Search Results (26)

Breast cancer continues to be a major challenge in global health, in part due to significant inequalities in access to costly diagnostic and therapeutic technologies based on antibodies. Their manufacturing requires complex and expensive bioproduction systems, resulting in limited availability of these tools—essential for early detection and targeted treatment—in many regions, particularly in Latin America. This gap has highlighted the need for cost-effective and scalable theranostic alternatives, increasing interest in aptamers. Obtained through SELEX technology, aptamers are synthetic DNA or RNA oligomers that fold into functional structures. Among their advantages are high affinity for their target, low immunogenicity, and chemical synthesis, which assures reproducible production. Aptamers have expanded the landscape of diagnostic platforms through the development of sensitive aptasensors, liquid biopsy strategies, and imaging systems based on nanomedicines. They also contribute to targeted therapy by recognizing cancer biomarkers selectively and enabling controlled drug delivery. This review presents a critical summary of advances in aptamer-based theranostics for breast cancer, addressing molecular mechanisms, structural folding, selective ligand binding, and nanomaterial interfacing. We also discuss applications in extracellular vesicle capture, cancer stem cell detection, and therapeutic conjugates, emphasizing their advantages and limitations relative to approaches based on antibodies. Overall, current advances show aptamers as emerging tools capable of democratizing precision oncology, particularly in regions where access to advanced technologies remains limited. Full article

This numerical study demonstrates the existence of a critical injection momentum threshold necessary for stable liquid film formation, highlighting that either excessive or insufficient momentum degrades cooling performance. This optimization is critical for maximizing cooling effectiveness from short injection holes in high-performance propulsion systems. By comparing Smoothed Particle Hydrodynamics (SPH) and Volume of Fluid (VOF) methods, we find that the SPH method predicts a thicker, more continuous coolant film due to its superior mass conservation during interface breakup. A key design insight emerges: cooling performance peaks at a distinct, critical coolant momentum. Insufficient momentum leads to poor coverage, while excess momentum causes film separation and is counter-productive. The identified configuration—defined by a precise combination of flow rate, pressure, and geometry—promotes immediate and stable film formation. The robustness of this finding is confirmed by the agreement between the two numerical methods on film thickness and the captured physical evolution of the film from a pronounced wave to a damped state. Full article

A solid/liquid continuous composite casting technology was developed to produce brass-clad copper stranded wire billets efficiently with continuous casting speeds ranging from 200 mm/min to 1000 mm/min. As the casting speed increased, the microstructure of the brass cladding transformed at an angle to the radial direction. The wire billet prepared at a casting speed of 600 mm/min was then subjected to drawing. As the percentage reduction in area of the billet increased from 11.9 to 81.5% during the drawing process, the tensile strength improved from 336 MPa to 534 MPa, while the elongation after fracture decreased from 30.1 to 4.7%. Meanwhile, dislocation, dislocation cells, and microbands successively formed in the pure copper strand wires, while twins, shear bands, dislocation pile-ups, and secondary twins gradually formed in the brass cladding. During the drawing process, the interface between copper and brass remained metallurgically bonded, exhibiting coordinated deformation behavior. This paper clarified the evolution of microstructure and mechanical properties of brass-clad copper stranded wires in high-speed solid/liquid continuous composite casting and drawing, which could provide important reference for industrial production. Full article

This study systematically investigates the formation mechanism and development characteristics of the “foamy oil” phenomenon during pressure depletion development of high-viscosity crude oil through a combination of physical experiments and numerical simulations. Using Venezuelan foamy oil as the research subject, an innovative heterogeneous pore-etched glass model was constructed to simulate the pressure depletion process, revealing for the first time that bubble growth predominantly occurs during the migration stage. Experimental results demonstrate that heavy components significantly delay degassing by stabilizing gas–liquid interfaces, while the continuous gas–liquid diffusion effect explains the unique development characteristics of foamy oil—high oil recovery and delayed phase transition—from a microscopic perspective. A multi-scale coupling analysis method was established: molecular-scale simulations were employed to model component diffusion behavior. By improving the traditional Volume of Fluid (VOF) method and introducing diffusion coefficients, a synergistic model integrating a single momentum equation and fluid volume fraction was developed to quantitatively characterize the dynamic evolution of bubbles. Simulation results indicate significant differences in dominant controlling factors: oil phase viscosity has the greatest influence (accounting for ~50%), followed by gas component content (~35%), and interfacial tension the least (~15%). Based on multi-factor coupling analysis, an empirical formula for bubble growth incorporating diffusion coefficients was proposed, elucidating the intrinsic mechanism by which heavy components induce unique development effects through interfacial stabilization, viscous inhibition, and dynamic diffusion. This research breaks through the limitations of traditional production dynamic analysis, establishing a theoretical model for foamy oil development from the perspective of molecular-phase behavior combined with flow characteristics. It not only provides a rational explanation for the “high oil production, low gas production” phenomenon but also offers theoretical support for optimizing extraction processes (e.g., gas component regulation, viscosity control) through quantified parameter weightings. The findings hold significant scientific value for advancing heavy oil recovery theory and guiding efficient foamy oil development. Future work will extend to studying multiphase flow coupling mechanisms in porous media, laying a theoretical foundation for intelligent control technology development. Full article

Solid-state lithium-ion batteries are gaining attention as a promising alternative to traditional lithium-ion batteries. By utilizing a solid electrolyte instead of a liquid, these batteries offer the potential for enhanced safety, higher energy density, and longer life cycles. The solid electrolyte typically consists of a polymer matrix integrated with ceramic fillers, which can significantly boost ionic conductivity. Research efforts are currently focused on advancing materials for the battery’s three primary components: the electrolyte, anode, and cathode. Furthermore, innovative strategies are being developed to optimize the interfaces between these components, addressing key challenges in performance and durability. Cutting-edge manufacturing techniques are also being explored to improve production efficiency and reduce costs. With continued advancements, solid-state lithium-ion batteries are poised to become integral to next-generation technologies, including electric vehicles and wearable electronics. Full article

In the era of Industry 4.0, 3D printing, or additive manufacturing (AM), has revolutionized product design and manufacturing across various sectors. This review explores the evolution of 3D printing technology and its impact on industrial innovation, highlighting advancements in aeronautics, the automotive industry, and biomedicine. Various AM processes, such as binder jetting, direct energy deposition, and powder bed fusion, and materials like metals, polymers, ceramics, and composites, are discussed. Innovations like high-speed sintering, continuous liquid interface production, and bioprinting demonstrate ongoing advancements. The potential of 3D printing in personalized medical applications is emphasized due to its flexibility in geometry and materials. Despite progress, challenges like standardization, material quality, recycling, sustainability, and economic feasibility hinder widespread adoption. Overcoming these challenges is crucial for optimizing 3D printing technologies, ensuring high-quality, efficient, and affordable production. The review also addresses the future prospects of 4D and 5D printing technologies and their potential applications in various industries. This overview underscores 3D printing’s role in shaping the future of manufacturing within the context of Industry 5.0, emphasizing human–machine collaboration and sustainability. Full article

Foamed concrete is increasingly utilized in engineering due to its light weight, excellent thermal insulation, fire resistance, etc. However, its low strength has always been the most crucial factor limiting its large-scale application. This study introduced an innovative method to enhance the strength of foamed concrete by using nano-Al₂O₃ (NA) as a foam stabilizer. NA was introduced into a foaming agent containing sodium dodecyl sulfate (SDS) and hydroxypropyl methylcellulose (HPMC) to prepare a highly stable foam. This approach significantly improved the foam stability and the strength of foamed concrete. Its drainage volume, settlement distance, microstructure, and stabilizing action were investigated, along with the strength, microstructure, and hydration products of foamed concrete. The presence of NA effectively reduced the drainage volume and settlement distance of the foam. NA is distributed at the gas–liquid interface and within the liquid film to play a hindering role, increasing the thickness of the liquid film, delaying the liquid discharge rate from the liquid film, and hindering bubble aggregation, thereby enhancing foam stability. Additionally, due to the stabilizing effect of NA on the foam, the precast foam forms a fine and uniform pore structure in the hardened foamed concrete. At 28 d, the compressive strength of FC0 (0% NAs in foam) is 2.18 MPa, while that of FC3 (0.18% NAs in foam) is 3.90 MPa, increased by 79%. The reason for this is that NA promotes the formation of AFt, and its secondary hydration leads to the continuous consumption of Ca(OH)₂, resulting in a more complete hydration reaction. This study presents a novel method for significantly improving the performance of foamed concrete by incorporating NA. Full article

Intravaginal rings (IVRs) represent a well-established, woman-controlled and sustained vaginal drug delivery system suitable for a wide range of applications. Here, we sought to investigate the differences in etonogestrel (ENG) and ethinyl estradiol (EE) release from a 3D-printed IVR utilizing continuous liquid interface production (CLIP™) (referred to as CLIP_LOW for low drug loading and CLIP_HIGH IVRs for high drug loading) and NuvaRing, a commercially available injection molded IVR. We conducted in vitro release studies in simulated vaginal fluid to compare the release of ENG and EE from CLIP_LOW IVRs and NuvaRing. CLIP_LOW IVRs had a similar hormone dose to NuvaRing and exhibited slightly slower ENG release and greater EE release in vitro compared to NuvaRing. When administered to female sheep, NuvaRing demonstrated greater ENG/EE levels in plasma, vaginal tissue and vaginal fluids compared to CLIP_LOW IVR despite similar drug loadings. Leveraging observed hormones levels in sheep from NuvaRing as an effective contraceptive benchmark, we developed a long-acting CLIP_HIGH IVR with increased ENG and EE doses that demonstrated systemic and local hormone levels greater than the NuvaRing for 90 days in sheep. No signs of toxicity were noted regarding general health, colposcopy, or histological analysis in sheep after CLIP_HIGH IVR administration. Our results provided (1) a comparison of ENG and EE release between a 3D-printed IVR and NuvaRing in vitro and in vivo, (2) a preclinical pharmacokinetic benchmark for vaginally delivered ENG and EE and (3) the generation of a 90-day CLIP IVR that will be utilized in future work to support the development of a long-acting ENG/EE IVR combined with an antiretroviral for the prevention of HIV and unplanned pregnancy. Full article

High-purity copper is essential for fabricating advanced microelectronic devices, particularly integrated circuit interconnects. As the industry increasingly emphasizes scalable and efficient purification methods, this study investigates the multi-physics interactions during the semi-continuous directional solidification process, utilizing a Cu-1 wt.%Ag model alloy. Coupled simulation calculations examine the spatial distribution patterns of the impurity element silver (Ag) within semi-continuously solidified ingots under varying pulling rates and melt temperatures. The objective is to provide technical insights into the utilization of the semi-continuous directional solidification method for high-purity copper purification. The findings reveal that increasing the pulling rate and melt temperature leads to a downward shift in the solid–liquid interface relative to the mold top during processing. Alongside the primary clockwise vortex flow, a secondary weak vortex emerges near the solid–liquid interface, facilitating the migration of the impurity element Ag toward the central axis and amplifying radial impurity fluctuations. Furthermore, diverse pulling rates and melt temperature conditions unveil a consistent trend along the ingot’s height, which is characterized by an initial increase in average Ag content, followed by stabilization and then a rapid ascent during the late stage of solidification, with higher pulling rates and melt temperatures expediting this rapid ascent. Leveraging these insights, a validation experiment using 4N-grade recycled copper in a small-scale setup demonstrates the effectiveness of the semi-continuous directional solidification process for high-purity copper production, with copper samples extracted at 1/4 and 3/4 ingot heights achieving a 5N purity level of 99.9994 wt.% and 99.9993 wt.%, respectively. Full article

Understanding the phenomena that cause jet oscillations inside funnel-type thin-slab molds is essential for ensuring continuous liquid steel delivery, improving flow pattern control, and increasing plant productivity and the quality of the final product. This research aims to study the effect of the nozzle’s internal design on the fluid dynamics of the nozzle-mold system, focusing on suppressing vorticity generation below the nozzle’s tip. The optimized design of the nozzle forms the basis of the results obtained through numerical simulation. Mathematical modeling involves fundamental equations, the Reynolds Stress Model for turbulence, and the Multiphase Volume of Fluid model. The governing equations are discretized and solved using the implicit iterative-segregated method implemented in FLUENT^®. The main results demonstrate the possibility of controlling jet oscillations even at high casting speeds and deep dives. The proposed modification in the internal geometry of the nozzle is considered capable of modifying the flow pattern inside the mold. The geometric changes correspond with 106% more elongation than the original nozzle; the change is considered 17% of an inverted trapezoidal shape. Furthermore, there was a 2.5 mm increase in the lower part of both ports to compensate for the inverted trapezoidal shape. The newly designed SEN successfully eliminated the issue of jet oscillations inside the mold by effectively preventing the intertwining of the flow. This improvement is a significant upgrade over the original design. At the microscale, a delicate force balance occurs at the tip of the nozzle’s internal bifurcation, which is influenced by fluctuating speeds and ferrostatic pressure. Disrupting this force balance leads to increased oscillations, causing variations in the mass flow rate from one port to another. Consequently, the proposed nozzle optimization design effectively controls microscale fluctuations above this zone in conjunction with changes in flow speed, jet oscillation, and metal–slag interface instability. Full article

The widespread use of pharmaceuticals and personal care products (PPCPs) in many fields has brought convenience to human lives but has also caused unavoidable environmental pollution issues. In particular, the resistance gene problem resulting from accumulating antibiotics that cannot be fully absorbed by biological individuals has been a concern; thus, it is urgent to find efficient technologies to boost the degradation efficiency of antibiotics in the environment. Here, an ε-MnO₂ catalyst was prepared by a novel droplet-interface-drying method and utilized as a Fenton-like catalyst for efficiently degrading ciprofloxacin (CIP). The ε-MnO₂ shell was formed preferentially at the gas–liquid interface and then continued to decompose into ε-MnO₂ with abundant O vacancies in the air-insulated microcavity. The XPS result confirms that this particular preparation method can regulate the content of O vacancies in the material. Compared with ε-MnO₂ samples obtained by the direct drying method (ε-MnO₂-B), the catalytic performance of ε-MnO₂ prepared by the droplet-interface-drying method (ε-MnO₂-P) is significantly improved. By activating peroxymonosulfate (PMS) with the ε-MnO₂-P catalyst, the CIP degradation efficiency can reach 84.1%. The detection and analysis of reactive oxygen species (ROS) in the ε-MnO₂-P/PMS oxidation system confirms that ·OH, SO₄^·− and ¹O₂ are the main ROS for CIP degradation. This study highlights the creation of miniature hypoxic space to regulate the content of O vacancies in ε-MnO₂, providing a new idea for the synthesis of other O-vacancy-rich materials. Full article

Vat photopolymerization (VP), including stereolithography (SLA), digital light processing (DLP), and volumetric printing, employs UV or visible light to solidify cell-laden photoactive bioresin contained within a vat in a point-by-point, layer-by-layer, or volumetric manner. VP-based bioprinting has garnered substantial attention in both academia and industry due to its unprecedented control over printing resolution and accuracy, as well as its rapid printing speed. It holds tremendous potential for the fabrication of tissue- and organ-like structures in the field of regenerative medicine. This review summarizes the recent progress of VP in the fields of tissue engineering and regenerative medicine. First, it introduces the mechanism of photopolymerization, followed by an explanation of the printing technique and commonly used biomaterials. Furthermore, the application of VP-based bioprinting in tissue engineering was discussed. Finally, the challenges facing VP-based bioprinting are discussed, and the future trends in VP-based bioprinting are projected. Full article

Steel is mainly produced through continuous casting; molten steel flows into the mold from the tundish, where it cools and then enters the secondary cooling zone, ultimately solidifying into a billet. During the continuous casting production process, the quality of the casting billet is mainly related to the lubrication state of the coated slag. In the upper part of the mold, the consumption of liquid protective slag directly affects the friction state of the initial solidified billet shell. Therefore, the flow and fluctuation characteristics of coated slag in the meniscus area are very important. There is limited research on the flow and fluctuation characteristics of coated slag in the meniscus area, and little consideration has been given to the shape of the meniscus. In this work, a two-dimensional numerical model for the flow and fluctuation of coated slag in the meniscus region was established, and the transient flow velocity of protective slag and molten steel at each moment of the vibration cycle was obtained, as well as the fluctuation of the slag/steel interface in the meniscus region. The results show that when the surface mold vibrated upwards, the protective slag in the meniscus area flowed clockwise. When the mold moved downwards, the protective slag in the slag pool generated a counterclockwise flow vortex. When the mold was in a positive slip state, the negative pressure formed by the upward flow of the protective slag on the meniscus and the inertia force of steel liquid pushed the meniscus toward the inner wall of the mold. During negative slip, the flow of coated slag generated positive pressure on the slag/steel interface, pushing the meniscus toward the steel liquid, and at the initial moment of negative slip, the steel liquid overflowed into the slag channel. This model could provide a theoretical basis for the flow control of protective slag. Full article

Polypropylene (PP) melt-blown (MB) filter cartridges are widely used in many fields requiring water purification, such as households, the food industry, industrial processes, and recycled water filtration. While the demand for filters has gradually increased, the environmental requirements and conditions have become severe. The filters are easily deformed from higher liquid pressure during operation and setup and need to be replaced frequently. With the lifetime of filters shortened, manpower increases to replace filters. Hence, the inner structure of a PP melt-blown filter cartridge is supported by a frame structure to resist higher liquid pressure for enhancing filtration efficiency and lifetime. The filter, known as a “frame-type melt-blown filter cartridge”, does not affect the user’s application environment and equipment. This article focuses on developing continuous production equipment for frame-type melt-blown filter cartridges. The core technology of the equipment is the mechanism design for conveying frame tubes integrated with the MB process. The PP fiber is simultaneously melted and blown on the frame tube, and the frame tube needs to be pushed forward while rotating. This mechanism can independently control the fiber’s rotational speed and push speed. The rotational speed affects the surface density, fiber diameter, and porosity of the melt-blown filter cartridge, and the push speed affects the core diameter and weight of the melt-blown filter cartridge. In addition, there is a frame tube feeding device at the input end of the conveying equipment for continuously carrying the frame tube. Then, the finally formed melt-blown filter cartridges enter the cutting machine to trim a certain length to complete a frame-type melt-blown filter cartridge. The complexity of the operation is simplified by a human–machine interactive interface. A programmable logic controller (PLC) and a LabVIEW human–machine interactive interface are used to dominate the equipment. The Modbus communication protocol is adopted for connecting and communicating between PLC and LabVIEW. The interface can integrate and analyze the process data, including overall equipment effectiveness (OEE), total effective equipment performance (TEEP), loading time, utilization, performance, and yield. The entire production process of the frame-type melt-blown filter cartridge is optimized, and the traditional output of 1000 per day is upgraded to 1300. Overall, the processing speed is increased by up to 30%. Full article

Water displacing oil is one of the main emptying methods for mobile pipelines. It has the advantages of being a simple process and highly safe. At present, the determination of a water displacing oil scheme of mobile pipelines is based on the oil–oil alternating transport theory of product oil pipelines. However, the insolubility of the oil phase and the water phase results in a great difference between the flow characteristics of water displacing oil and the oil–oil alternating transport of a product oil pipeline. In addition, due to the effect of buoyancy, the oil phase gathers at the high point of the pipeline and forms a liquid accumulation, which is difficult to carry away by water flow, resulting in the low emptying efficiency of the mobile pipeline. The essence of water displacing oil in a mobile pipeline is an oil–water two-phase unsteady displacement flow, involving liquid–liquid displacement flow, oil–water two-phase flow and water carrying oil. Aiming at such problems, domestic and foreign scholars have carried out a large number of theoretical and experimental studies, established the oil–water mixing model of water displacing oil and the relationship between macroscopic quantity (flow pattern, pressure drop and water content) and microscopic quantity (local flow field and droplet dispersion pattern, etc.) under each flow type, and explored the influence of pipeline diameter, oil phase velocity, pipeline inclination angle and other parameters on the capacity of carrying liquid accumulation. On this basis, this paper analyzes the shortcomings of the current research on the oil–water flow characteristics of water displacing oil in a mobile pipeline from three aspects: the formation mechanism of the oil–water mixture, displacing flow characteristics of immiscible fluids and flow characteristics of water carrying oil. Five future research directions are proposed, including the interface morphology and flow field characteristics of oil–water two-phase layered flow, local mixing characteristics of an oil–water two-phase dual continuous flow interface, droplet distribution and flow characteristics of oil–water two-phase dispersed flow, unsteady flow characteristics of the oil–water mixture of water displacing oil and oil accumulation and flow characteristics in topographic relief pipes. Full article