Search Results (52)

The development of stock markets is pivotal for economic growth, particularly through the mobilization of idle resources into productive investments. Despite recent reforms to enhance Uzbekistan’s capital market, public engagement remains limited. This study examines the behavioral determinants of stock market investment intention and participation among university students, employing the Theory of Planned Behavior (TPB) and Partial Least Squares Structural Equation Modeling (PLS-SEM). The model investigates the influence of digital literacy, financial literacy, social interaction, herding behavior, overconfidence bias, risk tolerance, and financial well-being on investment intention and behavior. A survey of 369 university students was conducted to assess the proposed relationships. The results reveal that risk tolerance, overconfidence bias, and herding behavior significantly and positively affect investment intention, while digital literacy demonstrates a notable negative effect, suggesting caution in assuming technology readiness automatically translates to investment readiness. Investment intention, in turn, strongly predicts actual participation and mediates several of these effects. Conversely, financial literacy, financial well-being, and social interaction showed no significant direct or mediating influence. Additionally, differences according to gender and academic background were observed in how intention translates into behavior. The findings underscore the need for integrated financial and behavioral education to enhance market participation and contribute to policy discourse on youth financial engagement in emerging economies. Full article

Consanguinity is the marriage of two related persons. This type of marriage is one of the main pillars when it comes to recessive hereditary diseases, birth defects, infertility, miscarriages, abortion, and infant deaths. Intermarriage continues to be a common practice in various communities in North Africa, the Middle East, and West and South Asia, as well as among migrants from Europe and North America, even though in more and more countries it has become illegal. Even if security and stability are some of the motivations for consanguineous marriage, studies show that women often suffer physical and verbal abuse from their husbands. However, because of the blood bond, tolerance for these habits is much higher. In addition, it seems that the divorce rate is much lower because separation would affect the entire state of the family. The choice of partner is significantly influenced by variables such as limited access to education and financial resources. Illiterate people coming from poor rural areas are much more likely to choose consanguineous marriage to maintain wealth in the family. The lack of medical knowledge about the negative effects of consanguinity leads to an increased rate of abortions, infant deaths, and births of children with congenital birth defects. Today, because of the process of urbanization and increased levels of knowledge, the younger generation is becoming increasingly less receptive to this particular form of marriage. In addition, as education has become more accessible to women, they have become more independent and eager to fulfill their own goals and not the wishes of the family. In conclusion, contrary to the many apparent advantages of consanguineous marriage, partners should put genetic risks first, as medical problems bring with them increased costs in the medical system and also within the family, leading to even lower economic status and consequently perpetuation of this type of marriage. Full article

Challenge, adventure, and risky play have repeatedly been found to be learning environments that positively shape childhood well-being and development. Extant evidence-based research conveys the physical, cognitive, and socio-emotional growth associated with risky play provision. However, understanding the interplay of risky play, injury, and safety is more nuanced and complex. The goal of this paper is to introduce a tool which allows educators, parents, health practitioners, urban planners, playground designers, certifiers, manufacturers, and inspectors to estimate both the benefit and risk of outdoor play and learning settings, such as playgrounds, adventure parks, or risk-taking activities. One of the key challenges associated with societal risk appetite or risk tolerance has been the inability to quantify the inherent benefits of risk taking in playgrounds and educational settings. Historically, the assessment of ‘benefit–risk’ has been dominated by a zero tolerance of incidents, whether in the workplace or road safety settings. Against this backdrop, if playgrounds and outdoor learning settings are boring, children will go elsewhere to seek thrills and adventure, which may often be manifested in antisocial behaviour. In 2023, ‘benefit–risk’ was formally recognised in the area of sport and recreation by the International Organisation for Standardisation, when it published the ISO 4980:2023 benefit–risk assessment for sport and recreational facilities, activities, and equipment. ISO 4980:2023 is a departure from the traditional view of risk management, in that it presents a perspective of risk which is not limited to framing risk as negative, but rather balances the calculation of positive benefits as well as the risks associated with the activity. Correspondingly, hazardous situations which have zero benefit should be eliminated or mitigated. The tool introduced in this paper offers playground inspectors and educators the ability to measure and assess both the benefit and risk of outdoor playgrounds and educational settings where children play, learn, and flourish. Full article

Background: As artificial intelligence (AI) continues to advance in healthcare, limited research has explored how nursing professionals perceive its integration into clinical practice and education—particularly among those directly involved in AI-driven initiatives. This qualitative study aimed to investigate the perceptions, experiences, and expectations of nursing educators and clinical practitioners regarding the application of AI in nursing and to provide insights for the advancement of AI-driven nursing science. Methods: A descriptive qualitative design was employed. Between September and December 2024, semi-structured interviews were conducted with 12 nursing professionals from universities and hospitals in Shanghai, Suzhou, and Chengdu, China. Participants were selected using maximum variation sampling, and data were analyzed using content analysis. Results: Three major themes and eleven sub-themes were identified: (1) The potential of multi-perspective development of AI-driven nursing science and practice, including aiding in decision-making, assisting with writing nursing documents, helping in care practices with high exposure risks and heavy physical exertion, and supporting the development of nursing activities. (2) A multi-dimensional response to the wave of intelligent nursing research and practice: education and scientific research come first, then we fully explore the application scenarios, and then conduct deep interdisciplinary integration. (3) Obstacles for intelligent nursing research and practice: interaction factors of “human–technology–machine” for application, transformation, and promotion; financial support and continuous investment; the controversy behind the intelligent maturity level; and application risk and fault tolerance. Conclusions: Participants emphasized the importance of evidence-based, cautious, and context-sensitive application of AI technologies to ensure that intelligent nursing evolves in alignment with clinical realities. The findings suggest a need for strengthened policy, education, and resource allocation to support the sustainable integration of AI in nursing. Full article

Diuretics are a class of pharmacological agents that promote the renal excretion of water and electrolytes, increasing urine output and reducing fluid retention. They play a critical role in the management of edematous syndromes, irrespective of their etiology (cardiac, renal, or hepatic), as well as in the treatment of hypertension (HTA). The mechanism of action of diuretics can be classified as either renal, as seen with saluretic diuretics that inhibit sodium and water reabsorption at various segments of the nephron, or extrarenal, involving alterations in the glomerular filtration pressure or osmotic mechanisms. Based on their site of action and mechanism, diuretics are categorized into multiple classes, including loop diuretics, thiazide and thiazide-like diuretics, potassium-sparing diuretics, carbonic anhydrase inhibitors, and osmotic diuretics. These agents are frequently used in combination with other antihypertensive or heart failure medications to optimize therapeutic efficacy. By reducing the blood volume and peripheral vascular resistance, diuretics improve cardiac function, lower blood pressure, and enhance exercise tolerance. Additionally, they are employed in managing chronic kidney disease (CKD), electrolyte imbalances, and specific metabolic disorders. Given the potential for adverse effects such as electrolyte disturbances and renal dysfunction, diuretic therapy should be individualized, with the careful monitoring of the dosage, patient response, and comorbid conditions. Patient education on adherence, lifestyle modifications, and the recognition of side effects is essential for optimizing the therapeutic outcomes and minimizing the risks associated with diuretic therapy. Full article

Background: Patients with hematological malignancies, including multiple myeloma (MM) and chronic lymphocytic leukemia (CLL), are at an increased risk of severe infections due to both disease- and therapy-related immunosuppression. This cross-sectional study evaluated awareness of infection risks and vaccination uptake among 150 adults with various hematological malignancies from major Polish centers. Methods: All participants completed a 30-item questionnaire capturing demographic data, treatment history, infection frequency, and vaccination attitude. Statistical analyses utilized Chi-square and Fisher’s exact tests, with p < 0.05 considered statistically significant. Results: Respondents had a median age of 57 years (range, 30–79), and 65.3% were female. MM was the most common diagnosis (64.7%), followed by CLL (4.0%) and other hematological malignancies (31.3%). Nearly all participants (99.3%) acknowledged their increased susceptibility to infections. Frequent infections (≥2 in the past 6 months) were significantly associated with transfusion dependency (p = 0.0001) and a history of hematopoietic stem cell transplantation (HSCT, p = 0.009). Although 69.3% expressed willingness to be vaccinated, 23.3% declined COVID-19 vaccination due to insufficient cancer-specific safety data. Higher education and urban residence correlated with greater acceptance of vaccines (p < 0.05). Conclusions: Our findings underscore the critical need for targeted educational strategies and robust vaccination guidelines in this immunocompromised population. Enhanced patient education and timely implementation of tailored vaccination regimens could reduce infection-related morbidity and improve the tolerability of cancer treatments. Full article

Sectoral and institutional context[s] are critical to understanding how workplace toxicity manifests and how it might best be addressed. The education sector, specifically higher education, is the focus of this study, drawing on qualitative data collected from Irish Higher Education Institutions [HEIs]. Underpinned by a multi-faceted conceptualisation of bullying, the study explores how it is experienced by university staff and how institutional or contextual factors impinge on that experience. The study employed a qualitative interpretive methodology involving one-to-one semi-structured interviews with self-selecting participants. Persons who currently work or have recently worked in higher education institutions were recruited into the study. A generic thematic approach resulted in five intersecting themes, converging on one overarching organising construct, i.e., bullying in higher education as a traumatic process. The data displayed relationality, institutionalisation and unethicality, which are underlying features of a multi-faceted conceptualisation of bullying. It was concluded that the processes and procedures in place to address bullying and provide redress do not appear to be sufficiently nuanced to accommodate the complex behaviours and power plays involved in bullying in Higher Education, assuming a rationality stripped of power dynamics, which risks aggravating the damage already inflicted by bullying. The findings suggest that the institutional response, or lack thereof, can sometimes be more traumatising than the bullying itself. Individual cases often reflect a wider organisational culture that tolerates bullying and victimisation. Institutional responses will need to tackle the entire HEI ecosystem, requiring and a more nuanced understanding of the power dynamics and organisational context. Full article

Respiratory tract diseases caused by influenza virus and SARS-CoV-2 can represent a serious threat to the health of pregnant women. Immunological remodulation for fetus tolerance and physiological changes in the gestational chamber expose both mother and child to fearful complications and a high risk of hospitalization. Vaccines to protect pregnant women from influenza and COVID-19 are strongly recommended and vaccine co-administration could be advantageous to increase coverage of both vaccines. The attitude to accept both vaccines is affected by several factors: social, cultural, and cognitive-behavioral. In Palermo, Italy, during the 2021–2022 influenza season, a cross-sectional study was conducted to evaluate pregnant women’s intention to adhere to co-administration of influenza and COVID-19 vaccines. The determinants of vaccination attitude were investigated through the administration of a questionnaire and the Health Action Process Approach theory was adopted to explore the cognitive behavioral aspects. Overall, 120 pregnant women were enrolled; mean age 32 years, 98.2% (n = 118) of Italian nationality and 25.2% (n = 30) with obstetric or pathological conditions of pregnancy at risk. Factors significantly associated with the attitude to co-administration of influenza and COVID-19 vaccines among pregnant women were: high level of education (OR = 13.96; p < 0.001), positive outcome expectations (OR = 2.84; p < 0.001), and self-efficacy (OR = 3.1; p < 0.001). Effective strategies to promote the co-administration of the influenza vaccine and the COVID-19 vaccine should be based on the communication of the benefits and positive outcomes of vaccine co-administration and on the adequate information of pregnant women. Full article

The landscape of cancer treatment has undergone a significant transformation with the introduction of Immune Checkpoint Inhibitors (ICIs). Patients undergoing these treatments often report prolonged clinical and radiological responses, albeit with a potential risk of developing immune-related adverse events (irAEs). Here, we reviewed and discussed the mechanisms of action of ICIs and their pivotal role in regulating the immune system to enhance the anti-tumor immune response. We scrutinized the intricate pathogenic mechanisms responsible for irAEs, arising from the evasion of self-tolerance checkpoints due to drug-induced immune modulation. We also summarized the main clinical manifestations due to irAEs categorized by organ types, detailing their incidence and associated risk factors. The occurrence of irAEs is more frequent when ICIs are combined; with neurological, cardiovascular, hematological, and rheumatic irAEs more commonly linked to PD1/PD-L1 inhibitors and cutaneous and gastrointestinal irAEs more prevalent with CTLA4 inhibitors. Due to the often-nonspecific signs and symptoms, the diagnosis of irAEs (especially for those rare ones) can be challenging. The differential with primary autoimmune disorders becomes sometimes intricate, given the clinical and pathophysiological similarities. In conclusion, considering the escalating use of ICIs, this area of research necessitates additional clinical studies and practical insights, especially the development of biomarkers for predicting immune toxicities. In addition, there is a need for heightened education for both clinicians and patients to enhance understanding and awareness. Full article

The adoption of effective coping strategies is crucial for successful adaptation to the impacts of climate change in the dairy sector. However, little attention has been paid to understanding the perceived constraints and motivations toward such strategies. A survey was conducted among 104 dairy farmers from three semi-arid regions of South India. The aim of the survey was to explore the dairy farmers’ perception of climate risk, how it impacts their dairy farming system, the coping strategies they employ, and the barriers they face when implementing these strategies. The survey also investigated the factors that facilitate the adoption of adaptation measures. The results indicate dairy farmers in the region perceive drought, pests and diseases, and high temperatures as the major risks associated with climate change, which has resulted in decreased dairy income, animal health problems, reduced fertility, and food intake problems for their cattle. In response to climate variability, dairy farmers have adopted various coping strategies. The most important strategies include buying livestock insurance, keeping low debt obligations, and growing drought-tolerant grass varieties. However, most farmers face significant constraints in adopting these and other strategies including a lack of climate forecast data, the high cost of adaptation activities, and weak institutional support. On the other hand, the key enabling factors that support the adoption of these strategies include milk production security, suitable feed growing conditions, and family interest. Most importantly, the study found that certain factors such as age, education, number of earning family members, annual milk production, monthly cattle expenses, and landholdings significantly influenced dairy farmers’ strategies for adapting to climate change. The study recommends that providing timely climate forecasts, implementing improved policies such as vaccination and cattle health services, and establishing strong institutional support systems can help dairy farmers become more resilient to climate change and protect their livelihoods. Full article

Patients with cancer and diabetes face unique challenges. Limited data are available on diabetes management in patients undergoing concurrent chemoradiotherapy (CCRT), a curative intent anticancer therapy commonly associated with glucocorticoid administration, weight fluctuations and enteral feeds. This retrospective case–control study examined the real-world incidence of acute diabetes-related complications in patients with head and neck cancer receiving CCRT, along with the impact of diabetes on CCRT tolerance and outcomes. Methods: Consecutive patients with head and neck squamous cell or nasopharyngeal cancer who underwent definitive or adjuvant CCRT between 2010 and 2019 at two large cancer centers in Australia were included. Clinicopathological characteristics, treatment complications and outcomes were collected from medical records. Results: Of 282 patients who received CCRT, 29 (10.3%) had pre-existing type 2 diabetes. None had type 1 diabetes. The majority (74.5%) required enteral feeding. A higher proportion of patients with diabetes required admission to a high-dependency or intensive care unit (17.2 versus 4.0%, p = 0.003). This difference was driven by the group who required insulin at baseline (n = 5), of which four (80.0%) were admitted to a high-dependency unit with diabetes-related complications, and three (60.0%) required omission of at least one cycle of chemotherapy. Conclusions: Patients with diabetes requiring insulin have a high risk of acute life-threatening diabetes-related complications while receiving CCRT. We recommend multidisciplinary management involving a diabetes specialist, educator, dietitian, and pharmacist, in collaboration with the cancer care team, to better avoid these complications. Full article

Patient-centered care (PCC) is recognized as a standard in healthcare for determining high quality. Honoring patients’ values, experiences, needs, and preferences in devising, coordinating, and delivering care underscores the enhancement of the therapeutic rapport between patients and healthcare providers. Wound treatment involves a multi-stage process encompassing diagnostics and local wound dressing, which reduces the risk of infection through a coordinated interdisciplinary team. Within this team, nurses undertake specific professional functions and roles. The implementation of local therapy using innovative and scientifically substantiated methods may be hindered by a deficit of knowledge or inappropriate knowledge among staff and patients themselves. This study presents the challenges concerning the care of patients with chronic wounds treated using Lucilia sericata larvae, based on a review of the current scientific literature. A critical analysis of the literature spanning from 2002 to 2022 was conducted using the Medline, PubMed, Cochrane, and Termedia databases, employing keywords such as “maggot debridement therapy” in relation to acceptance and perception. As a result of the preliminary selection, 472 papers were identified, of which 12 publications were included in the development of this concept. The acquired data were organized and presented in the concluding section in the form of tables, accompanied by descriptions and references to individual studies. Negative psychological and somatic sensations were among the most prominent challenges among patients treated with Maggot Debridement Therapy (MDT). Pain related to peripheral ischemia or infection in this group of patients requires pain prophylaxis, including hyperalgesia and allodynia, in order to improve method tolerance. On the other hand, augmenting patients’ understanding of MDT diminishes negative emotions, reinforces positive behaviors, and mitigates anxiety levels. MDT constitutes an effective and safe method. Its widespread use for chronic wounds requires substantial knowledge among healthcare professionals and patient education, along with that of their caregivers, to develop a positive attitude. Full article

Emulsifiers are food additives commonly found in processed foods to improve texture stabilization and food preservation. Dietary emulsifier intake can potentially damage the gut mucosal lining resulting in chronic inflammation such as Crohn’s disease. This study investigates the feasibility of a low-emulsifier diet among healthy female adults, as no previous reports have studied the feasibility of such a diet on healthy participants. A quasi-experimental study for a nutrition education and counseling intervention was conducted over 14 days among healthy Saudi participants aged 18 years and over. Assessment of dietary intake using 3-day food records was conducted at the baseline and 2-week follow-up. Participants attended an online educational session using the Zoom application illustrating instructions for a low-emulsifier diet. Daily exposure to emulsifiers was evaluated and nutrient intake was measured. A total of 30 participants completed the study. At baseline, 38 emulsifiers were identified, with a mean ± SD exposure of 12.23 ± 10.07 emulsifiers consumed per day. A significant reduction in the mean frequency of dietary emulsifier intake was observed at the end of the intervention (12.23 ± 10.07 vs. 6.30 ± 7.59, p < 0.01). However, intake of macronutrients and micronutrients was significantly reduced (p < 0.05). Good adherence to the diet was achieved by 40% of the participants, and 16.66% attained a 50% reduction of emulsifier intake. The study demonstrates that a low-emulsifier diet provided via dietary advice is feasible to follow and tolerable by healthy participants. However, the diet still needs further investigation and assessment of it is nutritional intake and quality before implementing it in patients with inflammatory bowel disease who are at high risk of poor nutritional intake. Full article

The study aimed to investigate the impact of COVID-19 restrictions on children’s access to the outdoors in early childhood education and care (ECEC) settings. An online survey comprised of a standardised scale and questions used in previous related studies was completed by 143 early childhood educators across Australia. Participants were asked to report children’s time spent outdoors, access to outdoor space, and restrictions imposed on children’s play during the pandemic compared to the pre-pandemic period. The survey responses were imported into SPSS for descriptive, correlation, and ordinal regression analyses. We examined the relationship between children’s outdoor time, space, restrictions imposed on children’s play, and educators’ characteristics, such as qualifications, professional development, and tolerance of risk or staff–child ratios during the pandemic in Australia. Most educators reported that children’s outdoor time and access to outdoor space remained the same compared to before the pandemic, while imposed restrictions on children’s outdoor play increased. The results of ordinal regressions indicated that educators with a higher tolerance of risk were less likely to impose additional restrictions on children’s outdoor play. The findings contribute to the understanding of how educators’ tolerance of risk influences children’s outdoor play opportunities and provide directions for future risk-reframing interventions. Full article

Entrepreneurs are those who take initiative and work tirelessly to turn their business ideas into viable, successful companies through innovation. Understanding entrepreneurial behaviour is essential to comprehend how entrepreneurs establish, promote, and expand new businesses. This study investigates the influence of entrepreneurial behaviour and innovation among undergraduate students of selected universities in southwest Nigeria. The target audience was made up of undergraduate students from selected private universities in southwest Nigeria. To be more precise, the purposive sampling method was used to choose the study’s participants. To gather information from a varied cross-section of students, 370 copies of the questionnaire were distributed. Only 296 copies of the surveys that were sent out were returned, which indicates an 80.2% response rate. Structural equation modelling was used to examine the data gathered. The results showed that opportunity identification significantly influences innovation more than self-efficacy and risk tolerance. Opportunity identification is the most important factor of entrepreneurial behaviour that helps students to be innovative and become entrepreneurs. The study recommended that to foster entrepreneurship behaviour and innovation among undergraduates, universities in Nigeria should integrate experiential learning opportunities across disciplines to nurture self-efficacy, opportunities identification, and risk tolerance through entrepreneurship education. Full article