Search Results (114)

Change point models are widely used in medical and epidemiological studies to capture the threshold effects of continuous covariates on health outcomes. These threshold effects represent critical points at which the relationship between biomarkers or risk factors and disease risk shifts, often reflecting underlying biological mechanisms or clinically relevant intervention points. While most existing methods focus on right-censored data, interval censoring is common in large-scale clinical trials and follow-up studies, where the exact event times are not observed but are known to fall within time intervals. In this paper, we propose a semiparametric transformation model with an unknown change point for interval-censored data. The model allows flexible transformation functions, including the proportional hazards and proportional odds models, and it accommodates both main effects and their interactions with the threshold variable. Model parameters are estimated via the EM algorithm, with the change point identified through a profile likelihood approach using grid search. We establish the asymptotic properties of the proposed estimators and evaluate their finite-sample performance through extensive simulations, showing good accuracy and coverage properties. The method is further illustrated through an application to the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial data. Full article

Over the past decade, the Chongqing land ticket model has played a pivotal role in the market-oriented reform of rural land factors and serves as a representative practice of the TDR program in China. This paper constructs a systematic evaluation framework from two perspectives—policy effectiveness and citizen feedback—to comprehensively understand the policy effect of this model. The study employs methods of policy texts bibliometrics and content analysis based on big data. The results indicate that the effectiveness of land ticket policies exhibit significant fluctuations, with peaks aligning with milestones in the model’s development. Policy measures are well-aligned with the goals set forth. However, policymakers in Chongqing have historically focused more on institutional construction within the land ticket model, only recently shifting attention to the protection of farmers’ rights and interests. This imbalance may have led to potential risks regarding the loss of farmers’ property rights. The analysis of citizen feedback from the online space further took into account the impact of policy content on its audience (farmers), revealing that shortening the compensation payment time rather than increasing the compensation amount is the most common and critical demand among farmers. This underscores the urgent need for a policy-related response from the government to meet farmer’s demands for “procedural justice”. Our conclusions address a gap in the existing literature by integrating policy text analysis with public opinion, thereby offering referential insights into understanding the evolutionary process, policy features, and implementation effects of TDR program in China. Full article

The paper considers one of the possible statements of inverse problems in gravimetric and magnetometric remote sensing, proposes a new approach to its solution and formulates algorithms that implement this approach. The problem under consideration consists of finding hypothetical sources of the corresponding potential fields at a given depth based on these fields measured on the Earth’s surface. The problem is reduced to solving systems of linear algebraic equations (SLAE) with ill-conditioned matrices. The proposed approach to the numerical solution is based on improving the condition number of the SLAE’s matrix. A numerical algorithm implementing the proposed approach that is applicable to the stable solution of degenerate and ill-conditioned SLAEs with an approximately given right-hand side is formulated in general form. The algorithm uses the SVD decomposition of the SLAE’s matrix and constructs a new matrix close to the original one with a better (smaller) condition number. An approximate solution to the original SLAE is calculated using the pseudoinverse of the new matrix. The results of a theoretical study of the algorithm are presented and the main properties of the new matrix are given. In particular, the reduction of its condition number is estimated. Several implementations of this algorithm are considered, in particular, the MPMI method, which is based on the use of so-called minimal pseudoinverse matrices. For the model problem, the advantage of the MPMI method over a number of other common methods is shown. The MPMI method is applied to solve the considered problems of gravity exploration and magnetic exploration both in the separate solution of these inverse problems and in their joint solution when processing geophysical data for the Kathu region, in the Northern Cape area of South Africa. Full article

Heritage conservation projects involve diverse stakeholders, such as property owners, communities, NGOs, and governments, whose “misaligned” incentives produce high transaction costs and often pose persistent challenges. Considering heritage sites as analogous to common pool resources (CPR), this study examines whether sustainable heritage projects adhere to Elinor Ostrom’s design principles for managing CPRs. The UNESCO Asia-Pacific Awards for Cultural Heritage Conservation are used as a benchmark to identify best practices in private–public collaborations over the past two decades. Through content analysis of award application dossiers, the researchers assess whether the design principles are applied differently between successful and unsuccessful projects and evaluate the sufficiency of Ostrom’s principles in the heritage conservation context. The findings indicate that four design principles are more consistently balanced in award-winning projects: “Collective Choice Arrangements”, “Congruence with Local Conditions”, “Monitoring Mechanisms”, and “Minimum Recognition of Rights”. Additionally, successful projects tend to incorporate “people growth-oriented activities”, such as skills training and education for local workers and youth, benefiting current and future project beneficiaries. These insights suggest that adapting Ostrom’s design principles can enhance the sustainability of heritage conservation efforts by better aligning stakeholder incentives and addressing the “misalignment of incentives” challenge commonly encountered in such projects. Full article

Background/objectives: Common carotid artery occlusion can cause oxidant and inflammatory damage to the optic nerve. In this study, the effect of sunitinib was investigated, the antioxidant and anti-inflammatory properties of which have been previously reported and shown to be protective in I/R injury and in preventing bilateral optic nerve ischemia–reperfusion (I/R) injuries after unilateral common carotid artery ligation in rats. Methods: In this study, 18 Albino Wistar male rats were divided into SG (sham-operated), CCU (clamping and unclamping), and SCCU (sunitinib + clamping and unclamping) groups. One hour before the surgical procedures, sunitinib (25 mg/kg, oral) was given to SCCU rats. Anesthesia was induced with ketamine (60 mg/kg, ip) and sevoflurane. The right common carotid arteries of all rats were accessed under anesthesia. While the skin opened in SG rats was closed with sutures, the right common carotid arteries of CCU and SCCU rats were clipped, and an ischemia period was created for 10 min. Then, reperfusion (6 h) was achieved by unclipping. After euthanasia with ketamine (120 mg/kg, intraperitoneally), the right and left optic nerves of the rats were removed and examined biochemically and histopathologically. Results: Malondialdehyde, tumor necrosis factor α, interleukin-1β, and interleukin-6 were increased, and total glutathione levels had decreased in both ipsilateral and contralateral optic nerves (p < 0.05). These changes were more prominent on the ipsilateral side. Similarly, histopathological damage was observed to be more on the ipsilateral side (p < 0.05). Biochemical and histopathological changes were significantly suppressed in rats receiving sunitinib treatment (p < 0.05). Conclusions: Sunitinib may protect optic nerve tissue against I/R injury by reducing oxidative stress and inflammation. Full article

In recent years, the internet has developed rapidly. With the popularity of social media, uploading and backing up digital images has become the norm. A huge number of digital images are circulating on the internet daily, and issues related to information security follow. To protect intellectual property rights, digital watermarking is an indispensable technology. However, the common lossy compression technology in the network transmission process is a big problem for watermarking. This paper describes an innovative semi-blind watermarking method with the use of deep convolutional generative adversarial networks (DCGANs) for hiding and extracting watermarks from JPEG-compressed images. The proposed method achieves an average peak signal-to-noise ratio (PSNR) of 49.99 dB, a structural similarity index (SSIM) of 0.95, and a bit error rate (BER) of 0.008 across varying JPEG quality factors. The process is based on an embedder, decoder, generator, and discriminator. It allows watermarking, decoding, or reconstruction to be symmetric such that there is less distortion and durability is improved. It constructs a specific generator for each image and watermark that is supposed to be protected. Experimental results show that, with the variety of JPEG quality factors, the restored watermark achieves a remarkably low corrupted rate, outstripping recent deep learning-based watermarking methods. Full article

Background: Gestational diabetes mellitus (GDM) is the most common complication in pregnancy, representing a serious risk for the mother and fetus. Identifying new biomarkers to ameliorate the screening and improving GDM diagnosis and treatment is crucial. During the last decade, a few studies have used speckle tracking echocardiography (STE) for assessing the myocardial deformation properties of fetuses (FGDM) and infants (IGDM) of GDM women, providing not univocal results. Accordingly, we performed a meta-analysis to examine the overall influence of GDM on left ventricular (LV) and right ventricular (RV) global longitudinal strain (GLS) in both FGDM and IGDM. Methods: All echocardiographic studies assessing conventional echoDoppler parameters and biventricular strain indices in FGDM and IGDM vs. infants born to healthy pregnant women, selected from PubMed and EMBASE databases, were included. The studies performed on FGDM and IGDM were separately analyzed. The subtotal and overall standardized mean differences (SMDs) in LV-GLS and RV-GLS in FGDM and IGDM studies were calculated using the random-effect model. Results: The full texts of 18 studies with 1046 babies (72.5% fetuses) born to GDM women and 1573 babies of women with uncomplicated pregnancy (84.5% fetuses) were analyzed. Compared to controls, FGDM/IGDM were found with a significant reduction in both LV-GLS [average value −18.8% (range −11.6, −24.2%) vs. −21.5% (range −11.8, −28%), p < 0.05)] and RV-GLS [average value −19.7% (range −13.7, −26.6%) vs. −22.4% (range −15.5, −32.6%), p <0.05)]. Large SMDs were obtained for both LV-GLS and RV-GLS studies, with an overall SMD of −0.91 (95%CI −1.23, −0.60, p < 0.001) and −0.82 (95%CI −1.13, −0.51, p < 0.001), respectively. Substantial heterogeneity was detected for both LV-GLS and RV-GLS studies, with an overall I² statistic value of 92.0% and 89.3%, respectively (both p < 0.001). Egger’s test gave a p-value of 0.10 for LV-GLS studies and 0.78 for RV-GLS studies, indicating no publication bias. In the meta-regression analysis, none of the moderators (gestational age, maternal age, maternal body mass index, maternal glycosylated hemoglobin, white ethnicity, GDM criteria, ultrasound system, frame rate, FGDM/IGDM heart rate, and anti-diabetic treatment) were significantly associated with effect modification in both groups of studies (all p > 0.05). The sensitivity analysis supported the robustness of the results. Conclusions: GDM is independently associated with biventricular strain impairment in fetuses and infants of gestational diabetic mothers. STE analysis may allow for the early detection of subclinical myocardial dysfunction in FGDM/IGDM. Full article

In China’s rural areas, as populations flow into cities, dependence on land has significantly decreased, leading to widespread land abandonment; however, the relationship between population and land in pastoral areas differs. This study conducted a five-year tracking survey on Sunite Right Banner in Xilingol League (Inner Mongolia), where macro data and in-depth home interviews were used for the mechanisms’ analysis. The findings demonstrate that the pastoral regions’ ecological pressure has increased with population immigration. There are several factors influencing such interaction between people and rangeland: First is the cost mechanism. The increasing cost of livestock production leads herders to increase their reliance on grazing rental systems to increase the number of livestock. The grazing rental system generates income for those migrating to adjacent urban regions. Second is the institutional mechanism. The “three-separating property right systems”, a recent rural land institutional reform policy, has marketized rural individualized rangelands, leading herders to focus more on the exchange value of rangelands rather than the use value, including ecological functions. Consequently, both lessors and lessees engage in high-intensity utilization of their individualized grazing lands. Third is the natural mechanism. Climate fluctuations influence herders’ migration patterns, prompting them to leave and return to grazing lands. These ecological dynamics force herders to oscillate between survival and development, intensifying pressure on the grasslands during favorable years and preventing them from recovering while increasing the occurrence of poor years, such as droughts. Fourth is the consumption mechanism. Herders who have migrated to urban regions must continue relying on rangeland resources to sustain their livelihoods. However, lower economic outputs of livestock production hardly catch up with the higher consumption levels in urban regions, which leads migrated herders to increase their pressure on rural rangelands. The final factor is a combination of the previous four mechanisms. The interplay between these previously mentioned four mechanisms encouraged higher herder population outflow, though their reliance on rangeland resources has continued. Based on the results, we argue that these dynamic relations between rural population change and land use patterns are becoming common issues across pastoral regions in Inner Mongolia, demanding innovative solutions. Full article

Background/Objectives: Urinary tract infections (UTIs) are infections that involve the urethra, bladder, and, in much more severe cases, even kidneys. These infections represent one of the most common diseases worldwide. Various pathogens are responsible for this condition, the most common being Escherichia coli (E. coli). Bromelain is a proteolytic complex obtained from the stem and stalk of Ananas comosus (L.) Merr. showing several beneficial activities. In addition to bromelain, N-acetylcysteine (NAC) has also been used. Methods: The purpose of this experiment was to evaluate the antibacterial, anti-motility, and anti-biofilm effects of a new polyenzymatic complex (DIF17BRO^®) in combination with NAC (the Formulation) on various strains of E. coli isolated from patients with UTIs. Subsequently, the anti-inflammatory and antioxidant effects of the Formulation were studied in an ex vivo model of cystitis, using bladder samples from mice exposed to E. coli lipopolysaccharide (LPS). Results: Our results showed that the Formulation significantly affects the capability of bacteria to form biofilm and reduces the bacteria amount in the mature biofilm. Moreover, it combines the interesting properties of NAC and a polyenzyme plant complex based on bromelain in a right dose to affect the E. coli adhesion capability. Finally, the Formulation exhibited protective effects, as confirmed by the inhibitory activities on multiple inflammatory and oxidative stress-related pathways on bladder specimens exposed to LPS. Conclusions: This blend of active compounds could represent a promising and versatile approach to use to overcome the limitations associated with conventional therapies. Full article

Climate change poses significant threats to coffee supply chains, highlighting the crucial role of coffee genetic resources in enhancing resilience and improving the livelihoods of coffee farmers. Increasing climate change effects are intensifying pressure to develop new high-performance resilient varieties. Current cultivated coffee species include Coffea arabica and C. canephora, while uncultivated genetic resources include C. stenophylla, C. racemosa, and many others among the 130 known coffee species. To protect and recognize the property rights of countries and people hosting and conserving genetic resources, the international community has developed regulations embodied in the Plant Treaty and the Nagoya Protocol, among others. The majority of coffee genetic resources originate in Africa and are maintained in large field collections, particularly in Côte d’Ivoire, Ethiopia, and Madagascar. The 2023 International Coffee Convention (ICC) highlighted the need for community awareness in applying these international regulations. To foster a common understanding and establish precise rules for exchanging coffee genetic resources, the Crop Trust and the International Coffee Organization organized an invitation-only satellite workshop in Mannheim, Germany, on 16 October 2024, in connection with ICC 2024. International experts on the Nagoya Protocol and Plant Treaty and genebank experts were invited to participate. This presentation summarizes key outcomes from the workshop, covering topics such as (i) key requirements of the Convention on Biological Diversity (CBD), its Nagoya Protocol, and the Plant Treaty specifically applicable to the coffee sector; (ii) assessment of the coffee sector’s readiness to implement these international regulations for the transparent use and exchange of coffee genetic resources; (iii) suggestions for mechanisms enabling transparent use and exchange of coffee genetic resources in compliance with international regulations; (iv) evaluation of strategies for generating benefits for communities hosting coffee genetic resources; (v) a practical, user-friendly checklist to ensure the correct handling of coffee genetic resources in line with international regulations; and (vi) a practical decision-making tree with examples to differentiate genetic resources falling under Nagoya/CBD and the Plant Treaty from others. The workshop’s discussions and outcomes expanded on these topics, yielding several concrete initiatives and recommendations. Most importantly, the workshop identified critical gaps in existing coffee genetic resource collections and proposed a global safety duplication strategy. Participants conceptualized a global platform to facilitate the exchange and use of coffee genetic resources, including a centralized database and a system for tracking benefit-sharing obligations. A comprehensive list categorizing coffee varieties based on their status under the Nagoya Protocol may be initiated to clarify access and benefit-sharing requirements. The workshop concluded with a clear roadmap for advancing coffee genetic resource conservation and exchange. Full article

Humanity faces numerous deeply interconnected systemic risks to sustainability—a global polycrisis. We need economic institutions that produce the knowledge required to address this polycrisis at the lowest cost, maximize the benefits that knowledge generates, and distribute those benefits fairly. Knowledge improves through use; its value is maximized when it is freely available. Intellectual property rights (IPRs), a form of monopoly, direct knowledge production towards market goods, raise the cost of doing research, and reduce the benefits by price-rationing access. Building on theories of the commons, the anticommons, and market failures, we propose the creation of a transnational green knowledge commons (TGKC) in which all knowledge that contributes to solving the polycrisis be made open access on the condition that any subsequent improvements also be open access. We argue that a TGKC is more sustainable, just, and efficient than restrictive IPRs and well suited to the motivations and governance institutions of public universities. We show how a single university could initiate the process and estimate that the cost would be more than offset by reduced IPR expenses. A TGKC would reduce the costs of generating and disseminating knowledge directed towards a sustainable future and help stimulate the transnational cooperation, reciprocity, and trust required for sustainable management of the global biophysical commons. Full article

Aims: Atrial fibrillation (AF) is the most common chronic/recurrent arrhythmia, which significantly impairs quality of life and increases cardiovascular morbidity and mortality. Therefore, the aim of the present study was to investigate the properties of three repolarizing potassium currents which were shown to contribute to AF-induced electrical remodeling, i.e., the transient outward (I_to), inward rectifier (I_K1) and acetylcholine-sensitive (I_K,ACh) potassium currents in isolated atrial myocytes obtained from dogs either with sinus rhythm (SR) or following chronic atrial tachypacing (400/min)-induced AF. Methods: Atrial remodeling and AF were induced by chronic (4–6 weeks of) right atrial tachypacing (400/min) in dogs. Transmembrane ionic currents were measured by applying the whole-cell patch-clamp technique at 37 °C. Results: The I_to current was slightly downregulated in AF cells when compared with that recorded in SR cells. This downregulation was also associated with slowed inactivation kinetics. The I_K1 current was found to be larger in AF cells; however, this upregulation was not statistically significant in the voltage range corresponding with atrial action potential (−80 mV to 0 mV). I_K,ACh was activated by the cholinergic agonist carbachol (CCh; 2 µM). In SR, CCh activated a large current either in inward or outward directions. The selective I_K,ACh inhibitor tertiapin (10 nM) blocked the outward CCh-induced current by 61%. In atrial cardiomyocytes isolated from dogs with AF, the presence of a constitutively active I_K,ACh was observed, blocked by 59% with 10 nM tertiapin. However, in “AF atrial myocytes”, CCh activated an additional, significant ligand-dependent and tertiapin-sensitive I_K,ACh current. Conclusions: In our dog AF model, I_to unlike in humans was downregulated only in a slight manner. Due to its slow inactivation kinetics, it seems that I_to may play a more significant role in atrial repolarization than in ventricular working muscle myocytes. The presence of the constitutively active I_K,ACh in atrial myocytes from AF dogs shows that electrical remodeling truly developed in this model. The I_K,ACh current (both ligand-dependent and constitutively active) seems to play a significant role in canine atrial electrical remodeling and may be a promising atrial selective drug target for suppressing AF. Full article

The energy transition involves transforming electricity supply systems. Smart grids are resilient, polycentric systems consisting of integrated, self-governed Microgrids including distributed energy systems (DES). Renewable energy requires high numbers and a huge variety of infrastructures, requiring large amounts of spaces, including land. Renewable energy flows and land are natural resources. This analysis applies Ostrom’s common pool resources (CPR) theory on the sustainable use of ecosystems and natural resources to explore DES as a “common good” with spaces and land as crucial scarce resources. Currently, electricity grids are monocultures with highly centralized and hierarchical governance structures, where the juxtaposition of electricity as public and private good is considered self-evident. The emergence of DES in smart Microgrids is disrupting these monocultures, which is one aspect of the full transformation from current centralized grids towards resilient, integrated Microgrids based on variety and adaptive capacity. The other component of the transformation concerns the essential resource of space. As land and other spaces, such as rooftops, are subject to diverse property regimes, CPR is also applicable for analyzing the required changes in property rights and land-use decision-making. Such changes are necessary to make sufficient space available for the infrastructures of community Microgrids. Full article

Agriculture is one of the most culturally and economically important livelihood activities of the Ganges River Delta. In recent years, coastal communities have experienced longer dry seasons and salinity intrusion, which is exacerbated by registration errors in land tenure that have led to increasing encroachment by external interests in the Dacope sub-district of Bangladesh. These challenges threaten to undermine the sustainability of smallholder access to canals that are collectively managed as common-pool resources (CPR). This paper explores how identity and collective action may empower farmers to secure irrigation access in the face of external pressures. Drawing primarily on qualitative data collected through focus group discussions with farmers in Dacope, our findings reveal that identity serves as a powerful force driving collective action and the sustainability of the agricultural community. A shared occupational identity fosters a sense of belonging and collective responsibility among farmers to maintain water flow through construction, annual dredging, and temporary dry-season protections. However, despite a strong commitment to maintaining their irrigation system, challenges remain in farmers’ ability to combat the powerful interests of wealthier members of the community that threaten to undermine the viability of the irrigation commons. Thus, formal support through policy and legislative avenues is also necessary to safeguard common property rights against the threat of privatization and illegal occupation of canals. These findings further underscore the need for more research on how collective identity may strengthen collective action, livelihoods, and sustainability in the absence of strong institutional arrangements that uphold community rights and access to common-pool resources. Full article

Forward head posture (FHP) is a common postural problem experienced by most people. However, its effect on brain activity is still unknown. Accordingly, we aimed to observe changes in brain waves at rest to determine the effect of FHP on the nervous systems. A total of 33 computer users (Male = 17; Female = 16; age = 22.18 ± 1.88) were examined in both FHP and neutral posture. For each session, brain waves were measured for 5 min, and then muscle mechanical properties and cranio-vertebral angle (CVA) were measured. Changes in brain waves between the neutral posture and FHP were prominent in gamma waves. A notable increase was confirmed in the frontal and parietal lobes. That is, eight channels in the frontal lobe and all channels in the parietal lobe showed a significant increase in FHP compared to neutral posture. Additionally, FHP changes were associated with a decrease in CVA (p < 0.001), an increase in levator scapulae tone (Right, p = 0.014; Left, p = 0.001), and an increase in right sternocleidomastoid stiffness (p = 0.002), and a decrease in platysma elasticity (Right, p = 0.039; Left, p = 0.017). The change in CVA was found to have a negative correlation with the gamma activity (P7, p = 0.044; P8, p = 0.004). Therefore, increased gamma wave activity in FHP appears to be related to CVA decrease due to external force that was applied to the nervous system and cervical spine. Full article