Search Results (52)

Background/Objectives: Women’s sexual quality of life is a multidimensional construct shaped by individual, psychological, relational, and health-related factors. This exploratory cross-sectional study aimed to identify selected determinants of sexual functioning in young women, with a particular focus on partner relationships and sexual dysfunction symptoms within the couple. Methods: Data from 199 female university students aged 18–30 years, recruited via Facebook, were analyzed. Participants completed the Female Sexual Function Index (FSFI) and an author-designed questionnaire assessing sociodemographic variables, relationship characteristics, and self-perceived sexual difficulties in themselves and their partners. Descriptive statistics, bivariate analyses, and multivariable linear regression models were used to examine factors associated with the FSFI total and domain scores. Results: In this self-selected, non-representative sample, over 75% of women reported at least one self-perceived sexual difficulty, while 35.2% obtained FSFI scores at or below the established cutoff, indicating an increased risk of female sexual dysfunction rather than a confirmed diagnosis. In multivariable analysis, higher intercourse frequency, greater overall sexual satisfaction in the last 12 months, and fewer self-reported dysfunction symptoms emerged as the strongest independent predictors of higher FSFI total scores. Women who perceived premature ejaculation in their male partners tended to report lower orgasm and satisfaction domain scores, although this perception was not independently associated with the FSFI total score after adjustment for individual and relationship factors. Conclusions: These findings underline the role of both individual and relational factors in young women’s sexual functioning and support a holistic, couple-centred perspective in sexual health assessment. Full article

Background and Objectives: This study aimed to evaluate the association between relationship dynamics as measured by dyadic adjustment and factors such as erectile function and lower urinary tract symptoms, adjusting for relevant clinical characteristics. Materials and Methods: This cross-sectional study collected data from 94 males in relationships of at least 6 months and with a prostate volume equal to or higher than 30 cc. Lower urinary tract symptoms, erectile function, and relationship dynamics were assessed with the International Prostate Symptom Score (I-PSS), International Index of Erectile Function (IIEF), Dyadic Adjustment Scale (DAS). Results: We found significant positive correlations between DAS affective expressions (AEs) and erectile dysfunction duration; between IIEF general satisfaction and DAS dyadic adjustment (DA), dyadic consensus (DC), and dyadic cohesion (DH); and between prostate width and DAS DA and DC (all ρ ≈ 0.2–0.3, p < 0.05). Further multiple regression analyses adjusting for age, prostate width, and comorbidities showed that the associations between IIEF general satisfaction and DAS DA (p = 0.013) and DH (p = 0.008) remained significant, while the relationship with DAS DC (p = 0.051) was borderline. Conclusions: Our findings highlight that general sexual satisfaction, as measured with the IIEF, had a small but independent association with higher affective expressions, dyadic cohesion, and dyadic consensus in couples, which are key domains of dyadic adjustment, regardless of relationship duration, prostate width, and comorbidities. These results emphasize the importance of considering sexual satisfaction in the context of relationship quality and, therefore, involving the female partner in the assessment and treatment of erectile dysfunction. Full article

Questioning motherhood as a social mandate has been one of the main objectives of feminism. Motherhood has traditionally been linked to the idea of femininity and the reproductive function, which has led to women being thought of as “compulsory mothers”. However, this idea is currently changing, despite the fact that judgment is exercised on non-mothers. This research is part of a cross-sectional descriptive study, whose objective is to analyze the barriers and incentives to childbearing in the female population. A questionnaire was designed and administered to a representative sample of 318 women who were selected for our analysis, with a confidence level of 95% and a margin of error of 5%. Results: Economic motives correlate positively with other variables, as well as work motives, the couple’s decision to not want to have children, and not having a stable partner, which suggests that these women have different motives for choosing not to have children. The main conclusions are that social and family pressures appear to have a limited impact on the decision not to have children, suggesting a change in social norms and expectations about the role of women in society, as women continue to gain autonomy and control over their reproductive decisions. Full article

As a patriarchal country with dominant religious and cultural values, it is not easy to accept feminism in Indonesia. However, the idea has been growing and gaining acceptance in Indonesia for the past couple of years, influenced by media and technology. Feminism is not only embraced by women but also by men, which may affect men’s sexual behaviour with their partners. Therefore, we conducted a cross-sectional study with an online data survey by distributing questionnaires involving 335 participants. Our pilot study reported the sexual behaviours of (heterosexual feminist) in Indonesia compared to (non-feminist) men. Despite some indifferent behaviour, feminist men tend to ensure the satisfaction of their female partners as a form of respect for their partners. Some sexual behaviours that were significantly different between heterosexual feminist and non-feminist men always began with foreplay duration of foreplay (average) asking for the position (p = 0.001), and asking if the partner was satisfied or not. This study implies that heterosexual feminist men exhibit tremendous respect toward women and can contribute to more equitable and fulfilling relationships, fostering mutual respect and more profound emotional connection. Full article

The Clean Propulsion Technologies (CPT) project, established in 2021, brought together 15 research partners and original equipment manufacturers. The goal was to create a common vision and sustainable business solutions so that the worldwide technological leadership of the Finnish powertrain industry is secured. With a EUR 15.5 M budget, CPT brought early-stage innovative concepts towards technology readiness level (TRL) 6. The project’s particular significance was its unique cross-coupling of marine and off-road sectors, which have similar emission reduction targets but which do not compete for similar customers. The project yielded 21 innovative solutions, from accelerated model-based design methodologies and progress in combustion and aftertreatment control to hybrid energy management solutions. These were encapsulated in four ground-breaking demonstrations, including a next-generation marine engine working in low-temperature, reactivity-controlled compression ignition (RCCI) mode and a hydrogen off-road engine. An advanced close-coupled selective catalyst reduction (SCR) system and a hybrid wheel-platform with digital hydraulics were also demonstrated. The University of Vaasa led the consortium and was responsible for coordinated model-based rapid prototyping. This report examines University of Vaasa’s achievements during the CPT in terms of 26 milestones, 13 deliverables, and 32 research papers. It focuses also on other aspects, including lessons learned from managing large-scale academic–industry research. Full article

Background/Objectives: Human Papillomavirus (HPV) cross-infection among couple’s partners is a widespread event and could lead to persistent infections. Unfortunately, the influence of male sexual partners of HPV-positive women on their cervical lesions and the potential role of HPV vaccines have been under-investigated. We evaluated the HPV prevalence in male partners of HPV-infected women, focusing on the possible correlation between partners’ cervical lesions and the role of HPV vaccination. Methods: Two samples, genital and urethral swabs, were collected for each of the 90 patients recruited. HPV-DNA detection was carried out by the Allplex HPV28 detection assay. Results: HPV prevalence was 66.7% (60/90); high-risk HPV (hrHPV) genotypes were detected in 90% (54/60) cases and multiple infections in 55% (33/60). The most frequent hrHPVs were HPV31 (p = 0.0265) and HPV52 (p = 0.002), found in 18.3% (11/60) of cases, and HPV53 (p = 0.0116) in 16.7% (10/60). Statistical analysis showed a higher probability of a less severe cytological diagnosis with the increase in the number of genotypes detected (p = 0.0146). Among the HPV-positive partners of females with cervical lesions, 18.7% (6/32) and 62.5% (20/32) had vaccine genotypes of the quadrivalent and nonavalent vaccines, respectively. The nonavalent vaccine showed a significantly higher potential to prevent lesions (62.5% vs. 18.7%, p = 0.0001), with an absolute additional potential impact (AAI) of 31.1% in histological and 32.4% in cytological diagnoses. Conclusions: These preliminary results provide new insight into the correlation between the number of partner genotypes and the severity of cervical lesions and show promising results for the preventive potential of vaccinating male partners. Full article

Although adults with depression struggle to effectively emotionally regulate themselves, these findings are limited to one partner in a romantic relationship, community samples, and cross-sectional designs. Hence, we aimed to address these gaps in the literature by investigating emotion regulation difficulties as a predictor of change in depression among couples in couple therapy. Additionally, we aimed to investigate whether emotion regulation difficulties mediated the well-established association between relationship satisfaction and changes in depression of couples in couple therapy. We examined 484 different-sex couples in couple therapy from the Marriage and Family Therapy Practice Research Network—a clinical dataset from clinics across the United States. Dyadic latent growth models revealed the actor and partner effects of emotion regulation difficulties at session 1, predicting decreases in depression trajectories across 16 sessions of couple therapy. Additionally, dyadic latent growth mediation models revealed that emotion regulation difficulties at session four did not mediate the associations between relationship satisfaction at session 1 with depression trajectories of sessions eight through 16. For couple therapy clinicians, emotion regulation difficulties can play a direct role in the treatment of depression. However, our results did not support emotion regulation difficulties as a mediator for the well-established association between relationship satisfaction and depression trajectories. Full article

(1) Pregnancy surveillance nursing consultations in the pandemic context have undergone some changes, namely the restriction of accompanying persons. In this sense, assessing the knowledge acquired by parents in pregnancy surveillance is of great importance. Since there are no studies on the subject in the period before the pandemic, we will only assess the knowledge acquired by parents in pregnancy monitoring. (2) For this reason, the aim of our study is to evaluate the knowledge acquired by parents in pregnancy surveillance. (3) This study is descriptive, cross-sectional and quantitative in nature, with a sample of 196 couples. A questionnaire was administered about the knowledge acquired by parents in pregnancy surveillance nursing consultations. (4) Pregnant mothers and their partners reported having some knowledge. The classification was assessed using a questionnaire with quantifiable response options from 1 to 5 points. Items with a score of 1 indicate a low level of knowledge and 5 indicates a higher level of knowledge. (5) We can verify that the level of knowledge acquired by the pregnant mother during the pregnancy surveillance nursing consultation is higher than the level of knowledge acquired by the father during the same consultation. Most parents consider it important to receive information through the pregnancy surveillance nursing consultations carried out by Maternal and Obstetric Health Nurse Specialists (midwives). Full article

This comparative cross-sectional study conducted at the “Pius Brinzeu” healthcare center in Timisoara explored the differential impacts of pregnancy planning status on sexual function, body image, and relationship satisfaction among pregnant women. Employing the Female Sexual Function Index (FSFI), Body Esteem Scale for Adolescents and Adults (BESAQ), and the Beck Depression Inventory (BDI-II), the study analyzed responses from 107 participants divided into groups of planned (n = 59, mean age 28.5 ± 5.2) and unplanned (n = 48, mean age 27.3 ± 4.8) pregnancies. In the first trimester, unplanned pregnancies reported higher median scores in desire (4.7 vs. 3.6, p = 0.005), arousal (4.5 vs. 3.8, p = 0.001), and lubrication (4.6 vs. 3.7, p = 0.015) compared to planned pregnancies. Satisfaction scores also favored unplanned pregnancies in the first trimester (4.8 vs. 3.9, p = 0.009). Similar trends were observed in subsequent trimesters, with unplanned pregnancies consistently reporting higher FSFI scores, indicating a robust sexual function. Risk factors significantly associated with sexual dysfunction were a higher BMI in the first trimester (beta coefficient: −0.124, p = 0.019), unmarried civil status (beta coefficient: −0.323, p = 0.045), history of previous abortion (beta coefficient: −0.451, p = 0.012), irregular menstrual cycles (beta coefficient: −0.384, p = 0.026), and rural living area (beta coefficient: −0.278, p = 0.034). Notably, unplanned pregnancy itself was not a significant risk factor for sexual dysfunction (beta coefficient: −0.054, p = 0.095). Regarding relationship dynamics, planned pregnancies exhibited significantly higher satisfaction with partner support (4.1 ± 0.9 vs. 3.7 ± 1.1, p = 0.041) and communication within the couple (4.0 ± 1.0 vs. 3.5 ± 1.2, p = 0.020), whereas unplanned pregnancies reported higher satisfaction with emotional closeness (4.3 ± 0.7 vs. 3.8 ± 1.0, p = 0.004). Concerns about managing professional activities and household chores were significantly more prevalent in the unplanned pregnancy group (62.50% vs. 33.90%, p = 0.014). Unplanned pregnancies demonstrated better initial sexual function but faced greater challenges in relationship satisfaction and managing pregnancy demands. Identifying and addressing the risk factors associated with sexual dysfunction can provide targeted interventions to improve the well-being of pregnant women, regardless of pregnancy planning status. Full article

This paper presents methods for the introduction and exchange of substituents in a nucleobase and its nucleosides and nucleotides with emphasis on the C8-position in the purine skeleton. The nucleobase is open for electrophilic and nucleophilic chemistry. The nucleophilic chemistry consists mainly of displacement reactions when the C8-substituent is a good leaving group such as a halogen atom. The heteroatom in amines, sulfides, or oxides is a good nucleophile. Halides are good reaction partners. Metal-promoted cross-coupling reactions are important for carbylations. Direct oxidative metalation reactions using sterically hindered metal amides offer chemo- and regio-selectivity besides functional tolerance and simplicity. The carbon site is highly nucleophilic after metalation and adds electrophiles resulting in chemical bond formation. Conditions for metal-assisted reactions are described for nucleobases and their glycosides. Full article

Subfertility is a global health issue, and as many as 30% of cases are attributed to unexplained reasons. A hypercaloric, high-fat diet stimulates the expansion of pro-inflammatory gut microbiota with a consequent rise in circulating lipopolysaccharides. Adverse gut microbiota remodeling can exacerbate insulin resistance, while sex and thyroid hormones may influence the variability in gut microbiota. This cross-sectional study included 150 participants and was designed to determine a biochemical, nutritional-related pattern that may distinguish subfertile from fertile individuals and couples. A panel of 28 biomarkers was assessed. Four biochemical phenotypes of unexplained subfertility were found, including two metabolic and two immune, when assessed using binary logistic regression models. Two phenotypes were distinguished in women: cardio-metabolic with atherogenic dyslipidemia (_LowHDL-cholesterol: OR = 10.9; p < 0.05) and autoimmune thyroid disorder (_Highanti-thyroid-peroxidase: OR = 5.5; p < 0.05) and two in men: hepato-metabolic with elevated liver injury enzymes (_HighHOMA-IR: OR = 6.1; p < 0.05) and immune type-2 response (_HighIgE: OR = 6.4; p < 0.05). The chances of a couple’s subfertility rose with the number of laboratory components of metabolic syndrome in the couple (OR = 1.7; p < 0.05) and if at least one partner had an elevated total IgE level (>100 kU/L) (OR = 6.5; p < 0.05). This study found that unexplained subfertility may be accompanied by mutually overlapping immune and metabolic dysregulations in individuals and couples. We propose one-time laboratory diagnostics taking into account the lipid profile, insulin resistance, anti-thyroid-peroxidase, and total IgE in both males and females with unexplained subfertility. This may allow for a one-time assessment of targeted medical and nutritional interventions and help optimize patients’ health. The gut–organ axes related to subfertility are discussed in the context of the obtained results. Full article

Background: Infertility can affect a couple’s mental health and marital and social relationships. The study aimed to investigate the prevalence of depression among infertile couples and their relationships with other factors. Methods: This study employed a cross-sectional survey. Validated tools were used to assess anxiety and depression, marital satisfaction, personality traits and sufficiency economy. The actor–partner interdependence model (APIM) was used for dyadic analysis. Results: The prevalence of depression in infertile couples was 6.7%. Aggression, extraversion and neuroticism were significantly correlated with depression, whereas the expectation of having children, marital satisfaction and sufficiency economy were negatively correlated with depression. The APIM model suggested that neuroticism and marital satisfaction were significant predictors of depression. Partner effect between the expectation of having children and depression was observed (p = 0.039). Conclusions: Like other populations, depression in infertile couples seems to be associated with aggression, extraversion and neuroticism. However, there are specific variables related to infertility that impact the depression levels of these couples. For instance, the expectation of having children can affect the partners of infertile couples, while the role of the sufficiency economy is a new factor that has been examined for depression in this sample and requires further exploration. Full article

This is a study on indicators related to marital dissatisfaction. The research was conducted by the psychology department of a reproductive health institution in Mexico City. The objective was to know the relation between marital satisfaction/dissatisfaction and gender roles, self-esteem, the types of coping strategies and the types of violence perceived from the partner. It was a nonexperimental, retrospective, cross-sectional study of two samples—one of women and one of men—classified by marital satisfaction or dissatisfaction. The nonprobability quota sampling included 208 participants: 104 women and 104 men. Comparisons, correlations and a discriminant analysis were made to identify the most significant variables. Women with marital dissatisfaction perceived blackmail, psychological violence and humiliation/devaluation from their partner; they preferably adopt a submissive gender role and use escape/avoidance as a coping strategy, and so do the men with marital dissatisfaction, who also perceived blackmail, control and psychological violence from their partner; they have low self-esteem, and they preferably adopt a submissive gender role. Isolating factors will allow for more specificity in terms of psychological care at health institutions as well as avoiding gender biases and preventing an increase of violence in couples. Full article

Polymeric nanoparticles with reactive functional groups are an attractive platform for drug carriers that can be conjugated with drugs through a cleavable covalent linkage. Since the required functional groups vary depending on the drug molecule, there is a need for development of a novel post-modification method to introduce different functional groups to polymeric nanoparticles. We recently reported phenylboronic acid (PBA)-containing nanoparticles (BNP) with a unique framboidal morphology created via one-step aqueous dispersion polymerization. Since BNPs have high surface area due to their framboidal morphology and contain a high density of PBA groups, these particles can be used as nanocarriers for drugs that can bind to PBA groups such as curcumin and a catechol-bearing carbon monoxide donor. To further explore the potential of BNPs, in this article we report a novel strategy to introduce different functional groups to BNPs via the palladium-catalyzed Suzuki–Miyaura cross-coupling reaction between the PBA groups and iodo- and bromo-coupling partners. We developed a new catalytic system that efficiently catalyzes Suzuki–Miyaura reactions in water without the need for an organic solvent, as confirmed by NMR. Using this catalyst system, we show that BNPs can be functionalized with carboxylic acids, aldehyde, and hydrazide groups while keeping their original framboidal morphology as confirmed via IR, alizarin red assay, and TEM. Furthermore, the potential of the functionalized BNP in drug delivery applications was demonstrated by conjugating the hydrogen sulfide (H₂S)-releasing compound anethole dithiolone to carboxylic acid-functionalized BNPs and show their H₂S-releasing capability in cell lysate. Full article

The deprotonation of an organic substrate is a common preactivation step for the enzymatic cofactorless addition of O${}_2$ to this substrate, as it promotes charge-transfer between the two partners, inducing intersystem crossing between the triplet and singlet states involved in the process. Nevertheless, the spin-forbidden addition of O${}_2$ to uncharged ligands has also been observed in the laboratory, and the detailed mechanism of how the system circumvents the spin-forbiddenness of the reaction is still unknown. One of these examples is the cofactorless peroxidation of 2-methyl-3,4-dihydro-1-naphthol, which will be studied computationally using single and multi-reference electronic structure calculations. Our results show that the preferred mechanism is that in which O${}_2$ picks a proton from the substrate in the triplet state, and subsequently hops to the singlet state in which the product is stable. For this reaction, the formation of the radical pair is associated with a higher barrier than that associated with the intersystem crossing, even though the absence of the negative charge leads to relatively small values of the spin-orbit coupling. Full article