Search Results (949)

During the transition of culture-featured district planning from static conservation to innovation-driven models, existing research remains constrained by mechanistic paradigms, reducing districts to functional containers and neglecting human perceptual interactions and meaning-production mechanisms. This study explores and quantifies the generative mechanisms of spatial communicability and cultural dissemination efficacy within human-centered frameworks. Grounded in humanistic urbanism, we analyze Harbin Central Street as a case study integrating historical heritage with contemporary vitality, developing a tripartite communicability assessment framework comprising perceptual experience, infrastructure utility, and behavioral dynamics. Machine learning-based threshold analysis reveals that spatial encoding elements govern communicability through significant nonlinear mechanisms. The conclusion shows synergies between street view-quantified greenery visibility and pedestrian accessibility establish critical human-centered design thresholds. Spatial data analysis integrating physiologically sensed emotional experiences and topologically analyzed spatial morphology resolves metric fragmentation while examining spatial encoding’s impact on interaction efficacy. This research provides data-driven decision support for sustainable urban renewal and enhanced cultural dissemination, advancing heritage sustainability. Full article

Existing research predominantly focuses on the preservation or renewal models of the physical forms of historic cultural districts, with limited exploration of their roles in stimulating tourists’ cognitive, affective resonance, and behavioral interactions. This study addresses historic cultural districts by evaluating the space quality and its impact on tourist experiences through the “cognition-affect-behavior” framework, integrating GIS, street view semantic segmentation, VR eye-tracking, and web crawling technologies. The findings reveal significant multidimensional differences in how space quality influences tourist experiences: the impact intensities of functional diversity, sky visibility, road network accessibility, green visibility, interface openness, and public facility convenience decrease sequentially, with path coefficients of 0.261, 0.206, 0.205, 0.204, 0.201, and 0.155, respectively. Additionally, space quality exerts an indirect effect on tourist experiences through the mediating roles of cognitive, affective, and behavioral dimensions, with a path coefficient of 0.143. This research provides theoretical support and practical insights for empowering cultural heritage space governance with digital technologies in the context of cultural and tourism integration. Full article

Murine microglia exhibit rapid self-renewal upon removal from the postnatal brain. However, the signaling pathways that regulate microglial repopulation remain largely unclear. To address this knowledge gap, we depleted microglia from mixed glial cultures using anti-CD11b magnetic particles and cultured them for 4 weeks to monitor their repopulation ability in vitro. Flow cytometry and immunocytochemistry revealed that anti-CD11b bead treatment effectively eliminated >95% of microglia in mixed glial cultures. Following removal, the number of CX3CR1-positive microglia gradually increased; when a specific threshold was reached, repopulation ceased without any discernable rise in cell death. Cell cycle and 5-ethynyl-2′-deoxyuridine incorporation assays suggested the active proliferation of repopulating microglia at d7. Time-lapse imaging demonstrated post-removal division of microglia. Colony-stimulating factor 1 receptor-phosphoinositide 3-kinase-protein kinase B signaling was identified as crucial for microglial repopulation, as pharmacological inhibition or neutralization of the pathway significantly abrogated repopulation. Transwell cocultures revealed that resident microglia competitively inhibited microglial proliferation probably through contact inhibition. This in vitro microglial removal system provides valuable insights into the mechanisms underlying microglial proliferation. Full article

This article examines the epistemological and homiletical implications of postmodernity for Christian preaching. It addresses the communicative crisis introduced by postmodern skepticism toward metanarratives. It proposes a constructive theological response through the re-articulation of the gospel as a coherent, storied, and transformative metanarrative. Drawing on interdisciplinary scholarship in theology, homiletics, epistemology, and cultural theory, this study argues that a thoughtful engagement with postmodern critique can serve as a catalytic force for ecclesial renewal. The article advocates for a homiletic method that re-engages Scripture’s narrative form while emphasizing relational epistemology, incarnational witness, and contextual sensitivity. By utilizing narrative theology, post-critical epistemologies, and performative models of preaching, this study proposes a recalibrated approach to gospel proclamation, adapted for fragmented and skeptical audiences, while safeguarding theological orthodoxy. Full article

Moringa peregrina (Forssk.) Fiori is a tropical tree in southern Iran known as the most important natural coagulant in the world. Today, plant tissue culture is a new method that has a very high potential to produce valuable medicinal compounds on a commercial level. Advances in in vitro cultivation methods have increased the usefulness of plants as renewable resources. In this study, in addition to the phytochemical analysis of the extract of M. peregrina using HPLC, the interaction effect of different concentrations of aqueous extract of M. peregrina (0, 1, 1.5, and 3 mg/L) in two types of MS and ½ MS basal culture media over three weeks on the in vitro growth of Staurogyne repens (Nees) Kuntze was studied. The amounts of quercetin, gallic acid, caffeic acid, and myricetin in the aqueous extract of M. peregrina were 64.9, 374.8, 42, and 4.6 mg/g, respectively. The results showed that using M. peregrina leaf aqueous extract had a positive effect on the length of the branches, the percentage of green leaves, rooting, and the fresh and dry weight of S. repens samples. The highest increase in growth indices was observed in the MS culture medium supplemented with 3 mg/L of M. peregrina leaf aqueous extract after three weeks of cultivation. Of course, this effect was significantly greater in the MS medium and at higher concentrations compared to the ½ MS medium. Three weeks after cultivation at a concentration of 3 mg/L of the extract, the length of the S. repens branches was 5.3 and 1.8 cm in the two basic MS and ½ MS culture media, and the percentage of green leaves was 14 and 4 percent, respectively. Also, rooting was measured at 9.6 and 3.6 percent, fresh weight at 6 and 1.4 g, and dry weight at 1.1 and 0.03 g, respectively. Therefore, adding M. peregrina leaf aqueous extract as a stimulant significantly increased the in vitro growth of S. repens. Full article

The growing environmental concerns associated with petroleum-based plastics require the development of sustainable, biodegradable alternatives. Polyhydroxyalkanoates (PHAs), a family of biodegradable bioplastics, offer a promising potential as eco-friendly substitutes due to their renewable origin and favorable degradation properties. This research investigates the use of synthetic condensate, mimicking the liquid fraction from drying and shredding of household food waste, as a viable substrate for PHA production using mixed microbial cultures. Two draw-fill reactors (DFRs) were operated under different feed organic concentrations (2.0 ± 0.5 and 3.8 ± 0.6 g COD/L), maintaining a consistent carbon-to-nitrogen ratio to selectively enrich microorganisms capable of accumulating PHAs through alternating nutrient availability and deficiency. Both reactors achieved efficient organic pollutant removal (>95% soluble COD removal), stable biomass growth, and optimal pH levels. Notably, the reactor with the higher organic load (DFR-2) demonstrated a modest increase in PHA accumulation (19.05 ± 7.18%) compared to the lower-loaded reactor (DFR-1; 15.19 ± 6.00%), alongside significantly enhanced biomass productivity. Polymer characterization revealed the formation of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), influenced by the substrate composition. Microbial community analysis showed an adaptive shift towards Proteobacteria dominance, signifying successful enrichment of effective PHA producers. Full article

Offsite construction (OSC) offers a promising alternative for accelerating refurbishment projects across Italy and Europe. However, its adoption remains limited due to technical, regulatory, and cultural barriers. This study, conducted as part of the OFFICIO project, maps the current European OSC landscape, with a focus on wood and light-steel technologies for sustainable building refurbishment. Combining a literature review, analysis of funded projects, and market data for 541 OSC products, the study develops tailored KPIs to assess these products’ technical maturity, prefabrication level, and environmental integration. The results reveal that wood-based OSC, although less widespread, is more mature and centered on the use of multi-layer panels, while steel-based systems, though more prevalent, remain largely tied to semi-offsite construction, indicating untapped development potential. Research efforts, especially concentrated in Mediterranean regions, focus on technological integration of renewable energy systems. A significant literature gap was identified in information concerning panel-to-wall connection, critical for renovation, limiting OSC’s adaptability to regeneration of existing buildings. The findings highlight the need for cross-sector collaboration, legislative clarity, and better alignment of public procurement standards with OSC characteristics. Addressing these issues is essential to bridge the gap between research prototypes and industrial adoption and accelerate the sustainable transformation of Europe’s construction sector to help meet climate neutrality targets. Full article

The biggest challenge in cancer therapy is tumor resistance to the classical approach. Thus, research interest has shifted toward the cancer stem cell population (CSC). CSCs are a small subpopulation of cancer cells within tumors with self-renewal, differentiation, and metastasis/malignant potential. They are involved in tumor initiation and development, metastasis, and recurrence. Method. A narrative review of significant scientific publications related to the topic and its applicability in endometrial cancer (EC) was performed with the aim of identifying current knowledge about the identification of CSC populations in endometrial cancer, their biological significance, prognostic impact, and therapeutic targeting. Results: Therapy against the tumor population alone has no or negligible effect on CSCs. CSCs, due to their stemness and therapeutic resistance, cause tumor relapse. They target CSCs that may lead to noticeable persistent tumoral regression. Also, they can be used as a predictive marker for poor prognosis. Reverse transcription–polymerase chain reaction (RT-PCR) demonstrated that the cultured cells strongly expressed stemness-related genes, such as SOX-2 (sex-determining region Y-box 2), NANOG (Nanog homeobox), and Oct 4 (octamer-binding protein 4). The expression of surface markers CD133+ and CD44+ was found on CSC as stemness markers. Along with surface markers, transcription factors such as NF-kB, HIF-1a, and b-catenin were also considered therapeutic targets. Hypoxia is another vital feature of the tumor environment and aids in the maintenance of the stemness of CSCs. This involves the hypoxic activation of the WNT/b-catenin pathway, which promotes tumor survival and metastasis. Specific antibodies have been investigated against CSC markers; for example, anti-CD44 antibodies have been demonstrated to have potential against different CSCs in preclinical investigations. Anti-CD-133 antibodies have also been developed. Targeting the CSC microenvironment is a possible drug target for CSCs. Focusing on stemness-related genes, such as the transcription pluripotency factors SOX2, NANOG, and OCT4, is another therapeutic option. Conclusions: Stemness surface and gene markers can be potential prognostic biomarkers and management approaches for cases with drug-resistant endometrial cancers. Full article

This article examines the scholarship of John Allegro on the Dead Sea Scrolls and the role his status as a scholar has played in the reception of his The Sacred Mushroom and the Cross. While the Dead Sea Scrolls play no prominent role in the book, people promoting Sacred Mushroom and its unorthodox proposals stress that Allegro is a respected scholar with great philological acumen by appealing to status as an expert on the Dead Sea Scrolls. But Allegro’s contribution to the field is much more mixed than is often acknowledged by proponents of Sacred Mushroom. Allegro was also one of the first to promote the corrosive conspiracy theory that the rest of the editorial team was being controlled by the Vatican. Recognizing that Allegro’s scholarship is infused with a kind of conspiratorial ideation helps understand his method and approach in Sacred Mushroom—that the evidence that Christianity began as a sacred mushroom cult was intentionally obscured by New Testament authors. To agree with Allegro, one must grant that the evidence is hidden and below the surface. The renewed popularity for Allegro’s work, which is out of sync with his reputation among Qumran scholars, can be understood as one example of the broader phenomenon of the popularity of conspiratorial theories in contemporary culture Full article

Cheese production is an ancient practice that is associated with the food and cultural identity of different peoples. There are over 500 cheese types globally, including 207 with protected denomination of origin (PDO) and 70 with protected geographical indication (PGI) status in the European Union (EU). Each cheese has various biochemical compositions, production methods, and maturation environments. This study has provided a critical review of the environmental impacts of cheese production, focusing on energy consumption, greenhouse gas (GHG) emissions, and the integration of renewable energy sources as sustainable strategies for this sector. Based on case studies and life cycle assessment (LCA) methodologies, the analysis revealed significant variability in energy use (3.0 to 70.2 MJ/kg) and GHG emissions (up to 22.13 kg CO₂ eq/kg), influenced by factors such as the cheese type, production complexity, system boundaries, and the technological or geographical context. Particular attention was given to heat treatment, refrigeration, and maturation processes, which contribute substantially to the overall energy footprint. The paper also discusses the methodological challenges in LCA studies, including the role of co-product allocation and database limitations. Finally, strategic renewable energy options, such as biogas recovery and solar thermal integration, are discussed as sustainable alternatives to reduce the environmental footprint of the dairy sector and support its sustainability. Full article

Renewable energy projects are critical for sustainable development, yet their success often hinges on local community acceptance. This study refines the Community Acceptance Framework to classify and better understand the social and behavioral factors that shape community responses to renewable energy projects. To support the reclassification, we draw selectively on three psychological concepts to refine definition and streamline categories. Based on a systematic review of 212 studies, we identified 29 influencing factors and categorized them into a seven-dimensional framework: social, economic, environmental, political, process, project details, and temporal. The findings reveal that financial capital, which reflects economic gains, emerges as the most frequently cited factor influencing local acceptance. However, when viewed dimensionally, the social dimension encompassing factors such as social capital, cognitive response, and cultural capital accounts for the largest share of influencing factors. Additionally, the often-overlooked political and temporal dimensions highlight the importance of governance quality and timely community engagement. While the framework offers a more robust and context-sensitive tool for analyzing acceptance dynamics, empirical validation is needed to assess its practical applicability. Nevertheless, the refined CAF can guide policymakers, researchers, and practitioners in designing renewable energy initiatives that are both technically sound, economically viable, and socially inclusive. Full article

Guadua amplexifolia J. Presl is a Neotropical bamboo native to southern Mexico through Central America to Colombia, where it thrives in riparian zones of the San Jorge River basin. Despite its ecological and socio-economic importance, its environmental dynamics and provision of ecosystem services remain poorly understood. This study (1) quantifies spatial and temporal land use/cover changes in the municipality of Montelíbano between 2002 and 2022 and (2) evaluates the ecosystem services that local communities derive from in 2002, 2012, and 2022, and they were classified in QGIS using G. amplexifolia. We applied a supervised classification of Landsat imagery (2002, 2012, 2022) in QGIS, achieving 85% overall accuracy and a Cohen’s Kappa of 0.82 (n = 45 reference points). For the social assessment, we held participatory workshops and conducted semi-structured interviews with artisans, fishers, authorities, and NGO representatives; responses were manually coded to extract key themes. The results show a 12% decline in total vegetated area from 2002 to 2012, followed by an 8% recovery by 2022, with bamboo-dominated stands following a similar pattern. Communities identified raw material provision (87% of mentions), climate regulation (82%), and cultural–recreational benefits (58%) as the most important services provided by G. amplexifolia. This is the first integrated assessment of G. amplexifolia’s landscape dynamics and community-valued services in the San Jorge basin, highlighting its dual function as a renewable resource and a natural safeguard against environmental risks. Our findings offer targeted recommendations for management practices and land use policies to support the species’ conservation and sustainable utilization. Full article

This study contributes to the broader sustainability discourse by evaluating public knowledge, awareness, and practices regarding air pollution among residents of Hanoi, Vietnam, focusing on its causes, health impacts, and mitigation strategies. A cross-sectional survey was conducted with 521 individuals in suburbs around Hanoi. A multistage sampling technique, combining cluster and simple random sampling, was used for participant recruitment. Three central and three suburban districts of Hanoi were randomly selected as clusters. One individual from each household was invited to participate and answer a structured survey, which assessed perceptions of air pollution, its human-induced causes, recognised health impacts, and individual and community-level mitigation behaviours. Nearly all participants (98.3%) were aware of air pollution, with 65.3% attributing it to human activities and 61.2% recognising specific air pollutants as primary contributors. The majority (93.9%) acknowledged health impacts, citing respiratory infections (55.1%) and sinus issues (51.2%) as prevalent concerns. Vulnerable groups, such as children under 5 (82.3%) and adults over 65 years old (77.4%), were identified as disproportionately affected. Social media (68.9%) and television (58.3%) were the dominant sources of information. Despite a recognition of air pollution’s importance (98.5%), there was limited engagement in systemic sustainability actions, such as supporting renewable energy initiatives. Most participants (84.3%) reported personal mitigation efforts, including energy-saving practices (35.5%) and walking instead of driving a car or bike (35.3%). While awareness of air pollution and its health impacts is high among Hanoi residents, proactive engagement in systemic solutions remains limited. Policymakers should prioritise community-based programs, public–private partnerships, sustainability education, and culturally tailored policy interventions to bridge gaps between awareness and action. Tailored interventions addressing demographic and cultural factors are essential to fostering socio-environmental sustainability in rapidly urbanising contexts. Full article

China’s rapid urbanization has given rise to the phenomenon of “urban villages”, which are often regarded as chaotic fringe areas in traditional studies. With the rise of the concept of resilient cities, the value of urban villages as potential carriers of sustainable development has been re-examined. This study adopted research methods such as field investigations, in-depth interviews, and conceptual sampling. By analyzing the interlinked governance relationship between Xiamen City and the urban villages in the Bay Area, aspects such as rural housing improvement, environmental governance, residents’ feedback, geographical pattern, and spatial production were evaluated. A field investigation was conducted in six urban villages within the four bays of Xiamen. A total of 45 people in the urban villages were interviewed, and the spatial status of the urban villages was recorded. This research found that following: (1) Different types of urban villages have formed significantly differentiated role positionings under the framework of regional governance. Residential community types XA and WL provide long-term and stable living spaces for migrant workers in Xiamen; tourism development types DS, HX, BZ, and HT allow the undertaking of short-term stay tourists and provide tourism services. (2) These urban villages achieve the construction of their resilience through resisting risks, absorbing policy resources, catering to the expansion of urban needs, and co-construction in coordination with planning. The multi-cultural inclusiveness of urban villages and their transformation led by cultural shifts have become the driving force for their sustainable development. Through the above mechanisms, urban villages have become the source of resilience and sustainability of healthy cities and provide a model reference for high-density urban construction. Full article

Templestay programs in South Korea represent a unique convergence of Buddhist ritual, cultural immersion, and wellness tourism. While often treated as niche cultural experiences, their broader significance within sustainable wellness tourism remains underexplored. This study examines participant reflections from the Beomeosa Templestay program through thematic analysis of over 600 reviews sourced from TripAdvisor, Google Reviews, and handwritten guestbooks. Using a triangulated framework combining Grounded Theory, Symbolic Interactionism, and the Wellness Tourism Model, the research identifies four recurring experiential themes: spiritual development, emotional healing, cultural immersion, and conscious consumption. Findings reveal cross-cultural variations: non-Korean participants emphasized spiritual exploration and cultural learning, while Korean participants prioritized emotional renewal and reconnection with heritage. Yet, across all groups, participants reported transformative outcomes, including heightened clarity, inner calm, and enhanced self-awareness. These results suggest that Templestays serve as accessible, culturally grounded wellness retreats that align with rising global demand for intentional, mindful travel. This study contributes to sustainable tourism scholarship by framing Templestays as low-impact, spiritually resonant alternatives to commercialized wellness retreats. Practical recommendations are offered to expand participation while maintaining program authenticity and safeguarding the spiritual and cultural integrity of monastic hosts in an increasingly globalized wellness landscape. Full article