Search Results (162)

Translocations of endangered species are a common method of conserving wildlife; however, the release of dietary specialists pose unique challenges for conservationists. In preparation for future releases of the red panda (Ailurus fulgens styani), a bamboo specialist, a proof-of concept test was performed using the ‘Human-Assisted Soft Release’ (HASR) method previously used with giant pandas. Two red pandas (one male, one female) were trained using positive reinforcement to recall to a researcher and voluntary placement of GPS collars as well as physical examinations. Afterwards, to simulate a translocation, the individuals were ‘mock-released’ into a large public access red panda enclosure. Following the ‘mock-release’, the pandas were monitored for four weeks via GPS collars mounted with accelerometers as well as the HASR method. The protocol proved operationally successful: across eight scheduled sessions, both individuals met all four predefined criteria in every session attended (8/8 and 7/7, the latter shortened by injury), permitting recall, collar changes, body examinations and weighing inside a public enclosure without anesthesia or physical restraint, and allowing an injury to be detected from collar data and treated the following morning. Alongside this operational record, activity and space use were monitored descriptively. The odds of being active in the first week rose to 1.9 and 1.6 times each individual’s own pre-release baseline (+13.7 and +8.3 percentage points; p < 0.001) before returning to baseline across the month, and the two individuals differed in the reshaping of their daily rhythm and in their use of space. With the limitation of two individuals and an overlap with the breeding season, the behavioral observations reported here are descriptive and hypothesis-generating rather than hypothesis-confirming and require replication. The operational findings nonetheless demonstrate that the HASR method is technically feasible with red pandas and provides a basis for the pre-release preparation of this endangered species. Full article

Background/Objectives: Detecting covert paroxysmal atrial fibrillation (AF) in patients with suspected embolic stroke of undetermined source (ESUS) is important for secondary prevention. This study evaluated the feasibility, AF detection, and wearability of the hitoe^® wearable electrocardiogram (ECG) monitoring system II, a Holter-type device recording continuously for up to 14 days. Methods: Between March 2022 and October 2023, 31 patients with suspected ESUS were enrolled. After excluding two cases, 29 patients (mean age 74.7 ± 17.3 years; 16 men) underwent ECG monitoring. Clinical outcomes were analyzed in 27 acute-phase patients and wearability in 24 questionnaire respondents. ECG recordings and questionnaire responses were analyzed descriptively, with between-group comparisons. Results: In 29 monitored patients, the mean recording duration was 12.4 ± 3.7 days, the ECG acquisition rate was 64.0 ± 23.4% (median 72.1%), and the mean analyzable duration was 8.1 ± 3.7 days. In the 27 acute-phase patients, covert paroxysmal AF was detected in 2 patients (7.4%), on days 1, 3, and 15 in one patient and on day 7 in the other. In AF-positive patients, the mean ectopic burden was 1.33% for supraventricular and 0.24% for ventricular activity. Wearability was favorable: 77.8% reported no interference with daily activities, none reported sleep disturbance, and 72.7% adapted within 1–4 days. Conclusions: The hitoe^® wearable ECG monitoring system II enabled prolonged monitoring across inpatient and outpatient settings, detecting covert paroxysmal AF in 7.4% of acute-phase patients with suspected ESUS. These findings support garment-type wearable ECG monitoring as a non-invasive option for extended rhythm surveillance. Full article

This article examines how professionals who use generative AI in their daily work reshape their temporal experience. Drawing on 21 semi-structured interviews with experienced AI users and developers in Romania, and building on Flaherty’s concept of “time work”, it introduces the notion of delegated time work: a form of temporal agency in which individuals transfer part of the time-shaping effort to an AI tool while retaining judgment over the temporal structure of activity. The results show clear support for delegated time work in three dimensions of temporal experience: duration, sequence, and allocation. Evidence for frequency, timing, and taking time is limited: delegation succeeds in the dimensions professionals control individually and fails in those governed by shared institutional rhythms. Delegation also generates its own temporal costs through learning and verification overheads, unevenly distributed between developers and users. Drawing on the “time capital” framework of Matei and Preda, the analysis traces three outcomes of the freed time: accumulation as a personal resource, conversion into professional or economic capital, and absorption by rising expectations, leaving workers faster but not freer. In Romania’s dependent market economy, market exposure shapes who keeps the time that AI frees. Full article

Introduction: River connectivity is a fundamental component of lotic ecosystems, frequently disrupted by anthropogenic barriers. Fishways are critical mitigation tools for restoring this connectivity; however, their temporal use by fish is often assumed to be restricted to specific seasonal windows (mainly spawning season). Understanding the fine-scale temporal dynamics of fishway use by native species such as the common barbel (Luciobarbus bocagei) is essential for effective, long-term river management and the conservation of Iberian freshwater biodiversity. Objective: This study aims to evaluate the daily and seasonal patterns of use of pool-type fishways by L. bocagei, in order to improve the determination of their temporal period of use and provide data-driven recommendations for their management. Methodology: The study was conducted in the middle reach of the Duero River (Burgos province). Over a multi-year period, more than 1000 individual barbels were captured, tagged with Passive Integrated Transponder (PIT) tags, and released. Movements were continuously monitored across two pool-type fishways. Telemetry detection data were analyzed to evaluate daily rhythms and seasonal use, as well as to estimate the start and end dates of the movement periods. Results: Our analysis revealed a highly marked daily pattern in fishway use, showing a clear increase during daylight hours, with more pronounced peaks at dawn and dusk. This daily activity dynamically adjusts throughout the year in response to the solar cycle. Furthermore, we successfully determined that the seasonal activity extends from March to November, a pattern that remained consistent throughout the different study years. Crucially, the telemetry data empirically demonstrated that L. bocagei utilizes fishways for a substantial portion of the year, indicating relevant non-reproductive movements. Conclusions: The extended temporal use of these fishways indicates their potential ecological functions throughout much of the year. This must be reflected in management and maintenance protocols that ensure sufficient flow conditions, cleaning, and active vigilance during most of the year. Additionally, this predictability reinforces the value of fishways as strategic biological monitoring stations for endemic populations. Full article

Background: Disruptions in social and circadian rhythms are increasingly recognized as key contributors to depressive symptomatology and impaired quality of life, particularly in older adults, for whom daily regularity represents a crucial determinant of psychological and functional stability. Understanding the interplay between rhythm dysregulation, mood disturbances, and perceived well-being may inform preventive strategies in aging populations. Objective: This study aimed to examine the association between social rhythm dysregulation, depressive symptoms, and perceived quality of life in a sample of community-dwelling older adults. Methods: A cross-sectional observational study was conducted among 119 older adults (mean age 72.26 ± 4.72 years) enrolled in an active aging program. Social rhythms were assessed using the Brief Social Rhythm Scale (BSRS), depressive symptoms with the Patient Health Questionnaire-9 (PHQ-9), and health-related quality of life with the SF-12 Health Survey. Pearson correlation analyses and multiple linear regression models were applied. Results: Greater social rhythm dysregulation was significantly associated with higher depressive symptom levels (r = 0.41, p < 0.001) and lower perceived quality of life (r = −0.39, p < 0.001). In multivariate analyses, both rhythm dysregulation (β = −0.1863, p < 0.001) and depressive symptoms (β = −0.2885, p = 0.037) independently predicted poorer quality of life. Conclusions: In community-dwelling older adults, irregular social rhythms and depressive symptoms are independently and jointly associated with reduced quality of life. These findings highlight social rhythm regulation as a relevant and potentially modifiable target for preventive and supportive interventions aimed at promoting mental well-being and resilience in later life. Full article

Background/Objectives: Circadian rhythm disruption is linked to cognitive decline, yet it remains unclear how behavioral and physiological rhythm markers are differently associated with cognition in amnestic mild cognitive impairment (aMCI). The primary aim of this study was to compare sleep–wake timing, rest–activity rhythm (RAR), and dim light melatonin onset (DLMO) between patients with aMCI and cognitively normal controls. Exploratory analyses further examined their associations with domain-specific cognitive performance. Methods: Eighteen aMCI patients and 21 cognitively normal controls (NC) enrolled. Cognitive function was assessed using the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease Neuropsychological Battery (CERAD-K). Participants underwent 5-day actigraphy to assess sleep–wake timing and non-parametric RAR variables, including interdaily stability (IS), intradaily variability (IV), and relative amplitude (RA). DLMO was determined from hourly salivary melatonin samples collected over five hours before sleep onset under dim-light conditions. Group comparisons of circadian markers were conducted as the primary analyses, and generalized linear models were used for exploratory analyses of associations between circadian markers and cognitive outcomes. Results: Groups did not significantly differ in sleep–wake timing, RAR parameters and DLMO. Sleep–wake timing variables and DLMO were not significantly associated with cognitive performance. Higher IS was associated with better visuospatial memory and executive function, whereas higher RA was associated with poorer verbal memory among aMCI patients. Conclusions: Although sleep–wake timing and melatonin phase did not differ between groups nor predict cognitive performance, higher daily rhythm stability was linked to better non-verbal memory and executive functioning. In contrast, high RA may relate to poorer verbal memory in aMCI, suggesting that elevated RA may not reflect true circadian robustness required for optimal cognition. Full article

Grazing is a widespread land use practice with significant implications for biodiversity and ecosystem functioning. Wild ungulates, as key components of terrestrial ecosystems, play a vital role in maintaining ecosystem health. Dietary overlap exposes wild ungulates to intense competition with livestock, yet the effects of grazing on them remain underexplored. Using camera-trapping data from Xinglong County in the mountains of Southeast China, we investigated the spatiotemporal responses of eight wild ungulates to livestock (cattle and horses). Our results showed the following: (1) The potential distribution of suitable habitats for ungulates was primarily shaped by elevation (ELE), distance to temple (DTT), precipitation of the coldest quarter (bio19), and distance to water (DTW). Among the species, blue sheep (Pseudois nayaur) showed the strongest response to livestock presence. (2) Spatially, most ungulates appeared to avoid livestock; forest musk deer (Moschus berezovskii) showed spatial avoidance of horses. (3) Temporally, the daily activity patterns of most ungulates generally showed low to moderate overlap with those of cattle. These findings suggest that livestock grazing may be associated with negative effects on wild ungulates in Xinlong County. Given the ecological importance of ungulates, the need to maintain wildlife community integrity, and the long history of grazing in the region, further research is warranted to understand the role of livestock in shaping wildlife communities. Full article

Circadian rhythms are predictable biological patterns that recur about every 24 h and, in mammals such as humans, are entrained to daylight by the hypothalamic suprachiasmatic nucleus (SCN). Although light is a potent zeitgeber for the SCN, cells outside of the SCN can synchronize to daily nutrient and metabolic cues. In these tissues, nutrient metabolic processes are regulated by the molecular clock in anticipation of food availability or scarcity. Furthermore, nutrients and metabolic processes themselves may act upon members of the molecular clock to regulate their expression and activity. These interactions maintain synchrony between the SCN and food-entrainable clocks when activity and nutrient intake align. However, the light-entrainable SCN and food-entrainable clocks can become desynchronized, particularly in modern society where humans are commonly exposed to shift work and jet lag. Therefore, the mechanisms for sensing nutrients at specific times of day are critical components of circadian timekeeping and organismal homeostasis. In the following narrative review, we aim to synthesize current evidence on time-of-day-dependent nutrient sensing in mammalian systems, examine how nutrient-derived signals and metabolic processes interact with molecular clock mechanisms across cellular and tissue levels, and evaluate the integration of central and peripheral clocks in regulating gene expression, energy utilization, and organismal homeostasis, including the impacts of feeding cycles and circadian disruption. While previous reviews have discussed circadian nutrient metabolism, this review provides conceptual support for the role of nutrients as time-of-day signaling mechanisms. Full article

Sleep abnormalities and circadian rhythm disruptions are frequently observed in psychiatric disorders such as depression and schizophrenia. However, most previous studies have examined circadian rhythms and sleep separately, limiting understanding of how these processes interact within individuals. This study examined circadian and sleep characteristics in depression and schizophrenia compared with healthy controls using multi-day wrist actigraphy. Circadian rhythms were assessed using parametric and non-parametric measures of rest–activity patterns, and sleep metrics were derived using a validated actigraphy-based algorithm. Distinct patterns were observed across diagnostic groups. Schizophrenia showed widespread disruption in daily activity patterns, with altered timing and reduced rhythm strength. Sleep was longer but highly fragmented, with frequent awakenings despite increased time in bed. In contrast, depression showed more limited changes, mainly in activity timing and overall activity levels, while sleep and daily patterns remained closer to controls. A key finding was the identification of distinct circadian–sleep profiles for each condition, with global disruption in schizophrenia and more selective alterations in depression. These findings show that combining circadian and sleep measures provides a clearer understanding of psychiatric disorders and may support monitoring and targeted interventions based on daily behavioral rhythms. Full article

Understanding how environmental factors such as shelter availability and hibernation influence amphibian behavior is critical for improving conservation and captive management. In this study, we examined the effects of shelter and hibernation on 24 h behavioral patterns of male Dybowski’s frogs (Rana dybowskii) across different age groups. Twenty adult and twenty juvenile frogs were observed during pre- and post-hibernation periods under controlled laboratory conditions using continuous video monitoring. Both adults and juveniles showed significantly increased resting behavior when provided with shelter, with adults resting more than 70% of the time and juveniles exceeding 80%. Hibernation induced clear changes in circadian rhythms, including shifts in peak activity times, and vocalizations increased post-hibernation in both age groups, reflecting physiological adjustments associated with reproductive activation. Juveniles displayed more pronounced activity rhythms and greater sensitivity to shelter availability, indicating age-specific differences in environmental adaptability. These findings demonstrate the importance of shelter in shaping behavioral patterns and highlight that hibernation leads to temporary but marked alterations in daily activity cycles. Full article

Background: This study investigated the diurnal variation in endurance performance and the corresponding ventilatory/metabolic responses during a maximal incremental cycling test. Methods: Thirty physically active young men (age = 23.5 ± 2.2 years; weekly exercise volume: ≥6 h·wk⁻¹) with regular daily routines were recruited for a randomized crossover study. Each participant completed two maximal incremental cycling tests to volitional exhaustion: one in the morning (07:00–09:00) and another in the evening (17:00–19:00). The two sessions were separated by a one-week washout period. Key ventilatory and metabolic variables, including maximal voluntary ventilation (MVV) and maximal oxygen uptake (VO_2max), were continuously measured, and time to exhaustion (TTE) was monitored. Paired-samples t-tests were used to compare morning versus evening outcomes. Results: Key performance and physiological variables, including MVV (p < 0.01), VO_2max (p < 0.01), and TTE (p < 0.01), were significantly improved in the evening as compared to the morning. Conclusions: Both ventilatory/metabolic function and endurance performance during a maximal incremental cycling test induce a pronounced diurnal rhythm in trained young men, with superior outcomes observed in the evening. Full article

Cardiometabolic and cardiovascular risks are commonly assessed using body mass index (BMI) and static measures of adiposity; however, individuals with similar BMI frequently exhibit markedly different metabolic and cardiovascular outcomes. This heterogeneity reflects not only differences in fat distribution but also variation in adipose tissue function and its temporal regulation. Adipose tissue contains intrinsic circadian clocks that coordinate daily rhythms in lipid storage and mobilization, insulin sensitivity, adipokine secretion, and immune activity in alignment with sleep–wake and feeding–fasting cycles. Circadian misalignment, as occurs with shift work, irregular sleep, or mistimed food intake, disrupts this coordination and promotes adipose tissue dysfunction characterized by impaired rhythmic lipid handling, altered endocrine signaling, inflammation, fibrosis, and oxidative stress. Emerging evidence suggests that circadian dysregulation may differentially affect adipose depots, including visceral, epicardial, and perivascular fat, thereby linking chronodisruption to insulin resistance, endothelial dysfunction, atherosclerosis, heart failure phenotypes, and arrhythmia susceptibility. This narrative review synthesizes human, experimental, and translational studies examining adipose tissue circadian regulation as a functional determinant of cardiometabolic and cardiovascular risk beyond BMI. We also discuss the clinical implications of circadian-informed strategies, including chrononutrition and time-restricted eating, as potential tools to improve risk stratification and cardiometabolic health. Full article

Premature Ventricular Complexes (PVCs) are among the most frequent ventricular arrhythmias observed in daily cardiology practice. Although often benign, sustained high ectopic activity can result in left ventricular dysfunction known as PVC-induced Cardiomyopathy (PVC-CMP), a condition that is frequently reversible when the arrhythmia is effectively suppressed. The underlying mechanisms are multifaceted, involving electromechanical dyssynchrony, contractile inefficiency, abnormal calcium cycling, neurohormonal activation, and progressive structural remodeling. The likelihood of developing PVC-CMP varies among individuals and is influenced by electrophysiological and structural factors. Diagnosis relies on prolonged rhythm monitoring, comprehensive multimodality imaging, and demonstration of ventricular recovery after reducing the ectopic burden, which, in turn, confirms causality. Over the past decade, major advances in electrocardiographic mapping, cardiac imaging, and ablation therapy have transformed this field, demonstrating excellent efficacy and safety profiles. In parallel, artificial intelligence and computational mapping are emerging as powerful tools for prediction and procedural guidance. Recognition of PVC-CMP as a distinct, treatable cardiomyopathy highlights the importance of early detection and individualized therapy, offering the prospect of complete functional recovery and the prevention of heart failure progression. Full article

Background/Objectives: Combined chronotherapy (CCT), which combines repeated sleep deprivation and light therapy, is used in the clinical treatment of severe depression. Despite its potential to rapidly reduce depressive symptoms, CCT is infrequently used in clinical practice. We explored whether actigraphy-derived within-patient changes in physical activity, sleep parameters, and sleep–wake patterns prior to CCT can help identify those most likely to benefit from this treatment, supporting personalized mental health care. Methods: Actigraphy data from nine severely depressed patients were collected before, during, and after CCT. Data were assessed with a questionnaire on depressive symptoms (Inventory of Depressive Symptomatology—Self Report, IDS-SR) and actigraphy measures for sleep–wake patterns and physical activity: daily mean activity level, rhythm (intradaily variability (IV), interdaily stability (IS)), Midpoint of Sleep (MSF), time in bed, sleep efficiency (SE), and the fragmentation index (FI). Variables were compared before and after CCT by systematic visual inspection due to the small sample size. A prior set Minimal Clinically Important Difference (MCID) of a 30% change in IDS scores from before and the week after CCT was used to categorize patients as responders (n = 3) or nonresponders (n = 6) to CCT. Results: After CCT, for both responders and nonresponders, there was a notable decrease in IDS, IV and FI. Prior to CCT, responders, compared to nonresponders, were characterized with higher IDS, more time in bed and higher FI, while having lower SE. Conclusions: We concluded that actigraphy assessments during regular CCT are feasible and found preliminary evidence that patients with the most disrupted sleep–wake patterns prior to treatment may benefit most from CCT. Full article

Introduction: Massage therapy delivers structured mechanosensory input that can influence brain function, yet the central mechanisms and potential for neuroplastic change have not been synthesized across neuroimaging modalities. This mechanistic review integrates evidence from electroencephalography (EEG), functional MRI (fMRI), and functional near-infrared spectroscopy (fNIRS) to map how massage alters human brain activity acutely and over time and to identify signals of longitudinal adaptation. Materials and Methods: We conducted a scoping, mechanistic review informed by PRISMA/PRISMA-ScR principles. PubMed/MEDLINE, Cochrane Library, Google Scholar, and ResearchGate were queried for English-language human trials (January 1990–July 2025) that (1) delivered a practitioner-applied manual massage (e.g., Swedish, Thai, shiatsu, tuina, reflexology, myofascial techniques) and (2) measured brain activity with EEG, fMRI, or fNIRS pre/post or between groups. Non-manual stimulation, structural-only imaging, protocols, and non-English reports were excluded. Two reviewers independently screened and extracted study, intervention, and neuroimaging details; heterogeneity precluded meta-analysis, so results were narratively synthesized by modality and linked to putative mechanisms and longitudinal effects. Results: Forty-seven studies met the criteria: 30 EEG, 12 fMRI, and 5 fNIRS. Results: Regarding EEG, massage commonly increased alpha across single sessions with reductions in beta/gamma, alongside pressure-dependent autonomic shifts; moderate pressure favored a parasympathetic/relaxation profile. Connectivity effects were state- and modality-specific (e.g., reduced inter-occipital alpha coherence after facial massage, preserved or reorganized coupling with hands-on vs. mechanical delivery). Frontal alpha asymmetry frequently shifted leftward (approach/positive affect). Pain cohorts showed decreased cortical entropy and a shift toward slower rhythms, which tracked analgesia. Somatotopy emerged during unilateral treatments (contralateral central beta suppression). Adjuncts (e.g., binaural beats) enhanced anti-fatigue indices. Longitudinally, repeated programs showed attenuation of acute EEG/cortisol responses yet improvements in stress and performance; in one program, BDNF increased across weeks. In preterm infants, twice-daily massage accelerated EEG maturation (higher alpha/beta, lower delta) in a dose-responsive fashion; the EEG background was more continuous. In fMRI studies, in-scanner touch and reflexology engaged the insula, anterior cingulate, striatum, and periaqueductal gray; somatotopic specificity was observed for mapped foot areas. Resting-state studies in chronic pain reported normalization of regional homogeneity and/or connectivity within default-mode and salience/interoceptive networks after multi-session tuina or osteopathic interventions, paralleling symptom improvement; some task-based effects persisted at delayed follow-up. fNIRS studies generally showed increased prefrontal oxygenation during/after massage; in motor-impaired cohorts, acupressure/massage enhanced lateralized sensorimotor activation, consistent with use-dependent plasticity. Some reports paired hemodynamic changes with oxytocin and autonomic markers. Conclusions: Across modalities, massage reliably modulates central activity acutely and shows convergent signals of neuroplastic adaptation with repeated dosing and in developmental windows. Evidence supports (i) rapid induction of relaxed/analgesic states (alpha increases, network rebalancing) and (ii) longer-horizon changes—network normalization in chronic pain, EEG maturation in preterm infants, and neurotrophic up-shifts—consistent with trait-level recalibration of stress, interoception, and pain circuits. These findings justify integrating massage into rehabilitation, pain management, mental health, and neonatal care and motivate larger, standardized, multimodal longitudinal trials to define dose–response relationships, durability, and mechanistic mediators (e.g., connectivity targets, neuropeptides). Full article