Developmental engineering (DE) aims to culture mammalian cells on corresponding modular scaffolds (scale: micron to millimeter), then assemble these into functional tissues imitating natural developmental biology processes. This research intended to...
Developmental engineering (DE) involves culturing various cells on modular scaffolds (MSs), yielding modular tissues (MTs) assembled into three-dimensional (3D) tissues, mimicking developmental biology. This study employs an integrated approach, merg...
Developmental engineering (DE) is a bottom-up strategy for generating functional tissues from modular tissues (MTs), offering potential advantages over conventional top-down approaches. However, scalable MT production remains constrained by limited u...
The purpose of this research is to examine the benefits and limitations of the implementation of novel digital academic advising systems based on the principles of authentic outcome-based education (OBE) using automated collection and reporting proce...
Over the last decade, organoid research has emerged as a transformative field in biomedical science, offering unparalleled opportunities in disease modeling, pharmacological testing, and tissue engineering [...]
The recent development of transposon and CRISPR-Cas9-based tools for manipulating the fly genome in vivo promises tremendous progress in our ability to study developmental processes. Tools for introducing tags into genes at their endogenous genomic l...
Tissue engineering (TE) was initially designed to tackle clinical organ shortage problems. Although some engineered tissues have been successfully used for non-clinical applications, very few (e.g., reconstructed human skin) have been used for clinic...
Human induced pluripotent stem cells (hiPSCs) have revolutionized cardiovascular research by providing a renewable source of patient-specific cardiomyocytes for disease modeling, drug discovery, precision medicine, and regenerative therapies. Tempora...
A project to formalise and expand Academic Advising has been implemented at the UCD Civil Engineering School. The goals of this project were twofold: on the one hand, it aimed at training faculty members in Academic Advising roles and providing them...
During early developmental stages, embryonic kidneys are not fully vascularized and are potentially exposed to hypoxic conditions, which is known to influence cell proliferation and survival, ureteric bud branching, and vascularization of the develop...
Tubular structures contribute to essential organ functions. Therefore, controlling tubulogenesis is essential for bottom-up tissue engineering approaches. Tissue engineering strategies to form tubular structures utilize extracellular matrix (ECM) com...
Plants, as sessile organisms, have evolved a remarkable developmental plasticity to cope with their changing environment. When growing in hostile desert conditions, plants have to grow and thrive in heat and drought. This review discusses how desert...
Human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) can be differentiated into cardiomyocytes (hESC-CMs and iPSC-CMs, respectively), which hold great promise for cardiac regenerative medicine and disease modeling efforts. Ho...
Chronic kidney disease is one of the deadliest diseases globally and treatment methods are still insufficient, relying mostly on transplantation and dialysis. Engineering of kidney tissues in vitro from induced pluripotent stem cells (iPSCs) could pr...
Tissue spheroids are self-organised 3D cellular aggregates that serve as a versatile platform in tissue engineering. While numerous high-throughput methods exist to characterise the cellular function of tissue spheroids, equivalent techniques for the...
Moso bamboo is well-known for its rapid-growth shoots and widespread rhizomes. However, the regulatory genes of these two processes are largely unexplored. GATA transcription factors regulate many developmental processes, but their roles in moso bamb...
Soybean (Glycine max) seeds are an important source of seed storage compounds, including protein, oil, and sugar used for food, feed, chemical, and biofuel production. We assessed detailed temporal transcriptional and metabolic changes in developing...
On behalf of the editorial board and MDPI Publishing, may we extend a very warm welcome to this first editorial of Geotechnics—a new and international, open access, scholarly journal aimed at showcasing and nurturing high-quality research and develop...
With the increasing prevalence of pirated software, reverse engineering is regarded as a key technology. Reverse engineering enables the reconstruction of compiled code into a high-level language, revealing its functions and characteristics. We analy...
Establishing plant regeneration systems and efficient genetic transformation techniques plays a crucial role in plant functional genomics research and the development of new crop varieties. The inefficient methods of transformation and regeneration o...
Antibody-drug conjugates (ADCs) appear to be in a developmental boom, with five FDA approvals in the last two years and a projected market value of over $4 billion by 2024. Major advancements in the engineering of these novel cytotoxic drug carriers...
Ensuring global food security under accelerating climate change requires transformative approaches to crop improvement that extend beyond the limits of traditional breeding and gene editing. While domestication and modern agriculture have delivered s...
The yak (Bos grunniens) is a unique breed living on the Qinghai–Tibet Plateau and its surrounding areas, providing locals with a variety of vital means of living and production. However, the yak has poor sexual maturity and low fertility. High-qualit...
In the past decade, a new frontier in scarless wound healing has arisen because of significant advances in the field of wound healing realised by incorporating emerging concepts from mechanobiology and immunology. The complete integumentary organ sys...
This paper introduces a Python framework for developing Deep Reinforcement Learning (DRL) in an open-source Godot game engine to tackle sim-to-real research. A framework was designed to communicate and interface with the Godot game engine to perform...
Apolipoprotein E (apoE) mimetic peptides are engineered fragments of the native apoE protein’s LDL-receptor binding site that improve the outcomes following a brain injury and intestinal inflammation in a variety of models. The vicious cycle of...
Background: Amelogenesis imperfecta (AI) has recently been realized as not only an inherited enamel anomaly, but also a genetically heterogeneous developmental disorder and a compelling model for the study of enamel biomineralization and craniofacial...
Family plays a role in supporting child development, by facilitating caregiving and other parental practices. Low- and middle-income families typically have a complex structure with many relatives living together in the same household. The role of fa...
Fish need to make different responses to different water flow conditions, as a variety of fish utilize or overcome the water flow while fish are in the water. This study aims to analyze the response of two types of carp (black carp and silver carp) t...
Against the backdrop of the global pursuit of carbon neutrality, research on coal pore structure has shifted from a single focus on coal mine safety to a dual orientation of hazard prevention and carbon sequestration, forming two distinct research di...
Neuroblastoma (NB), the most common extracranial solid tumor of childhood, exemplifies one of the most formidable paradigms of tumor immune evasion (TIME) in pediatric oncology. Despite significant advances in multimodal therapy and the clinical inte...
Background: Plant synthetic biology reprograms metabolic networks for the sustainable production of high-value compounds. Recent computational advances incorporate machine learning to accelerate the design-build-test-learn (DBTL) cycle, enabling more...
The craniofacial region comprises the most complex and intricate anatomical structures in the human body. As a result of developmental defects, traumatic injury, or neoplastic tissue formation, the functional and aesthetic intricacies of the face and...
Background/Objectives: This paper introduces a pedagogically grounded framework for transforming canonical literary texts in primary education through generative AI. Guided by multiliteracies theory, Vygotskian pedagogy, and epistemic justice, the sy...
The emergence of human-induced Pluripotent Stem Cells (hiPSCs) has dramatically improved our understanding of human developmental processes under normal and diseased conditions. The hiPSCs have been differentiated into various tissue-specific cells i...
Water deficit conditions trigger the production of a chemical signal, the phytohormone abscisic acid (ABA), which coordinates multiple responses at different temporal and spatial scales. Despite the complexity of natural drought conditions, the modul...
As an emerging field of life science, epigenetics plays a pivotal role in regulating gene expression. Epigenetic modifications including histone modifications, DNA methylation, chromatin remodeling, non-coding RNAs, and RNA modifications (particularl...
In parallel with the development and design of different technological advances, competencies in nursing have advanced. With the development of robotics, it is expected that nursing robotic competencies will also increase. The aim of this study is to...
Preparing engineers for rapidly changing sociotechnical environments requires a clear account of the competencies that undergraduate engineering programs should foster. This study used the term future outstanding engineers to refer to engineering und...
Accurate diagnosis of aero-engine faults and precise signal characterization are crucial to ensuring operational reliability and service life prediction. The structural complexity of engines and the variability of operating conditions pose significan...
The chicken egg, an excellent natural source of proteins, has been an overlooked native biomaterial with remarkable physicochemical, structural, and biological properties. Recently, with significant advances in biomedical engineering, particularly in...
Top-down tissue engineering aims to produce functional tissues using biomaterials as scaffolds, thus providing cues for cell proliferation and differentiation. Conversely, the bottom-up approach aims to precondition cells to form modular tissues unit...
Plants integrate time of day (TOD) information over an entire season to ensure optimal growth, flowering time, and grain fill. However, most TOD expression studies have focused on a limited number of combinations of daylength and temperature under la...
Potato (Solanum tuberosum L.) tuberization is a complex developmental transition in which a subterranean stolon is converted into a starch-accumulating tuber. This process is governed by long-distance systemic signals, local hormonal dynamics, and ex...
Tissue engineering is a growing field with multidisciplinary players in cell biology, engineering, and medicine, aiming to maintain, restore, or enhance functions of tissues and organs. The extracellular matrix (ECM) plays fundamental roles in tissue...
Organisms from the genus Streptomyces feature actinobacteria with complex developmental cycles and a great ability to produce a variety of natural products. These soil bacteria produce more than 2/3 of antibiotics used in medicine, and a large variet...
Biological genotypes do not code directly for phenotypes; developmental physiology is the control layer that separates genomes from capacities ascertained by selection. A key aspect is cellular competency, since cells are not passive materials but de...
Hybrid Clarias catfish account for more than 90% of farmed catfish production in Thailand, making hatchery resilience relevant to the continuity of freshwater fish supply. This secondary-data modelling study evaluated how early-life thermal stress ma...
Internal combustion engine downsizing and powertrain electrification trends in recent years have led to higher thermal loads on the cylinder head materials with an increased number of engine start–stop thermal load cycles. This requires designi...
End-stage organ failure remains a leading cause of morbidity and mortality across the globe. The only curative treatment option currently available for patients diagnosed with end-stage organ failure is organ transplantation. However, due to a critic...
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