Search Results (5)

Predictive Coding (PC) frameworks claim to model recognition via prediction–error loops, but they often lack explicit biological implementation of fast familiar recognition and impose latency that limits real-time robotic control. We begin with Experience-Based Pattern Matching (EBPM), a biologically grounded mechanism inspired by neural engram reactivation, enabling near-instantaneous recognition of familiar stimuli without iterative inference. Building upon this, we propose Dynamic Integrative Matching and Encoding (DIME), a hybrid system that relies on EBPM under familiar and low-uncertainty conditions and dynamically engages PC when confronted with novelty or high uncertainty. We evaluate EBPM, PC, and DIME across multiple image datasets (MNIST, Fashion-MNIST, CIFAR-10) and on a robotic obstacle-course simulation. Results from multi-seed experiments with ablation and complexity analyses show that EBPM achieves minimal latency (e.g., ~0.03 ms/ex in MNIST, ~0.026 ms/step in robotics) but poor performance in novel or noisy cases; PC exhibits robustness at a high cost; DIME delivers strong trade-offs—boosted accuracy in familiar clean situations (+4–5% over EBPM on CIFAR-10), while cutting PC invocations by ~50% relative to pure PC. Our contributions: (i) formalizing EBPM as a neurocomputational algorithm built from biologically plausible principles, (ii) developing DIME as a dynamic EBPM–PC integrator, (iii) providing ablation and complexity analyses illuminating component roles, and (iv) offering empirical validation in both perceptual and embodied robotic scenarios—paving the way for low-latency recognition systems. Full article

The differential diagnosis of acute-onset amnesia includes transient global amnesia (TGA), transient epileptic amnesia (TEA), and functional (or psychogenic) amnesia. The most common of these, TGA, is a rare but well-described condition characterised by a self-limited episode of dense anterograde amnesia with variable retrograde amnesia. Although the clinical phenomenology of TGA is well described, its pathogenesis is not currently understood, thus preventing the development of evidence-based therapeutic recommendations. Here, TGA, TEA, and functional amnesia are considered in light of the historical engram conception of memory, now informed by recent experimental research, as disturbances in distributed ensembles of engram neurones active during memory formation and recall. This analysis affords therapeutic implications for these conditions, should interventions to reactivate latent or silent engrams become available. Full article

The tryptophan and kynurenine pathway is well-known to play an important role in nervous, endocrine, and immune systems, as well as in the development of inflammatory diseases. It has been documented that some kynurenine metabolites are considered to have anti-oxidative, anti-inflammatory, and/or neuroprotective properties. Importantly, many of these kynurenine metabolites may possess immune-regulatory properties that could alleviate the inflammation response. The abnormal activation of the tryptophan and kynurenine pathway might be involved in the pathophysiological process of various immune-related diseases, such as inflammatory bowel disease, cardiovascular disease, osteoporosis, and/or polycystic ovary syndrome. Interestingly, kynurenine metabolites may be involved in the brain memory system and/or intricate immunity via the modulation of glial function. In the further deliberation of this concept with engram, the roles of gut microbiota could lead to the development of remarkable treatments for the prevention of and/or the therapeutics for various intractable immune-related diseases. Full article

Nerve cell death accounts for various neurodegenerative disorders, in which altered immunity to the integrated central nervous system (CNS) might have destructive consequences. This undesirable immune response often affects the progressive neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, schizophrenia and/or amyotrophic lateral sclerosis (ALS). It has been shown that commensal gut microbiota could influence the brain and/or several machineries of immune function. In other words, neurodegenerative disorders may be connected to the gut–brain–immune correlational system. The engrams in the brain could retain the information of a certain inflammation in the body which might be involved in the pathogenesis of neurodegenerative disorders. Tactics involving the use of probiotics and/or fecal microbiota transplantation (FMT) are now evolving as the most promising and/or valuable for the modification of the gut–brain–immune axis. More deliberation of this concept and the roles of gut microbiota would lead to the development of stupendous treatments for the prevention of, and/or therapeutics for, various intractable diseases including several neurodegenerative disorders. Full article

The name Eugen Bleuler is almost exclusively linked with matters concerning the nosology of schizophrenia and the relationship of clinical psychiatry and psychoanalysis. His bibliography lists different works which deal with contemporary topics concerning legislation, the fight against alcoholism and for the most part, from the later years, topics concerning general psychology. In this article subject matters from texts by Bleuler, including some which have been inaccessible up to now, will be reviewed, which either allow interpretative conclusions on his conception of the world or which explicitly have this as a topic.With explicit references to his different publications, often dealing with basic problems of medical psychology and a scientifically based ethic, Bleulers anti-religious and anti-philosophical position will be shown. An effort towards integration of seemingly incompatible, side-by-side standing, unrelated biological and psychological concepts, which probably is most likely to be explained by the contemporary background of ideas, is recognisable. In this context Eugen Bleuler refers to an already (especially by Richard Semon) systematically developed theory called “Mnemism” that he interpreted and applied to the psychological circumstances mentioned above. The theory of “mnemism”, which can be most adequately described as a biogenetic-vitalistic theory, is assuming that all organic life – independent of the possibility of a self-reflecting consciousness – is able to learn from experiences made by analysis of environment and to pass it on to following generations. Patterns of stimulus reactions are in the sense of this theory memorised and reactivated under similar situational circumstances by the psychological mode of association. It represents the benchmark for Bleuler’s standpoints, for example the question of determination of human acting.The assumption of the efficacy of specific, not necessarily consciously remembered “engrams” of memory suggests the hypothesis of the existence of unconsciousness. Full article