Search Results (14,675)

Background/Objectives: Burn injuries pose a significant challenge due to tissue damage and impaired healing. Cell-based therapies offer promise by delivering therapeutic cells to the wound site. However, effective cell delivery remains a critical hurdle. This study investigates the potential of non-crosslinked hyaluronic acid (HA) as a simple, versatile carrier for delivering autologous keratinocytes and fibroblasts to treat early burn wounds. Methods: Primary keratinocytes and fibroblasts were isolated from uninjured adult skin. In addition, fibroblasts and adipose stem cells (ASC) from polydactyly and progenitor fibroblasts were used. Non-cross-linked HA Redensity 1^® (RD1) solutions of varying concentrations were prepared and applied to various in vitro models. Cell viability, proliferation, migration, and collagen stimulation were assessed using standard assays. Additionally, cells were suspended in Redensity 1 and applied to an in vitro de-epidemalized dermis (DED) wound model to examine cell delivery and tissue reformation. Results: Preliminary data demonstrated the feasibility of using non-cross-linked HA RD1 gel as a cell carrier. RD1 gel enhanced cell viability, retention, migration, and collagen deposition. Histological analysis revealed improved cell adhesion and migration. Conclusions: This study provides valuable insight into the potential of non-cross-linked HA RD1 as a simple and effective delivery vehicle for cell therapies in early burn care. Successful translation of this approach could significantly improve clinical outcomes for burn patients. Full article

In this study, novel, high-strength polymer blends were synthesized using poly(butylene succinate) (PBS) modified with grafted polyrotaxane (GPR). Then, their mechanical properties and morphologies were evaluated. A unique, two-step, reactive kneading method was developed to substantially improve the mechanical properties of PBS, which promoted transesterification reaction using an organo-titanium catalyst (Ti) in the first step and a urethanization reaction using hexamethylene diisocyanate (HDI) in the second step. The optimized blend material, [PBS/GPR10/Ti]-HDI, achieved remarkable toughening, and its Izod impact strength increased approximately seven-fold compared with that of unmodified PBS. Scanning electron microscopy (SEM) of the fracture surfaces confirmed a transition from brittle to ductile fracture, attributed to the controlled reaction sequence. First, strong chemical bonds formed at the PBS/GPR interface via Ti-catalyzed transesterification. Then, HDI induced simultaneous internal crosslinking (gelation) of the GPR domains and chain extension of the PBS matrix. This modification strategy maintained the excellent inherent soil biodegradability of PBS while improving its degradability in marine environments. This study presents a new guideline for designing materials that can considerably enhance the mechanical properties of biodegradable plastics. Full article

Temperature-responsive hydrogels are sophisticated stimuli-responsive biomaterials that undergo rapid, reversible sol–gel phase transitions in response to subtle thermal stimuli, most notably around physiological temperature. This inherent thermosensitivity enables non-invasive, precise spatiotemporal control of material properties and bioactive payload release, rendering them highly promising for advanced biomedical applications. This review critically surveys recent advances in the design, synthesis, and translational potential of thermo-responsive hydrogels, emphasizing nanoscale and hybrid architectures optimized for superior tunability and biological performance. Foundational systems remain dominated by poly(N-isopropylacrylamide) (PNIPAAm), which exhibits a sharp lower critical solution temperature near 32 °C, alongside Pluronic/Poloxamer triblock copolymers and thermosensitive cellulose derivatives. Contemporary developments increasingly exploit biohybrid and nanocomposite strategies that incorporate natural polymers such as chitosan, gelatin, or hyaluronic acid with synthetic thermo-responsive segments, yielding materials with markedly enhanced mechanical robustness, biocompatibility, and physiologically relevant transition behavior. Cross-linking methodologies—encompassing covalent chemical approaches, dynamic physical interactions, and radiation-induced polymerization are rigorously assessed for their effects on network topology, swelling/deswelling kinetics, pore structure, and degradation characteristics. Prominent applications include on-demand drug and gene delivery, injectable in situ gelling systems, three-dimensional matrices for cell encapsulation and organoid culture, tissue engineering scaffolds, self-healing wound dressings, and responsive biosensing platforms. The integration of multi-stimuli orthogonality, nanotechnology, and artificial intelligence-guided materials discovery is anticipated to deliver fully programmable, patient-specific hydrogels, establishing them as pivotal enabling technologies in precision and regenerative medicine. Full article

Celebrity worship has become a pervasive phenomenon among Chinese undergraduates, yet its psychological mechanisms remain unclear. This cross-sectional study recruited 1103 Chinese undergraduate students via convenience sampling. Data on celebrity worship and subjective well-being were collected using the Celebrity Attitude Scale (CAS) and the Satisfaction with Life Scale (SWLS). To investigate the internal structure of celebrity worship and its relationship with subjective well-being, a network analysis approach was employed. The resulting networks revealed that 72.33% of possible edges among worship items were non-zero, indicating dense interconnectivity. Entertainment–social behaviors—particularly “obsessed by details of the celebrity’s life”—formed the most central nodes, whereas borderline-pathological beliefs emerged as the pivotal hub when well-being variables were integrated. BP displayed the strongest negative connection with shame and served as the primary bridge linking worship to reduced life satisfaction and heightened negative affect. Bootstrap analyses confirmed robust stability. These findings shift research from a global “total-score” to a “systems” paradigm, highlighting BP cognitions as high-priority targets for cognitive-reappraisal interventions to prevent the escalation from healthy enthusiasm to pathological obsession. Full article

The widespread application of polymer soft materials in cutting-edge fields such as flexible electronics and biomedicine has placed higher demands on their mechanical properties. Traditional chemically cross-linked or physically cross-linked polymers each have inherent limitations. In contrast, slide-ring polymers (SRPs), also known as sliding cross-linked polymers or topologically cross-linked polymers, effectively distribute chain tension through their slip-cross-link characteristics, thereby exhibiting remarkable toughness, elongation at break, and low hysteresis. Among them, cyclodextrin (CD) has emerged as an ideal building block, such as the CD-based rotaxane/polyrotaxane/pseudortaxane/polypseudortaxane, for constructing SRPs due to its unique cavity structure and ease of modification, enabling diverse regulation of material structure and function through molecular design. Currently, the preparation strategies for cross-linking are relatively well established. However, existing research on the physical and mechanical behavior of SRPs—particularly their responses and damage mechanisms under complex loading conditions—remains unsystematic. Furthermore, establishing a cross-scale correlation mechanism from molecular design to macroscopic performance remains a key challenge. This review systematically summarizes recent advances in the mechanics of cyclodextrin-based sliding cross-linked polymers (CD-based SRPs) focusing on the molecular design and network structures, physical and mechanical behaviors and properties, deformation mechanism and theoretical models, and simulation and prediction, to provide clear guidance for future development of these materials. Full article

Injectable hydrogels (IHs) have gained considerable interest in biomedical and aesthetic applications due to their minimally invasive delivery, selective localization, and sustained release of bioactive agents. They exhibit flowability during administration and undergo in situ gelation under physiological conditions. These behaviors are influenced by their tunable structural, physical, mechanical, and viscoelastic properties, modulating performance. Rheological parameters, including viscosity (η), storage modulus (G′), loss modulus (G″), and yield stress (τ_y) of IHs with time (t), shear rate ($\stackrel{·}{\gamma }$), and frequency (f), explaining their shear thinning, thixotropy, viscoelasticity, and gelatin kinetics, serve as key quantitative indicators of their injectability, self-healing capability, and structural and mechanical stability. The rheological characteristics reflect molecular interactions and crosslinking mechanisms within IH networks, thereby linking formulation to provide overall performance, including injectability, biodegradability, and controlled release. This review summarizes recent advances in IHs for diverse applications, with a primary focus on their rheological properties. It also briefly addresses their composition, intermolecular interactions, and correlated function and performance. The applications discussed include hemostatic and wound dressings, tissue engineering and regenerative medicine scaffolds, drug delivery systems, reconstructive and aesthetic materials, and functional bioinks for 3D printing. Overall, this review demonstrates that rheological characterization provides an essential framework for the rational engineering of next-generation IH systems. Full article

The cross-fertilization of video games and tourism has expanded in recent years, with digital narratives increasingly shaping real-world travel behavior, yet the mechanisms linking mythological video games to pre-trip travel intention remain underexplored. Using the Chinese mythological game Black Myth: Wukong as a case, this study examines how digital myth narratives relate to overseas audiences’ perceptions of, and travel intentions towards, Chinese tourist destinations in a cross-cultural context. Based on a large corpus of YouTube comments, we integrate topic modeling, sentiment analysis, and interpretable machine learning to identify semantic cues associated with travel intention. The results indicate that multidimensional perceptions elicited by digital myth narratives are associated with a gradual evolution of destination image from cognitive to affective and then intentional. Cultural symbol perception, cross-cultural understanding, aesthetic appreciation, and emotional resonance show positive relationships with travel intention and appear as important predictors in the model. SHAP analysis further suggests a nonlinear threshold effect, whereby the probability that a comment is classified as expressing travel intention increases when overall perception reaches a relatively high level. Embedding the cognition–emotion–intention path within a digital game context, this study provides empirical evidence on destination image and behavioral intention in digital narrative settings and offers implications for cross-cultural communication and sustainable tourism planning. Full article

Major depressive disorder (MDD) was long framed as a single clinical entity arising from a linear stress–monoamine–hypothalamic–pituitary–adrenal (HPA) axis cascade. This view was shaped by forced swim and learned helplessness tests in animals and by short-term symptom-based trials using scales such as the Hamilton Depression Rating Scale (HAM-D) and the Montgomery–Åsberg Depression Rating Scale (MADRS). This “unitary cascade” view has been dismantled by advances in neuroimaging, immune–metabolic profiling, sleep phenotyping, and plasticity markers, which reveal divergent circuit-level, inflammatory, and chronobiological patterns across anxiety-linked, pain-burdened, and cognitively weighted depressive presentations, all characterized by high rates of non-response and relapse. Translationally, face-valid rodent assays that equated immobility with despair have yielded limited bedside benefit, whereas cross-species bridges—electroencephalography (EEG) motifs, rapid eye movement (REM) architecture, effort-based reward tasks, and inflammatory/metabolic panels—are beginning to provide mechanistically grounded, clinically actionable readouts. In current practice, depression care is shifting toward systems psychiatry: inflammation-high and metabolic-high archetypes, anhedonia- and circadian-dominant subgroups, formal treatment-resistant depression (TRD) staging, connectivity-guided neuromodulation, esketamine, selected pharmacogenomic panels, and early digital phenotyping, as endpoints broaden to functioning and durability. A central gap is that heterogeneity is acknowledged but rarely built into trial design or implementation. This perspective advances a plasticity-centered systems psychiatry in which a testable prediction is that manipulating defined prefrontal–striatal and prefrontal–limbic circuits in sex-balanced, chronic-stress models will reproduce human network-defined biotypes and treatment response, and proposes hybrid effectiveness–implementation platforms that embed immune–metabolic and sleep panels, circuit-sensitive tasks, and digital monitoring under a shared, preregistered data standard. Full article

Ageism remains a pervasive yet under-addressed form of workplace discrimination, affecting employees across age groups. This study, conducted within the framework of the EU-funded project SNAW–Say No to Ageism in the Workplace, presents findings from a cross-national survey in Germany, Romania, Ireland, Portugal, and Greece, with 511 participants including employees and employers. The survey examined five dimensions of workplace ageism (cognitive, emotional, behavioural, institutional, and outcome-related) through questions on stereotypes, experiences, organisational practices, and perceived impacts. Results indicate that age-based stereotypes are widely recognised, especially in Germany, Ireland, and Greece. Older workers were often portrayed as resistant to change or technologically outdated, while younger workers were described as inexperienced or unreliable. Despite some positive perceptions, these ambivalent views contribute to exclusionary dynamics. Employees consistently reported higher levels of ageism than employers, revealing a “perception gap”. Institutional responses were uneven: awareness of policies or initiatives promoting age diversity was low, and their effectiveness remained uncertain. Across countries, respondents linked ageism to reduced job satisfaction and productivity, though the perceived severity varied. The findings highlight ageism as a multifaceted challenge that undermines well-being and organisational performance. Counteracting it requires raising awareness, transparent communication, inclusive policies, and leadership engagement across Europe. Full article

Lightweight vision models are widely deployed in mobile and embedded systems, where strict computational and memory budgets demand compact architectures. However, their evaluation remains dominated by ImageNet—a single, large natural-image dataset that requires substantial training resources. This creates a dilemma: lightweight models trained on ImageNet often reach capacity limits due to their constrained size, while scaling them to billions of parameters with specialized training tricks to achieve top-tier ImageNet accuracy does not guarantee proportional performance once the architectures are scaled back down to meet mobile constraints, particularly when re-evaluated on diverse data domains. These challenges raise two key questions: How should cross-dataset robustness be quantified in a simple and lightweight way, and which architectural elements consistently support generalization under tight resource constraints? To answer them, we introduce the Cross-Dataset Score (xScore), a simple metric that captures both average accuracy across domains and the stability of model rankings. Evaluating 11 representative lightweight models (2.5 M parameters) across seven datasets, we find that (1) ImageNet accuracy is a weak proxy for cross-domain performance, (2) xScore provides a simple and interpretable robustness metric, and (3) high-xScore models reveal architectural patterns linked to stronger generalization. Finally, the architectural insights and evaluation framework presented here provide practical guidance for measuring the xScore of future lightweight models. Full article

Hypertension (HTN) and intestinal permeability (IP) are increasingly recognized as interrelated processes driven by shared oxidative and inflammatory mechanisms. This review synthesizes evidence linking HTN-induced vascular dysfunction to alterations in intestinal barrier integrity and explores the potential of dietary flavonoids as modulators of these pathologies. A narrative approach was used to synthesize findings from cellular, animal, and human studies that specifically address how flavonoids influence the molecular pathway connecting HTN and IP. Emerging evidence suggests that HTN-driven vascular injury, which is characterized by reduced nitric oxide bioavailability, increased reactive oxygen species, and pro-inflammatory signaling, contributes to tight junction disruption and increased IP. Mechanistic evidence indicates that flavonoids exert both direct antioxidant effects and indirect actions via the modulation of key cellular pathways. Preclinical and clinical data demonstrate that flavonoid-rich foods and isolated compounds can lower blood pressure, enhance endothelial function, and preserve intestinal barrier integrity by stabilizing tight junction proteins and attenuating pro-inflammatory signaling. Together, these findings highlight flavonoids as cross-system modulators that may mitigate HTN-associated increases in IP. Further research addressing sex, race, and age differences, as well as flavonoid bioavailability and dose optimization, is needed to clarify their translational potential. Full article

To address the challenges of rutting and performance balance in asphalt pavements under high-temperature and heavy-load conditions, a novel polyolefin composite modifier (PCM-H) was developed from waste tire rubber powder, recycled ethylene vinyl acetate (EVA), acrylonitrile butadiene styrene (ABS), petroleum resin, and polymer additives. The chemical characteristics, thermal stability, and compatibility mechanisms of PCM-H were compared with those of two commercial modifiers (PCM-1 and PCM-2) using Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC). PCM-H exhibited superior compatibility and thermal stability. In contrast, PCM-2 tends to crystallize and precipitate within the 180–200 °C range, which is detrimental to the stability of the composite system. At an optimal dosage of 10 wt% in styrene–butadiene–styrene (SBS) modified asphalt, PCM-H formed a uniform dispersion and, through crosslinking reactions, established a three-dimensional network structure. Subsequently, the performance of composite modified asphalts, prepared with each of the three modifiers at their respective optimal dosages, was evaluated comparatively. Performance evaluations demonstrated that all polyolefin-modified asphalts significantly outperformed the conventional SBS modified asphalt. The PCM-H modified asphalt (PCM-H MA) exhibited the most superior performance, achieving a performance grade (PG) exceeding 94 °C, along with exceptional high-temperature elasticity and creep resistance, superior low-temperature cracking resistance, and enhanced fatigue healing capability. The results indicated that the crosslinked network structure effectively enhances asphalt cohesion, thereby providing a synergistic improvement in both high- and low-temperature performance. This study provides an effective solution and theoretical basis for developing high-performance pavement materials resistant to high temperatures and heavy loads conditions. Full article

Background/Objectives: Tooth loss is a key marker of ageing and is linked to functional, psychological, and nutritional decline. Removable dental prostheses (RDPs) are widely used, yet their impact on life satisfaction and oral health–related quality of life (OHRQoL) remains uncertain. This study aimed to: (1) identify dental deficiencies in adults aged ≥50 years; (2) assess the use of RDPs; and (3) examine the relationship between prosthetic status, life satisfaction, and OHRQoL. Methods: This retrospective cross-sectional analysis included 986 participants from the Białystok PLUS cohort (2018–2024). Dental examinations classified individuals into: Group 0 (no deficiencies), Group 1 (deficiencies without prostheses), and Group 2 (deficiencies with RDPs). Life satisfaction was measured using the Satisfaction with Life Scale (SWLS), and OHRQoL using the Geriatric Oral Health Assessment Index (GOHAI). Analyses included Kruskal–Wallis test and correspondence analysis. Results: Partial mandibular deficiencies were the most frequent and were less often rehabilitated than maxillary defects. Most prostheses were mucosa-supported. Life satisfaction (mean SWLS = 22.4) did not differ significantly between groups (p = 0.326). In contrast, OHRQoL differed significantly (mean GOHAI = 53.8; p = 0.0001), supporting an effect of prosthetic status. Group 0 showed the highest GOHAI scores (55.7), while Group 2 (52.7) scored lower than Group 1 (53.0). Prosthesis users most often reported dissatisfaction with appearance and eating comfort. Conclusions: Life satisfaction appears independent of prosthetic status. OHRQoL, however, is strongly associated with dentition: individuals without deficiencies report the highest outcomes, whereas RDPs—especially mucosa-supported types—do not improve, and may reduce, perceived OHRQoL. Full article

Rare earth elements (REE) are vital for renewable energy, electronics, and advanced technologies; however, the process-related evolution of REE research has not been systematically quantified. This study conducts the first large-scale bibliometric analysis of 76,768 REE-related publications (1975–2024) from Web of Science, using the Cross-Disciplinary Publication Index (CDPI) and Technology–Economic Linkage Model (TELM). Results reveal three development phases: publication growth from <300 (1975–1990) to >5000 after 2008, driven by China’s export restrictions and the global clean energy transition; China leads with 24.1% of publications, followed by the U.S. (11.7%) and Germany (6.4%). Interdisciplinary mapping identifies materials science as the central field (CDPI = 0.81) linked to nanotechnology (0.75) and environmental science (0.66). Four thematic clusters dominate: (i) deposit geology, (ii) material applications, (iii) green extraction technologies, and (iv) circular economy strategies. Recent emphasis on sustainable practices and unconventional sources—such as phosphorites, bauxite, coal fly ash, and urban mining—reflects a shift toward green innovation. The findings guide policies to diversify REE supply through unconventional deposits (~50 Mt coal-hosted REE), eco-friendly extraction, and recycling. Future priorities include AI-driven exploration, lifecycle assessment of secondary sources, and stronger global collaboration to secure resilient, sustainable REE supply chains. Full article

The rise of connected and automated vehicles has transformed in-vehicle infotainment (IVI) systems into critical gateways linking user interfaces, vehicular networks, and cloud-based fleet services. A concerning architectural reality is that hardcoded credentials like access point names (APNs) in IVI firmware create a cross-layer attack surface where local exposure can escalate into entire vehicle fleets being remotely compromised. To address this risk, we propose a cross-layer security framework that integrates firmware extraction, symbolic execution, and targeted fuzzing to reconstruct authentic IVI-to-backend interactions and uncover high-impact web vulnerabilities such as server-side request forgery (SSRF) and broken access control. Applied across seven diverse automotive systems, including major original equipment manufacturers (OEMs) (Mercedes-Benz, Tesla, SAIC, FAW-VW, Denza), Tier-1 supplier Bosch, and advanced driver assistance systems (ADAS) vendor Minieye, our approach exposes systemic anti-patterns and demonstrates a fully realized exploit that enables remote control of approximately six million Mercedes-Benz vehicles. All 23 discovered vulnerabilities, including seven CVEs, were patched within one month. In closed automotive ecosystems, we argue that the true measure of efficacy lies not in maximizing code coverage but in discovering actionable, fleet-wide attack paths, which is precisely what our approach delivers. Full article