Search Results (264)

Food defense encompasses both the prevention of accidental contamination and the protection of food and water systems against deliberate adulteration. Within this framework, algal toxins deserve greater attention because they occupy a critical intersection of water security, seafood and drinking-water safety, environmental change, supply-chain continuity, and public health preparedness. The novelty of this review lies in reframing algal toxins from a primarily environmental, seafood safety, or clinical toxicology topic into an integrated food and water defense problem. This perspective brings together harmful algal bloom ecology, toxin toxicology, seafood safety, drinking-water protection, preparedness for intentional adulteration, climate change risk, surveillance, and emergency response. Algal toxins can enter the human supply chain through multiple marine and freshwater pathways, are often undetectable by taste, odor, or appearance, may resist routine preparation measures, and can generate high-consequence disruptions even when contamination begins locally. The analysis further shows that prevention depends largely on upstream measures—including environmental surveillance, harvest-area restrictions, source-water protection, testing, supply-chain controls, and rapid public communication—rather than on consumer behavior. Framed in the context of the U.S. Food and Drug Administration’s Intentional Adulteration Rule under the Food Safety Modernization Act, this paper situates algal toxins within a preventive defense model that integrates monitoring, vulnerability reduction, and emergency preparedness. Although most harmful algal bloom events are naturally occurring, algal toxins warrant attention in food-defense planning because they can contaminate seafood and drinking-water systems, complicate detection and attribution, and expose vulnerabilities across interconnected food and water infrastructures. Full article

Microplastics (MPs) and nanoplastics (NPs) have emerged as pervasive environmental contaminants with increasing evidence of human exposure and biological accumulation. Recent studies have confirmed their presence in multiple human reproductive tissues and fluids, including semen, testicular tissue, ovarian follicular fluid, cervicovaginal secretions, placenta, and breast milk, raising concerns regarding their potential implications for reproductive health. Beyond their widespread distribution, MPs have been shown in experimental studies to interact with cellular and molecular processes, including oxidative stress, inflammatory responses, mitochondrial dysfunction, and DNA damage, which are pathways commonly implicated in carcinogenesis. This review provides a comprehensive and critical synthesis of current evidence linking microplastic exposure to reproductive cancers, including prostate, testicular, ovarian, endometrial, cervical, and vaginal malignancies. Available mechanistic studies suggest that MPs may influence cancer-related biological processes through dysregulation of programmed cell death, genotoxicity, endocrine disruption, and modulation of signaling pathways such as PI3K/AKT and MAPK. Experimental findings also indicate that MPs may alter the tumor microenvironment and affect cellular behaviors associated with proliferation, migration, and invasion. However, the majority of current evidence is derived from in vitro studies, animal models, and indirect mechanistic observations, while direct epidemiological evidence in humans remain limited. Furthermore, methodological heterogeneity in microplastic detection and characterization complicates comparisons across studies and hinders causal inference. Overall, current evidence supports the biological plausibility of an association between microplastic exposure and reproductive cancer-related processes, while highlighting the need for standardized methodologies and well-designed longitudinal human studies to clarify potential health risks. Full article

The extensive use of pesticides in modern agriculture has resulted in their persistent accumulation in environmental systems, posing significant risks to ecosystems and human health. Consequently, the development of integrated strategies for the sensitive detection and efficient removal of pesticide residues has become critically important. In this context, fluorescent inorganic–organic hybrid nanoparticles have emerged as versatile platforms owing to their tunable physicochemical properties and distinctive optical behavior. This review provides a comprehensive overview of recent advances in these hybrid nanomaterials for pesticide sensing and remediation. Particular emphasis is placed on the underlying photophysical mechanisms governing detection, including fluorescence quenching, Förster resonance energy transfer (FRET), inner filter effect (IFE), and photoinduced electron transfer (PET). In parallel, the role of interfacial interactions such as hydrogen bonding, electrostatic attraction, and π–π stacking in adsorption processes is critically discussed. Furthermore, these hybrid systems exhibit high adsorption capacities and rapid removal kinetics, enabling efficient pesticide elimination using both adsorption and catalytic degradation pathways. Overall, this review underscores the potential of fluorescent inorganic–organic hybrid nanoparticles as next-generation materials for sustainable environmental monitoring and remediation of pesticide contaminants. Full article

As climate change increasingly threatens sustainable development goals, climate risk has emerged as a critical factor shaping corporate strategic decisions and capital allocation behavior. Using a sample of Chinese A-share listed firms over the period 2008 to 2024, this study constructs a firm-level climate risk index through textual analysis of annual report disclosures and examines its effect on corporate green investment. We find that climate risk is positively associated with corporate green investment. Mechanism analysis reveals that climate risk operates through dual pathways: it enhances firms’ green strategic orientation as the internal governance mechanism, and heightens public green attention as the external governance mechanism, both of which are positively related to increasing firms’ green investment. Heterogeneity analysis shows that the promoting effect is more pronounced for state-owned enterprises, heavy-polluting firms, firms with negative media coverage, and firms located in northern regions of China. Further analysis reveals that climate risk is more strongly associated with green transformation investment over end-of-pipe treatment investment, and firms that increase green transformation investment in response to climate risk achieve stronger firm growth. These findings provide new evidence on how climate risk shapes corporate environmental behavior, offering practical insights for promoting sustainable investment and advancing corporate contributions to sustainable development. Full article

Background/Objectives: Delirium in patients with dementia is a multifactorial condition traditionally attributed to acute medical triggers. However, emerging evidence suggests that non-biological factors, including sensory deprivation and environmental instability, may contribute to delirium vulnerability, particularly in vulnerable populations. To explore the temporal associations between non-biological and environmental factors, particularly sensory deprivation and recurrent delirium in a patient with advanced Alzheimer’s disease and progressive vision loss, a narrative review was conducted. Methods: A narrative review of the literature on delirium risk factors, differential diagnosis, and non-pharmacological interventions was conducted. A retrospective longitudinal case report of a patient with advanced Alzheimer’s disease and progressive visual impairment, based on an eight-year observation, was used to contextualize the literature findings. Results: The literature indicates that delirium arises from the interaction between predisposing factors, such as cognitive impairment and reduced cognitive reserve, and precipitating factors, including both biological and environmental stressors. Sensory deprivation, particularly visual impairment, may significantly disrupt orientation and increase reliance on internally generated perceptual content, predisposing to hallucinations and delusions. Environmental instability, such as changes in caregivers, disrupted routines, and overstimulation, may further exacerbate this vulnerability. Evidence suggests that these factors may contribute to delirium even in the absence of identifiable classical medical triggers. In the presented case, individualized non-pharmacological interventions based on structured routines, environmental predictability, and sensory-adapted engagement were associated with periods of improved behavioral stability. Conclusions: The present case supports the hypothesis that delirium in dementia may involve impaired environmental integration, particularly in the context of sensory deprivation, in addition to established biological mechanisms. Person-centered non-pharmacological strategies aimed at maintaining familiarity, environmental predictability, and appropriate sensory support may represent valuable components of delirium prevention and management. These hypothesis-generating observations require confirmation in prospective studies involving larger patient populations. Full article

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social interactions, communication deficits, and excessive repetitive behaviors. While ASD has a strong genetic basis, growing evidence suggests that epileptic seizures may serve as environmental risk factors for ASD development. The high comorbidity between epilepsy and ASD (20–30%) suggests potential shared neurobiological mechanisms, yet the causal relationship remains poorly understood. To investigate the causal role of seizures in the development of ASD-like pathology, we exposed adolescent mice (3 weeks old) to electroconvulsive seizures (ECS) for 10 consecutive days. This repeated ECS exposure led to the emergence of autistic-like behaviors including significantly decreased sociability, increased repetitive self-grooming, enhanced marble burying behavior, and anxiety-like behaviors, without affecting general locomotor activity. Additionally, repeated exposure to ECS induced significant changes in glutamatergic neurotransmission in the mice’s prefrontal cortex and hippocampus, brain regions critically involved in social cognition and behavioral regulation. Interestingly, these changes occurred without alterations in other excitatory/inhibitory neuronal markers, suggesting a specific impact on glutamate receptor expression rather than a general disruption of excitatory/inhibitory balance. These findings suggest that repeated seizures may contribute to ASD-like symptoms by specifically affecting key glutamatergic neurotransmitter systems, providing insights into the neurobiological mechanisms underlying the comorbidity between epilepsy and autism. In addition, repeated ECS differentially regulated histone deacetylase (HDAC) transcripts in a region-specific manner and produced seizure-intensity-dependent transcriptomic signatures. Full article

Plant anthracnose, caused by Colletotrichum spp., is a class of significant diseases that severely threatens global crop production. Traditional management strategies, including chemical control, are hindered by inherent limitations such as the frequent emergence of pathogen resistance, low pesticide utilization efficiency, high environmental residue risks, and inconsistent field efficacy. Moreover, achieving further improvements in control efficacy is constrained by the complex biological characteristics of Colletotrichum species, particularly their hemibiotrophic lifestyle and latent infection strategies. In recent years, nanotechnology has emerged as a potential approach for the management of anthracnose. This review summarizes the research progress of various nanomaterials in the control of plant anthracnose. It analyzes the proposed multi-mechanism modes of action of nanomaterials tailored to the specific infection traits of Colletotrichum. Particular emphasis is placed on analyzing the theoretical mechanisms and preliminary in vitro evidence of nano-enabled controlled-release systems in addressing asymptomatic latent infections and achieving targeted, precise delivery. However, it must be emphasized that most current findings are derived from laboratory or controlled-environment studies, and the actual field-scale effectiveness, long-term environmental behavior, and multi-trophic safety of many nanomaterials remain insufficiently confirmed. Building upon these insights, this review thoroughly evaluates the critical challenges facing the agricultural field application of nanomaterials, such as ecotoxicity, formulation stability, scalable industrial production, and regulatory gaps. This review aims to provide objective theoretical support and technical references for achieving safe, efficient, and sustainable nano-enabled green management of plant anthracnose. Full article

Environmental degradation is no longer a distant threat; it now permeates social media feeds, casual conversations, and daily digital content. However, whether incidental exposure to environmental news leads to meaningful behavioral change remains poorly understood. This study examines how incidental environmental news exposure (IENE) relates to pro-environmental behavior (PEB) among Chinese social media users, with particular attention to the sequential chain-mediating roles of environmental belief (EB) and perceived environmental risk (PER). A theoretical model was developed and tested using survey data from 468 respondents collected in November and December 2024, and analyzed using structural equation modeling (SEM). The results indicate that IENE is significantly and positively associated with EB, PER, and PEB. Notably, EB was not directly associated with PEB; its association operated almost entirely through PER, which accounted for 87.6% of the total EB–PEB association. PER emerged as the principal psychological pathway linking passive news exposure to behavioral engagement, and the structural model explained 42.1% of the variance in PEB. Because the design is cross-sectional, the results establish covariance patterns consistent with the proposed sequence rather than temporal or causal order. These findings indicate that cognitive risk appraisal, rather than environmental belief alone, constitutes the proximal mediating mechanism within the modelled pathway to pro-environmental action. Policymakers and media practitioners should accordingly design communication strategies that extend beyond general awareness-raising to link environmental threats explicitly to perceived personal and societal risk. Full article

Developmental dyslexia is a common neurodevelopmental disorder characterized by persistent difficulties in accurate and fluent word reading despite adequate intelligence, educational opportunity, and intact sensory function. Contemporary neurobiological models have progressively shifted from localization-based explanations toward network-oriented perspectives emphasizing large-scale brain connectivity, developmental maturation, and neuroplasticity. Nevertheless, the developmental mechanisms underlying early right-hemisphere recruitment remain incompletely understood. Although increased right-hemisphere activation has traditionally been interpreted as a compensatory response to left-hemisphere dysfunction, accumulating evidence from longitudinal neuroimaging, intervention, and developmental studies indicates that this explanation alone does not adequately account for the heterogeneity of neurobiological findings observed across individuals with developmental dyslexia. This narrative review synthesizes evidence from developmental neurobiology, network neuroscience, longitudinal neuroimaging, and intervention research to examine the biological processes underlying early right-hemisphere recruitment. Across the reviewed literature, developmental dyslexia is increasingly characterized by atypical maturation of distributed reading networks involving alterations in white-matter development, functional connectivity, hemispheric lateralization, and experience-dependent neuroplasticity. Collectively, these findings suggest that reading networks remain dynamically modifiable throughout literacy acquisition and that multiple developmental pathways may contribute to diverse neurobiological and behavioral outcomes. Building on this evidence, we propose a Developmental Neuroplasticity Framework for Reading Network Reorganization that integrates existing neurobiological models within a unified developmental perspective. Rather than proposing a new neurobiological mechanism, the framework seeks to explain the heterogeneous patterns of early right-hemisphere recruitment that are not fully accounted for by compensation-based interpretations alone. Specifically, it conceptualizes early right-hemisphere recruitment as one possible adaptive developmental outcome emerging from interactions among early neurodevelopmental vulnerability, distributed network connectivity, developmental neuroplasticity, and environmental experience. By integrating evidence that has largely been considered within separate theoretical perspectives, the framework generates empirically testable predictions regarding developmental trajectories, network reorganization, and intervention-related variability, while providing a conceptual basis for earlier identification of children at risk and the development of more targeted, developmentally informed intervention strategies. Full article

Background: Dysregulated brain aging leads to dementia in some older adults. South Asia is one of the most populous regions of the world with a rapidly growing older adult population. Yet, very few studies have focused on quantifying the status and risk factors driving aging-related conditions such as dementia in this part of the world. Objectives: We explored multiple sources of global health data to quantify and compare all-cause dementia indices in South Asian countries. Design: Afghanistan, Bangladesh, Bhutan, India, Maldives, Nepal, Pakistan and Sri Lanka were considered. Population statistics and dementia as a priority area were examined using US Census Bureau and World Health Organization Global Dementia Observatory data. Crude and age-standardized rates (ASR) of dementia incidence, deaths and disability-adjusted life years (DALYs) were extracted and analyzed from the Global Burden of Disease (GBD) 2019 Study. Results: Our analysis reiterated that there are limited resources dedicated to dementia in this region. Sri Lanka and Afghanistan had the highest dementia crude rates and age-standardized rates, respectively [Crude DALYs, Sri Lanka = 321.52 (132.12–736.58); ASR DALYs, Afghanistan = 432.72 (179.01–1001.95)]. The burden of dementia in some South Asian countries was comparable to estimated global averages, and was largely driven by population aging. Analyses of available data on known biological, behavioral, environmental and disease risk factors in the region highlighted the role of metabolic dysregulation in dementia. Conclusions: Our preliminary analysis of available global health data highlights an emerging need for resources for dementia prevention and care in South Asia. There is also a critical need for future longitudinal follow-up studies focusing on dementia that are well-designed and can be harmonized with other dementia-related studies. We describe a roadmap for designing them—taking into account cultural, economic, public health and population aging dynamics that may be uniquely applicable to South Asian countries. Full article

Microplastics are increasingly recognized as prevalent contaminants in freshwater ecosystems, where they interact with a wide range of co-occurring pollutants, including heavy metals, pesticides, pharmaceuticals, and persistent organic pollutants. Evidence indicates that microplastics can act as vectors, enhancing pollutant mobility and facilitating trophic transfer, while also modulating toxicity through synergistic or antagonistic effects. Ecotoxicological studies reveal adverse impacts on aquatic organisms, ranging from physiological stress and impaired reproduction to altered community dynamics, with implications for ecosystem functioning and human health. Despite growing knowledge, significant gaps remain in understanding long-term environmental behavior, standardized methodologies, and risk assessment frameworks. This review synthesizes current findings on microplastic–pollutant interactions in freshwater systems, highlights emerging ecotoxicological risks, and identifies critical research needs to inform effective management and policy interventions. Full article

Glyphosate is one of the most widely used herbicides worldwide, and its extensive application has raised increasing concern regarding environmental occurrence, ecological exposure, and potential risks to non-target organisms. Its major degradation product, aminomethylphosphonic acid (AMPA), has also received growing attention because of its persistence, transport behavior, and contribution to long-term contamination profiles. To clarify the development and emerging priorities of this field, we conducted a bibliometric review of glyphosate-related publications indexed in the Web of Science Core Collection from 1974 to 2024. After screening and data cleaning, 7050 articles and reviews were included. Publication output increased markedly over time, with annual publications exceeding 300 after 2019 and reaching a peak of 488 in 2023. The United States ranked first with 1928 publications, accounting for 27.4% of the total output, followed by Brazil and China. Keyword co-occurrence, temporal overlay, and collaboration analyses showed that glyphosate research has shifted from early agronomic topics, including herbicide efficacy, crop selectivity, and resistance management, toward a broader environmental research framework. Three major research fronts were identified: mechanism-oriented ecotoxicology in non-target organisms, environmental fate and transport of glyphosate and AMPA across soil–water–sediment systems, and the development of analytical and sensing technologies for environmental monitoring. The results further indicate that the field is moving from single-compound residue assessment toward integrated contaminant-ecology perspectives linking occurrence, transformation, biological response, exposure assessment, and ecological risk. Future studies should strengthen the integration of long-term environmental monitoring, AMPA-inclusive risk assessment, realistic multi-stressor exposure scenarios, and field-deployable detection technologies. This review provides a quantitative overview of the global research landscape and identifies priority directions for environmental assessment and management of glyphosate and AMPA contamination. Full article

Business administration education relies on case analysis, strategic simulation, and complex decision-making, all of which generative artificial intelligence (GenAI) can substantially support. However, limited research has examined the mechanisms driving business students’ intention to use GenAI tools to support their learning. To address this gap, this study aims to investigate business administration students’ intention to use GenAI by drawing on an integrated Technology-Organization-Environment (TOE) framework and an extended Technology Acceptance Model (TAM) incorporating perceived trust and perceived risk. Using survey data from 385 Chinese business administration students, a hybrid analytical approach combining Partial Least Squares Structural Equation Modeling (PLS-SEM) and fuzzy-set Qualitative Comparative Analysis (fsQCA) is adopted to examine both the net effects and the configurational mechanisms underlying behavioral intention. The results show that perceived ease of use and perceived trust are the two strongest direct predictors of intention to use GenAI, jointly outweighing perceived usefulness, and that perceived trust serves as the sole significant mediator linking cognitive evaluations to intention to use. Perceived risk, in contrast, exhibits neither a direct nor a mediating effect, suggesting a risk tolerance pattern among business students. Among the TOE dimensions, environmental support (peer influence) emerges as the most potent contextual driver, whereas organizational support facilitates perceived ease of use but does not directly enhance perceived usefulness. The fsQCA findings further identify five typical pathways to high intention to use, namely TAM-driven, trust-compensated, environment-driven, organization-driven risk-tolerant, and comprehensive external-support configurations. These findings provide guidance for designing targeted GenAI-supported strategies and peer-driven interventions in higher business education. Full article

Secondhand smoke exposure (SHSE) remains a major environmental health risk among university students, particularly in socially shared settings. In the United Arab Emirates, culturally embedded practices such as shisha and midwakh use, combined with variable policy enforcement, sustain persistent exposure. This cross-sectional study examined SHSE-related knowledge and protective health behaviors among 360 university students and their sociodemographic correlates, using a self-report questionnaire with documented internal consistency in comparable populations. Data were analyzed using SPSS version 28. SHSE was highly prevalent, occurring mainly in public and university settings; knowledge was moderate and protective behavior varied. Knowledge emerged as a moderate-to-strong correlate of protective behavior (r = 0.70, p < 0.001, R² = 0.49). Age, employment, marital status, and number of children were associated with knowledge; age, gender, marital status, and income, but not employment, remained associated with behavior after adjusting for knowledge. Confirmatory factor analysis showed poor absolute fit for both the one- and two-factor solutions, and the behavioral-response factor did not satisfy the Fornell–Larcker criterion (√AVE = 0.750 < latent r = 0.836), providing only partial support for the empirical distinctiveness of the two constructs. Bootstrapped mediation analysis shows that knowledge partially mediated the employment–behavior association (~62% of the total effect); employment status was not, however, independently associated with behavior once knowledge was included, so this pathway is reported as hypothesis-generating. Still, more than a quarter of participants reported poor protective behavior, suggesting that unmeasured social and environmental factors, and possible overlap between the two constructs, may influence this relationship. Findings support integrated interventions combining health education, policy enforcement, and culturally tailored strategies. Full article

This study investigates consumers’ intentions to purchase high-risk, near-expired fresh meat via a supermarket mobile app, addressing food waste in a digital retail context. An integrated framework combining the technology acceptance model and the theory of planned behavior was employed, incorporating price discounts and food and environmental safety concerns. Data from 418 users of Taiwan’s leading supermarket chain were analyzed using partial least squares structural equation modeling (PLS-SEM). The findings reveal that perceived usefulness strongly drives app usage attitude while environmental concern shows no significant effect, highlighting the decoupling between environmental awareness and actual digital adoption behavior. Furthermore, although price discounts emerged as the strongest driver of purchase intention, heightened food safety concerns paradoxically stimulated purchases. This counterintuitive result demonstrates how a reputable retailer’s established credibility effectively mitigates consumer fears. Practically, this study provides actionable guidelines for retailers to optimize digital clearance strategies: retailers should prioritize real-time inventory transparency and economic incentives, while strategically leveraging their institutional credibility within the app to overcome consumer safety concerns regarding high-risk foods. Full article