Search Results (212)

Background: Early mobilization with permission for full weight bearing is a cornerstone of postoperative care after proximal femoral fractures (PFFs). However, its biomechanical implementation during gait remains unclear. Clinical scores such as the Charlson Comorbidity Index (CCI) and the American Society of Anesthesiologists (ASA) classification describe comorbidity burden, but their relationship with actual weight bearing and functional outcome regarding activities associated with daily living is insufficiently understood. Methods: In this prospective cohort study, patients aged > 65 years treated surgically for femoral neck fractures (FNFs) or trochanteric femoral fractures (TFFs) were included. Postoperative weight bearing was assessed after 4 to 7 days using sensor-based insoles. Average peak force of the operated limb, normalized to body weight, was the primary outcome. Associations with postoperative weight bearing and functional outcome were analyzed using multivariable linear regression models. Results: Early postoperative weight bearing remained below recommended levels, with lower limb loading in TFFs. Higher CCI values were associated with increased loading in TFF patients, and higher ASA classifications with reduced loading. Higher postoperative Barthel Index (BI) was independently associated with increased limb loading. Postoperative BI was influenced by age, preoperative BI, and fracture type. Conclusions: Despite permission for full weight bearing, early postoperative limb loading after PFF remains below recommended levels, particularly in TFFs. CCI and ASA show fracture type-specific associations with actual weight bearing, whereas BI is independent of ASA and CCI. The BI may serve as a surrogate parameter to identify patients at risk of insufficient limb loading who may benefit from targeted physiotherapeutic interventions. Full article

Background: Euthyroid Sick Syndrome (ESS) is a clinical condition characterized by reduced free triiodothyronine (FT3) levels in response to acute or chronic stress. Proximal femur fractures in geriatric patients are associated with high morbidity and mortality rates and ESS may influence outcomes in this population. This study aimed to investigate the role of ESS as a predictor of complications in elderly patients with hip fractures, analyzing its association with inflammatory and nutritional markers, including the Monocyte-to-Lymphocyte Ratio (MLR), Controlling Nutritional Status (CONUT) score and Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) score. Materials and Methods: We conducted a single-center retrospective analysis of patients aged 65 and older who were admitted with proximal femur fractures requiring surgical intervention. Thyroid hormone profiles, inflammatory markers and other clinical variables were analyzed preoperatively (T0) and on the first (T1) and third (T2) postoperative days. Logistic regression was used to identify predictors of complications and transfusion requirements. Results: The study included 103 patients (72 men, 31 women; mean age 85 ± 6.27 years). ESS was present in 30 patients (29%) and was associated with longer surgery duration (83.9 ± 35.5 vs. 68.9 ± 21.3 min; p = 0.042). At admission (T0), ESS patients had lower FT3 (1.91 ± 0.25 vs. 2.75 ± 0.28 pmol/L; p < 0.001) and higher TSH (1.55 ± 0.75 vs. 1.20 ± 0.80 mIU/L; p = 0.057). Postoperatively, MLR was significantly altered at T1 (p = 0.026) and T2 (p = 0.040). ESS was a significant predictor of complications at T0 but lost significance postoperatively, while MLR emerged as a key predictor at T2 (p = 0.003). Logistic regression confirmed MLR at T2 as an independent predictor of complications. Hemoglobin levels at T0 (p < 0.001), T1 (p < 0.001), and T2 (p < 0.001), along with albumin at T1 (2.67 ± 0.34 vs. 2.94 ± 0.33 g/dL; p = 0.001) and calcium at T1 (p = 0.006), were significant predictors of transfusion requirements. Nutritional and inflammatory scores were not predictive. Conclusions: ESS is a significant initial predictor of complications in geriatric patients with hip fractures, but inflammatory markers such as MLR assume greater relevance in the postoperative period. These findings emphasize the importance of monitoring ESS and MLR to enhance risk stratification and guide personalized management strategies. Full article

Background: Managing elderly patients with simultaneous acute cardiovascular and orthopedic emergencies presents a unique challenge. While ST-elevation myocardial infarction (STEMI) requires prompt revascularization and dual antiplatelet therapy (DAPT), pertrochanteric femoral fractures usually necessitate early surgical fixation to reduce morbidity and mortality. However, the combination of these conditions complicates both standard treatment pathways. Case presentation: We present the case of an 86-year-old woman admitted after a low-energy fall, with a radiologically confirmed unstable pertrochanteric fracture of the right femur (AO/OTA 31-A2). Upon routine electrocardiogram, anterior STEMI with new-onset atrial fibrillation was diagnosed. Although asymptomatic from a cardiac perspective, bedside echocardiography revealed a severely reduced left ventricular ejection fraction of 10%. Urgent coronary angiography demonstrated a critical mid-left anterior descending lesion, successfully treated with rotational atherectomy, intravascular lithotripsy, and stent implantation. She was initiated on DAPT (aspirin + clopidogrel) and anticoagulated with low-molecular-weight heparin. Given the extremely high bleeding risk, surgical intervention for the femoral fracture was deemed unsafe. Instead, conservative management with skeletal traction (6 kg) was employed. Despite optimal supportive care and early rehabilitation, the patient experienced a complicated hospital course, including delirium, hematuria, and lower respiratory tract infection. She passed away 52 days post-admission. Conclusions: This case illustrates the complexity of clinical decision-making in geriatric patients with competing acute conditions. Current evidence on how to proceed in patients requiring both antithrombotic therapy and urgent orthopedic surgery is limited. Multidisciplinary teams must carefully weigh the risks and benefits of both surgical and conservative strategies. Further guidelines addressing such scenarios in elderly patients are urgently needed. Full article

Introduction: Falls and subsequent fractures represent a major public health concern among older adults. While fall prevention interventions have demonstrated efficacy in reducing falls, their impact on fracture outcomes remains unclear. Methods: We conducted a systematic review and meta-analysis following PRISMA 2020 guidelines. We searched multiple databases up to 7 June 2025 for studies investigating fall prevention interventions and fracture outcomes in community-dwelling older adults. A primary outcome was hip fractures; secondary outcomes included any fractures, falls, and serious fall injuries. Risk ratios (RRs) with 95% confidence intervals (CIs) were calculated, using random-effects meta-analysis where appropriate. Results: Seventeen studies were included, spanning over 25,000 participants. Interventions included exercise programs, multifactorial approaches, medication optimization, and vitamin D supplementation. For hip fractures, only two randomized controlled trials (RCTs) reported extractable outcome data (12,489 participants; 132 events); both showed non-significant reductions favoring intervention (RR 0.80–0.87), precluding pooled meta-analysis. For any fractures, five studies (18,519 participants; 1343 events) demonstrated no significant effect (RR 0.91, 95% CI 0.72–1.14; p-value = 0.40) with significant heterogeneity (I² = 65%). Fall prevention interventions significantly reduced falls across 14 studies. GRADE assessment indicated very low certainty for both hip fractures and any fractures due to limited studies, inconsistency, and imprecision. Conclusions: Current evidence suggests fall prevention interventions may reduce hip fractures but do not significantly prevent fractures overall. Despite consistent fall reduction, the translation to fracture prevention remains uncertain, highlighting the need for integrated interventions targeting both fall risk and bone health. Full article

Background/Objectives: Hip fractures among elderly patients are associated with significant morbidity and mortality. Delayed surgery is common and often results in inadequate pain control and increased opioid consumption, which may have adverse effects. This study evaluates the effectiveness of preoperative intra-articular injection of multimodal analgesics (IA MDI) for reducing pain caused by a displaced femoral neck fracture (FNF). Methods: A prospective randomized controlled trial was conducted using 18 geriatric patients with displaced FNFs scheduled for hip arthroplasty. The patients were randomized into two groups: IA MDI and control groups (n = 9 each). The IA MDI group was administered a preoperative intra-articular injection of ropivacaine, morphine, and adrenaline, in addition to standard oral and intravenous (IV) analgesics, while the control group was administered standard oral and IV analgesics alone. The primary outcome was the perioperative pain score assessed via the 10-point numerical rating scale (NRS). The secondary outcomes were morphine consumption, perioperative complications, length of hospital stay, and functional outcome. Results: During the first 24 h preoperative period after admission, the IA MDI group exhibited a significant reduction in the average NRS at all timepoints (p < 0.05 all) and in the median dosage of morphine consumption (0 mg vs. 6 mg, p = 0.033) compared to the control group. There was no significant difference between groups in terms of postoperative pain and complications, length of hospital stays, or functional outcomes (p > 0.05 all). Conclusions: Preoperative IA MDI significantly reduced pain intensity and opioid consumption during the preoperative 24 h window among elderly patients with FNFs without provoking a corresponding increase in observed complications in this pilot randomized controlled study. IA MDI is a feasible option and could be a useful adjunct for preoperative pain management for FNFs. Full article

Background: Osteoporosis is a prevalent metabolic bone disorder characterized by reduced bone mineral density (BMD) and increased fracture risk, particularly among older adults. While individual medications have been implicated in bone loss, the cumulative impact of polypharmacy on skeletal health remains underexplored. Methods: This cross-sectional study included 1155 geriatric inpatients undergoing routine bone mineral density assessment. Medication use, demographic characteristics, and clinical variables were extracted from electronic medical records. BMD at the lumbar spine (L1–L4) and total hip was measured using dual-energy X-ray absorptiometry (DXA). Unadjusted analyses and multivariable linear regression models were used to examine associations between medication use, polypharmacy (defined as the use of ≥5 medications), and BMD, adjusting for age, sex, body mass index, and relevant clinical covariates. Results: The mean age of the study population was 85.0 ± 7.1 years, and 80.1% were female. Polypharmacy was present in 64.5% of patients. In medication-specific analyses, thyroid hormone use was associated with lower lumbar spine BMD (p = 0.032), and concomitant use of diuretics and proton pump inhibitors was associated with lower hip BMD (p = 0.049). Steroid use showed a marginally non-significant correlation with reduced BMD (p = 0.057). Polypharmacy was associated with lower lumbar spine BMD (p = 0.022), whereas no significant association was observed with hip BMD. Increasing age was consistently associated with lower BMD across skeletal sites (p < 0.001). Conclusions: In this geriatric inpatient cohort, polypharmacy and selected medication classes were associated with lower bone mineral density, particularly at the lumbar spine. Given the cross-sectional design, these findings reflect associations rather than causal relationships and may partly capture underlying multimorbidity and clinical complexity. Consideration of medication burden may be relevant when evaluating bone health in older adults. Polypharmacy is increasingly common in older adults and may contribute to bone fragility. In this cohort of 1155 geriatric inpatients, multiple medications and certain drug classes were associated with lower bone mineral density, particularly in the spine. These findings suggest that medication burden should be considered when evaluating osteoporosis risk in aging populations. Full article

Objective: This study aimed to investigate the association between time to admission (TTA) and long-term mortality in patients with hip fractures, enabling surgeons to assess individual risks and prevent adverse outcomes. Methods: Demographic and clinical data of patients with hip fractures were obtained from medical records in our hospital. Patients aged 65 years or older were included. TTA was defined as the time from injury to first presentation at our institution. The primary outcome was long-term all-cause mortality. The regular multivariate Cox regression, restricted cubic spline, and two-piecewise model were used to explain the linear and curvilinear association between TTA and long-term mortality. The analyses were performed using EmpowerStats and R. Results: A total of 2361 patients were included in our study. There were 743 males and 1618 females, with a mean age of 79.44 ± 6.71 years. There were 1745 intertrochanteric fractures and 616 femoral neck fractures. We divided the patients into four groups according to TTA distribution: TTA ≤ 6 h, 6 h < TTA ≤ 12 h, 12 h < TTA ≤ 24 h, and TTA > 24 h, and the corresponding long-term mortality rates were 254 (25.53%), 85 (32.20%), 127 (32.56%), and 267 (37.50%). A curvilinear association was observed between TTA delay and long-term mortality in geriatric hip fractures, with 24 h serving as an inflection point. When TTA was less than 24 h, every one-hour increase in TTA was associated with a 1.6% increase in long-term mortality (HR = 1.016, 95% CI: 1.008–1.024; p < 0.001). When TTA exceeded 24 h, the long-term mortality risk showed no significant further increase with TTA (HR = 1.000, 95% CI: 1.000–1.000; p = 0.531). Conclusions: This study suggests that delayed admission is associated with a worse prognosis, and the mortality risk increases by approximately 1.6% per hour of delay within the first 24 h, after which the risk appears to stabilize. The first 24 h post-injury may represent a critical window for intervention. Full article

Iron deficiency (ID) is highly prevalent in older adults and remains frequently underdiagnosed despite its relevant prognostic impact. ID may be absolute or functional and is observed across multiple geriatric clinical settings, including heart failure, chronic kidney disease, malnutrition, fragility fractures and long-term care facilities. Beyond anaemia, ID contributes to impaired mitochondrial function, reduced exercise capacity, frailty, cognitive and functional decline, increased hospitalizations and mortality. In heart failure and CKD, ID – irrespective of haemoglobin – worsens clinical outcomes. Systematic assessment of iron status should be integrated into geriatric evaluation. Oral iron therapy is often limited by poor tolerance and hepcidin-mediated malabsorption, whereas intravenous formulations show greater efficacy in selected patients. Early identification and targeted correction of ID may improve symptoms, quality of life and functional recovery in elderly populations, although further large trials in very old and frail subjects are needed. Full article

Background/Objectives: Older people with hip fractures (HF) are highly heterogeneous patients at risk of adverse events, which impacts healthcare and economic systems. Tools for estimating 30-day and 1-year mortality may help optimize patient management decisions. The Nottingham Hip Fracture Score (NHFS) is one of the most reliable tools for assessing 30-day mortality after surgery. The aim is to validate the NHFS in a cohort of Italian patients hospitalized due to HF and enhance its predictive capacity against 30-day and 1-year mortality. Methods: A prospective observational study among older patients with HF who underwent surgery after a comprehensive geriatric assessment (CGA). Data about 30-day and 1-year mortality were gathered from regional registries. Logistic regression analyses were performed to assess the predictive accuracy of the NHFS against 30-day and 1-year mortality. The adapted scores were measured using ROC curves, and a nomogram was developed. Result: Among 1169 patients, 30-day and 1-year mortality rates were 4.3% and 21.3%, respectively. The NHFS was validated and recalibrated in the study sample for 30-day mortality. The recalibrated NHFS showed better predictive capacity for 30-day mortality (AUC 0.693) than the ASA score (AUC 0.547) and remained a significant predictor for 1-year mortality (AUC 0.712). BADL and METs showed an association with mortality, so the modified NHFS was integrated, resulting in a more accurate prediction compared to the original score for 1-year mortality (AUC = 0.747). Conclusions: The NHFS is a reliable tool for estimating 30-day and 1-year mortality in Italian older adults with HF. The revised NHFS, which includes METs and BADL, offers higher predictive power than the original version in our sample, and the nomogram may facilitate its clinical use. Full article

Background/objective: Maxillofacial fractures continue to represent a significant public health issue, with incidence patterns shaped by regional and demographic variables. This study aimed to deliver a comprehensive 15-year epidemiological analysis of maxillofacial trauma cases in southern Hungary. Methods: The study included patients who received treatment for maxillofacial trauma at the University of Pécs from 2009 to 2023. Data collected encompassed demographic characteristics, injury etiology, fracture location and complexity, date of injury, presence of alcohol involvement, therapeutic interventions, postoperative complications and reasons, and number of fixation plates removed. Descriptive statistics and odds ratios were calculated, with statistical significance defined as p < 0.05. Results: Among 1948 patients (69.9% male), a total of 2826 fractures were reported, averaging 1.45 fractures per patient. The most frequently affected age group was 21–30 years; however, a notable increase in cases among the elderly was observed for recent years. Falls accounted for the highest proportion of injuries (44.4%), followed by assaults (28.3%) and traffic accidents (16.8%). Injuries predominantly occurred on weekends, with Saturdays being particularly common. Alcohol consumption was documented in 14.7% of cases. The condyle (27.9%), body (25.7%), and angle (25.0%) were the most common sites of mandibular fracture. The maxillary sinus and zygomatic body were the leading sites of maxillofacial fractures. Conservative treatment was implemented in 54.6% of all cases, whereas surgical intervention was more frequently required for mandibular injuries (76.7%). Plate removal was performed in 15.3% of patients. Conclusions: During the study period, the incidence of maxillofacial trauma demonstrated a consistent increase, accompanied by demographic changes indicative of an aging population and a reduction in assault-related cases. Falls—especially among older adults—became the leading cause of injury. These results emphasize the necessity for targeted prevention efforts, geriatric-specific trauma management, and the implementation of health policies tailored to regional needs. Full article

Fractures of the posterior malleolus are key determinants of ankle stability and long-term functional outcome in complex ankle injuries. The posterolateral rim fragment represents a bony avulsion of the posterior syndesmotic complex. Anatomical reduction of this fragment restores the fibular incisura, posterior tibiotalar stability, and syndesmotic integrity. Based on a geriatric case of a trimalleolar ankle fracture with a Bartoníček type 2 posterior malleolar component, this review describes a modified minimally invasive inside-out fixation technique performed under intraoperative three-dimensional imaging. The posterior malleolar fragment was stabilized using a posterior-to-anterior headless double-threaded compression screw. The medial malleolus was fixed with two parallel partially threaded cannulated cancellous screws, and the distal fibular fracture was stabilized using a reamed intramedullary locking nail. The surgical technique, potential complications, and postoperative management are described in detail. This approach combines the biomechanical advantages of direct posterior malleolar fixation with minimal soft-tissue disruption, providing a stable and reliable construct for the treatment of complex ankle fractures, particularly in geriatric patients and in those with compromised soft-tissue conditions. Full article

Background/Objectives: Unstable intertrochanteric femur fractures (IFFs) in geriatric patients are associated with high rates of morbidity and mortality due to poor bone quality, multiple comorbidities, and limited functional capacity. This study aimed to compare the clinical outcomes of cementless bipolar hemiarthroplasty (BHA) performed via a transtrochanteric approach and proximal femoral nailing (PFN) in elderly patients with unstable IFFs. Methods: This retrospective comparative study included 131 patients aged ≥70 years who underwent surgery for AO/OTA 31-A2 and 31-A3 unstable fractures between January 2021 and July 2025 were retrospectively reviewed. 64 patients received cementless BHA and 67 underwent PFN. Eligible patients were ambulatory prior to fracture (independently or with a cane/walker); patients with pathological fractures/malignancy, alternative procedures (cemented or posterolateral BHA, total hip arthroplasty, tumor prosthesis, or other osteosynthesis methods), incomplete records, or <6 months of follow-up were excluded. Demographics, perioperative variables, mechanical complications, revision requirement, time to mobilization, and 1- and 6-month mortality rates were analyzed. Primary outcomes were mortality and perioperative clinical parameters. Results: The two groups were comparable in age, sex, ASA scores, and fracture patterns. Intraoperative blood loss and transfusion requirements were significantly higher in the BHA group (both p < 0.001). Mobilization was observed earlier in patients treated with BHA (1 [1,2] vs. 3 [2,3] days; p < 0.001). Mechanical complications were more frequently observed after PFN, which was associated with a higher revision requirement (17.9% vs. 4.7%; p = 0.018). Operative time, hospital stay, and 1- and 6-month mortality rates showed no significant differences between the groups. Conclusions: In geriatric patients with unstable IFFs, cementless BHA performed via a transtrochanteric approach may be considered a viable surgical option with appropriate patient selection, taking into account its association with earlier mobilization and the observed mechanical complication profile. PFN offers advantages of reduced blood loss and lower transfusion needs. Surgical decision-making should be individualized based on fracture morphology, bone quality, and the patient’s overall medical condition. Given the heterogeneity of unstable fractures within the AO/OTA classification and the retrospective nature of the present study, larger, multicenter prospective investigations incorporating functional outcomes are warranted to further clarify optimal treatment strategies. Full article

Elderly patients with femoral fractures need specific rehabilitation after surgery that aims to improve their self-reliance and life quality, reducing their mortality rate. Although worsening patient body composition increased the risk of an unfavourable prognosis, it remains unclear whether evaluating bioelectrical impedance analysis (BIA) parameters can predict any functional recovery. A longitudinal design was conducted on 45 elders (84.59 ± 7.18 years, 75.6% female) who underwent femoral surgery to examine BIA features as rehabilitation biomarkers. The patient’s body composition, assessed by anthropometry and bioimpedance analysis (BIA), and self-reliance were evaluated three times during follow-up in both healthy and surgical lower limbs. The ANCOVA test, adjusted for gender and side of surgery, found improvements in daily living activities, while only thigh circumferences decreased over time. Regarding the BIA, the surgical leg showed a wider decrement in bioelectrical resistance (R), whereas the bioelectric reactance (Xc) exhibited similar trends. Females who underwent surgery on their dominant leg showed significant changes (p < 0.001) in bioimpedance vectorial analysis (BIVA), with a linear trend from baseline to postoperative time, while males exhibited beneficial variations only between baseline and time 2 (p < 0.01). Geriatric patients exhibit characteristic traits that require additional attention. BIA may be a feasible and non-invasive method for monitoring patient prognosis and reducing national health system costs. Full article

Background: Hip fractures in older adults are sentinel events linked to high mortality and functional decline. Few studies have quantified long-term survival probabilities, standardized mortality ratios (SMRs), and risks of new nursing home admission alongside patient-related predictors. Methods: We retrospectively analyzed 355 patients aged ≥ 60 years who underwent hip fracture surgery at a general hospital in Japan (2020–2024). Primary outcomes were mortality and new nursing home admission. Survival probabilities and remaining life expectancy were estimated, and SMRs were calculated using age- and sex-matched national data. Cox regression identified independent predictors. Results: Mean age was 84 years; 76% were female. Mortality probabilities at 1, 2, and 3 years were 23%, 41%, and 60%, respectively; SMRs consistently exceeded 9. Median remaining life expectancy was 260 days. New nursing home admissions occurred in 42%, with cumulative probabilities of 16%, 27%, and 35% at 1, 2, and 3 years, respectively, showing a rapid rise within 9 months. Independent predictors of mortality were delayed surgery, higher Charlson Comorbidity Index, and low Geriatric Nutritional Risk Index. Older age and failure to regain ambulatory ability at 3 months predicted institutionalization. Conclusions: Older adults with hip fractures face persistently high mortality and institutionalization risks, comparable to advanced malignancies or neurodegenerative diseases. Surgical timing, comorbidities, nutrition, and functional recovery critically influence prognosis and should guide perioperative care and discharge planning. Full article

Background/Objectives: Hip fracture is a condition with increasing hospital demand, and the determinants of hospital stay are crucial for improving clinical outcomes and costs in this vulnerable population. To establish the determinants of the length of hospital stay (HS) of older adult patients with hip fractures in a hospital in the Lambayeque region of Peru during 2017–2019. Methods: We conducted an observational study based on a secondary data analysis. The outcome variable was HS, measured in terms of days from admission to the hospitalization unit until discharge. The main independent variables were age, functional ambulation category scale, cognitive status index (Mental Red Cross scale), Barthel index, comorbidities, geriatric syndromes, trauma diagnosis, reason for surgical delay, preoperative time and preoperative complications. We performed a Poisson or negative binomial regression through crude and adjusted models. Results: Of 399 patients, the average age was 82.25 years, with 63.7% being female. A Poisson and negative binomial regression analysis were conducted for the variables that were significant in the crude model, which were sex, multimorbidity, mental Red Cross scale, Barthel index, functional ambulation, number of geriatric syndromes, traumatic diagnosis, reason for delay in the first model, preoperative complications in the first model, emergency stay, and preoperative time in the second model. According to the adjusted model, the analysis found that in the first model, advanced dementia as measured by the Mental Red Cross (MRC) scale was associated with an increase in hospital length of stay (IRR = 1.82, 95% CI = 1.03–3.23, p < 0.04); similarly, having preoperative complications increased hospital length of stay (IRR = 1.56, 95% CI = 1.30–1.86, p < 0.001), adjusted for clinical variables; in the second model, preoperative time was associated with an increase in hospital length of stay (IRR = 7.44, 95% CI = 6.96–7.96, p < 0.001), adjusted for emergency department stay. A third global model was developed, finding that advanced dementia as measured by the MRC (IRR = 1.82, 95% CI = 1.02–3.23, p < 0.04) and the presence of preoperative complications (IRR = 1.56, 95% CI = 1.30–1.86, p < 0.04) were associated with increased hospital length of stay, adjusted for clinical and hospital variables. Conclusions: The average HS of older adult hip fracture patients treated at a tertiary hospital in the Lambayeque region of Peru was 17 days. The main determinants of HS duration were advanced dementia and presence of preoperative complications. Full article