Leaflet Lengths and Commissural Dimensions as the Primary Determinants of Orifice Area in Mitral Regurgitation: A Sobol Sensitivity Analysis
by Ashkan Bagherzadeh, Vahid Keshavarzzadeh, Patrick Hoang, Steve Kreuzer, Jiang Yao, Lik Chuan Lee, Ghassan S. Kassab and Julius Guccione
Bioengineering 2026, 13(1), 97; https://doi.org/10.3390/bioengineering13010097 - 14 Jan 2026
Abstract
Mitral valve orifice area is a key functional metric that depends on complex geometric features, motivating a systematic assessment of the relative influence of these parameters. In this study, the mitral valve geometry is parameterized using twelve geometric variables, and a global sensitivity [...] Read more.
Mitral valve orifice area is a key functional metric that depends on complex geometric features, motivating a systematic assessment of the relative influence of these parameters. In this study, the mitral valve geometry is parameterized using twelve geometric variables, and a global sensitivity analysis based on Sobol indices is performed to quantify their relative importance. Because global sensitivity analysis requires many simulations, a Gaussian Process regressor is developed to efficiently predict the orifice area from the geometric inputs. Structural simulations of the mitral valve are carried out in Abaqus, focusing exclusively on the valve mechanics. The predicted distribution of orifice areas obtained from the Gaussian Process shows strong agreement with the ground-truth simulation results, and similar agreement is observed when only the most influential geometric parameters are varied. The analysis identifies a subset of geometric parameters that dominantly govern the mitral valve orifice area and can be reliably extracted from medical imaging modalities such as echocardiography. These findings establish a direct link between echocardiographic measurements and physics-based simulations and provide a framework for patient-specific assessment of mitral valve mechanics, with potential applications in guiding interventional strategies such as MitraClip placement. Full article
(This article belongs to the Section Biomedical Engineering and Biomaterials)
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18 pages, 306 KB  
Article
Hypermethylation of OPRM1: Deregulation of the Endogenous Opioid Pathway in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia
by Arne Wyns, Jolien Hendrix, Jente Van Campenhout, Yanthe Buntinx, Huan-Yu Xiong, Elke De Bruyne, Lode Godderis, Jo Nijs, David Rice, Daniel Chiang and Andrea Polli
Int. J. Mol. Sci. 2026, 27(2), 826; https://doi.org/10.3390/ijms27020826 - 14 Jan 2026
Abstract
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and fibromyalgia (FM) are debilitating disorders with overlapping symptoms such as chronic pain and fatigue. Dysregulation of the endogenous opioid system, particularly µ-opioid receptor function, may contribute to their pathophysiology. This study examined whether epigenetic modifications, specifically µ-opioid [...] Read more.
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and fibromyalgia (FM) are debilitating disorders with overlapping symptoms such as chronic pain and fatigue. Dysregulation of the endogenous opioid system, particularly µ-opioid receptor function, may contribute to their pathophysiology. This study examined whether epigenetic modifications, specifically µ-opioid receptor 1 gene (OPRM1) promoter methylation, play a role in this dysfunction. Using a repeated-measures design, 28 ME/CFS/FM patients and 26 matched healthy controls visited the hospital twice within four days. Assessments included blood sampling for epigenetic analysis, a clinical questionnaire battery, and quantitative sensory testing (QST). Global DNA (hydroxy)methylation was quantified via liquid chromatography–tandem mass spectrometry, and targeted pyrosequencing was performed on promoter regions of OPRM1, COMT, and BDNF. ME/CFS/FM patients reported significantly worse symptom outcomes. No differences in global (hydroxy)methylation were found. Patients showed significantly higher OPRM1 promoter methylation, which remained after adjusting for symptom severity and QST findings. Across timepoints, OPRM1 methylation consistently correlated with BDNF Promoter I and Exon III methylation. This is, to the best of our knowledge, the first study examining OPRM1 methylation in ME/CFS/FM. Increased OPRM1 methylation in patients, independent of symptoms or pain sensitivity measures, supports the hypothesis of dysregulated opioidergic signaling in these conditions. Full article
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
38 pages, 12112 KB  
Article
Enhanced Educational Optimization Algorithm Based on Student Psychology for Global Optimization Problems and Real Problems
by Wenyu Miao, Katherine Lin Shu and Xiao Yang
Biomimetics 2026, 11(1), 70; https://doi.org/10.3390/biomimetics11010070 - 14 Jan 2026
Abstract
To address the insufficient exploration ability, susceptibility to local optima, and limited convergence accuracy of the standard Student Psychology-Based Optimization (SPBO) algorithm in three-dimensional UAV trajectory planning, we propose an enhanced variant, Enhanced SPBO (ESPBO). ESPBO augments SPBO with three complementary strategies: (i) [...] Read more.
To address the insufficient exploration ability, susceptibility to local optima, and limited convergence accuracy of the standard Student Psychology-Based Optimization (SPBO) algorithm in three-dimensional UAV trajectory planning, we propose an enhanced variant, Enhanced SPBO (ESPBO). ESPBO augments SPBO with three complementary strategies: (i) Time-Adaptive Scheduling, which uses normalized time (τ=t/T) to schedule global step-size shrinking, Gaussian fine-tuning, and Lévy flight intensity, enabling strong early exploration and fine late-stage exploitation; (ii) Mentor Pool Guidance, which selects a top-K mentor set and applies time-varying guidance weights to reduce misleading attraction and improve directional stability; and (iii) Directional Jump Exploration, which couples a differential vector with Lévy flights to strengthen basin-crossing while keeping the differential step bounded for robustness. Numerical experiments on CEC2017, CEC2020 and CEC2022 benchmark functions compare ESPBO with Grey Wolf Optimization (GWO), Whale Optimization Algorithm (WOA), Improved multi-strategy adaptive Grey Wolf Optimization (IAGWO), Dung Beetle Optimization (DBO), Snake Optimization (SO), Rime Optimization (RIME), and the original SPBO. We evaluate best path length, mean trajectory length, standard deviation, and convergence curves and assess statistical stability via Wilcoxon rank-sum tests (p = 0.05) and the Friedman test. ESPBO significantly outperforms the comparison algorithms in path-planning accuracy and convergence stability, ranking first on both test suites. Applied to 3D UAV trajectory planning in mountainous terrain with no-fly zones, ESPBO achieves an optimal path length of 199.8874 m, an average path length of 205.8179 m, and a standard deviation of 5.3440, surpassing all baselines; notably, ESPBO’s average path length is even lower than the optimal path length of other algorithms. These results demonstrate that ESPBO provides an efficient and robust solution for UAV trajectory optimization in intricate environments and extends the application of swarm intelligence algorithms in autonomous navigation. Full article
(This article belongs to the Special Issue Exploration of Bio-Inspired Computing: 2nd Edition)
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