Search Results (100)

Energy storage plays an essential role in stabilizing fluctuations in renewable energy sources such as wind and solar, enabling surplus electricity retention, and delivering dynamic frequency regulation. However, relying solely on a single form of storage often proves insufficient due to constraints in performance, capacity, and cost-effectiveness. To tackle frequency regulation challenges in remote desert-based renewable energy hubs—where traditional power infrastructure is unavailable—this study introduces a planning framework for an electro-hydrogen energy storage system with grid-forming capabilities, designed to supply both inertia and frequency response. At the system design stage, a direct current (DC) transmission network is modeled, integrating battery and hydrogen storage technologies. Using this configuration, the capacity settings for both grid-forming batteries and hydrogen units are optimized. This study then explores how hydrogen systems—comprising electrolyzers, storage tanks, and fuel cells—and grid-forming batteries contribute to inertial support. Virtual inertia models are established for each technology, enabling precise estimation of the total synthetic inertia provided. At the operational level, this study addresses stability concerns stemming from renewable generation variability by introducing three security indices. A joint optimization is performed for virtual inertia constants, which define the virtual inertia provided by energy storage systems to assist in frequency regulation, and primary frequency response parameters within the proposed storage scheme are optimized in this model. This enhances the frequency modulation potential of both systems and confirms the robustness of the proposed approach. Lastly, a real-world case study involving a 13 GW renewable energy base in Northwest China, connected via a ±10 GW HVDC export corridor, demonstrates the practical effectiveness of the optimization strategy and system configuration. Full article

Background/Objectives: Selinexor is a selective nuclear-export inhibitor approved for hematologic malignancies, characterized by extensive plasma protein binding (>95%). However, a validated analytical method to accurately measure the clinically relevant unbound fraction of selinexor in human plasma has not yet been established. This study aimed to develop a fully validated bioanalytical assay for simultaneous quantification of total and unbound selinexor concentrations in human plasma. Methods: We established and fully validated an analytical method based on liquid chromatography–tandem mass spectrometry (LC-MS/MS) capable of quantifying total and unbound selinexor concentrations in human plasma. Unbound selinexor was separated using ultrafiltration, and selinexor was efficiently extracted from 50 μL of plasma by liquid–liquid extraction. Chromatographic separation was achieved on a C18 column using an isocratic mobile phase (0.1% formic acid:methanol, 12:88 v/v) with a relatively short runtime of 2.5 min. Results: Calibration curves showed excellent linearity over a range of 5–2000 ng/mL for total selinexor (r² ≥ 0.998) and 0.05–20 ng/mL for unbound selinexor (r² ≥ 0.995). The precision (%CV ≤ 10.35%) and accuracy (92.5–104.3%) for both analytes met the regulatory criteria. This method successfully quantified selinexor in plasma samples from renally impaired patients with multiple myeloma, demonstrating potential inter-individual differences in unbound drug concentrations. Conclusions: This validated bioanalytical assay enables precise clinical pharmacokinetic assessments in a short runtime using a small plasma volume and, thus, assists in individualized dosing of selinexor, particularly for renally impaired patients with altered protein binding. Full article

The purpose of this paper was to evaluate the international competitiveness of Polish fruits and their processed products in comparison to those of major global exporters. The adopted research approach is grounded in the theoretical foundations of international trade. A comparative analysis allows for identifying key competitive advantages and weaknesses. Quantitative data analysis was employed to measure international competitiveness using key indicators such as Market Share (MS), Trade Balance, Competitiveness Ratio (CR), Revealed comparative advantage (RCA), Intra-Industry Trade (IIT), and Terms of Trade (ToT). These metrics were calculated based on data obtained from Comtrade, with results presented in a time-series format to capture long-term trends. An extensive literature review was conducted to examine the various definitions and frameworks of international competitiveness. The decline in the level of indicators that include imports in their formulas (CRs) may lead to an increase in the level of indicators that take exports into account (e.g., foreign trade balance and share in global exports). For example, a strong increase in the import of concentrated apple juice results in an increase in the export of this product and an improvement in the competitive position on the global market. The insights from these indicators can assist policymakers in developing targeted strategies to enhance the competitiveness of the agricultural sector, such as improving production methods, negotiating better trade agreements, or investing in innovation and quality improvement. Full article

The demand for L-tryptophan (L-Trp) has been rapidly increasing across various industries, including pharmaceuticals, food, and animal feed. However, traditional production methods have been unable to efficiently meet this growing demand. Hence, this study aimed to develop strategies for enhancing L-Trp production in Escherichia coli. Firstly, an L-Trp-producing strain was selected and subjected to atmospheric and room temperature plasma (ARTP) mutagenesis to generate a mutant library. This was followed by high-throughput screening using an L-Trp-specific riboswitch and a yellow fluorescent protein (YFP)-based biosensor in a flow cytometric cell sorting (FACS) system. Among the screened mutants, GT3938 exhibited a 1.94-fold increase in L-Trp production. Subsequently, rational metabolic engineering was applied to GT3938 by knocking out the L-Trp intracellular transporter gene (tnaB), enhancing the expression of the aromatic amino acid exporter (YddG) and optimizing precursor supply pathways. The resulting strain, zh08, achieved an L-Trp titer of 3.05 g/L in shake-flask fermentation, representing a 7.71-fold improvement over the original strain. This study demonstrated an effective strategy for industrial strain development by integrating biosensor-assisted, high-throughput screening with rational metabolic engineering. Full article

Energy transition is a challenge for remote northern communities mainly relying on diesel for electricity generation and space heating. Solar-assisted ground-coupled heat pump (SAGCHP) systems represent an alternative that was investigated in this study for the Kuujjuaq Forum, a multi-activity facility in Nunavik, Canada. The energy requirements of community buildings facing a subarctic climate are poorly known. Based on energy bills, technical documents, and site visits, this study provided an opportunity to better document the energy consumption of such building, especially considering the recent solar photovoltaic (PV) system installed on part of the roof. A comprehensive model was developed to analyze the building’s heating demand and simulate the performance of a ground-source heat pump (GSHP) coupled with PV panels. The air preheating load, accounting for 268,200 kWh and 47% of the total heating demand, was identified as an interesting and realistic load that could be met by SAGCHP. The GSHP system would require a total length of at least 8000 m, with boreholes at depths between 170 and 200 m to meet this demand. Additional PV panels covering the entire roof could supply 30% of the heat pump’s annual energy demand on average, with seasonal variations from 22% in winter to 53% in spring. Economic and environmental analysis suggest potential annual savings of CAD 164,960 and 176.7 tCO₂eq emissions reduction, including benefits from exporting solar energy surplus to the local grid. This study provides valuable insights on non-residential building energy consumption in subarctic conditions and demonstrates the technical viability of SAGCHP systems for large-scale applications in remote communities. Full article

Oceanic tuna fisheries are a major contributor to the economic health of Pacific Island countries (PICs), with coastal fisheries underpinning the livelihoods of locals, providing food security, significant employment, culture, and human welfare. Livelihood development across various PICs is hindered by the inability to harness the maximum potential of coastal fishery resources, particularly through the lack of identifying targeted development needs. Development of coastal value chains facilitates resilience by reducing local reliance on tuna fisheries and associated vulnerability to tuna industry dynamics to support socio-economic development throughout the PICs while maintaining food security. The aim of this paper is to identify priority opportunities for developing coastal resource value chains in PICs, targeting increased local economic resilience and food security. A methodology developed by the World Bank was used to assist stakeholders and policymakers to coalesce around common strategies for the value chains. Six value chains were identified: beche-de-mer; ornamental black pearls and Trochus shell; fresh fish for the domestic market; reef fish exports; export of live lobsters; and export of aquarium fish products. Porter’s Five Forces framework was used for value chain analysis, and strategic repositioning considerations and areas for investment support within high-priority value chains were identified. Fisheries data collection, community-based sustainable management and aquaculture restocking programmes, habitat restoration, development of the cold chain, air freight logistics for export, and facilitating international market connections and market access were identified for external investment support. Full article

In this paper, a workflow for creating advanced aerodynamics design dashboards is proposed. A CAD modeler is directly linked to the CFD simulation results so that the designer can explore in real time, assisted by virtual reality (VR), how shape parameters affect the aerodynamics and choose the optimal combination to optimize performance. In this way, the time required for the conception of a new component can be drastically reduced because, even at the preliminary stage, the designer has all the necessary information to make more thoughtful choices. Thus, this work sets a highly ambitious and innovative goal: to create a smart design dashboard where every shape parameter is directly and in real-time linked to the results of the high-fidelity analyses. The OPAM (Open Parametric Aircraft Model), a simplified model of the Boeing 787, was considered as a case study. CAD parameterization and mesh morphing were combined to generate the design points (DPs), while Reduced Order Models (ROMs) were developed to link the results of the CFD analyses to the chosen parameterization. The ROMs were exported as FMUs (Functional Mockup Units) to be easily managed in any environment. Finally, a VR design dashboard was created in the Unity environment, enabling the interaction with the geometric model in order to observe in a fully immersive and intuitive environment how each shape parameter affects the physics involved. The MetaQuest 3 headset has been selected for these tests. Thus, the use of VR for a design platform represents another innovative aspect of this work. Full article

Colombian goldenberries that do not reach sufficient quality for export are exposed to waste, so the search for processes that provide added value while guaranteeing the conservation of this fruit is paramount. Thus, snacks by vacuum frying from goldenberries (Physalis peruviana L.) with low export quality were made. Goldenberry slices previously subjected to ultrasound-assisted osmotic dehydration were used for this purpose. Response surface methodology with different levels of temperature (110 °C and 130 °C), vacuum pressure (0.3 bar and 0.5 bar), and time (2 min and 6 min) was used to optimize the process. At optimal vacuum frying conditions (i.e., 108 °C, 0.5 bar, and 5.5 min), snacks with lower (p ≤ 0.05) oil content were produced, compared to atmospheric frying chips. The optimized snacks had 9% oil, 7% moisture, ΔE of 13 (with respect to fresh fruit), a_w of 0.3, and hardness of 14 N. The kinetics and modeling of moisture loss and oil uptake were performed under optimal conditions, obtaining the best fit with the Page (R² = 99%) and the first-order (R² = 96%) models, respectively. There was a clear correlation between oil uptake and moisture loss, as the highest oil retention in the product took place when the product had lost the greatest amount of water; therefore, the low initial moisture in the product due to pretreatment resulted in lower oil uptake in it. The obtained goldenberry snack showed adequate physicochemical properties, and the pretreatment yielded a product with much healthier characteristics (i.e., lower oil content, and therefore, a lower caloric intake); so, the proposed process could represent an alternative to the processing of low-export quality Colombian goldenberries. Full article

Background: Telematization is essential for improving port efficiency by reducing dwell times and simplifying document management. Currently, only a few ports use informatic document management tools like the Port Community System (PCS), and customs documents are produced and shared in paper format. This results in long port dwell times. Methods: A platform was developed to allow sharing of documents among port actors. The platform shares export documents of each given shipment between export and import port actors; moreover, it serves as a document management platform for ports lacking PCS. In addition, the platform helps in reorganizing the shipment in case of disruptions. Results: The platform has global validity as it allows users to share documents among all port actors worldwide. The platform is formed by the following menus: “Path”, which provides the intermodal freight path; “Shipment”, which allows one to create or change shipment data; “Send notify” to send notifies in case of disruptions; “PMIS and PCS”, which redirects to these platforms of ports involved in the project; and “Documents”, which allows one to upload and share customs documents at the global level. Conclusions: The app contributes to speeding up port operations by reducing dwell times, assists in managing shipment disruptions, and enhances intermodality in freight transportation. Full article

The safety engineering design of hydrogen systems and infrastructure, worker education and training, regulatory compliance, and engagement with other stakeholders are significant to the viability and public acceptance of hydrogen farms. The only way to ensure these are accomplished is for the field of hydrogen safety engineering (HSE) to grow and mature. HSE is described as the application of engineering and scientific principles to protect the environment, property, and human life from the harmful effects of hydrogen-related mishaps and accidents. This paper describes a whole hydrogen farm that produces hydrogen from seawater by alkaline and proton exchange membrane electrolysers, then details how the hydrogen gas will be used: some will be stored for use in a combined-cycle gas turbine, some will be transferred to a liquefaction plant, and the rest will be exported. Moreover, this paper describes the design framework and overview for ensuring hydrogen safety through these processes (production, transport, storage, and utilisation), which include legal requirements for hydrogen safety, safety management systems, and equipment for hydrogen safety. Hydrogen farms are large-scale facilities used to create, store, and distribute hydrogen, which is usually produced by electrolysis using renewable energy sources like wind or solar power. Since hydrogen is a vital energy carrier for industries, transportation, and power generation, these farms are crucial in assisting the global shift to clean energy. A versatile fuel with zero emissions at the point of use, hydrogen is essential for reaching climate objectives and decarbonising industries that are difficult to electrify. Safety is essential in hydrogen farms because hydrogen is extremely flammable, odourless, invisible, and also has a small molecular size, meaning it is prone to leaks, which, if not handled appropriately, might cause fires or explosions. To ensure the safe and dependable functioning of hydrogen production and storage systems, stringent safety procedures are required to safeguard employees, infrastructure, and the surrounding environment from any mishaps. Full article

The tightening of sanitary and phytosanitary (SPS) regulations, along with stringent private standards in international fresh produce trade, requires citrus producers, especially in developing regions, to adopt robust compliance mechanisms. This study examines the integration of a Risk Management System (RMS) into the existing Quality Management System (QMS) of citrus producers in the Western Cape (WC), South Africa, aimed at improving adherence to European Union (EU) market requirements. Through a comprehensive survey of citrus producers, the research identifies the primary barriers to effective risk management integration, such as financial constraints, limited human resources, and the prevalent non-compliance in the export chain, including pest infestations and exceeding Maximum Residue Limits (MRLs). The results highlight the fact that producers of varying scales face substantial challenges in resource allocation for RMS implementation. The study advocates for a strategic, top-down integration approach, which includes targeted financial support, the establishment of dedicated teams, and well-structured implementation plans. Additionally, the role of both governmental and private sector support is emphasised, particularly in providing training, technical assistance, and infrastructure investments to strengthen compliance efforts. These actions are crucial for ensuring sustained market access, enhancing the competitiveness of citrus producers, and promoting sustainable agricultural practices in the global market. Full article

Citrus farming in South Africa has become extremely lopsided in terms of economic opportunities. The statistics show that the wealthy large-scale farmers simultaneously control 100% of the international export market and 77.1% of the local market, hence endangering the prospect of the small- and medium-scale farmers. This research presents a novel, low-cost autonomous mobile robot (AMR) designed to support small- and medium-scale citrus farmers in South Africa, enhancing their competitiveness in both local and international markets. Developed using GENESYS software 2023 University Edition for systems integration, the AMR offers real-time crop monitoring to aid phytosanitary regulations compliance, autonomous navigation with object avoidance, error alerts, GPS functionality, and auto-homing when battery levels drop to 30%. Additionally, it captures periodic snapshots of citrus crops for visual inspection and assists with proof of protocols for sustaining citrus and treating infected trees, hence increasing its credibility and accountability for export and local markets. The AMR represents a significant advancement in affordable smart technology for sustainable citrus farming. Full article

Ensuring sustainability in the production and marketing of agricultural and food products after natural disasters is of critical importance to maintain beneficial nutrition for society. Examining the effects of earthquakes on the agricultural and food sectors is important in terms of drawing attention to the possible risks they may pose to societies that have not experienced large-scale earthquakes. This study examines firms in the agriculture and food sectors of Malatya province that were affected by the devastating earthquakes centered in Kahramanmaraş on 6 February 2023. This study aimed to determine the effects of earthquakes on firms in the agriculture and food sectors, the factors affecting firms’ production and marketing processes, and the priority issues for them. Data obtained from 44 firms registered in the agricultural and food sectors of the Organized Industrial Zone of Malatya province were used. This study reports their general structure and frequency distributions by firm characteristics. In addition, statistical analysis methods, such as the chi-squared test, t-test, and factor analysis, were used for data evaluation. The results showed that 79.5% of firms export and make a significant contribution to Türkiye’s agricultural and food product trade. The primary factors influencing firms, based on their size, included workforce availability, raw material supply, transportation logistics, and financial assistance. Firms’ earthquake insurance, providing earthquake training for their employees, and constructing durable buildings were the most important factors in ensuring sustainability in production and marketing. These results further show that firms in the agriculture and food sectors in Malatya province were greatly affected economically by the earthquakes. Important lessons emerged as a result of these earthquakes experienced in Türkiye. The economic disruption following earthquakes may be overcome with less damage by constructing disaster-resistant buildings, instilling awareness of living with earthquakes in society, and creating safe production environments. This field study will guide sector stakeholders in building a resilient supply, production, and marketing network in preparation for future earthquakes. Full article

Brazil is the second largest beef producer and a leading exporter, contributing to some 3000 t CWE in global markets (27.7% of market share). The sector has experienced substantial development, but yields remain far below potential, and there are growing concerns regarding land use change and greenhouse gas emissions. The need for sustainable technologies, such as sound pasture management and integrated farming systems, is evident, but adoption may be low amongst farmers unable to keep up with technological advances. This article describes the historical developments of Brazilian beef farming towards sustainability and discusses possible socioenvironmental outcomes. We combined an extensive literature review, public data, and our own insights as senior researchers to achieve that. The trajectory shown here evidenced the technological intensification of Brazilian beef farming, with strong support of public policies for decarbonizing agriculture. Nonetheless, the pace of this transition may affect small to medium farmers with limited access to information, technologies, and credit. Our recommendations involve a broad program of technical assistance and training on sustainable technologies, including financial and digital literacy. A novel approach to financing farmers is suggested to support a sustainable and inclusive transition in beef farming in Brazil. Full article

Cassava (Manihot esculenta Crantz) was introduced to Southeast Asia in the 16th–17th centuries and has since flourished as an industrial crop. Since the 1980s, Thailand has emerged as the leading producer and exporter of cassava products. This growth coincided with the initiation of cassava breeding programs in collaboration with the International Center for Tropical Agriculture (CIAT), focusing on root yield and starch production. The success of Thai cassava breeding programs can be attributed to the incorporation of valuable genetic diversity from international germplasm resources to cross with the local landraces, which has become the genetic foundation of many Thai commercial varieties. Effective evaluation under diverse environmental conditions has led to the release of varieties with high yield stability. A notable success is the development of Kasetsart 50. However, extreme climate change poses significant challenges, including abiotic and biotic stresses that threaten cassava root yield and starch content, leading to a potential decline in starch-based industries. Future directions for cassava breeding must include hybrid development, marker-assisted recurrent breeding, and gene editing, along with high-throughput phenotyping and flower induction. These strategies are essential to achieve breeding objectives focused on drought tolerance and disease resistance, especially for CMD and CBSD. Full article