Search Results (2,500)

This study presents a microfluidic chip platform designed using a multiscale 3D printing strategy for fabricating microfluidic chips with integrated, high-resolution, and customizable membrane structures. By combining two-photon polymerization (2PP) for submicron membrane fabrication with liquid crystal display printing for rapid production of larger components, this approach addresses key challenges in membrane integration, including sealing reliability and the use of transparent materials. Compared to fully 2PP-based fabrication, the multiscale method achieved a 56-fold reduction in production time, reducing total fabrication time to approximately 7.2 h per chip and offering a highly efficient solution for integrating complex structures into fluidic chips. The fabricated chips demonstrated excellent mechanical integrity. Burst pressure testing showed that all samples withstood internal pressures averaging 1.27 ± 0.099 MPa, with some reaching up to 1.4 MPa. Flow testing from ~35 $\mathsf{\mu }$L/min to ~345 $\mathsf{\mu }$L/min confirmed stable operation in 75 $\mathsf{\mu }$m square channels, with no leakage and minimal flow resistance up to ~175 $\mathsf{\mu }$L/min without deviation from the predicted behavior in the 75 $\mathsf{\mu }$m. Membrane-integrated chips exhibited outlet flow asymmetries greater than 10%, indicating active fluid transfer across the membrane and highlighting flow-dependent permeability. Overall, this multiscale 3D printing approach offers a scalable and versatile solution for microfluidic device manufacturing. The method’s ability to integrate precise membrane structures enable advanced functionalities such as diffusion-driven particle sorting and molecular filtration, supporting a wide range of biomedical, environmental, and industrial lab-on-a-chip applications. Full article

Optically pumped semiconductor disk lasers—known as vertical-external-cavity surface-emitting lasers (VECSELs)—are promising devices for ultrashort pulse formation. For it, a “SESAM-free” approach labeled “self-mode-locking” received considerable attention in the past decade, relying solely on a chip-related nonlinear optical property which can establish adequate pulsing conditions—thereby suggesting a reduced reliance on a semiconductor saturable-absorber mirror (the SESAM) in the cavity. Self-mode-locked (SML) VECSELs with sub-ps pulse durations were reported repeatedly. This motivated investigations on a Kerr-lensing type effect acting as an artificial saturable absorber. So-called Z-scan and ultrafast beam-deflection experiments were conducted to emphasize the role of nonlinear lensing in the chip for pulse formation. Recently, in addition to allowing stable ultrashort pulsed operation, self-starting mode-locked operation gave rise to another emission regime related to frequency comb formation. While amplitude-modulated combs relate to signal peaks in time, providing a so-called pulse train, a frequency-modulated comb is understood to cause quasi continuous-wave output with its sweep of instantaneous frequency over the range of phase-locked modes. With gain-bandwidth-enhanced chips, as well as with an improved understanding of the impacts of dispersion and nonlinear lensing properties and cavity configurations on the device output, an enhanced employment of SML VECSELs is to be expected. Full article

Next-generation smart sensing devices necessitate on-chip integration of power-efficient reference circuits. The latters are required to provide other circuit blocks with highly reliable bias signals, even in the presence of temperature shifts and supply voltage disturbances, while draining a small fraction of the overall power budget. In particular, it is especially challenging to design current references with enhanced robustness and efficiency; hence, thorough exploration of novel architectures and design approaches is needed for this type of circuits. In this work, we propose a novel CMOS-only current reference, achieving temperature compensation by exploiting geometry dependences of the threshold voltage (specifically, the reverse short-channel effect and the narrow-channel effect). This allows reaching first-order temperature compensation within a single current reference core. Implemented in 0.18 µm CMOS, a version of the proposed current reference designed to deliver 141 nA (with 377 nW of total power consumption) achieved an average temperature coefficient equal to 194 ppm/°C (from −20 °C to 80 °C) and an average line sensitivity of −0.017%/V across post-layout statistical Monte Carlo simulations. Based on such findings, the newly proposed design methodology stands out as a noteworthy solution to design robust current references for power-constrained mixed-signal systems-on-chip. Full article

This study examined the effect of build orientation on the surface finish of micro-optofludic (MoF) devices fabricated via a polydimethylsiloxane (PDMS)-based 3D-printing primary–secondary fabrication protocol, where an inkjet 3D-printing technique was implemented. The molds (i.e., primaries) for fabricating the MoF devices were 3D-printed in two orientations: along $XY$ (Dev-1) and across $YX$ (Dev-2) the printhead direction. Next, the surface finish was characterized using a profilometer to acquire the primary profile of the surface along the microchannel’s edge. The results indicated that the build orientation had a strong influence on the latter, since Dev-1 displayed a tall and narrow Gaussian distribution for a channel width of 398.43 ± 0.29 µm; Dev-2 presented a slightly lower value of 393.74 ± 1.67 µm, characterized by a flat and broader distribution, highlighting greater variability due to more disruptive, orthogonally oriented, and striated patterns. These results were also confirmed by hydrodynamically testing the two MoF devices with an air–water slug flow process. A large experimental study was conducted by analyzing the mean period trend in the slug flow with respect to the imposed flow rate and build orientation. Dev-1 showed greater sensitivity to flow rate changes, attributed to its smoother, more consistent microchannel geometry. The slightly narrower average channel width in Dev-2 contributed to increased flow velocity at the expense of having worse discrimination capability at different flow rates. This study is relevant for optimizing 3D-printing strategies for the fabrication of high-performance microfluidic devices, where precise flow control is essential for applications in biomedical engineering, chemical processing, and lab-on-a-chip systems. These findings highlight the effect of microchannel morphology in tuning a system’s sensitivity to flow rate modulation. Full article

To tackle the low-accuracy problem with analyzing urine component concentrations in real time, a fully automated dipstick analysis device of urine dry chemistry was designed, and a prediction method combining an image acquisition system with a whale optimization algorithm (WOA) for BP neural network optimization was proposed. The image acquisition system, which comprised an ESP32S3 chip and a GC2145 camera, was used to collect the urine test strip images, and then color data were calibrated by image processing and color correction on the upper computer. The correlations between reflected light and concentrations were established following the Kubelka–Munk theory and the Beer–Lambert law. A mathematical model of urine colorimetric value and concentration was constructed based on the least squares method. The WOA algorithm was applied to optimize the weight and threshold of the BP neural network, and substantial data were utilized to train the neural network and perform comparative analysis. The experimental results show that the MAE, RMSE and R² of predicted versus actual urine protein values were, respectively, 3.1415, 4.328 and approximately 1. The WOA-BP neural network model exhibited high precision and accuracy in predicting the urine component concentrations. Full article

Ascon is a family of lightweight cryptographic algorithms designed for Authenticated Encryption with Associated Data (AEAD), hashing, and Extendable Output Functions (XOFs) in resource-constrained environments. While the AEAD variants of Ascon provide confidentiality and authenticity, they do not inherently detect replayed messages. This work presents an FPGA implementation of Ascon-128, the primary AEAD variant, on a Xilinx Artix-7 device with integrated replay detection. A 128-bit Linear Feedback Shift Register (LFSR) is used to generate a unique sequential nonce per encryption, enabling high-speed, stateless nonce generation with minimal logic complexity. At the decryption end, replay detection is performed by hashing the received nonce using Ascon-XOF128 and verifying its freshness via a Bloom Filter stored in on-chip Block RAM (BRAM). Leveraging the flexibility of Ascon-XOF128 to generate variable length outputs, our design derives all ten Bloom Filter indices from a single 256-bit XOF output using the same permutation core as the AEAD data path, thereby eliminating the need for additional hashing logic. The Bloom Filter ensures zero false negatives, and our configuration achieves a low False Positive Rate (FPR) of 0.77% theoretically and 0.17% empirically after testing 100,000 nonces, consistent with analytical models. Replay detection is fully overlapped with decryption and introduces no additional delay for messages of 64 bytes or more when using the optimized two Rounds Per Clock Cycle (RPCC) permutation core operating at 100 MHz. This architecture extends Ascon with hardware-based replay protection, offering a lightweight and scalable security solution for practical IoT deployments. Full article

This study presents an innovative wedge-shaped inlet weir-type microfluidic chip designed to address common issues of clogging and inefficiency in microfiltration processes. Driven solely by centrifugal force, the chip integrates a crossflow separation mechanism and enables selective droplet sorting based on size, without the need for external pumps. Fabricated from PMMA, the device features a central elliptical chamber, a wedge-shaped inlet, and spiral microchannels. These structures leverage shear stress and Dean vortices under centrifugal fields to achieve high-throughput separation of droplets with different diameters. Using water-in-oil emulsions as a model system, we systematically investigated the effects of geometric parameters and rotational speed on separation performance. A theoretical model was developed to derive the critical droplet size based on force balance, accounting for centrifugal force, viscous drag, pressure differentials, and surface tension. Experimental results demonstrate that the chip can effectively separate droplets ranging from 0 to 400 μm in diameter at 200 rpm, achieving a sorting efficiency of up to 72% and a separation threshold (cutoff accuracy) of 98.2%. Fluorescence analysis confirmed the absence of cross-contamination during single-chip operation. This work offers a structure-guided, efficient, and contamination-free droplet sorting strategy with broad potential applications in biomedical diagnostics and drug screening. Full article

In this study, we present a comprehensive numerical investigation of alternating-current electrothermal (ACET) pumping strategies tailored for energy-efficient microfluidic applications. Using coupled electrokinetic and thermal multiphysics simulations in narrow microchannels, we systematically explore the effects of channel geometry, electrode asymmetry and external heating on flow performance and thermal management. A rigorous mesh convergence study confirms velocity deviations below ±0.006 µm/s across the entire operating envelope, ensuring reliable prediction of ACET-driven flows. We demonstrate that increasing channel height from 100 µm to 500 µm reduces peak temperatures by up to 79 K at a constant 2 W heat input, highlighting the critical role of channel dimensions in convective heat dissipation. Introducing a localized external heat source beneath asymmetric electrode pairs enhances convective circulations, while doubling the fluid’s electrical conductivity yields a ~29% increase in net flow rate. From these results, we derive practical design guidelines—combining asymmetric electrode layouts, tailored channel heights, and external heat bias—to realize self-regulating, low-power microfluidic pumps. Such devices hold significant promises for on-chip semiconductor cooling, lab-on-a-chip assays and real-time thermal control in high-performance microelectronic and analytical systems. Full article

This paper investigates a graphene-on-insulator power divider designed for terahertz applications based on spoof surface plasmon polaritons. We optimize structural parameters to maximize signal transmission from input to output ports while achieving a uniform and symmetrical electric field distribution at the output cross-section. Our findings indicate that utilizing three graphene layers significantly enhances power distribution and symmetry at output ports. We demonstrate electrical control over waveguide transmission properties by modulating the graphene chemical potential from 0 to 0.5 eV. The proposed device holds promise for applications in plasmonic circuits and on-chip interconnects operating within the terahertz frequency range. Full article

The disadvantages of traditional strip fertilization technology for corn planting in China include low fertilizer utilization rates, unstable operation quality, and environmental pollution. Therefore, in this study, a synchronous hole fertilization device for corn planting based on real-time intelligent control is designed, aiming to reduce fertilizer application and increase efficiency through the precise alignment technology of the seed and fertilizer. This device integrates an electric drive precision seeding unit, a slot wheel hole fertilization unit, and a multi-sensor coordinated closed-loop control system. An STM32 single-chip micro-computer is used to dynamically analyze the seed–fertilizer timing signal, and a double closed-loop control strategy (the position loop priority is higher than the speed loop) is used to correct the spatial phase difference between the seed and fertilizer in real time to ensure the precise control of the longitudinal distance (40~70 mm) and the lateral distance (50~80 mm) of the seed and fertilizer. Through the Box–Behnken response surface method, a field multi-factor test was carried out to analyze the mechanism of influence of the implemented forward speed (A), per-hole target fertilizing amount (B), and plant spacing (fertilizer hole interval) (C) on the seed–fertilizer alignment qualification rate (Y₁) and the coefficient of variation in the hole fertilizing amount (Y₂). The results showed that the order of primary and secondary factors affecting Y₁ was A > C > B, and that the order affecting Y₂ was C > B > A; the comprehensive performance of the device was best with the optimal parameter combination of A = 4.2 km/h, B = 4.4 g, and C = 30 cm, with Y₁ as high as 94.024 ± 0.694% and Y₂ as low as 3.147 ± 0.058%, which is significantly better than the traditional strip application method. The device realizes the precise regulation of 2~6 g/hole by optimizing the structural parameters of the outer groove wheel (arc center distance of 25 mm, cross-sectional area of 201.02 mm², effective filling length of 2.73~8.19 mm), which can meet the differentiated agronomic needs of ordinary corn, silage corn, and popcorn. Field verification shows that the device significantly improves the spatial distribution of the concentration of fertilizer, effectively reduces the amount of fertilizer applied, and improves operational stability and reliability in multiple environments. This provides technical support for the regional application of precision agricultural equipment. Full article

Microfluidics is a rapidly advancing field focused on optimizing microdevices for applications such as organ-on-a-chip systems and enhancing laboratory analyses. Understanding the physical parameters of droplet generation is crucial for these devices. Computational fluid dynamics (CFD) techniques are essential for providing insights into the limitations and efficiency of numerical methods for studying fluid dynamics and improving our understanding of various application conditions. However, the influence of different numerical methods on the analysis of physical parameters in problems involving droplet generation in microchannels remains an area of ongoing research. This study implements the Volume of Fluid (VOF) method to investigate key physical parameters, including droplet size and the effect of the capillary number on fluid regimes, in droplet generation within a microchannel featuring a T-junction geometry. We compare the VOF method with the widely used Level Set Method (LSM) to evaluate its suitability for this context. The results show that the VOF method agrees with the LSM in fundamental outcomes, such as the reduction in droplet diameter as the flow rate ratio increases and the identification of the capillary number’s influence on fluid regime classification. The VOF method provides a clearer understanding of transitions between fluid regimes by detecting stages of non-uniformity in droplet size. It identifies a transition region between regimes with variations in droplet size, proving to be effective at mapping fluid flow regimes. This study highlights the potential of the VOF method in offering more detailed insights into instabilities and transitions between fluid regimes at the microscale. Full article

Structural symmetry preservation and breaking play important roles in optical manipulation at subwavelength scales. By precisely engineering the symmetry of the nanostructures, metasurfaces can effectively realize various optical functions such as polarization control, wavefront shaping, and on-chip optical integration, with promising applications in information photonics, bio-detection, and flexible devices. In this article, we review the recent advances in chiral and achiral metasurfaces based on symmetry manipulation. We first introduce the fundamental principles of chiral and achiral metasurfaces, including methods for characterizing chirality and mechanisms for phase modulation. Then, we review the research on chiral metasurfaces based on material type and structural dimensions and related applications in high-sensitivity chiral sensing, reconfigurable chiral modulation, and polarization-selective imaging. We then describe the developments in the application of achiral metasurfaces, particularly in polarization-multiplexed holography, phase-gradient imaging, and polarization-insensitive metalenses. Finally, we provide an outlook on the future development of chiral and achiral metasurfaces. Full article

Applying Field Programmable Gate Array (FPGA) technology in cloud infrastructure and heterogeneous computations is of great interest today. FPGA as a Service assumes that the programmable logic device (PLD) is used as a remote (available over the Internet) service with an FPGA silicon chip on board. During the prototyping of FPGA-based projects within modern design flow, it is necessary to consider the processing delays caused by various factors, including the delay of data transfer between the kernel and host computer, limited clock frequency, and multiple parallel-running FPGA accelerator cards. To address these challenges, three techniques are proposed to reduce the required modification efforts and improve project performance. Based on the proposed models, the analytical evaluation of the functioning process of FPGA as a Service is performed to determine possibilities of improving productivity and reducing the response time. The practical experience of porting FPGA projects to new integrated environments is considered. The evaluation of the response time of FPGA as a Service using the queueing theory is proposed. It is shown that scaling and parallelization at the top level of project hierarchy, pipelining, and parameterization allow for the effective deployment of such FPGA systems for data centers and cloud infrastructures. The proposed techniques and models allow for an evaluation of the performance and response time of FPGA as a Service for formulating recommendations to improve technical characteristics. Full article

Recent advances in technologies such as blockchain, the Internet of Things (IoT), Cyber–Physical Systems (CPSs), and the Industrial Internet of Things (IIoT) have driven the digitalization and intelligent transformation of modern industries. However, embedded control devices within power system communication infrastructures have become increasingly susceptible to cyber threats due to escalating software complexity and extensive network exposure. We have seen that symmetric conventional patching techniques—both static and dynamic—often fail to satisfy the stringent requirements of real-time responsiveness and computational efficiency in resource-constrained environments of all kinds of power grids. To address this limitation, we have proposed a hardware-assisted runtime patching framework tailored for embedded systems in critical power system networks. Our method has integrated binary-level vulnerability modeling, execution-trace-driven fault localization, and lightweight patch synthesis, enabling dynamic, in-place code redirection without disrupting ongoing operations. By constructing a system-level instruction flow model, the framework has leveraged on-chip debug registers to deploy patches at runtime, ensuring minimal operational impact. Experimental evaluations within a simulated substation communication architecture have revealed that the proposed approach has reduced patch latency by 92% over static techniques, which are symmetrical in a working way, while incurring less than 3% CPU overhead. This work has offered a scalable and real-time model-driven defense strategy that has enhanced the cyber–physical resilience of embedded systems in modern power systems, contributing new insights into the intersection of runtime security and grid infrastructure reliability. Full article

Flexographic printing, traditionally used in the packaging industry, has emerged as a promising technology for microfluidic device fabrication due to enabling high resolution and being commercially available at a low cost compared to conventional techniques. This review explores the adaptation of a photopolymer flexographic printing plate mold (FMold) for microfluidics, examining its advantages, challenges, and applications. It offers a state-of-the-art view of the application of FMold for microfluidic systems, which offers a unique opportunity in terms of cost-effectiveness, scalability, and rapid prototyping. Applications are diverse: FMold has enabled the fabrication of microfluidic devices used in enhanced oil recovery to prepare rock-on-a-chip models, droplet generation and storage, suspension cell culture, monoclonal antibody production, complex cell differentiation pattern creation, phage screening, drug screening, cell detection, and cancer stem cell culture. Since its first appearance in 2018, FMold has been utilized in 50 publications in different laboratories around the world. Key advancements, current research trends, and future prospects are discussed to provide a comprehensive overview of this evolving tool. Full article